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The map label for this gene is metC [H]

Identifier: 197105094

GI number: 197105094

Start: 1838917

End: 1840080

Strand: Direct

Name: metC [H]

Synonym: PHZ_c1631

Alternate gene names: 197105094

Gene position: 1838917-1840080 (Clockwise)

Preceding gene: 197105092

Following gene: 197105095

Centisome position: 46.02

GC content: 73.37

Gene sequence:

>1164_bases
ATGTCCGACGAGACCCGCCTGATCCACGCCGGCGCCCAATCCGGGCCCATCTGCCGAACGGTCGGCCCGCCGATCCAGAA
GGGCTCCACGGTGCTGCTGCCCAACGCGGCGGCGCTCTACGACGACGACCATTGCACCACCTACGGCCGCAGCGGCCTGG
CGGCCCAGGCGACGCTGCGCGAGGCCCTGGCGGTCATGGAGGGGGCGGTGGGCGTCTCCCTCTACCCCTCGGGCCTGGCG
GCCATCTCGGGCGCGCTGCTGGCGGTGCTCAAGGCCGGCGACGAGATCCTGGTGGTCGACAACGTCTACAAGCCGGTCCG
GCGGTTCTGCGACCGGGTGCTTGGGGGCTTCGGCGTCGGGGTCAGCTACTTCGACCCGCGCACCGCGCCGGAGGCGCTCG
TCGGCGAGGCTTCGGACAAGACGCGGCTGATCCTGCTGGAGAGCCCGGGCTCGCTGACCCTCGAGATGCAGGACGTGCCG
GCCATCGCGCGCCTCGCCCGCGAGCGCGGGATCCTGACGGCGATCGACAACACCTGGGGCGCGGGCTTTCTGTTCCGCCC
GCTGGAGCACGGGGTCGACCTGTCGCTGCAGGCCCTGACCAAGTACGTCGGCGGCCATTCCGACGTGTTCATGGGCTCGG
CGGCCGCGCGCGACCCGGCGCTGGTGCGGGCGCTGAACGACGGCGTCGACGACCTCGGCTGGGCGGTCTCGGGCGAGGAC
GCCTACCAGGTGCTCCGCGGCGTCCGCACCCTGCCGCTGCGCCTCGCGGCCCAGGGCGAGGCGGGCCTGAGGGTCGCCGA
GTGGCTGAAGACCCAGCCGGAGGTGGCCGCCGTCCACCACCCCGCCCTGCCCGGCGATCCGGACCATGCGCTCTGGGCCC
GGGACTACCGGGGCGCCTGCGGCCTGTTCACCGTCGCGCTGAAGCCCGCGCCGCGGGCGGCGGTGGACGCCTTCCTCGAC
GCCCTGCAGGTGTTCGGCCTGGGTTTCTCGTGGGGCGGGTTCGAGAGCCTGGCGATCTGGTGCGACCCGCAGCTGAAGGC
CCGCCGGTTCAGGCGCGACTACGCCGGACCCTTGATCCGCCTGCACATCGGCCTGGAGGCCGTGGACGACCTGATCGCCG
ACCTGCGGCGGGGGTTGGACGCCTACGCGAAAACGGCGGCCTGA

Upstream 100 bases:

>100_bases
CATCCCAGCTCCTTGAAACGGAGAAACCCGGAGGTCTAAGTGCGAAGCTCTTAAGTGCGAGGGGCACTTTCGCCAGCGTC
GCCCGGAGCCGCAAGCCCGC

Downstream 100 bases:

>100_bases
GCCGGAACCTCGCGCCCTCCCCGGGATTGCACCGCGCAAGCACCCCGAAGGAGACGGCGATGACCAGCCAGGGACCCGGC
GGCGAGTTCCGCCAGGAGGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSDETRLIHAGAQSGPICRTVGPPIQKGSTVLLPNAAALYDDDHCTTYGRSGLAAQATLREALAVMEGAVGVSLYPSGLA
AISGALLAVLKAGDEILVVDNVYKPVRRFCDRVLGGFGVGVSYFDPRTAPEALVGEASDKTRLILLESPGSLTLEMQDVP
AIARLARERGILTAIDNTWGAGFLFRPLEHGVDLSLQALTKYVGGHSDVFMGSAAARDPALVRALNDGVDDLGWAVSGED
AYQVLRGVRTLPLRLAAQGEAGLRVAEWLKTQPEVAAVHHPALPGDPDHALWARDYRGACGLFTVALKPAPRAAVDAFLD
ALQVFGLGFSWGGFESLAIWCDPQLKARRFRRDYAGPLIRLHIGLEAVDDLIADLRRGLDAYAKTAA

Sequences:

>Translated_387_residues
MSDETRLIHAGAQSGPICRTVGPPIQKGSTVLLPNAAALYDDDHCTTYGRSGLAAQATLREALAVMEGAVGVSLYPSGLA
AISGALLAVLKAGDEILVVDNVYKPVRRFCDRVLGGFGVGVSYFDPRTAPEALVGEASDKTRLILLESPGSLTLEMQDVP
AIARLARERGILTAIDNTWGAGFLFRPLEHGVDLSLQALTKYVGGHSDVFMGSAAARDPALVRALNDGVDDLGWAVSGED
AYQVLRGVRTLPLRLAAQGEAGLRVAEWLKTQPEVAAVHHPALPGDPDHALWARDYRGACGLFTVALKPAPRAAVDAFLD
ALQVFGLGFSWGGFESLAIWCDPQLKARRFRRDYAGPLIRLHIGLEAVDDLIADLRRGLDAYAKTAA
>Mature_386_residues
SDETRLIHAGAQSGPICRTVGPPIQKGSTVLLPNAAALYDDDHCTTYGRSGLAAQATLREALAVMEGAVGVSLYPSGLAA
ISGALLAVLKAGDEILVVDNVYKPVRRFCDRVLGGFGVGVSYFDPRTAPEALVGEASDKTRLILLESPGSLTLEMQDVPA
IARLARERGILTAIDNTWGAGFLFRPLEHGVDLSLQALTKYVGGHSDVFMGSAAARDPALVRALNDGVDDLGWAVSGEDA
YQVLRGVRTLPLRLAAQGEAGLRVAEWLKTQPEVAAVHHPALPGDPDHALWARDYRGACGLFTVALKPAPRAAVDAFLDA
LQVFGLGFSWGGFESLAIWCDPQLKARRFRRDYAGPLIRLHIGLEAVDDLIADLRRGLDAYAKTAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=369, Percent_Identity=32.520325203252, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI299473759, Length=265, Percent_Identity=32.4528301886792, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI25453487, Length=368, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=38.974358974359, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790375, Length=369, Percent_Identity=32.2493224932249, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17538055, Length=354, Percent_Identity=32.4858757062147, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=356, Percent_Identity=31.7415730337079, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=28.6103542234332, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=318, Percent_Identity=42.7672955974843, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319307, Length=392, Percent_Identity=27.5510204081633, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=24.812030075188, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321254, Length=408, Percent_Identity=25.2450980392157, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323333, Length=384, Percent_Identity=24.21875, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922554, Length=344, Percent_Identity=35.1744186046512, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41183; Mature: 41051

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDETRLIHAGAQSGPICRTVGPPIQKGSTVLLPNAAALYDDDHCTTYGRSGLAAQATLR
CCCCCEEEECCCCCCCEECCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCHHHHHHH
EALAVMEGAVGVSLYPSGLAAISGALLAVLKAGDEILVVDNVYKPVRRFCDRVLGGFGVG
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCC
VSYFDPRTAPEALVGEASDKTRLILLESPGSLTLEMQDVPAIARLARERGILTAIDNTWG
CCCCCCCCCCHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEECCCCC
AGFLFRPLEHGVDLSLQALTKYVGGHSDVFMGSAAARDPALVRALNDGVDDLGWAVSGED
CCHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHCCHHHHCCEECCHH
AYQVLRGVRTLPLRLAAQGEAGLRVAEWLKTQPEVAAVHHPALPGDPDHALWARDYRGAC
HHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHCCCCCC
GLFTVALKPAPRAAVDAFLDALQVFGLGFSWGGFESLAIWCDPQLKARRFRRDYAGPLIR
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEE
LHIGLEAVDDLIADLRRGLDAYAKTAA
EEECHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDETRLIHAGAQSGPICRTVGPPIQKGSTVLLPNAAALYDDDHCTTYGRSGLAAQATLR
CCCCEEEECCCCCCCEECCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCHHHHHHH
EALAVMEGAVGVSLYPSGLAAISGALLAVLKAGDEILVVDNVYKPVRRFCDRVLGGFGVG
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCC
VSYFDPRTAPEALVGEASDKTRLILLESPGSLTLEMQDVPAIARLARERGILTAIDNTWG
CCCCCCCCCCHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEECCCCC
AGFLFRPLEHGVDLSLQALTKYVGGHSDVFMGSAAARDPALVRALNDGVDDLGWAVSGED
CCHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHCCHHHHCCEECCHH
AYQVLRGVRTLPLRLAAQGEAGLRVAEWLKTQPEVAAVHHPALPGDPDHALWARDYRGAC
HHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHCCCCCC
GLFTVALKPAPRAAVDAFLDALQVFGLGFSWGGFESLAIWCDPQLKARRFRRDYAGPLIR
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEE
LHIGLEAVDDLIADLRRGLDAYAKTAA
EEECHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]