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The map label for this gene is gudP [H]

Identifier: 197105828

GI number: 197105828

Start: 2678924

End: 2680045

Strand: Reverse

Name: gudP [H]

Synonym: PHZ_c2366

Alternate gene names: 197105828

Gene position: 2680045-2678924 (Counterclockwise)

Preceding gene: 197105831

Following gene: 197105827

Centisome position: 67.06

GC content: 62.12

Gene sequence:

>1122_bases
TTGGCGAGATCCAGGCCGATCGTTGTAATCTCCATCTGGGTGGCTCCCTTCGCTCGTGGTTGTTCGACAACTTCCACAAG
TCTGGCACTCAGATGCCGTGAGCGGGAGCCATCCACCCCATCTGCTTTCACCGCCGTTACTGGCGCAGCCACCACGCTCA
TGCAGCTGCTGGTCGTGCGCCTGCTGTTCGGTGTCGGCGAGGGCGCGTTCCCGGCGGCTTCATTCAAGACGATCGCGGCC
TGGTTTCCGAAGAAGGAGCGCGCGACGGCCAGCGCGGTCATGTTGACTGCGAACACCCTGGGCGCCGCCCTGAGCCCGCT
GATCGTCGTCGGGATCATGGCGACGTGGGGCTGGCGAGCGGTGTTCTTCGTTCTCCTGATCCCCGGAATTCTGGTTTCGA
TCCTGTTCTGGCTGGTGGTCAAGGATCGGCCTTCAGAGGTTCGCTCCGTCACGGAGCAGGAGCTGAATGAGATTGAGGGC
GATGATGCGCCAGGGGAGGTCGAGGGAGCTCAGCGGCGCACGCTGAAGGACATCCTGACGCCCGAGATCTGGAAGTATTT
CTTCGCCTTCTTCATCTTCGACATCGCCTATTGGGGGTTCACCAGCTGGCTGCCGACCTATCTCGTGCAGGCGCGCGGCT
TCTCGATGGTCGAAATGGGGGCCGCAGCCTCACTCCCATTCATCGTTGGCGCGGTGGGTCGTGTCGGAGGTGGCTGGCTG
TCGGACAGGTTCTTCAAGGACAATCGCCGCATCCTCGTCATCGGCACTCAGGTTTGCTCGGCGCTGTTCCTGTATCTGAC
GTTCGTCGCCACGAGCACATGGGCCCTGATCCTCTGCCAGACTGCGGCGGGCTTCTTCCTGAGCGTATTCCTGTCGTCCT
TCTGGGCCCTTCCCATGAGCACCATTCCGAAACGCGACATGGGCCTGGCAACCGGTTTCATAAACACCGGCGGTCAGATC
GGCGGCCTGATCTCGCCGCTTTGCATCGGCGCGCTCCTGCAGGTCGCGGACGGGGATTTCGGCACGACGTTCATCTTCCT
TGTGGCGTGCATTCTGGTGTCGCTCGTCATCGTGCTGATGATGGGGAAGAGGCCTCGGGCCGCAGCCGAAGTCGGCGTCT
GA

Upstream 100 bases:

>100_bases
CGGCGCGGTCTTGAAGAACGGCAGAACCTGGGCTCGTCGAAGAGCTTTGCGGACGATGACCTTCCCCTCGGCGTCAACCG
CGTGAACCTGAAAAACGCTC

Downstream 100 bases:

>100_bases
TCAGAGCTCCTGCGGCGGTACCGCGGAGACGGGATAAGGCGGCTCACGGCAAGCGGGGCCCGTTCGAGCGGCAGGCTGCT
CCGTGGTGATATCGCCTAGG

Product: permease of the major facilitator superfamily

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MARSRPIVVISIWVAPFARGCSTTSTSLALRCREREPSTPSAFTAVTGAATTLMQLLVVRLLFGVGEGAFPAASFKTIAA
WFPKKERATASAVMLTANTLGAALSPLIVVGIMATWGWRAVFFVLLIPGILVSILFWLVVKDRPSEVRSVTEQELNEIEG
DDAPGEVEGAQRRTLKDILTPEIWKYFFAFFIFDIAYWGFTSWLPTYLVQARGFSMVEMGAAASLPFIVGAVGRVGGGWL
SDRFFKDNRRILVIGTQVCSALFLYLTFVATSTWALILCQTAAGFFLSVFLSSFWALPMSTIPKRDMGLATGFINTGGQI
GGLISPLCIGALLQVADGDFGTTFIFLVACILVSLVIVLMMGKRPRAAAEVGV

Sequences:

>Translated_373_residues
MARSRPIVVISIWVAPFARGCSTTSTSLALRCREREPSTPSAFTAVTGAATTLMQLLVVRLLFGVGEGAFPAASFKTIAA
WFPKKERATASAVMLTANTLGAALSPLIVVGIMATWGWRAVFFVLLIPGILVSILFWLVVKDRPSEVRSVTEQELNEIEG
DDAPGEVEGAQRRTLKDILTPEIWKYFFAFFIFDIAYWGFTSWLPTYLVQARGFSMVEMGAAASLPFIVGAVGRVGGGWL
SDRFFKDNRRILVIGTQVCSALFLYLTFVATSTWALILCQTAAGFFLSVFLSSFWALPMSTIPKRDMGLATGFINTGGQI
GGLISPLCIGALLQVADGDFGTTFIFLVACILVSLVIVLMMGKRPRAAAEVGV
>Mature_372_residues
ARSRPIVVISIWVAPFARGCSTTSTSLALRCREREPSTPSAFTAVTGAATTLMQLLVVRLLFGVGEGAFPAASFKTIAAW
FPKKERATASAVMLTANTLGAALSPLIVVGIMATWGWRAVFFVLLIPGILVSILFWLVVKDRPSEVRSVTEQELNEIEGD
DAPGEVEGAQRRTLKDILTPEIWKYFFAFFIFDIAYWGFTSWLPTYLVQARGFSMVEMGAAASLPFIVGAVGRVGGGWLS
DRFFKDNRRILVIGTQVCSALFLYLTFVATSTWALILCQTAAGFFLSVFLSSFWALPMSTIPKRDMGLATGFINTGGQIG
GLISPLCIGALLQVADGDFGTTFIFLVACILVSLVIVLMMGKRPRAAAEVGV

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI148743791, Length=332, Percent_Identity=24.6987951807229, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789515, Length=324, Percent_Identity=27.7777777777778, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082320, Length=345, Percent_Identity=29.5652173913043, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789152, Length=334, Percent_Identity=28.1437125748503, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367379, Length=272, Percent_Identity=27.9411764705882, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788573, Length=329, Percent_Identity=25.2279635258359, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367193, Length=182, Percent_Identity=27.4725274725275, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082071, Length=293, Percent_Identity=25.938566552901, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082310, Length=210, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566884, Length=303, Percent_Identity=22.4422442244224, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560030, Length=286, Percent_Identity=22.3776223776224, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI32567120, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561502, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560966, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565914, Length=194, Percent_Identity=23.1958762886598, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565916, Length=194, Percent_Identity=23.1958762886598, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557432, Length=211, Percent_Identity=26.0663507109005, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115534564, Length=211, Percent_Identity=26.0663507109005, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25141341, Length=199, Percent_Identity=25.6281407035176, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24580790, Length=291, Percent_Identity=22.3367697594502, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922400, Length=292, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24654215, Length=291, Percent_Identity=24.7422680412371, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584153, Length=286, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648416, Length=325, Percent_Identity=24, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356189, Length=325, Percent_Identity=24, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40342; Mature: 40211

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSRPIVVISIWVAPFARGCSTTSTSLALRCREREPSTPSAFTAVTGAATTLMQLLVVR
CCCCCCEEEEEEHHHHHHCCCCCCCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLFGVGEGAFPAASFKTIAAWFPKKERATASAVMLTANTLGAALSPLIVVGIMATWGWRA
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
VFFVLLIPGILVSILFWLVVKDRPSEVRSVTEQELNEIEGDDAPGEVEGAQRRTLKDILT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
PEIWKYFFAFFIFDIAYWGFTSWLPTYLVQARGFSMVEMGAAASLPFIVGAVGRVGGGWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCCHH
SDRFFKDNRRILVIGTQVCSALFLYLTFVATSTWALILCQTAAGFFLSVFLSSFWALPMS
HHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TIPKRDMGLATGFINTGGQIGGLISPLCIGALLQVADGDFGTTFIFLVACILVSLVIVLM
HCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MGKRPRAAAEVGV
HCCCCCCHHCCCC
>Mature Secondary Structure 
ARSRPIVVISIWVAPFARGCSTTSTSLALRCREREPSTPSAFTAVTGAATTLMQLLVVR
CCCCCEEEEEEHHHHHHCCCCCCCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLFGVGEGAFPAASFKTIAAWFPKKERATASAVMLTANTLGAALSPLIVVGIMATWGWRA
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
VFFVLLIPGILVSILFWLVVKDRPSEVRSVTEQELNEIEGDDAPGEVEGAQRRTLKDILT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
PEIWKYFFAFFIFDIAYWGFTSWLPTYLVQARGFSMVEMGAAASLPFIVGAVGRVGGGWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCCHH
SDRFFKDNRRILVIGTQVCSALFLYLTFVATSTWALILCQTAAGFFLSVFLSSFWALPMS
HHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TIPKRDMGLATGFINTGGQIGGLISPLCIGALLQVADGDFGTTFIFLVACILVSLVIVLM
HCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MGKRPRAAAEVGV
HCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]