Click here to switch to the map view.

The map label for this gene is ilvE [H]

Identifier: 197105824

GI number: 197105824

Start: 2674808

End: 2675881

Strand: Reverse

Name: ilvE [H]

Synonym: PHZ_c2362

Alternate gene names: 197105824

Gene position: 2675881-2674808 (Counterclockwise)

Preceding gene: 197105825

Following gene: 197105823

Centisome position: 66.96

GC content: 68.9

Gene sequence:

>1074_bases
ATGCAGACCATCGTTGAACGTCATCCCGGCCTCACGCCGCCAGATCGCCGCGCCGAGCTGCTCCGAGAGCCAGGGTTCGG
GAAGGTGTTCACGGACCACATGGCCATGGCCTGGTGGCGCGACGGGGAGTGGACCGCGCCCCGCATCACGCCGCGTCGGC
CGCTGGCGCTCGATCCGGCCGCTGCGGTCCTGCACTACGCCCAGGAAATCTTCGAAGGCATGAAGGCCTATCGGACGGAG
GAGGGCGAAGTGCTGCTCTTTCGGCCCGAGGTCAACGCCAAGCGGTTCGCCCGATCGGCGGAGCGCATGGCGATGCCGCA
GGTCCCTGAGGCGCTGTTCAGCGCGGCGGTGGAGGCGCTCATCCGGACGGATCGCGACTGGATCCCCTCCGGCGAAGGCA
GTCTCTATCTGCGTCCGTTCATGATCGCCACCGAAGCCTTCCTCGGCGTTCGGCCGGCGACCGAGTATCTGTTCTGCGTG
CTGGCTTGCCCGGTCGGCGCCTACTTCAAGGGCGGCGCCAAGCCGGTCACGGTGTGGGCGTCGACCACCTTCACGCGCGC
CGCCGCCGGCGGAACGGGCGCGGCCAAGTGCGGCGGCAATTACGCCGGAAGCCTCATCGCTCAGGCGGAGGCGATCCGGC
ACGGTTGCGACCAGGTGGTCTTCCTCGACGCGGCAGAACACCGCTGGATCGAGGAGCTTGGCGGCATGAACGTGTTCTTC
CTGGTGGACGGCACGCTGATCACGCCCCCGCTGACCGGCACCATCCTGGAAGGGGTGACGCGCAGCAGCCTCCTGACCCT
CGCCCGGGAAGAAGGGCTGAAGGTTGAGGAAAGGCCGTATGACTTCGAGACGCTGAAGGCCGATGCCGCCAGCGGCCGCC
TGACCGAAGCGTTCGCCTGCGGTACGGCGGCGGTGGTGGCGGCGATCGGGGAAGTGCGCCACGCCGCGGGGGCGTTCGCC
ATCGCCGGCGGGGTGGAAGGTCCGGTGACGAGCACGTTGCGGCGGCGACTTACGGACATCCAGCGGGGGCAGGCTCCCGA
TCCTCACGGCTGGACGCGCCGCGTTCAATTGTGA

Upstream 100 bases:

>100_bases
TGGCGGTCGAGCTGGTCTGACGGGAGGGAGCCCGCCGTCGGGCGCGCCGCTTCCAGCCGAACCTTACGAACACACCTAAC
GCGCCTCGAGGGGATCCCAG

Downstream 100 bases:

>100_bases
GCCCCAGTTCGCCACGGCGTCGAAGACACTCGCTGCACCCGCCGGCTCCAGTCCACGAGGTTCCTGTGAGGGCCCGCACA
CCTGCCCCGCGCCGCATAGA

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MQTIVERHPGLTPPDRRAELLREPGFGKVFTDHMAMAWWRDGEWTAPRITPRRPLALDPAAAVLHYAQEIFEGMKAYRTE
EGEVLLFRPEVNAKRFARSAERMAMPQVPEALFSAAVEALIRTDRDWIPSGEGSLYLRPFMIATEAFLGVRPATEYLFCV
LACPVGAYFKGGAKPVTVWASTTFTRAAAGGTGAAKCGGNYAGSLIAQAEAIRHGCDQVVFLDAAEHRWIEELGGMNVFF
LVDGTLITPPLTGTILEGVTRSSLLTLAREEGLKVEERPYDFETLKADAASGRLTEAFACGTAAVVAAIGEVRHAAGAFA
IAGGVEGPVTSTLRRRLTDIQRGQAPDPHGWTRRVQL

Sequences:

>Translated_357_residues
MQTIVERHPGLTPPDRRAELLREPGFGKVFTDHMAMAWWRDGEWTAPRITPRRPLALDPAAAVLHYAQEIFEGMKAYRTE
EGEVLLFRPEVNAKRFARSAERMAMPQVPEALFSAAVEALIRTDRDWIPSGEGSLYLRPFMIATEAFLGVRPATEYLFCV
LACPVGAYFKGGAKPVTVWASTTFTRAAAGGTGAAKCGGNYAGSLIAQAEAIRHGCDQVVFLDAAEHRWIEELGGMNVFF
LVDGTLITPPLTGTILEGVTRSSLLTLAREEGLKVEERPYDFETLKADAASGRLTEAFACGTAAVVAAIGEVRHAAGAFA
IAGGVEGPVTSTLRRRLTDIQRGQAPDPHGWTRRVQL
>Mature_357_residues
MQTIVERHPGLTPPDRRAELLREPGFGKVFTDHMAMAWWRDGEWTAPRITPRRPLALDPAAAVLHYAQEIFEGMKAYRTE
EGEVLLFRPEVNAKRFARSAERMAMPQVPEALFSAAVEALIRTDRDWIPSGEGSLYLRPFMIATEAFLGVRPATEYLFCV
LACPVGAYFKGGAKPVTVWASTTFTRAAAGGTGAAKCGGNYAGSLIAQAEAIRHGCDQVVFLDAAEHRWIEELGGMNVFF
LVDGTLITPPLTGTILEGVTRSSLLTLAREEGLKVEERPYDFETLKADAASGRLTEAFACGTAAVVAAIGEVRHAAGAFA
IAGGVEGPVTSTLRRRLTDIQRGQAPDPHGWTRRVQL

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI50658084, Length=327, Percent_Identity=41.2844036697248, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI38176287, Length=329, Percent_Identity=41.6413373860182, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI296010906, Length=329, Percent_Identity=41.6413373860182, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI296010904, Length=337, Percent_Identity=41.2462908011869, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI296010902, Length=329, Percent_Identity=37.9939209726444, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI296010900, Length=329, Percent_Identity=37.9939209726444, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI258614015, Length=284, Percent_Identity=39.4366197183099, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI48994963, Length=299, Percent_Identity=33.7792642140468, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17568601, Length=347, Percent_Identity=39.7694524495677, Blast_Score=220, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17565728, Length=349, Percent_Identity=37.2492836676218, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322608, Length=359, Percent_Identity=40.3899721448468, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322002, Length=366, Percent_Identity=39.8907103825137, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24641779, Length=346, Percent_Identity=38.728323699422, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 38811; Mature: 38811

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIVERHPGLTPPDRRAELLREPGFGKVFTDHMAMAWWRDGEWTAPRITPRRPLALDPA
CCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHH
AAVLHYAQEIFEGMKAYRTEEGEVLLFRPEVNAKRFARSAERMAMPQVPEALFSAAVEAL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRTDRDWIPSGEGSLYLRPFMIATEAFLGVRPATEYLFCVLACPVGAYFKGGAKPVTVWA
HHCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCCEEEEEE
STTFTRAAAGGTGAAKCGGNYAGSLIAQAEAIRHGCDQVVFLDAAEHRWIEELGGMNVFF
CCCHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCEEEE
LVDGTLITPPLTGTILEGVTRSSLLTLAREEGLKVEERPYDFETLKADAASGRLTEAFAC
EECCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHH
GTAAVVAAIGEVRHAAGAFAIAGGVEGPVTSTLRRRLTDIQRGQAPDPHGWTRRVQL
HHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCC
>Mature Secondary Structure
MQTIVERHPGLTPPDRRAELLREPGFGKVFTDHMAMAWWRDGEWTAPRITPRRPLALDPA
CCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHH
AAVLHYAQEIFEGMKAYRTEEGEVLLFRPEVNAKRFARSAERMAMPQVPEALFSAAVEAL
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRTDRDWIPSGEGSLYLRPFMIATEAFLGVRPATEYLFCVLACPVGAYFKGGAKPVTVWA
HHCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCCEEEEEE
STTFTRAAAGGTGAAKCGGNYAGSLIAQAEAIRHGCDQVVFLDAAEHRWIEELGGMNVFF
CCCHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCEEEE
LVDGTLITPPLTGTILEGVTRSSLLTLAREEGLKVEERPYDFETLKADAASGRLTEAFAC
EECCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHH
GTAAVVAAIGEVRHAAGAFAIAGGVEGPVTSTLRRRLTDIQRGQAPDPHGWTRRVQL
HHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]