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The map label for this gene is 197105897

Identifier: 197105897

GI number: 197105897

Start: 2781732

End: 2783402

Strand: Reverse

Name: 197105897

Synonym: PHZ_c2436

Alternate gene names: NA

Gene position: 2783402-2781732 (Counterclockwise)

Preceding gene: 197105898

Following gene: 197105896

Centisome position: 69.65

GC content: 64.45

Gene sequence:

>1671_bases
GTGTCGTCAAACCTTTTCACGCTCGAGATCATCAAGGATTCGCTGGTGGCGGTCGGCGAAGAGATGTTCAACGCCATGCT
GCGGACCAGCATGAGCCCGATCATCTATGAGGGCACGGATTTCGCGGTCGGGGCGACGGACGCCAGAGGCAATCTGCTAG
CGCAGGGTAACGGCGTAGCCGCATTCCTGGCAGCCCTCGACACCGCCGTTGTCTCGGCGCTCGAGCACTACGATCCGAGC
GAGATTCGTCCCGGCGACGTGTTCATCACCAACACCCCCTACGAGGGCGGCGGCACGCACCTGTCTGACGTGGCGATCCT
CATCCCCGTGTTCCATGAGGGCCGGCTGATCGCCTGGACGGTGAACAAGGCCCATTGGACCGAAGTGGGCGGGGCGCAGC
CAGGCAGCGTGTCCAGTTCATCGACCGACATCTACCAGGAGGGCCTGCGCTTCACCTTCATCAAGCTCTACGACGAAGGA
CGGCTGAACCAGCCGGTCGTGCAGATCATCCGGGACAACGTCCGGCTTCCGGACTCGACCATCGGCGACATGCATGCCGG
GGTGGCGGCAGCGCGTGTCGGCGAAAAGCGGATCCTCGAACTCGTCGCCAGGTACGGCGCCGAGATGGTTCTCCAGGCGA
TGGATGAGCTGCTGGACTACGGGGAAAAAATGACCAGGGCCGCGCTGGCGACGATCCCGAGCGGCGTCTACGAAGCCGAG
GACATCATCGAGGAGGATGGTCTCGGAAACGGTCCCTTCAAGGTGAGGGTGAAGGTGACGGTCACCGGCGATCGTCTTGT
CGCCGACTTCACCGGCTCGTCGCCCCAGGCGCCGGGGCCTGTGAACACGACCTACTCGGGTCTGATGACCGGAGCGCGCT
GCCTTTTCAAGGCGATCACTGACCCGGGCATTCCGGCCAACGGCGGCTGTTTTCGAATGCTTGAGGTGGTCTGTCCGCCA
GGGACGGTTCTCACCGCCATCGAACCGGCTCCGGTTTCGATGAACTTTCAGGCGCGAAACGCCGCCGTCGACGTCATGTG
GAAGGCGCTGGCCCCCATTCTCCCGCACCGTCTGCCGGCGGGTCACCAGCAGTCGGTCTGCGCCACCTTCATCTCTGGCA
AGCATCCTGACACGGGGGAGCTCTTCGTGATCGGCGAGCCCCTGGTCGGCGGCTGGGGAGCCTCCCAGGACACCGATGGC
GACGCCGGCCAGTTCTGCAGCTCCAATGGCGAGACCTACAACATCCCCTGCGAGCTGTTCGAAGCGCGCTACGGGCTTCA
GGTCGCCCAATACGCCTTCCACGATCAGGACGGCGGCGCCGGACGCTACCGGGGCGGGAAGGGGGTCGTGCTCGATTATC
GCGTTACCGCCGAGCGTGCGTTTCTCACCTATGCCGCAGCCCGAACGTCATCTCGGCCCTGGGCCCTTCTGGGAGGTCAG
GAAGGCTCAAACAACTACGCGGAGATCCGTCGCCACGACGGATCGGTGGAACGCTACGGGATGTGCACGACCGTTCCGGT
CGAGCGCGACGAGATCATCCGCATCTACACGGCCACGGGCGGCGGCTACGGAGATCCCAGGACCAGGCCGCGGGAGCTCG
TGGAACAGGATATGAAGAACGGCTTCGTAACGCCCCAGCAGGCCGCCGAGCACTACGGCTATCGGCCCTGA

Upstream 100 bases:

>100_bases
GCCCTCGGTCACCTGCGTGGTGCCGCCCGGGCATCGCGTCAGCATCGACCAGTTCGGAAACTATCACATCCACCTGTCCT
TCGACGGGGAGGCCTAACCC

Downstream 100 bases:

>100_bases
CGCAGCCGCGGTTAAGGCCGCGCGCCACCCTTCTCACAACACTCCTGCAGCGGCCCCGTCACTGCAGTGGAGGTTCGCGT
CCTCATCCCTGGCTTCGATC

Product: 5-oxoprolinase (ATP-hydrolyzing)

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSSNLFTLEIIKDSLVAVGEEMFNAMLRTSMSPIIYEGTDFAVGATDARGNLLAQGNGVAAFLAALDTAVVSALEHYDPS
EIRPGDVFITNTPYEGGGTHLSDVAILIPVFHEGRLIAWTVNKAHWTEVGGAQPGSVSSSSTDIYQEGLRFTFIKLYDEG
RLNQPVVQIIRDNVRLPDSTIGDMHAGVAAARVGEKRILELVARYGAEMVLQAMDELLDYGEKMTRAALATIPSGVYEAE
DIIEEDGLGNGPFKVRVKVTVTGDRLVADFTGSSPQAPGPVNTTYSGLMTGARCLFKAITDPGIPANGGCFRMLEVVCPP
GTVLTAIEPAPVSMNFQARNAAVDVMWKALAPILPHRLPAGHQQSVCATFISGKHPDTGELFVIGEPLVGGWGASQDTDG
DAGQFCSSNGETYNIPCELFEARYGLQVAQYAFHDQDGGAGRYRGGKGVVLDYRVTAERAFLTYAAARTSSRPWALLGGQ
EGSNNYAEIRRHDGSVERYGMCTTVPVERDEIIRIYTATGGGYGDPRTRPRELVEQDMKNGFVTPQQAAEHYGYRP

Sequences:

>Translated_556_residues
MSSNLFTLEIIKDSLVAVGEEMFNAMLRTSMSPIIYEGTDFAVGATDARGNLLAQGNGVAAFLAALDTAVVSALEHYDPS
EIRPGDVFITNTPYEGGGTHLSDVAILIPVFHEGRLIAWTVNKAHWTEVGGAQPGSVSSSSTDIYQEGLRFTFIKLYDEG
RLNQPVVQIIRDNVRLPDSTIGDMHAGVAAARVGEKRILELVARYGAEMVLQAMDELLDYGEKMTRAALATIPSGVYEAE
DIIEEDGLGNGPFKVRVKVTVTGDRLVADFTGSSPQAPGPVNTTYSGLMTGARCLFKAITDPGIPANGGCFRMLEVVCPP
GTVLTAIEPAPVSMNFQARNAAVDVMWKALAPILPHRLPAGHQQSVCATFISGKHPDTGELFVIGEPLVGGWGASQDTDG
DAGQFCSSNGETYNIPCELFEARYGLQVAQYAFHDQDGGAGRYRGGKGVVLDYRVTAERAFLTYAAARTSSRPWALLGGQ
EGSNNYAEIRRHDGSVERYGMCTTVPVERDEIIRIYTATGGGYGDPRTRPRELVEQDMKNGFVTPQQAAEHYGYRP
>Mature_555_residues
SSNLFTLEIIKDSLVAVGEEMFNAMLRTSMSPIIYEGTDFAVGATDARGNLLAQGNGVAAFLAALDTAVVSALEHYDPSE
IRPGDVFITNTPYEGGGTHLSDVAILIPVFHEGRLIAWTVNKAHWTEVGGAQPGSVSSSSTDIYQEGLRFTFIKLYDEGR
LNQPVVQIIRDNVRLPDSTIGDMHAGVAAARVGEKRILELVARYGAEMVLQAMDELLDYGEKMTRAALATIPSGVYEAED
IIEEDGLGNGPFKVRVKVTVTGDRLVADFTGSSPQAPGPVNTTYSGLMTGARCLFKAITDPGIPANGGCFRMLEVVCPPG
TVLTAIEPAPVSMNFQARNAAVDVMWKALAPILPHRLPAGHQQSVCATFISGKHPDTGELFVIGEPLVGGWGASQDTDGD
AGQFCSSNGETYNIPCELFEARYGLQVAQYAFHDQDGGAGRYRGGKGVVLDYRVTAERAFLTYAAARTSSRPWALLGGQE
GSNNYAEIRRHDGSVERYGMCTTVPVERDEIIRIYTATGGGYGDPRTRPRELVEQDMKNGFVTPQQAAEHYGYRP

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=539, Percent_Identity=28.2003710575139, Blast_Score=166, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI133901900, Length=535, Percent_Identity=26.1682242990654, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI133901902, Length=508, Percent_Identity=25.9842519685039, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322634, Length=554, Percent_Identity=26.8953068592058, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550492, Length=586, Percent_Identity=25.938566552901, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 59888; Mature: 59757

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNLFTLEIIKDSLVAVGEEMFNAMLRTSMSPIIYEGTDFAVGATDARGNLLAQGNGVA
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCEEECCCCHH
AFLAALDTAVVSALEHYDPSEIRPGDVFITNTPYEGGGTHLSDVAILIPVFHEGRLIAWT
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHCEEEEEEEECCCEEEEEE
VNKAHWTEVGGAQPGSVSSSSTDIYQEGLRFTFIKLYDEGRLNQPVVQIIRDNVRLPDST
ECCCEEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCC
IGDMHAGVAAARVGEKRILELVARYGAEMVLQAMDELLDYGEKMTRAALATIPSGVYEAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DIIEEDGLGNGPFKVRVKVTVTGDRLVADFTGSSPQAPGPVNTTYSGLMTGARCLFKAIT
HHHHHCCCCCCCEEEEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DPGIPANGGCFRMLEVVCPPGTVLTAIEPAPVSMNFQARNAAVDVMWKALAPILPHRLPA
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
GHQQSVCATFISGKHPDTGELFVIGEPLVGGWGASQDTDGDAGQFCSSNGETYNIPCELF
CCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCHHHH
EARYGLQVAQYAFHDQDGGAGRYRGGKGVVLDYRVTAERAFLTYAAARTSSRPWALLGGQ
HHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCCEEEECCC
EGSNNYAEIRRHDGSVERYGMCTTVPVERDEIIRIYTATGGGYGDPRTRPRELVEQDMKN
CCCCCHHHHHHCCCCCHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHC
GFVTPQQAAEHYGYRP
CCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SSNLFTLEIIKDSLVAVGEEMFNAMLRTSMSPIIYEGTDFAVGATDARGNLLAQGNGVA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCEEECCCCHH
AFLAALDTAVVSALEHYDPSEIRPGDVFITNTPYEGGGTHLSDVAILIPVFHEGRLIAWT
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHCEEEEEEEECCCEEEEEE
VNKAHWTEVGGAQPGSVSSSSTDIYQEGLRFTFIKLYDEGRLNQPVVQIIRDNVRLPDST
ECCCEEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCC
IGDMHAGVAAARVGEKRILELVARYGAEMVLQAMDELLDYGEKMTRAALATIPSGVYEAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DIIEEDGLGNGPFKVRVKVTVTGDRLVADFTGSSPQAPGPVNTTYSGLMTGARCLFKAIT
HHHHHCCCCCCCEEEEEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DPGIPANGGCFRMLEVVCPPGTVLTAIEPAPVSMNFQARNAAVDVMWKALAPILPHRLPA
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
GHQQSVCATFISGKHPDTGELFVIGEPLVGGWGASQDTDGDAGQFCSSNGETYNIPCELF
CCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCEEECCHHHH
EARYGLQVAQYAFHDQDGGAGRYRGGKGVVLDYRVTAERAFLTYAAARTSSRPWALLGGQ
HHHHCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCCEEEECCC
EGSNNYAEIRRHDGSVERYGMCTTVPVERDEIIRIYTATGGGYGDPRTRPRELVEQDMKN
CCCCCHHHHHHCCCCCHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHC
GFVTPQQAAEHYGYRP
CCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]