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The map label for this gene is 197105831

Identifier: 197105831

GI number: 197105831

Start: 2684456

End: 2686192

Strand: Reverse

Name: 197105831

Synonym: PHZ_c2370

Alternate gene names: NA

Gene position: 2686192-2684456 (Counterclockwise)

Preceding gene: 197105832

Following gene: 197105828

Centisome position: 67.22

GC content: 64.54

Gene sequence:

>1737_bases
ATGGCAGAGAGAACGCAAACCCAGGACGCCGCGCCGCAACGCCAGTTCGATGCGATCGCGATGGAAGTCTTCAGCAATCG
CATGCTCTCGATCACCGAGAACATGGCGATCCACATGATGCGGTCGTCCTATTCGGCGCAGATCAAGGAGCGCCGCGACT
TCTCAGTCGGCATCTTCGACGCCCAAGGCCGCCTGATCGCCCAGGGCACCCACATTCCGATCCACCTTGGGTCACTGCTG
GGATCGGTCGAAGCTCTGCTGGCTCGCTATCGGATCACCGACATGGTGGAGGGTGACGCCTTCATCTGCAACGATCCTTA
TCTCGCCGGGGGGACGCACATGCCGGACGTCTCCATCGTCACCCCCGTGTTTATCGATGGCCAGGTGGCGGCCTTCGCCG
CCAACATTGGGCACCATTCCGACCTCGGTGGTGCGGTTCCGGGCTCGATCTCACCCGACGCTCGCTCGATCTTCGAAGAA
GGCCTTCGCCTTCCGATCATCCGGATCGCGCGAGGTGGCGAAATTGATGAGGACCTGCTCAACCTGATCGCGGCGAACTC
GCGCATGCCAGAAGAGCGGCGCCTCGATCTCAGGGTTCAGGTCGCCGTCAACGTACGCGGCGGCGACGAGACGCGAGCCC
TCTTCAAGCGCATGGGGCTGGCCAATGCGCAGGCCGCCGTGGAGGACGTGTTCGCCTACACAGCCGAGCGGCTGCGGCGG
CGGATCTCTGCGCTCCCGGCAGGCGAGCACACCTTCCGGACCTGGCTCGACGACGACGGCGCCGGCAGCGGCCCGGTTCC
TATCGTTGTCACTGCCAAGACTGGCGGCAATGCGCTCCATCTCGATCTTGAGGGCACTGGGCCCCAGGCCGGAGGCGCCT
TCAACGTTCCGGCGAGCGCGCTCAGGGCGACGGTGTACTATTGCGTCAAAGCCCTGCTGGACCCGGAGCTGATGCCCAAC
AGCGGCATGTTCGAAGCGGTGACGATCTCAGCGCCTAAGGGCTCGATCGCAAACCCCAACTATCCGGCGGCGACCGGCGT
CCGAAGCAACACCTGTCAGAAGATCGCTGGCGCTGTATTCGGCGCTTTCCGGGGGCTCGTGCCGACCGATCGGCAGATCG
CATCGAGTCACGATCTGCTTCCGTCCTTCTTTTTCTCTGGGGTGAATCCCGAAACCGGCCGCTTCTATGTATGCGCTGAG
ACCGTCGGCGGGGGCAGCGGCGCTCGCGAAAACGACGACGGCGCGGACGCCATCCACGTGCATATCACGAACAGCCTGAA
CTTGCCGACCGAGGCGATGGAGAACGAGTACCCGTTGCTCTGCGAGGGCTACTCGCTTGCCGTGGACTCAGGCGGCGCGG
GCCGACAGCGCGGCGGTCTTGGTATCGTAAGGCATGTCCGAGCGCTGCAGGACAACACGGTCTTCTCCGCCAGATCCGAC
GCCTACATCCATGGCGCCGAAGGAATTTATGGCGGTCGCACCGGGGGCCTGAGTTCCGTTATTCGCAATGCGGGCCGCGC
CGATGAGCAGGTTCTGCCCACCAAGGTGCCGAACCTGGTGCTCGCCGCTGGGGAAAGCATTCGCGTGCAAACGCCGGGCG
GCGGCGGCTTCGGCCCGTGTGACGAGCGGCCGCTCGGGGAGATCGCCCGGGATCTGAGGGACGGGATCATCACCCAGTCT
GCGGCTGAACGAGACTATGGCGCGGCTCGAGTTCGCGAGGCCCTCAACCTGCTCTAG

Upstream 100 bases:

>100_bases
GTCATCGAGGAAATGAGCTCCACGACCGTGGTGCTCCGCGGTCAGACCGCCACGATCGACGCCTACGGCAACATCATCAT
CACGAGCTGAGCATCAGGCT

Downstream 100 bases:

>100_bases
GACTGGAGGGGGCCCGGCCCGGCTCTGGGCGCCATCGGACCAGCCGTGTCCCGCCCAGAGCCGGGTCATCTTCCGGCTGG
CGGGAGATGGCCGTCGAGCC

Product: N-methylhydantoinase B/acetone carboxylase, alpha subunit

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MAERTQTQDAAPQRQFDAIAMEVFSNRMLSITENMAIHMMRSSYSAQIKERRDFSVGIFDAQGRLIAQGTHIPIHLGSLL
GSVEALLARYRITDMVEGDAFICNDPYLAGGTHMPDVSIVTPVFIDGQVAAFAANIGHHSDLGGAVPGSISPDARSIFEE
GLRLPIIRIARGGEIDEDLLNLIAANSRMPEERRLDLRVQVAVNVRGGDETRALFKRMGLANAQAAVEDVFAYTAERLRR
RISALPAGEHTFRTWLDDDGAGSGPVPIVVTAKTGGNALHLDLEGTGPQAGGAFNVPASALRATVYYCVKALLDPELMPN
SGMFEAVTISAPKGSIANPNYPAATGVRSNTCQKIAGAVFGAFRGLVPTDRQIASSHDLLPSFFFSGVNPETGRFYVCAE
TVGGGSGARENDDGADAIHVHITNSLNLPTEAMENEYPLLCEGYSLAVDSGGAGRQRGGLGIVRHVRALQDNTVFSARSD
AYIHGAEGIYGGRTGGLSSVIRNAGRADEQVLPTKVPNLVLAAGESIRVQTPGGGGFGPCDERPLGEIARDLRDGIITQS
AAERDYGAARVREALNLL

Sequences:

>Translated_578_residues
MAERTQTQDAAPQRQFDAIAMEVFSNRMLSITENMAIHMMRSSYSAQIKERRDFSVGIFDAQGRLIAQGTHIPIHLGSLL
GSVEALLARYRITDMVEGDAFICNDPYLAGGTHMPDVSIVTPVFIDGQVAAFAANIGHHSDLGGAVPGSISPDARSIFEE
GLRLPIIRIARGGEIDEDLLNLIAANSRMPEERRLDLRVQVAVNVRGGDETRALFKRMGLANAQAAVEDVFAYTAERLRR
RISALPAGEHTFRTWLDDDGAGSGPVPIVVTAKTGGNALHLDLEGTGPQAGGAFNVPASALRATVYYCVKALLDPELMPN
SGMFEAVTISAPKGSIANPNYPAATGVRSNTCQKIAGAVFGAFRGLVPTDRQIASSHDLLPSFFFSGVNPETGRFYVCAE
TVGGGSGARENDDGADAIHVHITNSLNLPTEAMENEYPLLCEGYSLAVDSGGAGRQRGGLGIVRHVRALQDNTVFSARSD
AYIHGAEGIYGGRTGGLSSVIRNAGRADEQVLPTKVPNLVLAAGESIRVQTPGGGGFGPCDERPLGEIARDLRDGIITQS
AAERDYGAARVREALNLL
>Mature_577_residues
AERTQTQDAAPQRQFDAIAMEVFSNRMLSITENMAIHMMRSSYSAQIKERRDFSVGIFDAQGRLIAQGTHIPIHLGSLLG
SVEALLARYRITDMVEGDAFICNDPYLAGGTHMPDVSIVTPVFIDGQVAAFAANIGHHSDLGGAVPGSISPDARSIFEEG
LRLPIIRIARGGEIDEDLLNLIAANSRMPEERRLDLRVQVAVNVRGGDETRALFKRMGLANAQAAVEDVFAYTAERLRRR
ISALPAGEHTFRTWLDDDGAGSGPVPIVVTAKTGGNALHLDLEGTGPQAGGAFNVPASALRATVYYCVKALLDPELMPNS
GMFEAVTISAPKGSIANPNYPAATGVRSNTCQKIAGAVFGAFRGLVPTDRQIASSHDLLPSFFFSGVNPETGRFYVCAET
VGGGSGARENDDGADAIHVHITNSLNLPTEAMENEYPLLCEGYSLAVDSGGAGRQRGGLGIVRHVRALQDNTVFSARSDA
YIHGAEGIYGGRTGGLSSVIRNAGRADEQVLPTKVPNLVLAAGESIRVQTPGGGGFGPCDERPLGEIARDLRDGIITQSA
AERDYGAARVREALNLL

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=551, Percent_Identity=31.2159709618875, Blast_Score=212, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133901900, Length=547, Percent_Identity=30.3473491773309, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI133901902, Length=514, Percent_Identity=29.5719844357977, Blast_Score=196, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6322634, Length=555, Percent_Identity=29.3693693693694, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI45550492, Length=549, Percent_Identity=30.7832422586521, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 61419; Mature: 61288

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERTQTQDAAPQRQFDAIAMEVFSNRMLSITENMAIHMMRSSYSAQIKERRDFSVGIFD
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AQGRLIAQGTHIPIHLGSLLGSVEALLARYRITDMVEGDAFICNDPYLAGGTHMPDVSIV
CCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHEECCCEEEECCCEECCCCCCCCCEEE
TPVFIDGQVAAFAANIGHHSDLGGAVPGSISPDARSIFEEGLRLPIIRIARGGEIDEDLL
CEEEECCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHH
NLIAANSRMPEERRLDLRVQVAVNVRGGDETRALFKRMGLANAQAAVEDVFAYTAERLRR
HHHHHCCCCCHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RISALPAGEHTFRTWLDDDGAGSGPVPIVVTAKTGGNALHLDLEGTGPQAGGAFNVPASA
HHHHCCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHH
LRATVYYCVKALLDPELMPNSGMFEAVTISAPKGSIANPNYPAATGVRSNTCQKIAGAVF
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GAFRGLVPTDRQIASSHDLLPSFFFSGVNPETGRFYVCAETVGGGSGARENDDGADAIHV
HHHHCCCCCCHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEE
HITNSLNLPTEAMENEYPLLCEGYSLAVDSGGAGRQRGGLGIVRHVRALQDNTVFSARSD
EEECCCCCCHHHHCCCCCEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCC
AYIHGAEGIYGGRTGGLSSVIRNAGRADEQVLPTKVPNLVLAAGESIRVQTPGGGGFGPC
CEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCC
DERPLGEIARDLRDGIITQSAAERDYGAARVREALNLL
CCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AERTQTQDAAPQRQFDAIAMEVFSNRMLSITENMAIHMMRSSYSAQIKERRDFSVGIFD
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AQGRLIAQGTHIPIHLGSLLGSVEALLARYRITDMVEGDAFICNDPYLAGGTHMPDVSIV
CCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHEECCCEEEECCCEECCCCCCCCCEEE
TPVFIDGQVAAFAANIGHHSDLGGAVPGSISPDARSIFEEGLRLPIIRIARGGEIDEDLL
CEEEECCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHH
NLIAANSRMPEERRLDLRVQVAVNVRGGDETRALFKRMGLANAQAAVEDVFAYTAERLRR
HHHHHCCCCCHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RISALPAGEHTFRTWLDDDGAGSGPVPIVVTAKTGGNALHLDLEGTGPQAGGAFNVPASA
HHHHCCCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCHHH
LRATVYYCVKALLDPELMPNSGMFEAVTISAPKGSIANPNYPAATGVRSNTCQKIAGAVF
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GAFRGLVPTDRQIASSHDLLPSFFFSGVNPETGRFYVCAETVGGGSGARENDDGADAIHV
HHHHCCCCCCHHHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEE
HITNSLNLPTEAMENEYPLLCEGYSLAVDSGGAGRQRGGLGIVRHVRALQDNTVFSARSD
EEECCCCCCHHHHCCCCCEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCC
AYIHGAEGIYGGRTGGLSSVIRNAGRADEQVLPTKVPNLVLAAGESIRVQTPGGGGFGPC
CEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCC
DERPLGEIARDLRDGIITQSAAERDYGAARVREALNLL
CCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]