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The map label for this gene is caiC [H]

Identifier: 197104063

GI number: 197104063

Start: 636277

End: 638064

Strand: Direct

Name: caiC [H]

Synonym: PHZ_c0597

Alternate gene names: 197104063

Gene position: 636277-638064 (Clockwise)

Preceding gene: 197104061

Following gene: 197104065

Centisome position: 15.92

GC content: 69.02

Gene sequence:

>1788_bases
ATGCGCCTGAAGGCAAGGCTCCAGCGCGAGTGGCGTTTCGTGCGCGGGCTGAACCGGACGCTGAAGCGGGTGAAGTCGAT
CTCGAAGGAGAGCCCCAATCTCCTCTGCGACGACCTGCAGGCCGCGATGGACAAGTGGCGCGGCCGCCCGGCGATCACCT
TCGAAGGGCGCACGATCACCTATGGCGATCTCGACGCCATGGCCAACCGCTACGCCCACTGGGCCAAGGGGTTGGGCCTG
CGGCGCGGCCAGGTCGTGGCGCTCTTCATGCCCAACCGCATCGAGTACCTGCCGATCTGGTACGGGCTCTCCAAGGTCGG
GGTGGTCACGGCCCTCATCAACAACCAGCTCGCCGGCCTGCCGCTGGCCCACTGCCTGAACATCTCGGGCGCCTCGCACG
TGATCGTCGACGCCGAGACCTCGCCGGTGTTCGAGCCGGCCAAGGGGCTCCTCGAGAAGACGCTGCAGCAGTGGGTGCTG
GGCCCCGCGCACGGCGACCAGCGCGACCTCGTTCAGGCGCTGAAGAGCTGCAGCCAGCTGCCGCCCGACCGGTCGGTGCG
CGAGGACATGACCGCCGCCGACACGGCGCTGCTGATCTTCACCTCGGGCACCACGGGCATGCCCAAGGCCGCCCGGATCA
CCCACATGCGCGGCCAGCTCTACATGCGCGGCTTCGCCGGCTCGACGGGCGCGCGCGCCGAGGACCGCGTCTACGTCGCC
CTGCCGCTCTACCACGCCACCGGCGGCCTCTGCGCCATGGGCGCGGCGCTACTGAACGGCGGGTCAGTAGTGCTCCGGCG
CAAGTTCTCGGCCACCCACTTCTGGCCCGAGGTCGTCGCCGAGGGCTGCACCATGTTCGTCTACATCGGCGAGCTGTGCC
GCTACCTCGTGAACCACGAGCCCGACCCCGACGAGACCCGGCACAAGATCCGCATGGCCTTCGGCAACGGCCTGCGCCCG
GACATCTGGCCGGTGATGAAGCAGCGCTTCCGCATCCCCGAGATCCTCGAGTTCTACGGCTCGACGGAGGGGAACGTCAG
CATGTTCAACTTCGACGGCCGGGAGGGGGCGATCGGCCGCGTGCCGAAGTGGCTGCGCAGCCGCTTCAACATCCGGCTGG
TCCAGTTCGACGTCGAGAAGGAGCAGGTGATCCGCGGGACCGACGGCTTCGGCATCGAGTGCGGGCCGGGCCAGATCGGC
GAGTGCATCGGCAAGATCGGCGGCGAGGCGCGCGCGGAGTACACCGGCTACCTCGACCGCAAGGCCTCGGACAAGAAGGT
GCTGCGCGACGTCTTCGAGCGCGGCGACGCCTGGTTCGCCACGGGCGACCTGATGCGCATGGACGCCGACGGCTACTTCT
ACTTCGTGGACCGGATCGGCGACACCTTCCGCTGGAAGGGCGAGAACGTCTCCACCAACGAGGTGGCCGAGCGGCTGCAG
GCCTGTCCGGGCGTCGAGCAGGCCACGGTCTACGGCGTGGCGGTCGAGGGCGCGGAAGGGCGCGCCGGCATGGCGGCCCT
GGTGGTCGGCCCGGACTTCGACATCAAGCTGCTCGGCGAGCACGTGACCCGGGAGCTGCCGCCCTACGCTCAGCCCCTGT
TCGTCCGGCTGCTGCCGGCCATGGAGACGACCGGCACCTTCAAGATCCGCAAGATGGACCTGGTGGCCGACGGCTACGAC
CCGGGCAAGGTGCGCGGGCCGCTCTACTTCCACGACCCCAAGAAGGGCTATGTGAAGGTCACCAAGGCGGTGTTCGACAA
GATCGCCGCCGGCGGCGTGAAGGTCTGA

Upstream 100 bases:

>100_bases
GCGCGGCCTGTTACGCAGCTGTGACCGATCGGTCGCCAAGCCTCGCTTGACCGTATGGGGCGGTCCTCTCCAAGGTCGGG
TCTGGAAGTCGGAGGAATGA

Downstream 100 bases:

>100_bases
GGCCTCAGCGTCGGTCCAGCGGCAGGCGCACCCGGCAGACGAGCCCCGCGGCGGCGAAGTCCAGTTCGGCCGCGCCGCCC
AGGGCGCCCTCCAGGCTGCG

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MRLKARLQREWRFVRGLNRTLKRVKSISKESPNLLCDDLQAAMDKWRGRPAITFEGRTITYGDLDAMANRYAHWAKGLGL
RRGQVVALFMPNRIEYLPIWYGLSKVGVVTALINNQLAGLPLAHCLNISGASHVIVDAETSPVFEPAKGLLEKTLQQWVL
GPAHGDQRDLVQALKSCSQLPPDRSVREDMTAADTALLIFTSGTTGMPKAARITHMRGQLYMRGFAGSTGARAEDRVYVA
LPLYHATGGLCAMGAALLNGGSVVLRRKFSATHFWPEVVAEGCTMFVYIGELCRYLVNHEPDPDETRHKIRMAFGNGLRP
DIWPVMKQRFRIPEILEFYGSTEGNVSMFNFDGREGAIGRVPKWLRSRFNIRLVQFDVEKEQVIRGTDGFGIECGPGQIG
ECIGKIGGEARAEYTGYLDRKASDKKVLRDVFERGDAWFATGDLMRMDADGYFYFVDRIGDTFRWKGENVSTNEVAERLQ
ACPGVEQATVYGVAVEGAEGRAGMAALVVGPDFDIKLLGEHVTRELPPYAQPLFVRLLPAMETTGTFKIRKMDLVADGYD
PGKVRGPLYFHDPKKGYVKVTKAVFDKIAAGGVKV

Sequences:

>Translated_595_residues
MRLKARLQREWRFVRGLNRTLKRVKSISKESPNLLCDDLQAAMDKWRGRPAITFEGRTITYGDLDAMANRYAHWAKGLGL
RRGQVVALFMPNRIEYLPIWYGLSKVGVVTALINNQLAGLPLAHCLNISGASHVIVDAETSPVFEPAKGLLEKTLQQWVL
GPAHGDQRDLVQALKSCSQLPPDRSVREDMTAADTALLIFTSGTTGMPKAARITHMRGQLYMRGFAGSTGARAEDRVYVA
LPLYHATGGLCAMGAALLNGGSVVLRRKFSATHFWPEVVAEGCTMFVYIGELCRYLVNHEPDPDETRHKIRMAFGNGLRP
DIWPVMKQRFRIPEILEFYGSTEGNVSMFNFDGREGAIGRVPKWLRSRFNIRLVQFDVEKEQVIRGTDGFGIECGPGQIG
ECIGKIGGEARAEYTGYLDRKASDKKVLRDVFERGDAWFATGDLMRMDADGYFYFVDRIGDTFRWKGENVSTNEVAERLQ
ACPGVEQATVYGVAVEGAEGRAGMAALVVGPDFDIKLLGEHVTRELPPYAQPLFVRLLPAMETTGTFKIRKMDLVADGYD
PGKVRGPLYFHDPKKGYVKVTKAVFDKIAAGGVKV
>Mature_595_residues
MRLKARLQREWRFVRGLNRTLKRVKSISKESPNLLCDDLQAAMDKWRGRPAITFEGRTITYGDLDAMANRYAHWAKGLGL
RRGQVVALFMPNRIEYLPIWYGLSKVGVVTALINNQLAGLPLAHCLNISGASHVIVDAETSPVFEPAKGLLEKTLQQWVL
GPAHGDQRDLVQALKSCSQLPPDRSVREDMTAADTALLIFTSGTTGMPKAARITHMRGQLYMRGFAGSTGARAEDRVYVA
LPLYHATGGLCAMGAALLNGGSVVLRRKFSATHFWPEVVAEGCTMFVYIGELCRYLVNHEPDPDETRHKIRMAFGNGLRP
DIWPVMKQRFRIPEILEFYGSTEGNVSMFNFDGREGAIGRVPKWLRSRFNIRLVQFDVEKEQVIRGTDGFGIECGPGQIG
ECIGKIGGEARAEYTGYLDRKASDKKVLRDVFERGDAWFATGDLMRMDADGYFYFVDRIGDTFRWKGENVSTNEVAERLQ
ACPGVEQATVYGVAVEGAEGRAGMAALVVGPDFDIKLLGEHVTRELPPYAQPLFVRLLPAMETTGTFKIRKMDLVADGYD
PGKVRGPLYFHDPKKGYVKVTKAVFDKIAAGGVKV

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807357, Length=624, Percent_Identity=39.2628205128205, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI227499619, Length=585, Percent_Identity=38.2905982905983, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI62865631, Length=556, Percent_Identity=37.9496402877698, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI13325055, Length=556, Percent_Identity=37.9496402877698, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI38524616, Length=548, Percent_Identity=41.0583941605839, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI13236579, Length=523, Percent_Identity=41.1089866156788, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI13325057, Length=595, Percent_Identity=38.3193277310924, Blast_Score=355, Evalue=6e-98,
Organism=Homo sapiens, GI227499621, Length=585, Percent_Identity=34.8717948717949, Blast_Score=324, Evalue=2e-88,
Organism=Homo sapiens, GI42544132, Length=522, Percent_Identity=21.8390804597701, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI221142682, Length=442, Percent_Identity=30.0904977375566, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1788107, Length=560, Percent_Identity=24.2857142857143, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI145693145, Length=520, Percent_Identity=23.8461538461538, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17551278, Length=549, Percent_Identity=41.1657559198543, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI115534440, Length=523, Percent_Identity=40.9177820267686, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319515, Length=515, Percent_Identity=35.5339805825243, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6319699, Length=364, Percent_Identity=25.5494505494505, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281364798, Length=596, Percent_Identity=37.9194630872483, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24583465, Length=596, Percent_Identity=37.9194630872483, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24583463, Length=596, Percent_Identity=37.9194630872483, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI28573631, Length=544, Percent_Identity=41.5441176470588, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI20130353, Length=544, Percent_Identity=41.5441176470588, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI45552801, Length=585, Percent_Identity=37.9487179487179, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45550496, Length=585, Percent_Identity=37.9487179487179, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19922652, Length=451, Percent_Identity=22.6164079822616, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 66108; Mature: 66108

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKARLQREWRFVRGLNRTLKRVKSISKESPNLLCDDLQAAMDKWRGRPAITFEGRTIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEE
YGDLDAMANRYAHWAKGLGLRRGQVVALFMPNRIEYLPIWYGLSKVGVVTALINNQLAGL
ECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCC
PLAHCLNISGASHVIVDAETSPVFEPAKGLLEKTLQQWVLGPAHGDQRDLVQALKSCSQL
CHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PPDRSVREDMTAADTALLIFTSGTTGMPKAARITHMRGQLYMRGFAGSTGARAEDRVYVA
CCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCEEEEE
LPLYHATGGLCAMGAALLNGGSVVLRRKFSATHFWPEVVAEGCTMFVYIGELCRYLVNHE
EEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHCCCCHHHHHHHHHHHHHCCC
PDPDETRHKIRMAFGNGLRPDIWPVMKQRFRIPEILEFYGSTEGNVSMFNFDGREGAIGR
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCCCC
VPKWLRSRFNIRLVQFDVEKEQVIRGTDGFGIECGPGQIGECIGKIGGEARAEYTGYLDR
CCHHHHCCCCEEEEEEECCHHHHEECCCCCCEECCCCHHHHHHHHCCCCCCHHHHCCCCC
KASDKKVLRDVFERGDAWFATGDLMRMDADGYFYFVDRIGDTFRWKGENVSTNEVAERLQ
CCCHHHHHHHHHHCCCCEEEECCEEEECCCCEEEEEECCCCCEEECCCCCCHHHHHHHHH
ACPGVEQATVYGVAVEGAEGRAGMAALVVGPDFDIKLLGEHVTRELPPYAQPLFVRLLPA
HCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHHCCCCCCCHHHHHHHHH
METTGTFKIRKMDLVADGYDPGKVRGPLYFHDPKKGYVKVTKAVFDKIAAGGVKV
HCCCCCEEEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLKARLQREWRFVRGLNRTLKRVKSISKESPNLLCDDLQAAMDKWRGRPAITFEGRTIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEE
YGDLDAMANRYAHWAKGLGLRRGQVVALFMPNRIEYLPIWYGLSKVGVVTALINNQLAGL
ECCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCC
PLAHCLNISGASHVIVDAETSPVFEPAKGLLEKTLQQWVLGPAHGDQRDLVQALKSCSQL
CHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PPDRSVREDMTAADTALLIFTSGTTGMPKAARITHMRGQLYMRGFAGSTGARAEDRVYVA
CCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCEEEEE
LPLYHATGGLCAMGAALLNGGSVVLRRKFSATHFWPEVVAEGCTMFVYIGELCRYLVNHE
EEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHCCCCHHHHHHHHHHHHHCCC
PDPDETRHKIRMAFGNGLRPDIWPVMKQRFRIPEILEFYGSTEGNVSMFNFDGREGAIGR
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCCCC
VPKWLRSRFNIRLVQFDVEKEQVIRGTDGFGIECGPGQIGECIGKIGGEARAEYTGYLDR
CCHHHHCCCCEEEEEEECCHHHHEECCCCCCEECCCCHHHHHHHHCCCCCCHHHHCCCCC
KASDKKVLRDVFERGDAWFATGDLMRMDADGYFYFVDRIGDTFRWKGENVSTNEVAERLQ
CCCHHHHHHHHHHCCCCEEEECCEEEECCCCEEEEEECCCCCEEECCCCCCHHHHHHHHH
ACPGVEQATVYGVAVEGAEGRAGMAALVVGPDFDIKLLGEHVTRELPPYAQPLFVRLLPA
HCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCEEHHHHHHHCCCCCCCHHHHHHHHH
METTGTFKIRKMDLVADGYDPGKVRGPLYFHDPKKGYVKVTKAVFDKIAAGGVKV
HCCCCCEEEEEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA