Click here to switch to the map view.

The map label for this gene is murC

Identifier: 197105784

GI number: 197105784

Start: 2633352

End: 2634785

Strand: Reverse

Name: murC

Synonym: PHZ_c2322

Alternate gene names: 197105784

Gene position: 2634785-2633352 (Counterclockwise)

Preceding gene: 197105785

Following gene: 197105783

Centisome position: 65.93

GC content: 70.78

Gene sequence:

>1434_bases
ATGAATCGCCGCCCCGTCCCCTTCGAGATCGGCCCCGTCCACTTCGTGGGGATCGGCGGCATCGGCATGAGCGGCATCGC
CGAGATCATGCTGCGCACCGGCTACCAAGTGCAGGGCTCGGACGCCAAGCCCTCGGCCAATACCGAGCGGCTCGAGAAGC
TGGGCGCGAGGATCTTCATCGGCCACGACGCCAAGAACGTCGAAGGCGCCTACGCCATCGTCTATTCGACGGCGGTCAAG
CCCGACAATCCCGAGATGGTGGAAGGCCGCGCGCGGCGTCTGCCGCTGGTCCGCCGGGCCGAGATGCTGGCCGAGCTGAT
GCGGCTGCAGTTCTCGATCGCCGTGGGCGGCACGCACGGCAAGACCACCACCACCTCGATGGTGGCCGCCATCCTCGACG
CGGGCGGGCTCGATCCGACGGTGGTCAACGGCGGCATCATCAACGCCTACGGCACCAACGCGAAGGTGGGGGCCGGCGAC
TGGATCGTGGTCGAGGCCGACGAGAGCGACGGCACCTTCCTGAAGCTGAAGTCCACCGTCGCCGTGGTCACCAACATCGA
CCCCGAGCACCTCGACCACTACGGCGACTTCGAGGCGGTGAAGAAGGCCTTCCAGGACTTCGTCGAGAACATCCCGTTCT
ACGGCTTCGCCGCCGTCTGCCTCGACCATCCGGAGGTCCAGGCCATGACCGCGCGGGTCGAGAACCGCCGGCTCGTGACC
TACGGCGTGAACCCCCAGGCCGAGGTGCGCGCGCACAACATCCGCATGGGCCCCGAGGGCGCCCGCTTCTCGGTGGTGAT
CCAGCCGCGCGACGGCGGCTTCATCAGCTTCGACGACCTGCTGCTGCCGATGGCCGGCCAGCACAACGTCCAGAACGCCC
TGGCCGCCATCGCCGTGGCCCGGGAGCTCGGCGTCTCGCCCGACGCCATCCGCAAGGGCCTGGCGGCCTTCGGCGGGGTG
AAGCGCAGGTTCACGACCACGGGCGTGGCCGGCGGCGTGCGCGTGGTGGACGACTACGGCCACCATCCGGTGGAGATCGC
CTCGGTCCTGAAGGCCGCCCGCGCGGTCAGCGAGGGCAAGGTGATCGCGGTGGTCCAGCCGCACCGCTACACCCGGCTGC
GCGACCTGTTCGAGGACTTCTGCGCCTGCTTCAACGACGCCGACACGGTGATCGTGGCCGACGTCTACGCGGCCGGCGAG
GCGCCCATCGAGGGCGTCGGCAAGGAGAGCCTGGTGGAGGGCCTGCGCCGCTACGGCCACCGCCGCGTGCTGCCGCTTCC
GGCCCCCGCCGGCCTGGCGGCGCTGGTGCGCGAGGAGGCCCACCCCGGCGATCTCGTCGTGCTGCTGGGCGCCGGCGACA
TCACCAGCTGGGCCTACGCCCTGCCGGGCGAGCTCGAGGCCCTGAGCGCCTCGGGGGGCGCGGCCGCGGAATGA

Upstream 100 bases:

>100_bases
CCGACGTGGTGGAGCAGACGGCGCGCGGCCGCTGATCCGCGATGACGAACGTGCGGGGGCATATATTTCCCCCGCCGCGC
CGATGCGCTAGCAGGACTCC

Downstream 100 bases:

>100_bases
GCTGGCCCAAATGACCTGGAAGGACAGGCTCCCCGCCGTCCGCGGCAAGCTCCTGCGGGACGAGCCGCTGGCGCCGTTCA
CCTGGTTCCGCGTCGGCGGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNRRPVPFEIGPVHFVGIGGIGMSGIAEIMLRTGYQVQGSDAKPSANTERLEKLGARIFIGHDAKNVEGAYAIVYSTAVK
PDNPEMVEGRARRLPLVRRAEMLAELMRLQFSIAVGGTHGKTTTTSMVAAILDAGGLDPTVVNGGIINAYGTNAKVGAGD
WIVVEADESDGTFLKLKSTVAVVTNIDPEHLDHYGDFEAVKKAFQDFVENIPFYGFAAVCLDHPEVQAMTARVENRRLVT
YGVNPQAEVRAHNIRMGPEGARFSVVIQPRDGGFISFDDLLLPMAGQHNVQNALAAIAVARELGVSPDAIRKGLAAFGGV
KRRFTTTGVAGGVRVVDDYGHHPVEIASVLKAARAVSEGKVIAVVQPHRYTRLRDLFEDFCACFNDADTVIVADVYAAGE
APIEGVGKESLVEGLRRYGHRRVLPLPAPAGLAALVREEAHPGDLVVLLGAGDITSWAYALPGELEALSASGGAAAE

Sequences:

>Translated_477_residues
MNRRPVPFEIGPVHFVGIGGIGMSGIAEIMLRTGYQVQGSDAKPSANTERLEKLGARIFIGHDAKNVEGAYAIVYSTAVK
PDNPEMVEGRARRLPLVRRAEMLAELMRLQFSIAVGGTHGKTTTTSMVAAILDAGGLDPTVVNGGIINAYGTNAKVGAGD
WIVVEADESDGTFLKLKSTVAVVTNIDPEHLDHYGDFEAVKKAFQDFVENIPFYGFAAVCLDHPEVQAMTARVENRRLVT
YGVNPQAEVRAHNIRMGPEGARFSVVIQPRDGGFISFDDLLLPMAGQHNVQNALAAIAVARELGVSPDAIRKGLAAFGGV
KRRFTTTGVAGGVRVVDDYGHHPVEIASVLKAARAVSEGKVIAVVQPHRYTRLRDLFEDFCACFNDADTVIVADVYAAGE
APIEGVGKESLVEGLRRYGHRRVLPLPAPAGLAALVREEAHPGDLVVLLGAGDITSWAYALPGELEALSASGGAAAE
>Mature_477_residues
MNRRPVPFEIGPVHFVGIGGIGMSGIAEIMLRTGYQVQGSDAKPSANTERLEKLGARIFIGHDAKNVEGAYAIVYSTAVK
PDNPEMVEGRARRLPLVRRAEMLAELMRLQFSIAVGGTHGKTTTTSMVAAILDAGGLDPTVVNGGIINAYGTNAKVGAGD
WIVVEADESDGTFLKLKSTVAVVTNIDPEHLDHYGDFEAVKKAFQDFVENIPFYGFAAVCLDHPEVQAMTARVENRRLVT
YGVNPQAEVRAHNIRMGPEGARFSVVIQPRDGGFISFDDLLLPMAGQHNVQNALAAIAVARELGVSPDAIRKGLAAFGGV
KRRFTTTGVAGGVRVVDDYGHHPVEIASVLKAARAVSEGKVIAVVQPHRYTRLRDLFEDFCACFNDADTVIVADVYAAGE
APIEGVGKESLVEGLRRYGHRRVLPLPAPAGLAALVREEAHPGDLVVLLGAGDITSWAYALPGELEALSASGGAAAE

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=43.6008676789588, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1790680, Length=397, Percent_Identity=29.7229219143577, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PHEZH (B4RFG2)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002131161.1
- ProteinModelPortal:   B4RFG2
- GeneID:   6791843
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c2322
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50747; Mature: 50747

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRPVPFEIGPVHFVGIGGIGMSGIAEIMLRTGYQVQGSDAKPSANTERLEKLGARIFI
CCCCCCCEEECCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEEE
GHDAKNVEGAYAIVYSTAVKPDNPEMVEGRARRLPLVRRAEMLAELMRLQFSIAVGGTHG
ECCCCCCCCEEEEEEEECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHEEEEEECCCCC
KTTTTSMVAAILDAGGLDPTVVNGGIINAYGTNAKVGAGDWIVVEADESDGTFLKLKSTV
CCHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEEEEEE
AVVTNIDPEHLDHYGDFEAVKKAFQDFVENIPFYGFAAVCLDHPEVQAMTARVENRRLVT
EEEECCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEE
YGVNPQAEVRAHNIRMGPEGARFSVVIQPRDGGFISFDDLLLPMAGQHNVQNALAAIAVA
ECCCCCCEEEEEEEEECCCCCEEEEEEEECCCCEEEHHHHHCCCCCCCHHHHHHHHHHHH
RELGVSPDAIRKGLAAFGGVKRRFTTTGVAGGVRVVDDYGHHPVEIASVLKAARAVSEGK
HHHCCCHHHHHHHHHHHCCCHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCC
VIAVVQPHRYTRLRDLFEDFCACFNDADTVIVADVYAAGEAPIEGVGKESLVEGLRRYGH
EEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
RRVLPLPAPAGLAALVREEAHPGDLVVLLGAGDITSWAYALPGELEALSASGGAAAE
CEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHEECCCCCEEEECCCCCCCC
>Mature Secondary Structure
MNRRPVPFEIGPVHFVGIGGIGMSGIAEIMLRTGYQVQGSDAKPSANTERLEKLGARIFI
CCCCCCCEEECCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCEEEE
GHDAKNVEGAYAIVYSTAVKPDNPEMVEGRARRLPLVRRAEMLAELMRLQFSIAVGGTHG
ECCCCCCCCEEEEEEEECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHEEEEEECCCCC
KTTTTSMVAAILDAGGLDPTVVNGGIINAYGTNAKVGAGDWIVVEADESDGTFLKLKSTV
CCHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEEEEEE
AVVTNIDPEHLDHYGDFEAVKKAFQDFVENIPFYGFAAVCLDHPEVQAMTARVENRRLVT
EEEECCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEE
YGVNPQAEVRAHNIRMGPEGARFSVVIQPRDGGFISFDDLLLPMAGQHNVQNALAAIAVA
ECCCCCCEEEEEEEEECCCCCEEEEEEEECCCCEEEHHHHHCCCCCCCHHHHHHHHHHHH
RELGVSPDAIRKGLAAFGGVKRRFTTTGVAGGVRVVDDYGHHPVEIASVLKAARAVSEGK
HHHCCCHHHHHHHHHHHCCCHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCC
VIAVVQPHRYTRLRDLFEDFCACFNDADTVIVADVYAAGEAPIEGVGKESLVEGLRRYGH
EEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCC
RRVLPLPAPAGLAALVREEAHPGDLVVLLGAGDITSWAYALPGELEALSASGGAAAE
CEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA