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The map label for this gene is virB10 [H]

Identifier: 197105817

GI number: 197105817

Start: 2667004

End: 2668044

Strand: Direct

Name: virB10 [H]

Synonym: PHZ_c2355

Alternate gene names: 197105817

Gene position: 2667004-2668044 (Clockwise)

Preceding gene: 197105816

Following gene: 197105818

Centisome position: 66.74

GC content: 69.93

Gene sequence:

>1041_bases
ATGATCGACCGTCCCTACGCACAGGCGCCAGGGGCGGAGCCGCCCCTGAACCGCGGCATCTCCCCCATTGCGGGAGCCCA
GCGCCGCCGGGTTGGCGCGGTCGTCGTCTTCGGGGGTCTGGTCGTCGGCTGCGCCGCCCTTGCTGCGTTCGGCTGGACGC
CGGGCGGGACCACCCCCACGCCGCCGCCGCAGCAGCCAGCACGTCAGGTCGTCGCCTTTGAGGGCCTGCGGCCAACCCTT
GATCAGCCTGGGCCGGACGCTCCGCAACTTGTTCCTGCGGACCCGGCCAGACCTGTCCCTGCGCTCGATCCCCAAGGAAC
GTCCCTCGCGGCGTCGACGCCCGGCGGCCGGAGCGCTCAGAGCGATGAAAGTGTCCGACGGGCGCCCCTGCTCGCCTATA
GTCGCCGCGTTGCGGTCGCCGCTCCCGACATGATCAGGCCGCCCGCGCCGCAGGCCGATGAGCCAACCGTGAAGGCGCGG
CGGCTCGGAGACCGGAATTATCTGATCCTCGCGGGCTCGAGTCTGCCCTGCGTGCTGCAGACCGCGATGGACTCCACCAC
GCCCGGCCCTGTCACCTGCGTCATCCCGTCGGACGTCCATTCGGATAATGGCGCGCTGGTTCTCCTGGAGAAGGGTACCC
GGGTGAGCGGCGAGTACAGGACCGGCCTCAAGCGAGGGCAACGCCGTCTGCACGTGCTGTGGACCCGCGCCGTGACGCCG
AACGGGATCGTCCTGCAACTGACGTCGCCCGCCGCCGACGCGCTGGGCCGCGCCGGATTCGATGGCGAGGTTGACCATCA
CTTCTGGGAGCGCTTCGGCGCCGGCCTCCTGCTCACGGTCGTCGACGCCGGCGCATCCGGCGTCACGGCGGCGCTCGACA
CTCCTGGCCTGGTCAGACTGCCGTCCCCAGCGGCGTCGACCGCCCTCGAAGGCGGTCGCGATATTTCGCCCACCCTGCGC
AAGCCACAGGGATCAGAGGTGACCATCATGGCTGCACACGACTTTGATTTCTCTGAAGTCTACGGCCTCAAGGCGCGCTG
A

Upstream 100 bases:

>100_bases
TGCTCTGCATCCATAATCTCGCCTGGAGCCCCCGTGGCCCGCGCCTGACCACCGGCACGGCCGCCCCTCAGGTCGATCGG
ATCCTGAAGGAACAACGCCG

Downstream 100 bases:

>100_bases
CATGGGCGACGTGGCGATCCTCAATCACCACCTCCGCCCTTTGCGAGCTGCGCTCGACGCCGACGGGACGACAGAGCTTG
TGGTCAATCGACCAGGCGAG

Product: type IV secretory pathway, VirB10 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MIDRPYAQAPGAEPPLNRGISPIAGAQRRRVGAVVVFGGLVVGCAALAAFGWTPGGTTPTPPPQQPARQVVAFEGLRPTL
DQPGPDAPQLVPADPARPVPALDPQGTSLAASTPGGRSAQSDESVRRAPLLAYSRRVAVAAPDMIRPPAPQADEPTVKAR
RLGDRNYLILAGSSLPCVLQTAMDSTTPGPVTCVIPSDVHSDNGALVLLEKGTRVSGEYRTGLKRGQRRLHVLWTRAVTP
NGIVLQLTSPAADALGRAGFDGEVDHHFWERFGAGLLLTVVDAGASGVTAALDTPGLVRLPSPAASTALEGGRDISPTLR
KPQGSEVTIMAAHDFDFSEVYGLKAR

