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The map label for this gene is aas [H]

Identifier: 197105201

GI number: 197105201

Start: 1947210

End: 1948763

Strand: Direct

Name: aas [H]

Synonym: PHZ_c1738

Alternate gene names: 197105201

Gene position: 1947210-1948763 (Clockwise)

Preceding gene: 197105198

Following gene: 197105209

Centisome position: 48.73

GC content: 70.59

Gene sequence:

>1554_bases
TTGCGTTCGTTCGACAGCGCCCAGGCGCAGTCTTCCGTCTTCGACGCCCTCATCGACGCGGCGAAGACCCACGGGGCCAA
GAAGCCGATCCTGGAGGACCAGGAGCGCAACCCCCTCACCTACACCGACCTGATCCGGGCCTCCTTCGCCCTCGGGCGCA
AGCTGTCGGGCCTGACGAGAAAGGGCGAGCGCGTGGGCGTGATGCTGCCGTCCAGCGCGGGCGGCGTTGTCACGTTCTTC
GCCCTGCACGCCTTCGGGCGCGTCCCCACCATGCTGAACTTCACGGCCGGGATCCGGAACCTGAAGGCGGCCTGCGATCT
GGCCGGCGTGAAGCGGGTGCTGACCTCCCACCGCTTCGTCGAGCAGGGCAAGCTGCACGACCTGATCGACGCGCTCGAGG
ACCGGGCGCAGATCACCTACCTGGAGGACGTCCGCGCCACCATCGGCCTGCCCGACAAGCTGTATGCGGCGGCCGCCGGC
GCCCTGCCGAAGCAGTTCCGGGCCTCCGTGGCGCCGTCGGACCCCGGCGTGATCCTCTTCACCTCGGGCAGCTTCGGCGC
GCCGCGCGGGGTGGTCCTGACCCATGCGAACCTCGTGGCCAACTGCCGGCAGATCGCGACGCACATCGCGCTCGATCCGA
ACTGGGTGTTCTTCAACCCGCTGCCGATCTTCCACGTCTTCGGCCTGACCGGCGGGGTCCTGCTGCCGATCCTGACGGGC
ATGAAGGCGTTCCAGTACCCCTCGCCCCTGCACACCAAGCAGATCCCGCCGCTGATCAAGGACTCCAAGGCGGCGGTGCT
GCTGGCCACCGACACCTTCGTGAACCAGTACGCCCGCGCCGCCGACTCCGACGAGCTGGCGGGCCTGAACTTCGTCGTCT
GCGGGGCCGAGAAGGTGCGCGACGAGACCCACAACCTGATCGCCGAGAAGTTCGGGCCGATCCCGTTGCTGGAGGGCTAC
GGGGCCACCGAGGCCTCGCCGGTGATCGCGGTGAACAAGCCCACCGACAACCGCCGCGGCACCGTGGGCGGCCTCCTGCC
CGGCATGGAGACGAAGCTGGAGCCGGTGGAGGGCATCCCCGGCGGCGGCAAGCTGCTGGTGCGCGGGCCCAACGTCATGG
CCGGCTACCTGCGGCCCGACGGCGGCATCGACCCGCCCGCGGGCGGCTGGCACGACACCGGCGACGTGGTCTCCATCACC
GACGACGGCTGGGTGAAGATCCTCGGCCGGGTGAAGCGCTTCGCCAAGGTCGGCGGCGAGATGGTCTCGCTGACCGCCGC
CGAGGACCTAGCCGCGGCCGTGTGGCCTGACTGCCGCCACGCCGTGGTGGCCGTGCCCGACGCCAAGAAGGGCGAACGCC
TGATCCTGGTCACCGACCGGCGGGACGCCGAGGCGGCGCCCCTGCTGGCCCACGCCCAGAAGGCAGGCGCGCCCGAACTG
GCCGTGCCGCGTCGGATCATCAAGGTCCCGGAGATCCCCGTCCTCGGGACCGGCAAGACCGACTACGTGGCGCTCCAGAG
GATCGTGGAAGCCGAGCTGCGGCGGGCGGCGTAA

Upstream 100 bases:

>100_bases
CCGCAGGCTGCGGCGTTCACGCTCTGTAACCGATCTTTTCATTTTAAAGTCCGACCGATAGGTTCCCGAGCCAACGAGAA
CAGTCCGGGAGCGTACGCCC

Downstream 100 bases:

