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The map label for this gene is baiB [H]

Identifier: 197105978

GI number: 197105978

Start: 2888376

End: 2889848

Strand: Reverse

Name: baiB [H]

Synonym: PHZ_c2517

Alternate gene names: 197105978

Gene position: 2889848-2888376 (Counterclockwise)

Preceding gene: 197105979

Following gene: 197105976

Centisome position: 72.31

GC content: 71.89

Gene sequence:

>1473_bases
ATGTCCAACGAGGGTGTCCCGCTCGGTTCCATCCTGGCCTACCACGCACGCCGGTCGCCAGGCCGCGCGGCGTTGGTCGT
GGAGGGCGCCGCGGTCGGTTTCGGCGAGCTGGACGCGCGGGCGAACCGGCGGGCGCGGATGCTGGCGGCGCATGGCGTCA
TGGCGGGCGACTTCGTCACCGTCGCCTTGCCGAACGGCGCCGAGTTCTACGAGACCGTCTTTTCGATCTGGAAGCTGGGG
GCGATCCCGAACATCGTCTCGGCCAGGCTCGCGCGCCCGGAGATGGAGGCCATTCTCGATCTCGTCCGCCCAAGGCTGTT
CGTCGGCGAGCCGCCGGGACCGGGGACGCCGGCGCTTCCCGCGAACCTGCCGGGCCTGGAGGGGTATTCGGCCGATCCGC
TGCCCGCGGCCGTCTCGCCGCACTGGAAGGCGATGACGAGCGGCGGTTCGACCGGCCGCCCCAAGGTGATCGTGGACGCG
ACGCCGGCGCGCTGGGACCCGCGCGAGGGCTTCCTGCTGCAGCGCCCCGGCGACGTGATCCTCAATCCGGGGCCGCTCTA
CCACAACGCCCCGTTCCACTGCATCAGCATGGGCCTCTTCGTCGGCGCCACGATCGTCGAGATGGGCCGGTTCGACCCGC
TTCGGGCCCTGGAGCTGATCGAGGCGCACGAGGTGAACTGGGTCACCATGGTGCCGACGATGATGCATCGCATCTGGCGC
CTCGGCCCAGACGTGCTGTCGCGCTTCACCCTGCCCAGCCTGCGCCTGATGCTGCACATGGCCGCCCCCTGCGCCCCGTG
GCTCAAGGAGGCGTGGATCGGCTGGCTGGGGAGCGAGCGGGTCTGGGAATACTACGGCACGACCGAGGGCACCGGCTCGA
CCATGATCTCCGGCGCGGACTGGCTGACCCATCGCGGCTCGGTGGGACGGGTTCGCGAGGGCTACGCGCTGAAGATCCTG
GATGACGCCGGCCAGGAGCGGCCCGTGGGCGAGGTCGGCGAGGTCTACTTCCGGCCGGCCGGCGGTCCGGGCTCGACCTA
CCACTACCTCGGCAGCACGCCGAAGCGGGTCGGCGAGTGGGAGACCCAGGGCGACCTGGGGCACGTGGACGAGGAGGGCT
ACCTGTACCTGTCGGACCGCCGCAACGACCTGATCATCTCGGGTGGGGCGAACATCTACCCGGCGGAGGTGGAGGCCGCG
CTCGAGGCGCATCCGGACGTGCGGAGCAGCGCAGTGATCGGCCTGCCGGACGAGGAGTGGGGCGCGCGCGTCCACGCGAT
CGTCCAGCCCGTGGAGGGCGGGAGGCCCGACGAGGCGGAGCTGCTCGCGTTCGTGGCGGGGCGGCTGGCGTCCTACAAGC
GCCCCAGGACCCTGGAGTTCACGGGCGAGCCCCTGCGCGACGAGGCCGGCAAGGTGCGCCGGGCGGCGCTCCGTCAGGCG
AGGCTGGGCCAGGCGAGGGTGGAGGAGGCGTGA

Upstream 100 bases:

>100_bases
CGACTAAATTAATGACGCCACTGTTTCAGTCGCCCTGATCCGCACGCGCCGACGCAAAGGCGGCGTGAGCGGGGAGGGCG
TCCAGGGAGGCGTCGCCGAT

Downstream 100 bases:

>100_bases
GGTGGCGCGTGAGCGCGCCTATCCGGCCTGTTTCCTGCGCCCGTACAGCGCCTCGAACCCGCCGGCCATGAAGGTGACGA
AGCGCTCGCGGACCGCCTCG

Product: long-chain fatty-acid-CoA ligase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSNEGVPLGSILAYHARRSPGRAALVVEGAAVGFGELDARANRRARMLAAHGVMAGDFVTVALPNGAEFYETVFSIWKLG
AIPNIVSARLARPEMEAILDLVRPRLFVGEPPGPGTPALPANLPGLEGYSADPLPAAVSPHWKAMTSGGSTGRPKVIVDA
TPARWDPREGFLLQRPGDVILNPGPLYHNAPFHCISMGLFVGATIVEMGRFDPLRALELIEAHEVNWVTMVPTMMHRIWR
LGPDVLSRFTLPSLRLMLHMAAPCAPWLKEAWIGWLGSERVWEYYGTTEGTGSTMISGADWLTHRGSVGRVREGYALKIL
DDAGQERPVGEVGEVYFRPAGGPGSTYHYLGSTPKRVGEWETQGDLGHVDEEGYLYLSDRRNDLIISGGANIYPAEVEAA
LEAHPDVRSSAVIGLPDEEWGARVHAIVQPVEGGRPDEAELLAFVAGRLASYKRPRTLEFTGEPLRDEAGKVRRAALRQA
RLGQARVEEA

Sequences:

>Translated_490_residues
MSNEGVPLGSILAYHARRSPGRAALVVEGAAVGFGELDARANRRARMLAAHGVMAGDFVTVALPNGAEFYETVFSIWKLG
AIPNIVSARLARPEMEAILDLVRPRLFVGEPPGPGTPALPANLPGLEGYSADPLPAAVSPHWKAMTSGGSTGRPKVIVDA
TPARWDPREGFLLQRPGDVILNPGPLYHNAPFHCISMGLFVGATIVEMGRFDPLRALELIEAHEVNWVTMVPTMMHRIWR
LGPDVLSRFTLPSLRLMLHMAAPCAPWLKEAWIGWLGSERVWEYYGTTEGTGSTMISGADWLTHRGSVGRVREGYALKIL
DDAGQERPVGEVGEVYFRPAGGPGSTYHYLGSTPKRVGEWETQGDLGHVDEEGYLYLSDRRNDLIISGGANIYPAEVEAA
LEAHPDVRSSAVIGLPDEEWGARVHAIVQPVEGGRPDEAELLAFVAGRLASYKRPRTLEFTGEPLRDEAGKVRRAALRQA
RLGQARVEEA
>Mature_489_residues
SNEGVPLGSILAYHARRSPGRAALVVEGAAVGFGELDARANRRARMLAAHGVMAGDFVTVALPNGAEFYETVFSIWKLGA
IPNIVSARLARPEMEAILDLVRPRLFVGEPPGPGTPALPANLPGLEGYSADPLPAAVSPHWKAMTSGGSTGRPKVIVDAT
PARWDPREGFLLQRPGDVILNPGPLYHNAPFHCISMGLFVGATIVEMGRFDPLRALELIEAHEVNWVTMVPTMMHRIWRL
GPDVLSRFTLPSLRLMLHMAAPCAPWLKEAWIGWLGSERVWEYYGTTEGTGSTMISGADWLTHRGSVGRVREGYALKILD
DAGQERPVGEVGEVYFRPAGGPGSTYHYLGSTPKRVGEWETQGDLGHVDEEGYLYLSDRRNDLIISGGANIYPAEVEAAL
EAHPDVRSSAVIGLPDEEWGARVHAIVQPVEGGRPDEAELLAFVAGRLASYKRPRTLEFTGEPLRDEAGKVRRAALRQAR
LGQARVEEA

Specific function: Active with a large number of C-24 bile acids possessing unhindered C-24 carboxyl groups. Requires ATP and produces AMP and pyrophosphate in addition to the bile-acid CoA thioester [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=560, Percent_Identity=23.3928571428571, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI42544132, Length=496, Percent_Identity=24.7983870967742, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI38505220, Length=501, Percent_Identity=25.9481037924152, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI122937307, Length=244, Percent_Identity=33.6065573770492, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI58082049, Length=293, Percent_Identity=31.0580204778157, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI157311624, Length=293, Percent_Identity=30.7167235494881, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI157311622, Length=293, Percent_Identity=30.7167235494881, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI115511026, Length=217, Percent_Identity=33.1797235023041, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI187761345, Length=524, Percent_Identity=25.763358778626, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI187761343, Length=524, Percent_Identity=25.763358778626, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI221142682, Length=505, Percent_Identity=25.1485148514851, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI145693145, Length=531, Percent_Identity=24.6704331450094, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788107, Length=321, Percent_Identity=27.1028037383178, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=25.1417769376182, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790505, Length=288, Percent_Identity=25.6944444444444, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=505, Percent_Identity=25.9405940594059, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=302, Percent_Identity=28.8079470198675, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=497, Percent_Identity=26.1569416498994, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994694, Length=354, Percent_Identity=28.5310734463277, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=347, Percent_Identity=28.5302593659942, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=354, Percent_Identity=28.5310734463277, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=354, Percent_Identity=28.5310734463277, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531443, Length=538, Percent_Identity=22.1189591078067, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=314, Percent_Identity=26.1146496815287, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=339, Percent_Identity=25.3687315634218, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=316, Percent_Identity=27.8481012658228, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=296, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=319, Percent_Identity=28.5266457680251, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355181, Length=483, Percent_Identity=25.879917184265, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24648253, Length=509, Percent_Identity=23.9685658153242, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648255, Length=509, Percent_Identity=24.1650294695481, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648260, Length=515, Percent_Identity=25.631067961165, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356441, Length=515, Percent_Identity=21.9417475728155, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358303, Length=485, Percent_Identity=21.4432989690722, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24648257, Length=531, Percent_Identity=23.728813559322, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI18859661, Length=352, Percent_Identity=25.8522727272727, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581924, Length=345, Percent_Identity=27.8260869565217, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130357, Length=345, Percent_Identity=26.9565217391304, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653035, Length=523, Percent_Identity=20.8413001912046, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355225, Length=291, Percent_Identity=26.1168384879725, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922652, Length=282, Percent_Identity=24.822695035461, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281365686, Length=263, Percent_Identity=24.3346007604563, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656500, Length=366, Percent_Identity=25.4098360655738, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356947, Length=169, Percent_Identity=29.585798816568, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161076582, Length=531, Percent_Identity=20.15065913371, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62472339, Length=540, Percent_Identity=21.6666666666667, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667955, Length=540, Percent_Identity=21.6666666666667, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24667959, Length=375, Percent_Identity=24, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 53257; Mature: 53126

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEGVPLGSILAYHARRSPGRAALVVEGAAVGFGELDARANRRARMLAAHGVMAGDFVT
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEECCEEE
VALPNGAEFYETVFSIWKLGAIPNIVSARLARPEMEAILDLVRPRLFVGEPPGPGTPALP
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCC
ANLPGLEGYSADPLPAAVSPHWKAMTSGGSTGRPKVIVDATPARWDPREGFLLQRPGDVI
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEE
LNPGPLYHNAPFHCISMGLFVGATIVEMGRFDPLRALELIEAHEVNWVTMVPTMMHRIWR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHH
LGPDVLSRFTLPSLRLMLHMAAPCAPWLKEAWIGWLGSERVWEYYGTTEGTGSTMISGAD
CCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHEEECCCCCCCCCEEECCCH
WLTHRGSVGRVREGYALKILDDAGQERPVGEVGEVYFRPAGGPGSTYHYLGSTPKRVGEW
HHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCHHHHCCC
ETQGDLGHVDEEGYLYLSDRRNDLIISGGANIYPAEVEAALEAHPDVRSSAVIGLPDEEW
CCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHH
GARVHAIVQPVEGGRPDEAELLAFVAGRLASYKRPRTLEFTGEPLRDEAGKVRRAALRQA
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHH
RLGQARVEEA
HHCCHHCCCC
>Mature Secondary Structure 
SNEGVPLGSILAYHARRSPGRAALVVEGAAVGFGELDARANRRARMLAAHGVMAGDFVT
CCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEECCEEE
VALPNGAEFYETVFSIWKLGAIPNIVSARLARPEMEAILDLVRPRLFVGEPPGPGTPALP
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCC
ANLPGLEGYSADPLPAAVSPHWKAMTSGGSTGRPKVIVDATPARWDPREGFLLQRPGDVI
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEE
LNPGPLYHNAPFHCISMGLFVGATIVEMGRFDPLRALELIEAHEVNWVTMVPTMMHRIWR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHH
LGPDVLSRFTLPSLRLMLHMAAPCAPWLKEAWIGWLGSERVWEYYGTTEGTGSTMISGAD
CCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHEEECCCCCCCCCEEECCCH
WLTHRGSVGRVREGYALKILDDAGQERPVGEVGEVYFRPAGGPGSTYHYLGSTPKRVGEW
HHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCHHHHCCC
ETQGDLGHVDEEGYLYLSDRRNDLIISGGANIYPAEVEAALEAHPDVRSSAVIGLPDEEW
CCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHH
GARVHAIVQPVEGGRPDEAELLAFVAGRLASYKRPRTLEFTGEPLRDEAGKVRRAALRQA
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHH
RLGQARVEEA
HHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2254270; 1551828 [H]