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The map label for this gene is virB11 [H]

Identifier: 197105818

GI number: 197105818

Start: 2668046

End: 2669038

Strand: Direct

Name: virB11 [H]

Synonym: PHZ_c2356

Alternate gene names: 197105818

Gene position: 2668046-2669038 (Clockwise)

Preceding gene: 197105817

Following gene: 197105819

Centisome position: 66.76

GC content: 67.07

Gene sequence:

>993_bases
ATGGGCGACGTGGCGATCCTCAATCACCACCTCCGCCCTTTGCGAGCTGCGCTCGACGCCGACGGGACGACAGAGCTTGT
GGTCAATCGACCAGGCGAGTTTGCGGTGGAGCGCCGCGGCGCCTGGTTGTGGCATGAGGCGCCGGAGCTGACGACCGAGT
GGCTGCGCACTCTGGCGATCGGGGCGGCCGCAGCGACGGCCCAGGATGTCAGCCCCGACCGTCCGATCTGCTCCACCGTC
CTTCCGTCCGGCGAGCGCTGCCAGATCGTCCTGCCACCCGCAGCAGAGCACCCCTCGCTCACACTGAGACGCCCCTCGCC
AACAGCCTTTGAACTCGCGGACCTGGCCCGGTCAGGGTTGTTCGAGAACGTCGCCACCGCCCCGGACGACGAGGCAGATG
CGGCCATGCGCGCCCTGCAGGCCGCTGGAGACTGGCCCGGCTTCTTCGGCCGCGCCGTCCGCGCGCGTCGAAACATCGTC
GTGAGCGGAGCGACCGGCTCCGGCAAGACAACGCTCGCCAAGGCGCTACTCCGCCTGATCCCTCCGGATGAGCGGTTGAT
CACGGTGGAGGACGCCCGCGAATTCATCACCCCGCACCGAAACGTCGTCCACCTGCTCTACTCGAAGGACGGACAGGGCC
TCGCGAAGGTGGGCCCGAAGGCTCTCCTGGAAAGCGCGCTGCGCATGCGACCCGACCGCATCCTTCTTCAGGAGCTGCGC
GACGAAAGCGCCTTCTTCTATCTGCGCAACGTCAACTCAGGTCATCCCGGCTCGATCACCACCGTCCATGCCGACTCCGC
GAGCCTCGCCTTCGAGCAGCTGACCCTGCTCATCAAGGAGAGCGAAGGCGGCCGTCACCTGGCTCGTGAGGACATCCGGG
GCATGCTCCGCATGCTGGTCGATGTGGTGGTTCACGTCGTCCGCAGAGGTGAGCGCTTCGGGGTTCGCGAGATCTGGTAT
GATCCCGAGCTCAAGCGCACCCTCGCCGCTTAG

Upstream 100 bases:

>100_bases
ATTTCGCCCACCCTGCGCAAGCCACAGGGATCAGAGGTGACCATCATGGCTGCACACGACTTTGATTTCTCTGAAGTCTA
CGGCCTCAAGGCGCGCTGAC

Downstream 100 bases:

>100_bases
GGTTGTCGGGTACGCCATCGCCGCAGCGGCGGGCGGCGTATTCGTGTTCTCCATGGCTGCGCTTGTCGCGCTGGCTGGCC
TTGGCCGCCTCAGCCCCGAC

Product: virB11 type IV secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGDVAILNHHLRPLRAALDADGTTELVVNRPGEFAVERRGAWLWHEAPELTTEWLRTLAIGAAAATAQDVSPDRPICSTV
LPSGERCQIVLPPAAEHPSLTLRRPSPTAFELADLARSGLFENVATAPDDEADAAMRALQAAGDWPGFFGRAVRARRNIV
VSGATGSGKTTLAKALLRLIPPDERLITVEDAREFITPHRNVVHLLYSKDGQGLAKVGPKALLESALRMRPDRILLQELR
DESAFFYLRNVNSGHPGSITTVHADSASLAFEQLTLLIKESEGGRHLAREDIRGMLRMLVDVVVHVVRRGERFGVREIWY
DPELKRTLAA

Sequences:

>Translated_330_residues
MGDVAILNHHLRPLRAALDADGTTELVVNRPGEFAVERRGAWLWHEAPELTTEWLRTLAIGAAAATAQDVSPDRPICSTV
LPSGERCQIVLPPAAEHPSLTLRRPSPTAFELADLARSGLFENVATAPDDEADAAMRALQAAGDWPGFFGRAVRARRNIV
VSGATGSGKTTLAKALLRLIPPDERLITVEDAREFITPHRNVVHLLYSKDGQGLAKVGPKALLESALRMRPDRILLQELR
DESAFFYLRNVNSGHPGSITTVHADSASLAFEQLTLLIKESEGGRHLAREDIRGMLRMLVDVVVHVVRRGERFGVREIWY
DPELKRTLAA
>Mature_329_residues
GDVAILNHHLRPLRAALDADGTTELVVNRPGEFAVERRGAWLWHEAPELTTEWLRTLAIGAAAATAQDVSPDRPICSTVL
PSGERCQIVLPPAAEHPSLTLRRPSPTAFELADLARSGLFENVATAPDDEADAAMRALQAAGDWPGFFGRAVRARRNIVV
SGATGSGKTTLAKALLRLIPPDERLITVEDAREFITPHRNVVHLLYSKDGQGLAKVGPKALLESALRMRPDRILLQELRD
ESAFFYLRNVNSGHPGSITTVHADSASLAFEQLTLLIKESEGGRHLAREDIRGMLRMLVDVVVHVVRRGERFGVREIWYD
PELKRTLAA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36249; Mature: 36118

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDVAILNHHLRPLRAALDADGTTELVVNRPGEFAVERRGAWLWHEAPELTTEWLRTLAI
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCEEECCCHHHHHHHHHHHHH
GAAAATAQDVSPDRPICSTVLPSGERCQIVLPPAAEHPSLTLRRPSPTAFELADLARSGL
HHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHH
FENVATAPDDEADAAMRALQAAGDWPGFFGRAVRARRNIVVSGATGSGKTTLAKALLRLI
HHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHC
PPDERLITVEDAREFITPHRNVVHLLYSKDGQGLAKVGPKALLESALRMRPDRILLQELR
CCCCCEEEHHHHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHHC
DESAFFYLRNVNSGHPGSITTVHADSASLAFEQLTLLIKESEGGRHLAREDIRGMLRMLV
CCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHH
DVVVHVVRRGERFGVREIWYDPELKRTLAA
HHHHHHHHCCCCCCCHHHCCCCHHHHHHCC
>Mature Secondary Structure 
GDVAILNHHLRPLRAALDADGTTELVVNRPGEFAVERRGAWLWHEAPELTTEWLRTLAI
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCEEECCCHHHHHHHHHHHHH
GAAAATAQDVSPDRPICSTVLPSGERCQIVLPPAAEHPSLTLRRPSPTAFELADLARSGL
HHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHH
FENVATAPDDEADAAMRALQAAGDWPGFFGRAVRARRNIVVSGATGSGKTTLAKALLRLI
HHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHC
PPDERLITVEDAREFITPHRNVVHLLYSKDGQGLAKVGPKALLESALRMRPDRILLQELR
CCCCCEEEHHHHHHHHCCCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHHC
DESAFFYLRNVNSGHPGSITTVHADSASLAFEQLTLLIKESEGGRHLAREDIRGMLRMLV
CCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHH
DVVVHVVRRGERFGVREIWYDPELKRTLAA
HHHHHHHHCCCCCCCHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]