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The map label for this gene is moeA-1 [H]

Identifier: 197117737

GI number: 197117737

Start: 1555128

End: 1556351

Strand: Reverse

Name: moeA-1 [H]

Synonym: Gbem_1349

Alternate gene names: 197117737

Gene position: 1556351-1555128 (Counterclockwise)

Preceding gene: 197117738

Following gene: 197117736

Centisome position: 33.72

GC content: 65.44

Gene sequence:

>1224_bases
ATGCCAAGCTTTGAAGAAGCACGCGATATCATCCTGGCCAACGTGCACCCCCTGGGAGAAGAGATGGTTCCCCTCCTGGA
GGCCGTGGGCCGGGTGGTGAAACGGGACGTCGTCGCCCCCTGGGACCTGCCTCAGTTCGACAATTCCGCCATGGACGGCT
TCGCCGTTCGCGCCGCTAATTGCAGCAAGGTTCCGGCGGAGCTTAGCGTCACAGGGTTCCTGCCGGCCGGCGGTGACGGG
CCGGCCGCACTAGAGACAGGGTGCGCGGTACGCATCATGACCGGCGCCCCTATTCCCCCAGGATGCAACGCGGTGGTCCC
CATTGAAGAAACCGAGGAGATGGGCGACCGTGTGGTGATCCGGCAGAAAGTGCAGCCGCGGCAACACATCCGGCATCAAG
GTTCCGACGTCGCGGCGGGAGCGCCGATCCTGGAGGCCGGCACCACGGTACGCCCCGCCGAAATCGGCATGCTGGCGGCC
ATGGGGCAGGCGCTGGTCCCGGTCCACAGAAAGGTCCGCGTGGCGATACTTTCCACAGGCGACGAGCTGATTGAATTGGG
CGAAGCCCCGTCCCCCGGGCGGGTGATAAACTCCAACGCCCTCTCGCTTGCCGCCGCCGTGCGCGAGGCGGGAGCCGAGC
CGGTGCTGCTGGGGATCGCCAGGGACGACATCGAGAGCCACCGGGAGAAGATACAGCAGGGGTTCCGGTTCGACGCCCTG
ATCACCTCGGCCGGAGTATCGGCTGGAGACCGCGACCTGGTCCGGGAAGTTCTGGCAGAGCTCGGGGCGCAGGAGCAGTT
CTGGAAGGTCGCCATGAAGCCCGGCGGCCCGACCGCATTCGCCCTCCAGGATGGAAGGCCCGTCTTCTCGCTTCCCGGCA
ACCCCGTGTCCACCATGATCACCTTCGAACTGCTGGTCAAACCCGCGCTCTTGAAGATGATGGGCTACCGGAAGGTGGTG
CGCCCGTTCATGAAGGGGATACTGGCGGAGGATGCCCACAAGAAGGAAGGAAAGACCCACTTCATCCGGGTCACCGTCAA
GAAGAGGCATGGCCGCTACGTCGCCTACTGCGCCGGAGACCAGCACACCGCAATACTGAGCACCATGACCAGGTGCGACG
GGCTCGCCGCCCTCCCCTCCGAGGCCACCTTCGTCCCGGCAGGAAGCGAGGTCGATCTGGTCCTCTTGAGGGACGTGGAG
CTGGTGCCGGAAACCACCTCGTAG

Upstream 100 bases:

>100_bases
ACGTTCCCGTGATTTCCCGTGATTTCCCGGAGGAGCCTTGAGGGAGAGGGAGAGCTGGAAATAGGCGCGAACTCCGCCTG
AGAGAAACGCGAGGTATCAA

Downstream 100 bases:

>100_bases
CCGCAGGCGAAACAGGAGAAACCATGTTCAACCACTTCGACGAGCAGGGACAGGCCATCATGGTCGACGTGAGCGGCAAA
ACCTGCACGCTCAGGACCGC

Product: molybdopterin--molybdenum ligase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MPSFEEARDIILANVHPLGEEMVPLLEAVGRVVKRDVVAPWDLPQFDNSAMDGFAVRAANCSKVPAELSVTGFLPAGGDG
PAALETGCAVRIMTGAPIPPGCNAVVPIEETEEMGDRVVIRQKVQPRQHIRHQGSDVAAGAPILEAGTTVRPAEIGMLAA
MGQALVPVHRKVRVAILSTGDELIELGEAPSPGRVINSNALSLAAAVREAGAEPVLLGIARDDIESHREKIQQGFRFDAL
ITSAGVSAGDRDLVREVLAELGAQEQFWKVAMKPGGPTAFALQDGRPVFSLPGNPVSTMITFELLVKPALLKMMGYRKVV
RPFMKGILAEDAHKKEGKTHFIRVTVKKRHGRYVAYCAGDQHTAILSTMTRCDGLAALPSEATFVPAGSEVDLVLLRDVE
LVPETTS

Sequences:

>Translated_407_residues
MPSFEEARDIILANVHPLGEEMVPLLEAVGRVVKRDVVAPWDLPQFDNSAMDGFAVRAANCSKVPAELSVTGFLPAGGDG
PAALETGCAVRIMTGAPIPPGCNAVVPIEETEEMGDRVVIRQKVQPRQHIRHQGSDVAAGAPILEAGTTVRPAEIGMLAA
MGQALVPVHRKVRVAILSTGDELIELGEAPSPGRVINSNALSLAAAVREAGAEPVLLGIARDDIESHREKIQQGFRFDAL
ITSAGVSAGDRDLVREVLAELGAQEQFWKVAMKPGGPTAFALQDGRPVFSLPGNPVSTMITFELLVKPALLKMMGYRKVV
RPFMKGILAEDAHKKEGKTHFIRVTVKKRHGRYVAYCAGDQHTAILSTMTRCDGLAALPSEATFVPAGSEVDLVLLRDVE
LVPETTS
>Mature_406_residues
PSFEEARDIILANVHPLGEEMVPLLEAVGRVVKRDVVAPWDLPQFDNSAMDGFAVRAANCSKVPAELSVTGFLPAGGDGP
AALETGCAVRIMTGAPIPPGCNAVVPIEETEEMGDRVVIRQKVQPRQHIRHQGSDVAAGAPILEAGTTVRPAEIGMLAAM
GQALVPVHRKVRVAILSTGDELIELGEAPSPGRVINSNALSLAAAVREAGAEPVLLGIARDDIESHREKIQQGFRFDALI
TSAGVSAGDRDLVREVLAELGAQEQFWKVAMKPGGPTAFALQDGRPVFSLPGNPVSTMITFELLVKPALLKMMGYRKVVR
PFMKGILAEDAHKKEGKTHFIRVTVKKRHGRYVAYCAGDQHTAILSTMTRCDGLAALPSEATFVPAGSEVDLVLLRDVEL
VPETTS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=35.5163727959698, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=35.5163727959698, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1787049, Length=375, Percent_Identity=40, Blast_Score=234, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI25147659, Length=416, Percent_Identity=30.0480769230769, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=359, Percent_Identity=25.6267409470752, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=364, Percent_Identity=29.6703296703297, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24638841, Length=364, Percent_Identity=29.6703296703297, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43442; Mature: 43311

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFEEARDIILANVHPLGEEMVPLLEAVGRVVKRDVVAPWDLPQFDNSAMDGFAVRAAN
CCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECC
CSKVPAELSVTGFLPAGGDGPAALETGCAVRIMTGAPIPPGCNAVVPIEETEEMGDRVVI
CCCCCCCEEEEEECCCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHCCCEEEE
RQKVQPRQHIRHQGSDVAAGAPILEAGTTVRPAEIGMLAAMGQALVPVHRKVRVAILSTG
HHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DELIELGEAPSPGRVINSNALSLAAAVREAGAEPVLLGIARDDIESHREKIQQGFRFDAL
HHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCHHHH
ITSAGVSAGDRDLVREVLAELGAQEQFWKVAMKPGGPTAFALQDGRPVFSLPGNPVSTMI
HHHCCCCCCCHHHHHHHHHHCCCCCHHHEEEECCCCCEEEEEECCCEEEECCCCCHHHHH
TFELLVKPALLKMMGYRKVVRPFMKGILAEDAHKKEGKTHFIRVTVKKRHGRYVAYCAGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEEEEECCCCEEEEEECC
QHTAILSTMTRCDGLAALPSEATFVPAGSEVDLVLLRDVELVPETTS
CCHHHHHHHHHCCCCEECCCCCEEECCCCCEEEEEEECCEECCCCCC
>Mature Secondary Structure 
PSFEEARDIILANVHPLGEEMVPLLEAVGRVVKRDVVAPWDLPQFDNSAMDGFAVRAAN
CCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECC
CSKVPAELSVTGFLPAGGDGPAALETGCAVRIMTGAPIPPGCNAVVPIEETEEMGDRVVI
CCCCCCCEEEEEECCCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHCCCEEEE
RQKVQPRQHIRHQGSDVAAGAPILEAGTTVRPAEIGMLAAMGQALVPVHRKVRVAILSTG
HHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DELIELGEAPSPGRVINSNALSLAAAVREAGAEPVLLGIARDDIESHREKIQQGFRFDAL
HHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCHHHH
ITSAGVSAGDRDLVREVLAELGAQEQFWKVAMKPGGPTAFALQDGRPVFSLPGNPVSTMI
HHHCCCCCCCHHHHHHHHHHCCCCCHHHEEEECCCCCEEEEEECCCEEEECCCCCHHHHH
TFELLVKPALLKMMGYRKVVRPFMKGILAEDAHKKEGKTHFIRVTVKKRHGRYVAYCAGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEEEEECCCCEEEEEECC
QHTAILSTMTRCDGLAALPSEATFVPAGSEVDLVLLRDVELVPETTS
CCHHHHHHHHHCCCCEECCCCCEEECCCCCEEEEEEECCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]