>100_bases
GTCCTCCCTCCCGTTCAAGGGAGGGAAGCAGCGTCAGATGTGCAGAACCCGCCCGTAGGCGTCGAGCGCGGCCTCGTGCA
TGGCCTCGCTCATGGTCGGG

Product: acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MRSFDSAQAQSSVFDALIDAAKTHGAKKPILEDQERNPLTYTDLIRASFALGRKLSGLTRKGERVGVMLPSSAGGVVTFF
ALHAFGRVPTMLNFTAGIRNLKAACDLAGVKRVLTSHRFVEQGKLHDLIDALEDRAQITYLEDVRATIGLPDKLYAAAAG
ALPKQFRASVAPSDPGVILFTSGSFGAPRGVVLTHANLVANCRQIATHIALDPNWVFFNPLPIFHVFGLTGGVLLPILTG
MKAFQYPSPLHTKQIPPLIKDSKAAVLLATDTFVNQYARAADSDELAGLNFVVCGAEKVRDETHNLIAEKFGPIPLLEGY
GATEASPVIAVNKPTDNRRGTVGGLLPGMETKLEPVEGIPGGGKLLVRGPNVMAGYLRPDGGIDPPAGGWHDTGDVVSIT
DDGWVKILGRVKRFAKVGGEMVSLTAAEDLAAAVWPDCRHAVVAVPDAKKGERLILVTDRRDAEAAPLLAHAQKAGAPEL
AVPRRIIKVPEIPVLGTGKTDYVALQRIVEAELRRAA

Sequences:

>Translated_517_residues
MRSFDSAQAQSSVFDALIDAAKTHGAKKPILEDQERNPLTYTDLIRASFALGRKLSGLTRKGERVGVMLPSSAGGVVTFF
ALHAFGRVPTMLNFTAGIRNLKAACDLAGVKRVLTSHRFVEQGKLHDLIDALEDRAQITYLEDVRATIGLPDKLYAAAAG
ALPKQFRASVAPSDPGVILFTSGSFGAPRGVVLTHANLVANCRQIATHIALDPNWVFFNPLPIFHVFGLTGGVLLPILTG
MKAFQYPSPLHTKQIPPLIKDSKAAVLLATDTFVNQYARAADSDELAGLNFVVCGAEKVRDETHNLIAEKFGPIPLLEGY
GATEASPVIAVNKPTDNRRGTVGGLLPGMETKLEPVEGIPGGGKLLVRGPNVMAGYLRPDGGIDPPAGGWHDTGDVVSIT
DDGWVKILGRVKRFAKVGGEMVSLTAAEDLAAAVWPDCRHAVVAVPDAKKGERLILVTDRRDAEAAPLLAHAQKAGAPEL
AVPRRIIKVPEIPVLGTGKTDYVALQRIVEAELRRAA
>Mature_517_residues
MRSFDSAQAQSSVFDALIDAAKTHGAKKPILEDQERNPLTYTDLIRASFALGRKLSGLTRKGERVGVMLPSSAGGVVTFF
ALHAFGRVPTMLNFTAGIRNLKAACDLAGVKRVLTSHRFVEQGKLHDLIDALEDRAQITYLEDVRATIGLPDKLYAAAAG
ALPKQFRASVAPSDPGVILFTSGSFGAPRGVVLTHANLVANCRQIATHIALDPNWVFFNPLPIFHVFGLTGGVLLPILTG
MKAFQYPSPLHTKQIPPLIKDSKAAVLLATDTFVNQYARAADSDELAGLNFVVCGAEKVRDETHNLIAEKFGPIPLLEGY
GATEASPVIAVNKPTDNRRGTVGGLLPGMETKLEPVEGIPGGGKLLVRGPNVMAGYLRPDGGIDPPAGGWHDTGDVVSIT
DDGWVKILGRVKRFAKVGGEMVSLTAAEDLAAAVWPDCRHAVVAVPDAKKGERLILVTDRRDAEAAPLLAHAQKAGAPEL
AVPRRIIKVPEIPVLGTGKTDYVALQRIVEAELRRAA

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=493, Percent_Identity=23.9350912778905, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789201, Length=524, Percent_Identity=40.8396946564886, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788107, Length=500, Percent_Identity=25.4, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI145693145, Length=346, Percent_Identity=27.4566473988439, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786810, Length=522, Percent_Identity=22.4137931034483, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560308, Length=494, Percent_Identity=24.4939271255061, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17559526, Length=315, Percent_Identity=30.7936507936508, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=511, Percent_Identity=23.8747553816047, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=511, Percent_Identity=23.4833659491194, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=354, Percent_Identity=25.9887005649718, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=511, Percent_Identity=23.4833659491194, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=511, Percent_Identity=23.4833659491194, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=370, Percent_Identity=27.027027027027, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=318, Percent_Identity=26.7295597484277, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=358, Percent_Identity=25.4189944134078, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=303, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=366, Percent_Identity=25.6830601092896, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859661, Length=347, Percent_Identity=30.5475504322767, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581924, Length=371, Percent_Identity=26.1455525606469, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355181, Length=561, Percent_Identity=23.8859180035651, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 55105; Mature: 55105

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSFDSAQAQSSVFDALIDAAKTHGAKKPILEDQERNPLTYTDLIRASFALGRKLSGLTR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
KGERVGVMLPSSAGGVVTFFALHAFGRVPTMLNFTAGIRNLKAACDLAGVKRVLTSHRFV
CCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQGKLHDLIDALEDRAQITYLEDVRATIGLPDKLYAAAAGALPKQFRASVAPSDPGVILF
HCCCHHHHHHHHHHHHEEEEHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCCEEEE
TSGSFGAPRGVVLTHANLVANCRQIATHIALDPNWVFFNPLPIFHVFGLTGGVLLPILTG
ECCCCCCCCCEEEECHHHHHHHHHHHHHEEECCCEEEECCCHHHHHHHCCCHHHHHHHHH
MKAFQYPSPLHTKQIPPLIKDSKAAVLLATDTFVNQYARAADSDELAGLNFVVCGAEKVR
HHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEECHHHHH
DETHNLIAEKFGPIPLLEGYGATEASPVIAVNKPTDNRRGTVGGLLPGMETKLEPVEGIP
HHHHHHHHHHCCCCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGKLLVRGPNVMAGYLRPDGGIDPPAGGWHDTGDVVSITDDGWVKILGRVKRFAKVGGE
CCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
MVSLTAAEDLAAAVWPDCRHAVVAVPDAKKGERLILVTDRRDAEAAPLLAHAQKAGAPEL
EEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCH
AVPRRIIKVPEIPVLGTGKTDYVALQRIVEAELRRAA
HHCHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSFDSAQAQSSVFDALIDAAKTHGAKKPILEDQERNPLTYTDLIRASFALGRKLSGLTR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
KGERVGVMLPSSAGGVVTFFALHAFGRVPTMLNFTAGIRNLKAACDLAGVKRVLTSHRFV
CCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQGKLHDLIDALEDRAQITYLEDVRATIGLPDKLYAAAAGALPKQFRASVAPSDPGVILF
HCCCHHHHHHHHHHHHEEEEHHHHHHHCCCCHHHHHHHHCCCCHHHHCCCCCCCCCEEEE
TSGSFGAPRGVVLTHANLVANCRQIATHIALDPNWVFFNPLPIFHVFGLTGGVLLPILTG
ECCCCCCCCCEEEECHHHHHHHHHHHHHEEECCCEEEECCCHHHHHHHCCCHHHHHHHHH
MKAFQYPSPLHTKQIPPLIKDSKAAVLLATDTFVNQYARAADSDELAGLNFVVCGAEKVR
HHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEECHHHHH
DETHNLIAEKFGPIPLLEGYGATEASPVIAVNKPTDNRRGTVGGLLPGMETKLEPVEGIP
HHHHHHHHHHCCCCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGKLLVRGPNVMAGYLRPDGGIDPPAGGWHDTGDVVSITDDGWVKILGRVKRFAKVGGE
CCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
MVSLTAAEDLAAAVWPDCRHAVVAVPDAKKGERLILVTDRRDAEAAPLLAHAQKAGAPEL
EEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCH
AVPRRIIKVPEIPVLGTGKTDYVALQRIVEAELRRAA
HHCHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA