Click here to switch to the map view.

The map label for this gene is nuoF [H]

Identifier: 197105262

GI number: 197105262

Start: 2014597

End: 2015910

Strand: Reverse

Name: nuoF [H]

Synonym: PHZ_c1799

Alternate gene names: 197105262

Gene position: 2015910-2014597 (Counterclockwise)

Preceding gene: 197105263

Following gene: 197105261

Centisome position: 50.44

GC content: 69.63

Gene sequence:

>1314_bases
ATGCCGGGCATCCTGGCCGACAAGGACCGCATCTTCCTCAACCTCTACGGCCTGCACGACTGGGGCCTGGAGGGCGCGAA
GGCGCGCGGGGCGTGGAACGGGACGAAGGACATCGTCGCCCAGAGCCCTGAGTGGATCTGCGACCAGATCAAGGCGTCCG
GCCTGCGCGGCCGGGGCGGGGCGGGCTTCCCCACCGGGCTGAAGTGGACCTTCATGCCCAAGCAGGAGAGCGAGCGGCCG
CACTACCTCGTGGTCAACGCCGACGAGTCCGAGCCCGGCGCGTGCAAGGACCGTGAGATCCTGCGCAACGATCCGCACCT
GCTGATCGAGGGCTGCCTGATCGCCTGCCGGGCGATCCGGGCGCACACGGCCTACATCTACATCCGCGGCGAATACGTGC
ACGAGCGCGAGCGCCTGACGGCGGCGATCCAGCAGGCCTACGACGCCAAGCTGATCGGCCCGGGCAACATCCACGGCTGG
GACTGCGACGTCCGCATCCAGCACGGGGGCGGGGCCTACATCTGCGGCGACGAGACCGCCCTGATGGAAAGCCTGGAAGG
CAAGAAGGGCCAGCCGCGGCTGAAGCCGCCGTTCCCGGCCGGCGCCGGCATCTGGGGCGCGCCCACCACCATCAACAACG
TCGAGTCCATCTCGGTCGTCGGCACCATCCTGCGCCGCGGGGCCGACTGGTTCGCCGGCTTCGGCACCGAGAAGTCCACC
GGGACCAAGCTGTTCGCGGCCTCGGGCCACGTGAACAAGCCCTGCGTGGTCGAGGACGCGGTCGGCATTCCGGTGCGGCA
GCTGATCGAGGAGCACTTCGGCGGCGTGCGCGGCGGCTGGGGCAACCTGAAGGCGGTCATCCCGGGCGGCATCTCGGTGC
GCATGATCCCGGCCCACGAGGCCGAGGAAGCCGTGATGACCTACGAGGACCTGCAGGCCCGCGGCTCCGGCCTCGGCACC
GGCACCATGATCGTGTTCGACAAGGACGCCGACCTGGTGAAGGCGATCGCCCGGGCCAGCTACTTCTACAAGCACGAGAG
CTGCGGCCAGTGCACGCCGTGCCGTGAGGGCACCGGCTGGATGTGGCGGGTCATGGAGCGGATGGTCACCGGCGAGGCCG
AGATGTCCGAAATCGACCTGCTGCTCGACGTCGCCAGCCAGGTCGAAGGCCACACGATCTGCGGCCTGGGCGATGCGGCC
GCCTGGCCGATCCAGGGCCTCTTCCGCCACTTCCGCCACGAGGTGGAGGAGCGGATCACCAGTTACCGCGCGCGCAAGGG
CTCGTACGCCGGCGCTTCCATCGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
CCGAGGGCGGGCCCATGACGCTGACCGATCCGAAGCTCTACGACGGCTCGCTCGCCAAGAAGATCAAGATCCCGAACCTG
CCCTCGAAGGAGCCTGTGTG

Downstream 100 bases:

>100_bases
GCGAGAATGCCTATCGCCAAGGTCGACGGGGTCGAGGTCGAGTTCGAGCCGGGGATGAACGTCCTCCAGGTCTGCGAGCT
CGCCGGCAAGGAGATCCCGC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPGILADKDRIFLNLYGLHDWGLEGAKARGAWNGTKDIVAQSPEWICDQIKASGLRGRGGAGFPTGLKWTFMPKQESERP
HYLVVNADESEPGACKDREILRNDPHLLIEGCLIACRAIRAHTAYIYIRGEYVHERERLTAAIQQAYDAKLIGPGNIHGW
DCDVRIQHGGGAYICGDETALMESLEGKKGQPRLKPPFPAGAGIWGAPTTINNVESISVVGTILRRGADWFAGFGTEKST
GTKLFAASGHVNKPCVVEDAVGIPVRQLIEEHFGGVRGGWGNLKAVIPGGISVRMIPAHEAEEAVMTYEDLQARGSGLGT
GTMIVFDKDADLVKAIARASYFYKHESCGQCTPCREGTGWMWRVMERMVTGEAEMSEIDLLLDVASQVEGHTICGLGDAA
AWPIQGLFRHFRHEVEERITSYRARKGSYAGASIAAE

Sequences:

>Translated_437_residues
MPGILADKDRIFLNLYGLHDWGLEGAKARGAWNGTKDIVAQSPEWICDQIKASGLRGRGGAGFPTGLKWTFMPKQESERP
HYLVVNADESEPGACKDREILRNDPHLLIEGCLIACRAIRAHTAYIYIRGEYVHERERLTAAIQQAYDAKLIGPGNIHGW
DCDVRIQHGGGAYICGDETALMESLEGKKGQPRLKPPFPAGAGIWGAPTTINNVESISVVGTILRRGADWFAGFGTEKST
GTKLFAASGHVNKPCVVEDAVGIPVRQLIEEHFGGVRGGWGNLKAVIPGGISVRMIPAHEAEEAVMTYEDLQARGSGLGT
GTMIVFDKDADLVKAIARASYFYKHESCGQCTPCREGTGWMWRVMERMVTGEAEMSEIDLLLDVASQVEGHTICGLGDAA
AWPIQGLFRHFRHEVEERITSYRARKGSYAGASIAAE
>Mature_436_residues
PGILADKDRIFLNLYGLHDWGLEGAKARGAWNGTKDIVAQSPEWICDQIKASGLRGRGGAGFPTGLKWTFMPKQESERPH
YLVVNADESEPGACKDREILRNDPHLLIEGCLIACRAIRAHTAYIYIRGEYVHERERLTAAIQQAYDAKLIGPGNIHGWD
CDVRIQHGGGAYICGDETALMESLEGKKGQPRLKPPFPAGAGIWGAPTTINNVESISVVGTILRRGADWFAGFGTEKSTG
TKLFAASGHVNKPCVVEDAVGIPVRQLIEEHFGGVRGGWGNLKAVIPGGISVRMIPAHEAEEAVMTYEDLQARGSGLGTG
TMIVFDKDADLVKAIARASYFYKHESCGQCTPCREGTGWMWRVMERMVTGEAEMSEIDLLLDVASQVEGHTICGLGDAAA
WPIQGLFRHFRHEVEERITSYRARKGSYAGASIAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=421, Percent_Identity=60.332541567696, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI260656005, Length=421, Percent_Identity=60.332541567696, Blast_Score=534, Evalue=1e-152,
Organism=Escherichia coli, GI1788620, Length=416, Percent_Identity=39.9038461538462, Blast_Score=301, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17531727, Length=432, Percent_Identity=57.4074074074074, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI19920794, Length=424, Percent_Identity=59.4339622641509, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550452, Length=431, Percent_Identity=57.5406032482599, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24653819, Length=423, Percent_Identity=44.4444444444444, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24653817, Length=423, Percent_Identity=41.1347517730496, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47618; Mature: 47486

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGILADKDRIFLNLYGLHDWGLEGAKARGAWNGTKDIVAQSPEWICDQIKASGLRGRGG
CCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
AGFPTGLKWTFMPKQESERPHYLVVNADESEPGACKDREILRNDPHLLIEGCLIACRAIR
CCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
AHTAYIYIRGEYVHERERLTAAIQQAYDAKLIGPGNIHGWDCDVRIQHGGGAYICGDETA
CEEEEEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCEEEECCHHH
LMESLEGKKGQPRLKPPFPAGAGIWGAPTTINNVESISVVGTILRRGADWFAGFGTEKST
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCC
GTKLFAASGHVNKPCVVEDAVGIPVRQLIEEHFGGVRGGWGNLKAVIPGGISVRMIPAHE
CCEEEEECCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCC
AEEAVMTYEDLQARGSGLGTGTMIVFDKDADLVKAIARASYFYKHESCGQCTPCREGTGW
CHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
MWRVMERMVTGEAEMSEIDLLLDVASQVEGHTICGLGDAAAWPIQGLFRHFRHEVEERIT
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
SYRARKGSYAGASIAAE
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PGILADKDRIFLNLYGLHDWGLEGAKARGAWNGTKDIVAQSPEWICDQIKASGLRGRGG
CCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
AGFPTGLKWTFMPKQESERPHYLVVNADESEPGACKDREILRNDPHLLIEGCLIACRAIR
CCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
AHTAYIYIRGEYVHERERLTAAIQQAYDAKLIGPGNIHGWDCDVRIQHGGGAYICGDETA
CEEEEEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCEEEECCHHH
LMESLEGKKGQPRLKPPFPAGAGIWGAPTTINNVESISVVGTILRRGADWFAGFGTEKST
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCC
GTKLFAASGHVNKPCVVEDAVGIPVRQLIEEHFGGVRGGWGNLKAVIPGGISVRMIPAHE
CCEEEEECCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCC
AEEAVMTYEDLQARGSGLGTGTMIVFDKDADLVKAIARASYFYKHESCGQCTPCREGTGW
CHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
MWRVMERMVTGEAEMSEIDLLLDVASQVEGHTICGLGDAAAWPIQGLFRHFRHEVEERIT
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
SYRARKGSYAGASIAAE
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]