Click here to switch to the map view.

The map label for this gene is murB

Identifier: 197105783

GI number: 197105783

Start: 2632439

End: 2633341

Strand: Reverse

Name: murB

Synonym: PHZ_c2321

Alternate gene names: 197105783

Gene position: 2633341-2632439 (Counterclockwise)

Preceding gene: 197105784

Following gene: 197105782

Centisome position: 65.9

GC content: 72.31

Gene sequence:

>903_bases
ATGACCTGGAAGGACAGGCTCCCCGCCGTCCGCGGCAAGCTCCTGCGGGACGAGCCGCTGGCGCCGTTCACCTGGTTCCG
CGTCGGCGGGCCGGCGGACGTGATCTTCCTGCCCGAGGACGAGGACGATCTGGCCGCCTTCCTGAAGGCCCTGCCGGCCG
AGGTTCCCGTGACGGTGCTGGGCGTCGGCTCCAACACCCTGGTCCGCGACGGCGGAGTGGACGGGGTGGTGATCCGCCTG
GGCAAGGCCTTCGCCAAGGTCGAGCCGCGTGGCGAGGGACGCCTCTACGCCGGCGCCGCGGCCTTGGACGCCGTCGTCGC
GCGCGAGGCTGGCAAGGCCGGCATCGCGGGCCTGGAGTTCTACCGCGGCGTGCCCGGCACGATCGGCGGGGCCCTGGTGA
TGAACGCCGGCTGCTACGGCGCCGAGACCAAGGACGTGCTCGTCGAGGCCTATGCGCTGACCCGCGCGGGGGAGCGGCTG
ACGCTCTCCAACGCCGACCTGGGCTACAGCTACCGCAAGTCGGCCCGCGCCGCCGCCGAGCCGCTGATCTTCCTGGGCGC
CCTGTTCGAGGGCCGGCCCGACGACCCGGCCGCCATCGAGGCGCGCATGGCCGAGATCACCGAGCGGCGCGAGAAGACCC
AGCCGATCCGCGAGAAGACTGGCGGCTCGACGTTCAAGAACCCGCCCGGCCACTCCTCCTGGAAGCTGGTGGACGAGGCC
GGCTGGCGCGGCAAGCTGTTCGGCGGGGCGATGTTCTCGCCGCTGCACTCCAACTTCCTGATCAACACCGGCGAGGCGAC
CGCCGCCGACCTCGAGGGCCTGGGCGAGGCGGTCCGCGCCGACGTGAAGGCCAAGTTCGGCGTCGACCTCGACTGGGAGA
TCAAGCGGATCGGGCGTCCCTGA

Upstream 100 bases:

>100_bases
CTGGGCGCCGGCGACATCACCAGCTGGGCCTACGCCCTGCCGGGCGAGCTCGAGGCCCTGAGCGCCTCGGGGGGCGCGGC
CGCGGAATGAGCTGGCCCAA

Downstream 100 bases:

>100_bases
GGCGCCCGGCGCGTTCCGCTACTGCCACGCTTGTCAGCAGGCGGCCTTGACGGAATCTCGCCGCCCGCGCACGCCGGGGC
CATGCGCAATCTTGCTCTGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTWKDRLPAVRGKLLRDEPLAPFTWFRVGGPADVIFLPEDEDDLAAFLKALPAEVPVTVLGVGSNTLVRDGGVDGVVIRL
GKAFAKVEPRGEGRLYAGAAALDAVVAREAGKAGIAGLEFYRGVPGTIGGALVMNAGCYGAETKDVLVEAYALTRAGERL
TLSNADLGYSYRKSARAAAEPLIFLGALFEGRPDDPAAIEARMAEITERREKTQPIREKTGGSTFKNPPGHSSWKLVDEA
GWRGKLFGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVKAKFGVDLDWEIKRIGRP

Sequences:

>Translated_300_residues
MTWKDRLPAVRGKLLRDEPLAPFTWFRVGGPADVIFLPEDEDDLAAFLKALPAEVPVTVLGVGSNTLVRDGGVDGVVIRL
GKAFAKVEPRGEGRLYAGAAALDAVVAREAGKAGIAGLEFYRGVPGTIGGALVMNAGCYGAETKDVLVEAYALTRAGERL
TLSNADLGYSYRKSARAAAEPLIFLGALFEGRPDDPAAIEARMAEITERREKTQPIREKTGGSTFKNPPGHSSWKLVDEA
GWRGKLFGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVKAKFGVDLDWEIKRIGRP
>Mature_299_residues
TWKDRLPAVRGKLLRDEPLAPFTWFRVGGPADVIFLPEDEDDLAAFLKALPAEVPVTVLGVGSNTLVRDGGVDGVVIRLG
KAFAKVEPRGEGRLYAGAAALDAVVAREAGKAGIAGLEFYRGVPGTIGGALVMNAGCYGAETKDVLVEAYALTRAGERLT
LSNADLGYSYRKSARAAAEPLIFLGALFEGRPDDPAAIEARMAEITERREKTQPIREKTGGSTFKNPPGHSSWKLVDEAG
WRGKLFGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVKAKFGVDLDWEIKRIGRP

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_PHEZH (B4RFG1)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131160.1
- GeneID:   6791842
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2321
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32008; Mature: 31877

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 223-223 ACT_SITE 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWKDRLPAVRGKLLRDEPLAPFTWFRVGGPADVIFLPEDEDDLAAFLKALPAEVPVTVL
CCCHHHCCHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCEEEE
GVGSNTLVRDGGVDGVVIRLGKAFAKVEPRGEGRLYAGAAALDAVVAREAGKAGIAGLEF
ECCCCCEEECCCCCEEEEEHHHHHHHCCCCCCCCEEECHHHHHHHHHHHCCCCCCCHHHH
YRGVPGTIGGALVMNAGCYGAETKDVLVEAYALTRAGERLTLSNADLGYSYRKSARAAAE
HCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHC
PLIFLGALFEGRPDDPAAIEARMAEITERREKTQPIREKTGGSTFKNPPGHSSWKLVDEA
HHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECC
GWRGKLFGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVKAKFGVDLDWEIKRIGRP
CCCCEECCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TWKDRLPAVRGKLLRDEPLAPFTWFRVGGPADVIFLPEDEDDLAAFLKALPAEVPVTVL
CCHHHCCHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCEEEE
GVGSNTLVRDGGVDGVVIRLGKAFAKVEPRGEGRLYAGAAALDAVVAREAGKAGIAGLEF
ECCCCCEEECCCCCEEEEEHHHHHHHCCCCCCCCEEECHHHHHHHHHHHCCCCCCCHHHH
YRGVPGTIGGALVMNAGCYGAETKDVLVEAYALTRAGERLTLSNADLGYSYRKSARAAAE
HCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHC
PLIFLGALFEGRPDDPAAIEARMAEITERREKTQPIREKTGGSTFKNPPGHSSWKLVDEA
HHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECC
GWRGKLFGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVKAKFGVDLDWEIKRIGRP
CCCCEECCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA