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The map label for this gene is caiD [H]

Identifier: 197105996

GI number: 197105996

Start: 2910019

End: 2910798

Strand: Reverse

Name: caiD [H]

Synonym: PHZ_c2535

Alternate gene names: 197105996

Gene position: 2910798-2910019 (Counterclockwise)

Preceding gene: 197105997

Following gene: 197105995

Centisome position: 72.84

GC content: 74.74

Gene sequence:

>780_bases
ATGTCCGCTGAGCAGTCCGACGAGTTGCTCCTGGAACGACGCGGCCCCGTCCTCGTGGCGTTGCTGAACCGTCCTGCGAA
GCGCAACGCTATCAACCGGGCGATTTCGGAGCGGCTGCTCGAGGCGGTGCGCCAGGTCGACGAGGACCCCGGGCTGAACG
CCGGCGTCCTGGCGTCGTCCACGCCCGGGATGTTCTGCGCCGGCGCGGACCTCGCGGCCATGGCGGCGGGGGACCTCCTG
CGCCCGGACGGAGACCCGCGCCCGAGCTTCACGCGGCAGCCGCGCAGGAAGCCCTGGATCGCGGCGGTCGCCGGCCCGGC
CCTGGGCGGCGGCTTCGAGATGGCCCTGGCCTGCGAAATGATCGTGGCGGGCGAGAACACGACGTTCGGCTTGCCAGAGG
CGCGGCGAGGCCTCCTGGCCGCAGGCGGTGGCGTATTCCGCGCCGTGCGGGCGCTGCCGCGGGCGATCGGCATGGAGCTG
GTGCTCACGGGCCGGACGATGGACGCCGCCGAGGCGGGACGACTCGGCCTCGTCAACCGCGTCGCCCCAGACGCCGAGGT
CCTCGAGCAGGCCGTCGACCTGGCGCAGGCCGTGGCCGCCTGCGCGCCGCTCGCGGTGCAGGAGAGCCTGGCCCTGGCGC
GGCGGGCGACCGAGGCGCCGGAGACGGACCTCTGGCCGGAGGCCCGCGCGGCGCTGACGCGCCTCATGAGCGGCGCGGAT
GCGAAGGAGGGCATGCGCGCCTTCCTGGAACGGCGTGCGCCGGTCTGGAGGGGAGAGTGA

Upstream 100 bases:

>100_bases
CGCTGCCCGATCCGGCGGACGACGCTCTATGCCGACGCGGCCGTCTGCGCCCCAGCGGCGGCCTGAAGGGGCGCGGCGAT
GCGCCGGACGGGAGGTGCAG

Downstream 100 bases:

>100_bases
GGGAGGAGCGTTCCGTGGGCATGCCGCTGGAAGGCGTCCGGGTCCTGGACCTGACGCGGGTGATCGCCGGGCCGCTCTGC
ACCCAGATGCTGGCGGAGTT

Product: enoyl-CoA hydratase/carnithine racemase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSAEQSDELLLERRGPVLVALLNRPAKRNAINRAISERLLEAVRQVDEDPGLNAGVLASSTPGMFCAGADLAAMAAGDLL
RPDGDPRPSFTRQPRRKPWIAAVAGPALGGGFEMALACEMIVAGENTTFGLPEARRGLLAAGGGVFRAVRALPRAIGMEL
VLTGRTMDAAEAGRLGLVNRVAPDAEVLEQAVDLAQAVAACAPLAVQESLALARRATEAPETDLWPEARAALTRLMSGAD
AKEGMRAFLERRAPVWRGE

Sequences:

>Translated_259_residues
MSAEQSDELLLERRGPVLVALLNRPAKRNAINRAISERLLEAVRQVDEDPGLNAGVLASSTPGMFCAGADLAAMAAGDLL
RPDGDPRPSFTRQPRRKPWIAAVAGPALGGGFEMALACEMIVAGENTTFGLPEARRGLLAAGGGVFRAVRALPRAIGMEL
VLTGRTMDAAEAGRLGLVNRVAPDAEVLEQAVDLAQAVAACAPLAVQESLALARRATEAPETDLWPEARAALTRLMSGAD
AKEGMRAFLERRAPVWRGE
>Mature_258_residues
SAEQSDELLLERRGPVLVALLNRPAKRNAINRAISERLLEAVRQVDEDPGLNAGVLASSTPGMFCAGADLAAMAAGDLLR
PDGDPRPSFTRQPRRKPWIAAVAGPALGGGFEMALACEMIVAGENTTFGLPEARRGLLAAGGGVFRAVRALPRAIGMELV
LTGRTMDAAEAGRLGLVNRVAPDAEVLEQAVDLAQAVAACAPLAVQESLALARRATEAPETDLWPEARAALTRLMSGADA
KEGMRAFLERRAPVWRGE

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=265, Percent_Identity=31.3207547169811, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI70995211, Length=215, Percent_Identity=37.2093023255814, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=27.710843373494, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI20127408, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4502327, Length=265, Percent_Identity=31.6981132075472, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI150378541, Length=243, Percent_Identity=32.0987654320988, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI68989263, Length=234, Percent_Identity=31.6239316239316, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI37594469, Length=196, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI37594471, Length=196, Percent_Identity=27.5510204081633, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI116235487, Length=244, Percent_Identity=23.7704918032787, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=39.622641509434, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787659, Length=254, Percent_Identity=37.7952755905512, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI87082183, Length=251, Percent_Identity=28.2868525896414, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788682, Length=198, Percent_Identity=35.3535353535354, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788597, Length=239, Percent_Identity=26.3598326359833, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=34.4, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25145438, Length=257, Percent_Identity=35.7976653696498, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17560910, Length=250, Percent_Identity=30.4, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17536985, Length=255, Percent_Identity=28.2352941176471, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=181, Percent_Identity=31.4917127071823, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=262, Percent_Identity=25.1908396946565, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25144276, Length=235, Percent_Identity=30.2127659574468, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=235, Percent_Identity=30.2127659574468, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=235, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=256, Percent_Identity=27.734375, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320241, Length=182, Percent_Identity=29.1208791208791, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24653139, Length=269, Percent_Identity=33.8289962825279, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=35.5102040816327, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=35.5102040816327, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=35.3535353535354, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357171, Length=203, Percent_Identity=31.0344827586207, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24654903, Length=200, Percent_Identity=28.5, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921000, Length=173, Percent_Identity=37.5722543352601, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583077, Length=173, Percent_Identity=37.5722543352601, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583079, Length=173, Percent_Identity=37.5722543352601, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920382, Length=224, Percent_Identity=30.8035714285714, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=259, Percent_Identity=22.007722007722, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 27307; Mature: 27176

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEQSDELLLERRGPVLVALLNRPAKRNAINRAISERLLEAVRQVDEDPGLNAGVLASS
CCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
TPGMFCAGADLAAMAAGDLLRPDGDPRPSFTRQPRRKPWIAAVAGPALGGGFEMALACEM
CCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
IVAGENTTFGLPEARRGLLAAGGGVFRAVRALPRAIGMELVLTGRTMDAAEAGRLGLVNR
HEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCHHHH
VAPDAEVLEQAVDLAQAVAACAPLAVQESLALARRATEAPETDLWPEARAALTRLMSGAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
AKEGMRAFLERRAPVWRGE
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SAEQSDELLLERRGPVLVALLNRPAKRNAINRAISERLLEAVRQVDEDPGLNAGVLASS
CCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
TPGMFCAGADLAAMAAGDLLRPDGDPRPSFTRQPRRKPWIAAVAGPALGGGFEMALACEM
CCCCEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHH
IVAGENTTFGLPEARRGLLAAGGGVFRAVRALPRAIGMELVLTGRTMDAAEAGRLGLVNR
HEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCHHHH
VAPDAEVLEQAVDLAQAVAACAPLAVQESLALARRATEAPETDLWPEARAALTRLMSGAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
AKEGMRAFLERRAPVWRGE
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA