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The map label for this gene is dxs-2 [H]

Identifier: 197117646

GI number: 197117646

Start: 1454307

End: 1456247

Strand: Direct

Name: dxs-2 [H]

Synonym: Gbem_1258

Alternate gene names: 197117646

Gene position: 1454307-1456247 (Clockwise)

Preceding gene: 197117645

Following gene: 197117647

Centisome position: 31.51

GC content: 66.25

Gene sequence:

>1941_bases
ATGCCGTCCATCCTGGAAGGGATTAAAGAACCGGGGCAGTTGAAGGCGCTCTCGCTGAGCGAGCTGGAAACCCTTGCGGC
CGAGCTCCGCGAGCGGATCATCGAGACCTGCGCCGCAAACGGCGGACACCTGGCGCCGAGCCTTGGCGTGGTCGAGCTCA
CCATCGCCCTGCACCGCGTTTTCGATTCCCCCAAGGACAAGATCGTCTGGGACGTCGGCCATCAGGCCTACGCCCACAAG
CTTTTAACCGGCAGGAACGAGCGCTTCGGCACGCTGCGGACCCTCGGGGGGATCAGCGGCTTTCCCAAACGGGCCGAGTC
CCCCCACGACTGCTTCGATGTCGGGCACTCCTCCACCTCCATTTCGGCCGGGGTGGGCTTCGCCGTGGCGCGCGACCTGA
AGGGGGAGCGCAACAAGGTGCTGACCGTGATCGGGGACGGTTCCATGACCGGCGGCCTGGCGCTGGAGGGGCTGAACCAC
GCCGGCGAGCTGAACAAGGACCTGGTGGTGATCCTGAACGACAACGAGATGTCCATCTCGGAAAACGTCGGCGCCCTCTC
CAATCTCCTCTCCCGCACCATAACCAGCGAATACGTGCACCGGGCCAAGAAGGACCTGGAGGCTTTCCTGGAGGGGCTCC
CCATGTTCGGCAAGTCGGTCCTGAAGATAGCCAAGAGGGCCGAGGAGTCGCTTAAGACCCTCTTCACACCCGGCATGCTC
TTCGAGGCCTTCGGCTTCGAGTACATAGGTCCCATCGACGGGCACGACATCGGCAAGCTCGTGGAGACCCTGGAGAACGT
GAAGCGTTTCGACGACGCGGTGCTGATCCATGTCCTCACCAAGAAGGGGAAGGGTTACCCCGCCGCGGAGGCCAACCCGT
CTCTTTTCCACGGCGTTGGGCCGTTCGACGTGCAGACCGGTAAGGTGCACAAGGGGAAAGGCGGCCCCGCCTCCTACACC
GGGGTCTTCGGCGAGGCTCTTAAGAGGCTGGCCCAGGACAACGAGAAGATCGTCGCCATTACCGCCGCCATGCCGGACGG
CACCGGGCTCACCCCGTTCGCCAAGGAATTCCCCGCGCGGTTCTTCGACGTGGGGATCGCCGAGCAGCACGCCGTCACTT
TCGCGGCGGGGCTTGCCGCGGAAGGGTTCCGTCCGGTGGTGGCGCTTTATTCCTCGTTCCTGCAGCGCGGCTTCGACCAG
CTCTGCCACGACGTCTGCCTGCAGGAACTCCCGGTCGTCTTCGCCATCGACCGCGCCGGCGTGGTCGGCAACGACGGCCC
GACCCACCATGGCGTGTTCGACCTCTCCTATCTGCGGCAGCTCCCCGGGCTCACCGTTATGGCGCCCAAGGACGAGAACG
AGCTGCAGCACATGTTCTTCACCGCCTTCTCGCTCGATGGCCCCTCGGCGGTGCGTTATCCGCGCGGCGGCGGCCTGGGC
GTCCCCATGGACCAGATCCTGGAGCCGCTTCCGGTAGGGAAGGGGGAGTTGGTCCGGGAGGGGAAAGACGGCGCCATCCT
GGCCGTGGGCACCATGGTGCACCCCGCCCAGCAGGCGGCGGCGGCGCTTGCCCTCGAAGGGTTGGACCTCGCCGTCATGA
ACGTCCGTTTCGTCAAACCCCTGGACCGCGACCTGATCCTCTCCCTCGCGGCTACCCGCTTCCTGGTCACCGCCGAAGAG
AACGTGCTGCAGGGCGGTTTCGGCACCTCCATCCTGGAACTTTTGGAGGAGTGCGGCGTCACCGGCGTACGGGTGATCCG
CCTGGGGTACCCCGACAGCTTCGTGGAGCAGGGGGAGCAGGCCGAGCTCAAGGCCGCCTACGGCCTCGACGCCGCCGGTA
TCGCCCGGAGCATCCGGGAGGCGAGGGGGCAGTCGCCGCAGGAGTTGGTCCTGGAACCGGCGGACCGGCCCGACGGCGCC
GATCTGTCGTCCCGACCATGA

Upstream 100 bases:

>100_bases
AGAACTGGTGCAGATCGCCTTGAACGCGCTGGAGCCGTTCGACGAGCGGGCAGAACCTTTGCGGGCCATAGCTTCGTACA
TAGTGAAAAGGAAATCGTAG

Downstream 100 bases:

>100_bases
AGAAGCTTTCCTTTCTCGCCTTTATCCTCATGCTGGCGTTCGCCGCCACGGCGGTCGCCGGGGATCCCGTCACCTATGCC
GCCAAGGCCCGGCAGCTGAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1 [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MPSILEGIKEPGQLKALSLSELETLAAELRERIIETCAANGGHLAPSLGVVELTIALHRVFDSPKDKIVWDVGHQAYAHK
LLTGRNERFGTLRTLGGISGFPKRAESPHDCFDVGHSSTSISAGVGFAVARDLKGERNKVLTVIGDGSMTGGLALEGLNH
AGELNKDLVVILNDNEMSISENVGALSNLLSRTITSEYVHRAKKDLEAFLEGLPMFGKSVLKIAKRAEESLKTLFTPGML
FEAFGFEYIGPIDGHDIGKLVETLENVKRFDDAVLIHVLTKKGKGYPAAEANPSLFHGVGPFDVQTGKVHKGKGGPASYT
GVFGEALKRLAQDNEKIVAITAAMPDGTGLTPFAKEFPARFFDVGIAEQHAVTFAAGLAAEGFRPVVALYSSFLQRGFDQ
LCHDVCLQELPVVFAIDRAGVVGNDGPTHHGVFDLSYLRQLPGLTVMAPKDENELQHMFFTAFSLDGPSAVRYPRGGGLG
VPMDQILEPLPVGKGELVREGKDGAILAVGTMVHPAQQAAAALALEGLDLAVMNVRFVKPLDRDLILSLAATRFLVTAEE
NVLQGGFGTSILELLEECGVTGVRVIRLGYPDSFVEQGEQAELKAAYGLDAAGIARSIREARGQSPQELVLEPADRPDGA
DLSSRP

Sequences:

>Translated_646_residues
MPSILEGIKEPGQLKALSLSELETLAAELRERIIETCAANGGHLAPSLGVVELTIALHRVFDSPKDKIVWDVGHQAYAHK
LLTGRNERFGTLRTLGGISGFPKRAESPHDCFDVGHSSTSISAGVGFAVARDLKGERNKVLTVIGDGSMTGGLALEGLNH
AGELNKDLVVILNDNEMSISENVGALSNLLSRTITSEYVHRAKKDLEAFLEGLPMFGKSVLKIAKRAEESLKTLFTPGML
FEAFGFEYIGPIDGHDIGKLVETLENVKRFDDAVLIHVLTKKGKGYPAAEANPSLFHGVGPFDVQTGKVHKGKGGPASYT
GVFGEALKRLAQDNEKIVAITAAMPDGTGLTPFAKEFPARFFDVGIAEQHAVTFAAGLAAEGFRPVVALYSSFLQRGFDQ
LCHDVCLQELPVVFAIDRAGVVGNDGPTHHGVFDLSYLRQLPGLTVMAPKDENELQHMFFTAFSLDGPSAVRYPRGGGLG
VPMDQILEPLPVGKGELVREGKDGAILAVGTMVHPAQQAAAALALEGLDLAVMNVRFVKPLDRDLILSLAATRFLVTAEE
NVLQGGFGTSILELLEECGVTGVRVIRLGYPDSFVEQGEQAELKAAYGLDAAGIARSIREARGQSPQELVLEPADRPDGA
DLSSRP
>Mature_645_residues
PSILEGIKEPGQLKALSLSELETLAAELRERIIETCAANGGHLAPSLGVVELTIALHRVFDSPKDKIVWDVGHQAYAHKL
LTGRNERFGTLRTLGGISGFPKRAESPHDCFDVGHSSTSISAGVGFAVARDLKGERNKVLTVIGDGSMTGGLALEGLNHA
GELNKDLVVILNDNEMSISENVGALSNLLSRTITSEYVHRAKKDLEAFLEGLPMFGKSVLKIAKRAEESLKTLFTPGMLF
EAFGFEYIGPIDGHDIGKLVETLENVKRFDDAVLIHVLTKKGKGYPAAEANPSLFHGVGPFDVQTGKVHKGKGGPASYTG
VFGEALKRLAQDNEKIVAITAAMPDGTGLTPFAKEFPARFFDVGIAEQHAVTFAAGLAAEGFRPVVALYSSFLQRGFDQL
CHDVCLQELPVVFAIDRAGVVGNDGPTHHGVFDLSYLRQLPGLTVMAPKDENELQHMFFTAFSLDGPSAVRYPRGGGLGV
PMDQILEPLPVGKGELVREGKDGAILAVGTMVHPAQQAAAALALEGLDLAVMNVRFVKPLDRDLILSLAATRFLVTAEEN
VLQGGFGTSILELLEECGVTGVRVIRLGYPDSFVEQGEQAELKAAYGLDAAGIARSIREARGQSPQELVLEPADRPDGAD
LSSRP

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=307, Percent_Identity=29.9674267100977, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4507521, Length=307, Percent_Identity=29.9674267100977, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI133778974, Length=433, Percent_Identity=24.9422632794457, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637463, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI225637459, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI225637461, Length=303, Percent_Identity=26.7326732673267, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI156564403, Length=234, Percent_Identity=26.0683760683761, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786622, Length=609, Percent_Identity=48.7684729064039, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17539652, Length=670, Percent_Identity=24.3283582089552, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551847, Length=641, Percent_Identity=25.2730109204368, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45550715, Length=641, Percent_Identity=25.2730109204368, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24666278, Length=602, Percent_Identity=25.4152823920266, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645119, Length=530, Percent_Identity=25.4716981132075, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21358145, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69050; Mature: 68919

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSILEGIKEPGQLKALSLSELETLAAELRERIIETCAANGGHLAPSLGVVELTIALHRV
CCCHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
FDSPKDKIVWDVGHQAYAHKLLTGRNERFGTLRTLGGISGFPKRAESPHDCFDVGHSSTS
HCCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCC
ISAGVGFAVARDLKGERNKVLTVIGDGSMTGGLALEGLNHAGELNKDLVVILNDNEMSIS
CCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCHH
ENVGALSNLLSRTITSEYVHRAKKDLEAFLEGLPMFGKSVLKIAKRAEESLKTLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
FEAFGFEYIGPIDGHDIGKLVETLENVKRFDDAVLIHVLTKKGKGYPAAEANPSLFHGVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCCEECCC
PFDVQTGKVHKGKGGPASYTGVFGEALKRLAQDNEKIVAITAAMPDGTGLTPFAKEFPAR
CCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCHH
FFDVGIAEQHAVTFAAGLAAEGFRPVVALYSSFLQRGFDQLCHDVCLQELPVVFAIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
VVGNDGPTHHGVFDLSYLRQLPGLTVMAPKDENELQHMFFTAFSLDGPSAVRYPRGGGLG
CCCCCCCCCCCEEEHHHHHHCCCCEEECCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCC
VPMDQILEPLPVGKGELVREGKDGAILAVGTMVHPAQQAAAALALEGLDLAVMNVRFVKP
CCHHHHHCCCCCCCCHHHHCCCCCCEEEEECHHCHHHHHHHHHHHCCCCEEEEEEHCCCC
LDRDLILSLAATRFLVTAEENVLQGGFGTSILELLEECGVTGVRVIRLGYPDSFVEQGEQ
CCHHHHHHHHHHHHEEECCHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCC
AELKAAYGLDAAGIARSIREARGQSPQELVLEPADRPDGADLSSRP
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSILEGIKEPGQLKALSLSELETLAAELRERIIETCAANGGHLAPSLGVVELTIALHRV
CCHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
FDSPKDKIVWDVGHQAYAHKLLTGRNERFGTLRTLGGISGFPKRAESPHDCFDVGHSSTS
HCCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCC
ISAGVGFAVARDLKGERNKVLTVIGDGSMTGGLALEGLNHAGELNKDLVVILNDNEMSIS
CCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCHH
ENVGALSNLLSRTITSEYVHRAKKDLEAFLEGLPMFGKSVLKIAKRAEESLKTLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
FEAFGFEYIGPIDGHDIGKLVETLENVKRFDDAVLIHVLTKKGKGYPAAEANPSLFHGVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCCEECCC
PFDVQTGKVHKGKGGPASYTGVFGEALKRLAQDNEKIVAITAAMPDGTGLTPFAKEFPAR
CCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCHH
FFDVGIAEQHAVTFAAGLAAEGFRPVVALYSSFLQRGFDQLCHDVCLQELPVVFAIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
VVGNDGPTHHGVFDLSYLRQLPGLTVMAPKDENELQHMFFTAFSLDGPSAVRYPRGGGLG
CCCCCCCCCCCEEEHHHHHHCCCCEEECCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCC
VPMDQILEPLPVGKGELVREGKDGAILAVGTMVHPAQQAAAALALEGLDLAVMNVRFVKP
CCHHHHHCCCCCCCCHHHHCCCCCCEEEEECHHCHHHHHHHHHHHCCCCEEEEEEHCCCC
LDRDLILSLAATRFLVTAEENVLQGGFGTSILELLEECGVTGVRVIRLGYPDSFVEQGEQ
CCHHHHHHHHHHHHEEECCHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCC
AELKAAYGLDAAGIARSIREARGQSPQELVLEPADRPDGADLSSRP
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA