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The map label for this gene is fbiC [H]

Identifier: 197105997

GI number: 197105997

Start: 2910833

End: 2913157

Strand: Reverse

Name: fbiC [H]

Synonym: PHZ_c2536

Alternate gene names: 197105997

Gene position: 2913157-2910833 (Counterclockwise)

Preceding gene: 197105998

Following gene: 197105996

Centisome position: 72.9

GC content: 72.6

Gene sequence:

>2325_bases
ATGAAGCAAGCGGACCTGCGGCGGCGGCTGATGCGGTCGCCGATCGAGGCGCTGACAGCGGAGAGCGGGGCCCGGCGGGA
CGCCGCCTTCGGCAGGACGCTGACCTATTCGCGCAAGGTGTTCGTCCCGCTGACCCAGCTCTGCCGGGACGTCTGCCACT
ACTGCACCTTCGCCAAGGCGCCCCGGGCGGCGCCTTCGGCCTACCTGGACCTCGACGAGGTGCTGGAGATCGCGCGCGCC
GGCGCCCGGGCGGGCTGCAAGGAGGCGCTCTTCACCCTGGGCGACAAGCCTGAGCTCAGGTATCCGGCCGCCCGCAAGGC
GCTCGATCGCCTGGGCTTCGCCTCCACCGTGGAATACCTCGCCTTCGCGGCGGGGCGGGTGCTCGAGGAGACCGGGCTGC
TGCCCCACATCAACGCCGGCGTCCTCTCGGCGGAGGACTACGCCCGCCTGCGCCCGGTGTCGGCATCCATGGGGCTCATG
CTGGAGAGCGCATCCGAGCGCCTGTGCCGGCGCGGCGGCCCCCACTTCGGCTCTCCGGACAAACATCCTGCCGTGCGTCT
TGCGTCGATCTCGGCCGCAGGCGAGGCGCAGGTTCCGTTCACGAGCGGGCTGCTGATCGGGATCGGCGAAACGCGCGAGG
AGCGGCTCGACGCCCTGTTTGAGCTTCAGGCGCTTCACGACCGCCACGGGCATCTGCAGGAAATCATCGTGCAGAACTTC
CGGGCCAAGCCCGGCACCCGCATGGCCTCGGCGCCCGAGTCGCCGGCCGAGGAGCTGCTGTGGACGCTCGCCGCCGCCCG
GCTGATCCTGCCCGAGACCGTCAGCGTTCAGGCCCCTCCGAACCTCAGTCCCGGCGCCGCCGCGGCGCTGATCCAGGCGG
GCCTCGACGACTTCGGCGGAATCTCTCCCGTCACCATAGACCACGTGAACCCCGAGGCGCCCTGGCCCCAGATCGCCGCG
CTGGAGGCGACCTGCGCCGAGGCCGGCCGCCGGCTGACGGAGCGGCTCACGGCCTATCCGCGCTTCGTGCGCGAGGCGGA
GCGCTGGATGGAGCCGGGGGTTCGCCGGGCCGTCCTGCGGCTGTCGGACTCCGTGGGCCTCACGCGCGACGGCGCGTGGA
GCCCGGGCGTAACGGGGAAGGCGCCCGGCGGCCCCGCCGACCCCCTCGGAACGGGCGTGCCGGCGCCGCCCCTGGTGCGG
GACCGCGTCCTCGAGCGCTGCCTGCAGGCGGTCCGCGGCGGACGGGCGCCGGCCGAGGCGGACCTCGTCGGCCTGTTCGC
CGCGCGTGGAGCCGAGGCCGCCGACATCGCGGCGGCGGCCGACGACCTGCGCCGGGAGACCTGCGGCGATGCGGTGAGCT
ACGTGGTCAACCGCAACATCAACTACACCAACATCTGCGCCTACAGCTGCTCGTTCTGCGCGTTCTCCAAGGCCTCGTCG
AAGGCCGGGCATCGCGATCGGCCCTATGTGCTGGAGCTCCCGGAACTGGCGCGCCGCGCGCAGGAGGCATGGGACCGCGG
GGCGACCGAAGTGTGCCTGCAGGGCGGCATTCATCCGCGCTTCACGGGCCGGACCTACCTCGACGTCGTGCGGGCGGTGA
AGGAGGCCTGTCCCGGAATGCACGTCCACGCCTTCTCGCCCCTGGAGATCGCGCACGGGGCCGAGACCCTCGAGATTCCG
GTCGGCGACTTCCTGCGGATGCTGAAGGACGAGGGCCTGGGGTCCCTACCGGGCACCGCCGCCGAAATCCTGCACGACGA
CGTCCGGCGCAGGATCTGTCCGGACAAGCTGACGACCGCCCAGTGGCTCGAGGTCGTGGAGACCGCCCACCGGATCGGCC
TGCCGACCACCTCGACCATCATGTTCGGCCACGTCGAGACGCCCGAACACTGGGCCAGCCATCTCCTCGCCCTGCGTGAC
CTGCAGGCGCGCACCGGCGGGATCACGGAGTTCGTGCCCCTGCCGTTCGTGCACATGGAGGCACCGGTCTACCTGCGCGG
CGAGGCGCGGCGGGGGCCGACCTGGCGCGAGAGCGTCCTGATGCATGCGGTCGGCCGGATCGCGCTGCACGGCCAGATCC
GCAACGTGCAGGCGTCGTGGGTGAAGCTCGGGCTGGACGGCGCTTCTGCGCTGCTGGCGGCCGGCGTCAACGATCTCGGC
GGGGTCCTGATGAACGAGTCGATCAGCCGGGCCGCCGGCGCCGCCCACGGCCAGGAACTGGGCGTCGGCGACCTCGAGGC
CGCCATCCTCGCCGCCGGCCGCTGCCCGATCCGGCGGACGACGCTCTATGCCGACGCGGCCGTCTGCGCCCCAGCGGCGG
CCTGA