Sequences:

>Translated_346_residues
MIDRPYAQAPGAEPPLNRGISPIAGAQRRRVGAVVVFGGLVVGCAALAAFGWTPGGTTPTPPPQQPARQVVAFEGLRPTL
DQPGPDAPQLVPADPARPVPALDPQGTSLAASTPGGRSAQSDESVRRAPLLAYSRRVAVAAPDMIRPPAPQADEPTVKAR
RLGDRNYLILAGSSLPCVLQTAMDSTTPGPVTCVIPSDVHSDNGALVLLEKGTRVSGEYRTGLKRGQRRLHVLWTRAVTP
NGIVLQLTSPAADALGRAGFDGEVDHHFWERFGAGLLLTVVDAGASGVTAALDTPGLVRLPSPAASTALEGGRDISPTLR
KPQGSEVTIMAAHDFDFSEVYGLKAR
>Mature_346_residues
MIDRPYAQAPGAEPPLNRGISPIAGAQRRRVGAVVVFGGLVVGCAALAAFGWTPGGTTPTPPPQQPARQVVAFEGLRPTL
DQPGPDAPQLVPADPARPVPALDPQGTSLAASTPGGRSAQSDESVRRAPLLAYSRRVAVAAPDMIRPPAPQADEPTVKAR
RLGDRNYLILAGSSLPCVLQTAMDSTTPGPVTCVIPSDVHSDNGALVLLEKGTRVSGEYRTGLKRGQRRLHVLWTRAVTP
NGIVLQLTSPAADALGRAGFDGEVDHHFWERFGAGLLLTVVDAGASGVTAALDTPGLVRLPSPAASTALEGGRDISPTLR
KPQGSEVTIMAAHDFDFSEVYGLKAR

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 36040; Mature: 36040

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRPYAQAPGAEPPLNRGISPIAGAQRRRVGAVVVFGGLVVGCAALAAFGWTPGGTTPT
CCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCCC
PPPQQPARQVVAFEGLRPTLDQPGPDAPQLVPADPARPVPALDPQGTSLAASTPGGRSAQ
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
SDESVRRAPLLAYSRRVAVAAPDMIRPPAPQADEPTVKARRLGDRNYLILAGSSLPCVLQ
CCHHHHHHHHHHHHCEEEEECCHHCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHH
TAMDSTTPGPVTCVIPSDVHSDNGALVLLEKGTRVSGEYRTGLKRGQRRLHVLWTRAVTP
HHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEEECCC
NGIVLQLTSPAADALGRAGFDGEVDHHFWERFGAGLLLTVVDAGASGVTAALDTPGLVRL
CCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCEEEC
PSPAASTALEGGRDISPTLRKPQGSEVTIMAAHDFDFSEVYGLKAR
CCCHHHHHHCCCCCCCHHHCCCCCCEEEEEEECCCCHHHHCCCCCC
>Mature Secondary Structure
MIDRPYAQAPGAEPPLNRGISPIAGAQRRRVGAVVVFGGLVVGCAALAAFGWTPGGTTPT
CCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCCC
PPPQQPARQVVAFEGLRPTLDQPGPDAPQLVPADPARPVPALDPQGTSLAASTPGGRSAQ
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
SDESVRRAPLLAYSRRVAVAAPDMIRPPAPQADEPTVKARRLGDRNYLILAGSSLPCVLQ
CCHHHHHHHHHHHHCEEEEECCHHCCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHH
TAMDSTTPGPVTCVIPSDVHSDNGALVLLEKGTRVSGEYRTGLKRGQRRLHVLWTRAVTP
HHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEEECCC
NGIVLQLTSPAADALGRAGFDGEVDHHFWERFGAGLLLTVVDAGASGVTAALDTPGLVRL
CCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCEEEC
PSPAASTALEGGRDISPTLRKPQGSEVTIMAAHDFDFSEVYGLKAR
CCCHHHHHHCCCCCCCHHHCCCCCCEEEEEEECCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]