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The map label for this gene is silP [H]

Identifier: 197116514

GI number: 197116514

Start: 137849

End: 140056

Strand: Reverse

Name: silP [H]

Synonym: Gbem_0114

Alternate gene names: 197116514

Gene position: 140056-137849 (Counterclockwise)

Preceding gene: 197116515

Following gene: 197116507

Centisome position: 3.03

GC content: 69.11

Gene sequence:

>2208_bases
ATGCCTACGACAGCGGCCGCTAGCACCATGGAGCACTATTCTTGCGCGCACTGCGGACTCCCGGTGGCAACCCCCTCGCT
TGGGAAAGCCCCCTCTACTCTCGACCGGCAGGAGATCTTCTGCTGCCACGCCTGCAGGCTGGTCTCCGCCATCGTCGGAA
ACCGGCAGGGGGAGCAGGGGTGGCACCTGTTCCGGCTCGGCATCGGCGCGCTCCTGGCCATGAACGTGATGATGATTTCC
CTGCTCCTCTACGCCGGGAGCGTGGAGACGCAGCTGATCCCCCTGTTCCGCCGCATACTCCTCGTGCTTTCCATCCCCGC
CATGCTGATCCTGATCCCCCCGTTTCTTTCCGGCGCGCTACGCGAGATCTCGTCGCGGCGCTTTTGCCTCGACTTCCTCA
TCGCGCTCGGATCCCTCTCCGCCTTCTCCCTGAGCGCGGTGAACGCGGTCGTCGGCTCCGGAGAGGTCTATTTCGACACC
GCCACCATGCTTCCGGTGCTGGTTACCCTGGGAAAATTCATCGAGGCGTCGGTGAAAAGGAAGGCGAGCGAGCTCCTGGA
AACACTGGAGACGCTGCTGCCGCGGACCGCGCTCCGGGTGACCGGGGAGGGGACCGACGAGGTGGCGCTGGACGCGCTGC
AGCCGGGCGACCTGGTGCGGGTGCGGCCGGGCGAGCGAGTGGCGGTGGACGGCACCGTGGTGGAAGGGACGAGCAGCATC
GAGGAGGCACCCTTCACCGGCGAGTTCCTCCCCAGGCTCTGCCGCAAAGGGGACGCGGTCACAGCCGGCACGGTGAACGG
CCAGGGGACCCTGCTGTTGCGCGCCGACCGGACCGGGTCGCAGCTTTTATTGCACAGTATCGCCGACATGGTGCAGCAGG
CCTGGCGCGCCCCTTCGCAGAGCGAGCGGCTGGCGCAGAAGGCGGCCATGCTTTTTCTGCCGGCGGTGCTCCTGGTCTCC
GTCGGCGCGCTCATCTGCTGGTCATTCAAGGGCCTTCCCGACCAGGCGCTCCTGAGTGCGCTTTCCGTGCTGGTGGTCGC
CTGCCCCTGCACCATGGGGATAGCCACCCCCCTTGCCACCTCGCTGGCCGTAGCCCGTGCCGCGCGCGCCGGCATCGTCG
TGCGCGGCGGCAGCGTCATGGAGGGGATAGCCGGCACTGGTACAGTCTTCTTCGACAAGACCGGCACCGTCACCTCCGGC
ACCCCGGTGCTGAGCGAGATGGAGCTGCTGGATCCGCTCACGACCCGCGCCGAACTGCTGGGGAGGCTGGCCGCCCTGGA
ATCGGCAAGCGAGCACCCGCTGGCGGCGGCGGTCAAGGCCGCGGCGGCTGCCTGCGGCGCAGCCCCCGGCACCGCAACGC
AGGTCGAGCTCTCGGCTGGGTGCGGCATCAGCGGCACGGTGACCTGGAAAGGGGTGGCGACGAGGATGTGGGCAGGAAAC
GCCTCATGCGCCGACGGCGATGTGGGGTGCGAGGATCTGCCGGGGGAGGGTGCGGTGGTGTTCGCGGGGTGGGATGGGAG
GCTCAGGGCGAGGCTTCATTTCGCCGATCCGCTCAAAGACGATGCGGCAAGCTCCCTGGACGCGCTGCACCGGTTGGGTT
TGACGAGCGTGCTCCTCTCGGGCGACCGCTTTTCCTCGGCCCAGGTGGCGGCCAAGCGGCTGGGGATCCGCCGGGTCGAG
GCCCCCTCCCCTCCGGACCGCAAGCTGGAGCTCATCGCCGGCTACATCGCCAAGGGGCGGAAGGTGGCCATGGTGGGGGA
CGGGGTAAACGACGCGCCCGCCCTCGCCGCGGCCCAGACCGGGATCGCGCTCGGAACCGGGATGGAGCTCGCCCAGGTGG
CGGGGAACGTGGTGATCCTGTCGGGGCGGCTGTCGCAAATTCCCTGGCTGATCGCGCTCAGCCGGCGCGCCGGGAACATC
ATCCGCGGGAATCTCGCCTTAAGCTTCGCCTACAACGCGGTGGCGCTGGCCGCGGCGGCTGCAGGCCTGCTCCATCCGCT
TCTGGCCGCGGTCGCCATGGTGGTCTCCAGCCTCACCGTGCTGGGAAACTCCCTGCGCATCGGCGCCTTTCCCGCCCCCT
CCGCCCTCCCGGCACGAAGCCGGGAGACGGCGTCGCCGCAGCCTAAGGGCGTGTTGCCGGCGATGCCCCTTGAGGAGGCT
CCGGCTGCGCAGGGTCGGTGTGCTGGTGCAGGTGGTTTTCCGGCGTGA

Upstream 100 bases:

>100_bases
GGATCCGCCTTCTACCACAGGCTCCTCGGCTGCCCCCCCACCCCCGGGCCGCAGATAATCAGCGCCAGCGCTCATTCCGC
GACCGGCGCCTGGAGGGGCG

Downstream 100 bases:

>100_bases
AGAACTCGGTGACCGCGTCCGCGGCCACCGGGCGCGACACCAGGAAGCCCTGGATCTCGTGGCAACCCTGATCCTTTAGC
TTCTCCAACTGGTCCACCGT

Product: heavy metal-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MPTTAAASTMEHYSCAHCGLPVATPSLGKAPSTLDRQEIFCCHACRLVSAIVGNRQGEQGWHLFRLGIGALLAMNVMMIS
LLLYAGSVETQLIPLFRRILLVLSIPAMLILIPPFLSGALREISSRRFCLDFLIALGSLSAFSLSAVNAVVGSGEVYFDT
ATMLPVLVTLGKFIEASVKRKASELLETLETLLPRTALRVTGEGTDEVALDALQPGDLVRVRPGERVAVDGTVVEGTSSI
EEAPFTGEFLPRLCRKGDAVTAGTVNGQGTLLLRADRTGSQLLLHSIADMVQQAWRAPSQSERLAQKAAMLFLPAVLLVS
VGALICWSFKGLPDQALLSALSVLVVACPCTMGIATPLATSLAVARAARAGIVVRGGSVMEGIAGTGTVFFDKTGTVTSG
TPVLSEMELLDPLTTRAELLGRLAALESASEHPLAAAVKAAAAACGAAPGTATQVELSAGCGISGTVTWKGVATRMWAGN
ASCADGDVGCEDLPGEGAVVFAGWDGRLRARLHFADPLKDDAASSLDALHRLGLTSVLLSGDRFSSAQVAAKRLGIRRVE
APSPPDRKLELIAGYIAKGRKVAMVGDGVNDAPALAAAQTGIALGTGMELAQVAGNVVILSGRLSQIPWLIALSRRAGNI
IRGNLALSFAYNAVALAAAAAGLLHPLLAAVAMVVSSLTVLGNSLRIGAFPAPSALPARSRETASPQPKGVLPAMPLEEA
PAAQGRCAGAGGFPA

Sequences:

>Translated_735_residues
MPTTAAASTMEHYSCAHCGLPVATPSLGKAPSTLDRQEIFCCHACRLVSAIVGNRQGEQGWHLFRLGIGALLAMNVMMIS
LLLYAGSVETQLIPLFRRILLVLSIPAMLILIPPFLSGALREISSRRFCLDFLIALGSLSAFSLSAVNAVVGSGEVYFDT
ATMLPVLVTLGKFIEASVKRKASELLETLETLLPRTALRVTGEGTDEVALDALQPGDLVRVRPGERVAVDGTVVEGTSSI
EEAPFTGEFLPRLCRKGDAVTAGTVNGQGTLLLRADRTGSQLLLHSIADMVQQAWRAPSQSERLAQKAAMLFLPAVLLVS
VGALICWSFKGLPDQALLSALSVLVVACPCTMGIATPLATSLAVARAARAGIVVRGGSVMEGIAGTGTVFFDKTGTVTSG
TPVLSEMELLDPLTTRAELLGRLAALESASEHPLAAAVKAAAAACGAAPGTATQVELSAGCGISGTVTWKGVATRMWAGN
ASCADGDVGCEDLPGEGAVVFAGWDGRLRARLHFADPLKDDAASSLDALHRLGLTSVLLSGDRFSSAQVAAKRLGIRRVE
APSPPDRKLELIAGYIAKGRKVAMVGDGVNDAPALAAAQTGIALGTGMELAQVAGNVVILSGRLSQIPWLIALSRRAGNI
IRGNLALSFAYNAVALAAAAAGLLHPLLAAVAMVVSSLTVLGNSLRIGAFPAPSALPARSRETASPQPKGVLPAMPLEEA
PAAQGRCAGAGGFPA
>Mature_734_residues
PTTAAASTMEHYSCAHCGLPVATPSLGKAPSTLDRQEIFCCHACRLVSAIVGNRQGEQGWHLFRLGIGALLAMNVMMISL
LLYAGSVETQLIPLFRRILLVLSIPAMLILIPPFLSGALREISSRRFCLDFLIALGSLSAFSLSAVNAVVGSGEVYFDTA
TMLPVLVTLGKFIEASVKRKASELLETLETLLPRTALRVTGEGTDEVALDALQPGDLVRVRPGERVAVDGTVVEGTSSIE
EAPFTGEFLPRLCRKGDAVTAGTVNGQGTLLLRADRTGSQLLLHSIADMVQQAWRAPSQSERLAQKAAMLFLPAVLLVSV
GALICWSFKGLPDQALLSALSVLVVACPCTMGIATPLATSLAVARAARAGIVVRGGSVMEGIAGTGTVFFDKTGTVTSGT
PVLSEMELLDPLTTRAELLGRLAALESASEHPLAAAVKAAAAACGAAPGTATQVELSAGCGISGTVTWKGVATRMWAGNA
SCADGDVGCEDLPGEGAVVFAGWDGRLRARLHFADPLKDDAASSLDALHRLGLTSVLLSGDRFSSAQVAAKRLGIRRVEA
PSPPDRKLELIAGYIAKGRKVAMVGDGVNDAPALAAAQTGIALGTGMELAQVAGNVVILSGRLSQIPWLIALSRRAGNII
RGNLALSFAYNAVALAAAAAGLLHPLLAAVAMVVSSLTVLGNSLRIGAFPAPSALPARSRETASPQPKGVLPAMPLEEAP
AAQGRCAGAGGFPA

Specific function: Component of the sil cation-efflux system that confers resistance to silver [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=635, Percent_Identity=31.6535433070866, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI55743073, Length=564, Percent_Identity=31.3829787234043, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI115529486, Length=444, Percent_Identity=28.8288288288288, Blast_Score=187, Evalue=3e-47,
Organism=Escherichia coli, GI1786691, Length=623, Percent_Identity=34.1894060995185, Blast_Score=271, Evalue=2e-73,
Organism=Escherichia coli, GI1789879, Length=591, Percent_Identity=28.9340101522843, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786914, Length=561, Percent_Identity=27.6292335115865, Blast_Score=119, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17556548, Length=402, Percent_Identity=33.0845771144279, Blast_Score=165, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319772, Length=667, Percent_Identity=29.8350824587706, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320475, Length=682, Percent_Identity=27.8592375366569, Blast_Score=217, Evalue=6e-57,
Organism=Drosophila melanogaster, GI221329854, Length=440, Percent_Identity=32.7272727272727, Blast_Score=173, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR007029 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase; PF04945 YHS [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 75822; Mature: 75691

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTAAASTMEHYSCAHCGLPVATPSLGKAPSTLDRQEIFCCHACRLVSAIVGNRQGEQG
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
WHLFRLGIGALLAMNVMMISLLLYAGSVETQLIPLFRRILLVLSIPAMLILIPPFLSGAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REISSRRFCLDFLIALGSLSAFSLSAVNAVVGSGEVYFDTATMLPVLVTLGKFIEASVKR
HHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KASELLETLETLLPRTALRVTGEGTDEVALDALQPGDLVRVRPGERVAVDGTVVEGTSSI
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCEEEECCCCEEEECCEEECCCCCH
EEAPFTGEFLPRLCRKGDAVTAGTVNGQGTLLLRADRTGSQLLLHSIADMVQQAWRAPSQ
HCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCH
SERLAQKAAMLFLPAVLLVSVGALICWSFKGLPDQALLSALSVLVVACPCTMGIATPLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLAVARAARAGIVVRGGSVMEGIAGTGTVFFDKTGTVTSGTPVLSEMELLDPLTTRAELL
HHHHHHHHHCCEEEECCHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
GRLAALESASEHPLAAAVKAAAAACGAAPGTATQVELSAGCGISGTVTWKGVATRMWAGN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCEEEEECCC
ASCADGDVGCEDLPGEGAVVFAGWDGRLRARLHFADPLKDDAASSLDALHRLGLTSVLLS
CCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCHHHHHCC
GDRFSSAQVAAKRLGIRRVEAPSPPDRKLELIAGYIAKGRKVAMVGDGVNDAPALAAAQT
CCCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHC
GIALGTGMELAQVAGNVVILSGRLSQIPWLIALSRRAGNIIRGNLALSFAYNAVALAAAA
CCEECCCCHHHHHCCCEEEEECCCCCCCEEEEECCCCCCEEECCEEEEHHHHHHHHHHHH
AGLLHPLLAAVAMVVSSLTVLGNSLRIGAFPAPSALPARSRETASPQPKGVLPAMPLEEA
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAAQGRCAGAGGFPA
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTTAAASTMEHYSCAHCGLPVATPSLGKAPSTLDRQEIFCCHACRLVSAIVGNRQGEQG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
WHLFRLGIGALLAMNVMMISLLLYAGSVETQLIPLFRRILLVLSIPAMLILIPPFLSGAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REISSRRFCLDFLIALGSLSAFSLSAVNAVVGSGEVYFDTATMLPVLVTLGKFIEASVKR
HHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KASELLETLETLLPRTALRVTGEGTDEVALDALQPGDLVRVRPGERVAVDGTVVEGTSSI
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCEEEECCCCEEEECCEEECCCCCH
EEAPFTGEFLPRLCRKGDAVTAGTVNGQGTLLLRADRTGSQLLLHSIADMVQQAWRAPSQ
HCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCH
SERLAQKAAMLFLPAVLLVSVGALICWSFKGLPDQALLSALSVLVVACPCTMGIATPLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLAVARAARAGIVVRGGSVMEGIAGTGTVFFDKTGTVTSGTPVLSEMELLDPLTTRAELL
HHHHHHHHHCCEEEECCHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
GRLAALESASEHPLAAAVKAAAAACGAAPGTATQVELSAGCGISGTVTWKGVATRMWAGN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCEEEEECCC
ASCADGDVGCEDLPGEGAVVFAGWDGRLRARLHFADPLKDDAASSLDALHRLGLTSVLLS
CCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCHHHHHCC
GDRFSSAQVAAKRLGIRRVEAPSPPDRKLELIAGYIAKGRKVAMVGDGVNDAPALAAAQT
CCCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHC
GIALGTGMELAQVAGNVVILSGRLSQIPWLIALSRRAGNIIRGNLALSFAYNAVALAAAA
CCEECCCCHHHHHCCCEEEEECCCCCCCEEEEECCCCCCEEECCEEEEHHHHHHHHHHHH
AGLLHPLLAAVAMVVSSLTVLGNSLRIGAFPAPSALPARSRETASPQPKGVLPAMPLEEA
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAAQGRCAGAGGFPA
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]