Upstream 100 bases:

>100_bases
ACCTCGATCGGCCCGAGGACGCGGTGGAGGTGGCGCGCGGGCCCTGCGGCCGGCGGACGGCCGAAGTCCTGAGCGATCTC
AAGAGCCGCTGGAGAGCCCA

Downstream 100 bases:

>100_bases
AGGGGCGCGGCGATGCGCCGGACGGGAGGTGCAGATGTCCGCTGAGCAGTCCGACGAGTTGCTCCTGGAACGACGCGGCC
CCGTCCTCGTGGCGTTGCTG

Product: FO synthase

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase [H]

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MKQADLRRRLMRSPIEALTAESGARRDAAFGRTLTYSRKVFVPLTQLCRDVCHYCTFAKAPRAAPSAYLDLDEVLEIARA
GARAGCKEALFTLGDKPELRYPAARKALDRLGFASTVEYLAFAAGRVLEETGLLPHINAGVLSAEDYARLRPVSASMGLM
LESASERLCRRGGPHFGSPDKHPAVRLASISAAGEAQVPFTSGLLIGIGETREERLDALFELQALHDRHGHLQEIIVQNF
RAKPGTRMASAPESPAEELLWTLAAARLILPETVSVQAPPNLSPGAAAALIQAGLDDFGGISPVTIDHVNPEAPWPQIAA
LEATCAEAGRRLTERLTAYPRFVREAERWMEPGVRRAVLRLSDSVGLTRDGAWSPGVTGKAPGGPADPLGTGVPAPPLVR
DRVLERCLQAVRGGRAPAEADLVGLFAARGAEAADIAAAADDLRRETCGDAVSYVVNRNINYTNICAYSCSFCAFSKASS
KAGHRDRPYVLELPELARRAQEAWDRGATEVCLQGGIHPRFTGRTYLDVVRAVKEACPGMHVHAFSPLEIAHGAETLEIP
VGDFLRMLKDEGLGSLPGTAAEILHDDVRRRICPDKLTTAQWLEVVETAHRIGLPTTSTIMFGHVETPEHWASHLLALRD
LQARTGGITEFVPLPFVHMEAPVYLRGEARRGPTWRESVLMHAVGRIALHGQIRNVQASWVKLGLDGASALLAAGVNDLG
GVLMNESISRAAGAAHGQELGVGDLEAAILAAGRCPIRRTTLYADAAVCAPAAA

Sequences:

>Translated_774_residues
MKQADLRRRLMRSPIEALTAESGARRDAAFGRTLTYSRKVFVPLTQLCRDVCHYCTFAKAPRAAPSAYLDLDEVLEIARA
GARAGCKEALFTLGDKPELRYPAARKALDRLGFASTVEYLAFAAGRVLEETGLLPHINAGVLSAEDYARLRPVSASMGLM
LESASERLCRRGGPHFGSPDKHPAVRLASISAAGEAQVPFTSGLLIGIGETREERLDALFELQALHDRHGHLQEIIVQNF
RAKPGTRMASAPESPAEELLWTLAAARLILPETVSVQAPPNLSPGAAAALIQAGLDDFGGISPVTIDHVNPEAPWPQIAA
LEATCAEAGRRLTERLTAYPRFVREAERWMEPGVRRAVLRLSDSVGLTRDGAWSPGVTGKAPGGPADPLGTGVPAPPLVR
DRVLERCLQAVRGGRAPAEADLVGLFAARGAEAADIAAAADDLRRETCGDAVSYVVNRNINYTNICAYSCSFCAFSKASS
KAGHRDRPYVLELPELARRAQEAWDRGATEVCLQGGIHPRFTGRTYLDVVRAVKEACPGMHVHAFSPLEIAHGAETLEIP
VGDFLRMLKDEGLGSLPGTAAEILHDDVRRRICPDKLTTAQWLEVVETAHRIGLPTTSTIMFGHVETPEHWASHLLALRD
LQARTGGITEFVPLPFVHMEAPVYLRGEARRGPTWRESVLMHAVGRIALHGQIRNVQASWVKLGLDGASALLAAGVNDLG
GVLMNESISRAAGAAHGQELGVGDLEAAILAAGRCPIRRTTLYADAAVCAPAAA
>Mature_774_residues
MKQADLRRRLMRSPIEALTAESGARRDAAFGRTLTYSRKVFVPLTQLCRDVCHYCTFAKAPRAAPSAYLDLDEVLEIARA
GARAGCKEALFTLGDKPELRYPAARKALDRLGFASTVEYLAFAAGRVLEETGLLPHINAGVLSAEDYARLRPVSASMGLM
LESASERLCRRGGPHFGSPDKHPAVRLASISAAGEAQVPFTSGLLIGIGETREERLDALFELQALHDRHGHLQEIIVQNF
RAKPGTRMASAPESPAEELLWTLAAARLILPETVSVQAPPNLSPGAAAALIQAGLDDFGGISPVTIDHVNPEAPWPQIAA
LEATCAEAGRRLTERLTAYPRFVREAERWMEPGVRRAVLRLSDSVGLTRDGAWSPGVTGKAPGGPADPLGTGVPAPPLVR
DRVLERCLQAVRGGRAPAEADLVGLFAARGAEAADIAAAADDLRRETCGDAVSYVVNRNINYTNICAYSCSFCAFSKASS
KAGHRDRPYVLELPELARRAQEAWDRGATEVCLQGGIHPRFTGRTYLDVVRAVKEACPGMHVHAFSPLEIAHGAETLEIP
VGDFLRMLKDEGLGSLPGTAAEILHDDVRRRICPDKLTTAQWLEVVETAHRIGLPTTSTIMFGHVETPEHWASHLLALRD
LQARTGGITEFVPLPFVHMEAPVYLRGEARRGPTWRESVLMHAVGRIALHGQIRNVQASWVKLGLDGASALLAAGVNDLG
GVLMNESISRAAGAAHGQELGVGDLEAAILAAGRCPIRRTTLYADAAVCAPAAA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 83090; Mature: 83090

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQADLRRRLMRSPIEALTAESGARRDAAFGRTLTYSRKVFVPLTQLCRDVCHYCTFAKA
CCHHHHHHHHHHCHHHHHHHCCCCCHHHHHCCEEECCCEEHHHHHHHHHHHHHHHHHHCC
PRAAPSAYLDLDEVLEIARAGARAGCKEALFTLGDKPELRYPAARKALDRLGFASTVEYL
CCCCCHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHH
AFAAGRVLEETGLLPHINAGVLSAEDYARLRPVSASMGLMLESASERLCRRGGPHFGSPD
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
KHPAVRLASISAAGEAQVPFTSGLLIGIGETREERLDALFELQALHDRHGHLQEIIVQNF
CCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RAKPGTRMASAPESPAEELLWTLAAARLILPETVSVQAPPNLSPGAAAALIQAGLDDFGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCHHHCC
ISPVTIDHVNPEAPWPQIAALEATCAEAGRRLTERLTAYPRFVREAERWMEPGVRRAVLR
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LSDSVGLTRDGAWSPGVTGKAPGGPADPLGTGVPAPPLVRDRVLERCLQAVRGGRAPAEA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DLVGLFAARGAEAADIAAAADDLRRETCGDAVSYVVNRNINYTNICAYSCSFCAFSKASS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHC
KAGHRDRPYVLELPELARRAQEAWDRGATEVCLQGGIHPRFTGRTYLDVVRAVKEACPGM
CCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
HVHAFSPLEIAHGAETLEIPVGDFLRMLKDEGLGSLPGTAAEILHDDVRRRICPDKLTTA
EEECCCCHHHHCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
QWLEVVETAHRIGLPTTSTIMFGHVETPEHWASHLLALRDLQARTGGITEFVPLPFVHME
HHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
APVYLRGEARRGPTWRESVLMHAVGRIALHGQIRNVQASWVKLGLDGASALLAAGVNDLG
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHEECCCHHHHHHHHCHHHHH
GVLMNESISRAAGAAHGQELGVGDLEAAILAAGRCPIRRTTLYADAAVCAPAAA
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHCCCCC
>Mature Secondary Structure
MKQADLRRRLMRSPIEALTAESGARRDAAFGRTLTYSRKVFVPLTQLCRDVCHYCTFAKA
CCHHHHHHHHHHCHHHHHHHCCCCCHHHHHCCEEECCCEEHHHHHHHHHHHHHHHHHHCC
PRAAPSAYLDLDEVLEIARAGARAGCKEALFTLGDKPELRYPAARKALDRLGFASTVEYL
CCCCCHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHH
AFAAGRVLEETGLLPHINAGVLSAEDYARLRPVSASMGLMLESASERLCRRGGPHFGSPD
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
KHPAVRLASISAAGEAQVPFTSGLLIGIGETREERLDALFELQALHDRHGHLQEIIVQNF
CCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RAKPGTRMASAPESPAEELLWTLAAARLILPETVSVQAPPNLSPGAAAALIQAGLDDFGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCHHHCC
ISPVTIDHVNPEAPWPQIAALEATCAEAGRRLTERLTAYPRFVREAERWMEPGVRRAVLR
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LSDSVGLTRDGAWSPGVTGKAPGGPADPLGTGVPAPPLVRDRVLERCLQAVRGGRAPAEA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DLVGLFAARGAEAADIAAAADDLRRETCGDAVSYVVNRNINYTNICAYSCSFCAFSKASS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHC
KAGHRDRPYVLELPELARRAQEAWDRGATEVCLQGGIHPRFTGRTYLDVVRAVKEACPGM
CCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
HVHAFSPLEIAHGAETLEIPVGDFLRMLKDEGLGSLPGTAAEILHDDVRRRICPDKLTTA
EEECCCCHHHHCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
QWLEVVETAHRIGLPTTSTIMFGHVETPEHWASHLLALRDLQARTGGITEFVPLPFVHME
HHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
APVYLRGEARRGPTWRESVLMHAVGRIALHGQIRNVQASWVKLGLDGASALLAAGVNDLG
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHEECCCHHHHHHHHCHHHHH
GVLMNESISRAAGAAHGQELGVGDLEAAILAAGRCPIRRTTLYADAAVCAPAAA
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]