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The map label for this gene is thlA [H]

Identifier: 197105825

GI number: 197105825

Start: 2675962

End: 2677146

Strand: Reverse

Name: thlA [H]

Synonym: PHZ_c2363

Alternate gene names: 197105825

Gene position: 2677146-2675962 (Counterclockwise)

Preceding gene: 197105826

Following gene: 197105824

Centisome position: 66.99

GC content: 72.57

Gene sequence:

>1185_bases
ATGAACTCCGATCCCGTCGTCATCGCCGCCTACGCCCGCACGCCGATGGGCGGCTTCCAGGGCGTCCTCTCGGGCGTGAA
GGCCACCGAGCTCGGCGCCGCCGCCGTGAAGGCCGCCGTCGAGCGGGCGGGCGTCTCGCCTGAGGCCGTCGAGCAGATCC
TGATGGGTTGCGTGCTGCCGGCGGGCCTGGGCCAGGCGCCGGCCCGGCAGGCGGCGCTGGGCGCGGGGCTGCCGACCTCG
GTCGAGGCCACCACGGTCAACAAGATGTGCGGCTCGGGCATGCAGGCGGCGATCCTGGCGCACGACGCCCTGGCGGCCGG
CACGGCCGACGTCATCGTCGCCGGCGGCATGGAGAGCATGACCGGCGCGCCGTACCTGATGACCAAGCACCGCGGCGGCG
CCCGGATCGGCCACGACACCATGTACGACCACATGTACCTGGACGGGCTGGAGGACGCCTACGAGCCCGGCCGGCTGATG
GGCAGCTTCGCCGAGGAGACGGCCAGGCAGTACCAGTTCACCCGCGAGGCCATGGACGAGTACGCCATCACCTCGCTGAA
GCGGGCCAAGGCGGCGACCGAGAGCGGCGCGTTCGCCAAGGAGATCGTCCCGGTGCAGGTCACCGACCGCAAGGGCGTGA
CGACGGTCGAGCACGACGAGCAGCCGCTGAAGGCCGACCCGGCCAAGATCCCGACGCTGAAGCCCGCGTTCGCCAAGGAC
GGCGGCATCACGGCGGCCAACGCCAGCTCGATCTCGGACGGCGCGGCGGCCCTGGTGATGACCCGCGAGAGCGTCGCCAA
GAAGCTCGGCCTGAACGTGGTGGCCCGGGTGGTCAGCCACGCCGCCCACGCCCACGAGCCCAGCCAGTTCACGACCGCGC
CGGTCCAGGCGGTGCAGAAGGCCCTGAAGCGGGCCGGCTGGAGCGTCGAGGACGTCGACCTGTTCGAGATCAACGAGGCC
TTCGCGGTCGTCGCCATGATCGCCGAGCGCGACCTGGGCATCCCGCGCGACAAGCTGAACGTCAACGGCGGCGCCTGCGC
CCTGGGCCACCCGATCGGCGCCTCGGGCGCGCGGATCCTGGCGACCCTGCTGTCGGCGCTGGAAGCGCGCGGGGCCAAGA
AGGGCGTCGCCAGCCTCTGCATCGGCGGCGGCGAGGCCACGGCCATGGCGGTCGAGCTGGTCTGA

Upstream 100 bases:

>100_bases
TGGCGCGGGCCGCCCTGAGCGCCTTGCGCGAGGACCTGACGAACCGGGTCGCCGCCCTGGAGGCCGCTGAACATCAACTT
ATCAAGGCAGTCAGCGCCGC

Downstream 100 bases:

>100_bases
CGGGAGGGAGCCCGCCGTCGGGCGCGCCGCTTCCAGCCGAACCTTACGAACACACCTAACGCGCCTCGAGGGGATCCCAG
ATGCAGACCATCGTTGAACG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MNSDPVVIAAYARTPMGGFQGVLSGVKATELGAAAVKAAVERAGVSPEAVEQILMGCVLPAGLGQAPARQAALGAGLPTS
VEATTVNKMCGSGMQAAILAHDALAAGTADVIVAGGMESMTGAPYLMTKHRGGARIGHDTMYDHMYLDGLEDAYEPGRLM
GSFAEETARQYQFTREAMDEYAITSLKRAKAATESGAFAKEIVPVQVTDRKGVTTVEHDEQPLKADPAKIPTLKPAFAKD
GGITAANASSISDGAAALVMTRESVAKKLGLNVVARVVSHAAHAHEPSQFTTAPVQAVQKALKRAGWSVEDVDLFEINEA
FAVVAMIAERDLGIPRDKLNVNGGACALGHPIGASGARILATLLSALEARGAKKGVASLCIGGGEATAMAVELV

Sequences:

>Translated_394_residues
MNSDPVVIAAYARTPMGGFQGVLSGVKATELGAAAVKAAVERAGVSPEAVEQILMGCVLPAGLGQAPARQAALGAGLPTS
VEATTVNKMCGSGMQAAILAHDALAAGTADVIVAGGMESMTGAPYLMTKHRGGARIGHDTMYDHMYLDGLEDAYEPGRLM
GSFAEETARQYQFTREAMDEYAITSLKRAKAATESGAFAKEIVPVQVTDRKGVTTVEHDEQPLKADPAKIPTLKPAFAKD
GGITAANASSISDGAAALVMTRESVAKKLGLNVVARVVSHAAHAHEPSQFTTAPVQAVQKALKRAGWSVEDVDLFEINEA
FAVVAMIAERDLGIPRDKLNVNGGACALGHPIGASGARILATLLSALEARGAKKGVASLCIGGGEATAMAVELV
>Mature_394_residues
MNSDPVVIAAYARTPMGGFQGVLSGVKATELGAAAVKAAVERAGVSPEAVEQILMGCVLPAGLGQAPARQAALGAGLPTS
VEATTVNKMCGSGMQAAILAHDALAAGTADVIVAGGMESMTGAPYLMTKHRGGARIGHDTMYDHMYLDGLEDAYEPGRLM
GSFAEETARQYQFTREAMDEYAITSLKRAKAATESGAFAKEIVPVQVTDRKGVTTVEHDEQPLKADPAKIPTLKPAFAKD
GGITAANASSISDGAAALVMTRESVAKKLGLNVVARVVSHAAHAHEPSQFTTAPVQAVQKALKRAGWSVEDVDLFEINEA
FAVVAMIAERDLGIPRDKLNVNGGACALGHPIGASGARILATLLSALEARGAKKGVASLCIGGGEATAMAVELV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=47.0737913486005, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=46.7866323907455, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=39.0745501285347, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=37.4358974358974, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.1627906976744, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=29.9479166666667, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=45.8762886597938, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=50.2577319587629, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI1787663, Length=392, Percent_Identity=39.2857142857143, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=38.1188118811881, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=31.3817330210773, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=42.5974025974026, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=43.9086294416244, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=41.2658227848101, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=33.4164588528678, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.8235294117647, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=46.4019851116625, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=34.4473007712082, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=48.6005089058524, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=43.9588688946015, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=35.8778625954198, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.5164319248826, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40485; Mature: 40485

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDPVVIAAYARTPMGGFQGVLSGVKATELGAAAVKAAVERAGVSPEAVEQILMGCVLP
CCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
AGLGQAPARQAALGAGLPTSVEATTVNKMCGSGMQAAILAHDALAAGTADVIVAGGMESM
CCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHHH
TGAPYLMTKHRGGARIGHDTMYDHMYLDGLEDAYEPGRLMGSFAEETARQYQFTREAMDE
CCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YAITSLKRAKAATESGAFAKEIVPVQVTDRKGVTTVEHDEQPLKADPAKIPTLKPAFAKD
HHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC
GGITAANASSISDGAAALVMTRESVAKKLGLNVVARVVSHAAHAHEPSQFTTAPVQAVQK
CCCEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ALKRAGWSVEDVDLFEINEAFAVVAMIAERDLGIPRDKLNVNGGACALGHPIGASGARIL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEECCCCCCCCHHHHH
ATLLSALEARGAKKGVASLCIGGGEATAMAVELV
HHHHHHHHHCCHHHCHHHHEECCCCEEEEEEEEC
>Mature Secondary Structure
MNSDPVVIAAYARTPMGGFQGVLSGVKATELGAAAVKAAVERAGVSPEAVEQILMGCVLP
CCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
AGLGQAPARQAALGAGLPTSVEATTVNKMCGSGMQAAILAHDALAAGTADVIVAGGMESM
CCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHHH
TGAPYLMTKHRGGARIGHDTMYDHMYLDGLEDAYEPGRLMGSFAEETARQYQFTREAMDE
CCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YAITSLKRAKAATESGAFAKEIVPVQVTDRKGVTTVEHDEQPLKADPAKIPTLKPAFAKD
HHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC
GGITAANASSISDGAAALVMTRESVAKKLGLNVVARVVSHAAHAHEPSQFTTAPVQAVQK
CCCEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ALKRAGWSVEDVDLFEINEAFAVVAMIAERDLGIPRDKLNVNGGACALGHPIGASGARIL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEECCCCCCCCHHHHH
ATLLSALEARGAKKGVASLCIGGGEATAMAVELV
HHHHHHHHHCCHHHCHHHHEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]