Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 197104065

GI number: 197104065

Start: 639540

End: 641528

Strand: Direct

Name: uvrC [H]

Synonym: PHZ_c0599

Alternate gene names: 197104065

Gene position: 639540-641528 (Clockwise)

Preceding gene: 197104063

Following gene: 197104066

Centisome position: 16.0

GC content: 68.68

Gene sequence:

>1989_bases
GTGGCGATCTCGTCCGATGTAAGCTTCACGCTGAACCCCCGATTTGCTCCCAACGTGCAACGGCGAAGCTGGTTGCATCG
TGGTCGCATGCCCTGCCGACGCGGCGCGAACCTGCCTATATTCCCGCCCATGCTGGAAACCCAGGCGCCGCTGAAGGGCG
CTGCGCTCATCAAAGACGAGGTCAGGCGCCTGCCCGATCGGCCCGGCGTCTATCGCATGATCGGCGAGGACGGCGAGGTG
CTCTATGTGGGCAAGGCCCGCTCGCTGAAGAAGCGGGTGCTTCAATATGCGCAGGGGCGGTTCCACACCCAGCGTATCGC
CCACATGGTCGACCTGACGCGGGCGATGGAGTTCGTCACCACCCGCACCGAGACCGACGCCCTGCTGCTCGAGATCAACC
TGATCAAGCAGCTGAAGCCGCGCTTCAACGTCCTGCTGCGCGACGACAAGAGCTTCCCCGAGATCGTCATCCGCCGGGAC
CACGCCGCGCCGCAGCTGCGTAAGCACCGCGGCGCCCATTCGATCAAGGGCGACTACTTCGGCCCCTTCGCCAGCGCCTG
GGCGGTCAACCGCACCCTGAACACCCTGCAGAAGGCCTTCCTGCTGCGGTCGTGCTCGGACAGCGTCTACGAGACGCGCA
CCCGGCCCTGCATGCTGCACCAGATCCGCCGCTGCTCCGCGCCGTGCACCGGCCTGATCAGCCTCGAGGACTACAACGCC
CTCGTGGACGAGGCCGGGGCCTTCCTGCGCGGCAAGAGCCGGGCGGTCATGGAGCGGATGGCGGGGGAGATGCAGGCCGC
CGCAGAGGACCTGGAGTTCGAGCGCGCCGCGCGCCTGCGCGACCGCATCCGGGCGCTGGCCTCGGTGGCCCAGGAGCAGC
AGATCAATCCCGAGACGGTGGACGAGGCCGACGTCTTCGCCCTGCACGCCGAGGGCGGCCAGGCCTGCGTGCAGGTGTTC
TTCTTCCGCGCCGGCCAGAACTGGGGCAACCGCGCCTACTTCCCGCGGGTGGACAAGTCGGACGAGGACCCGGACGTGAT
GGGCGCGTTCCTGGGCCAGTTCTACGACGACAAGCCGATCCCCAGGATGATCCTGGTGAACGTCGTGCCGGCCGAGTGCG
AGCTGCTGTCCGAGGCTTTCTGCCAGAAGAGCGGCCGCAAGGTGGAGATCAGCCGGCCGCAGCGCGGCGAGAAGCGCCAG
ATCGTGCAGCACGCCCTGACCAACGCCCGCGAGGCGCTGGGCCGCAAGATGGCCGAGAGCTCGGCCCAGTCCAAGCTGCT
GGCCGGGGTCTGCGAGGCCTTCGGGCTGGAGGGCTCGCCCGAGCGGATCGAGGTCTACGACAACAGCCACATCATGGGCA
CGAACGCGGTGGGCGGCATGATCGTGGCCGGGCCGGAGGGCTTCCAGAAGAGCCAGTACCGCAAGTTCAACATCCGCTCG
TCCGAGCTCACGCCCGGCGACGACTACGGCATGATGCGCGAGGTGCTGCGCCGCAGGTTCTCGCGGCTGGTGAAGGAAGA
GGAGGAGGGCGGCGAGGCCGTCCGCCCGGACCTGGTGCTGATCGACGGCGGCCGGGGGCAGCTGGACGCGGCCATGGAGG
TGATGGCCGACCTGGGCGTCGACGACATTCCGGTGGTCGGCGTCGCTAAGGGGCCCGACCGGGACGCGGGGCTCGAGCGG
TTCTTCATGCCGGGCAAGGAGCCGTTCATGCTCGAGCCCAAGAGCCCGGTGCTCTACTACCTCCAGCGCCTGCGCGACGA
GGCGCACCGCTTCGCCATCGGCAGCCATCGCACGCGGCGGGCCATGGACATGAAGAAGAACCCGCTGGACGAGATCGACG
GCGTGGGGCCGGGCCGCAAGCGCGCCCTGCTGCACACCTTCGGATCGGCGCGCGGCGTCTCACGCGCCTCGGTGGCCGAC
CTCGCCAAGGTGGAGGGCGTCAGCGAGGCCCTGGCCCAGCGGATCTACGATCATTTCCATAAGGCCTGA

Upstream 100 bases:

>100_bases
CTCGACGTAGCGCAGGTCGCGATCGATGATCATGTAGGGGCTGGGAAGCGCGCGGAAGGCGGCCTCGAAGTCGGGCCGCT
CAAGGGTCGGCTCGACCACC

Downstream 100 bases:

>100_bases
TCCACAGGGCCTGATCCATAGGGCCTGATCCATGGGGCCTGACGCGCAGGCCGGGGAACAGCTAAGCTCGGGAACGAACC
GCCGGACCGGACGCTCGATT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MAISSDVSFTLNPRFAPNVQRRSWLHRGRMPCRRGANLPIFPPMLETQAPLKGAALIKDEVRRLPDRPGVYRMIGEDGEV
LYVGKARSLKKRVLQYAQGRFHTQRIAHMVDLTRAMEFVTTRTETDALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRD
HAAPQLRKHRGAHSIKGDYFGPFASAWAVNRTLNTLQKAFLLRSCSDSVYETRTRPCMLHQIRRCSAPCTGLISLEDYNA
LVDEAGAFLRGKSRAVMERMAGEMQAAAEDLEFERAARLRDRIRALASVAQEQQINPETVDEADVFALHAEGGQACVQVF
FFRAGQNWGNRAYFPRVDKSDEDPDVMGAFLGQFYDDKPIPRMILVNVVPAECELLSEAFCQKSGRKVEISRPQRGEKRQ
IVQHALTNAREALGRKMAESSAQSKLLAGVCEAFGLEGSPERIEVYDNSHIMGTNAVGGMIVAGPEGFQKSQYRKFNIRS
SELTPGDDYGMMREVLRRRFSRLVKEEEEGGEAVRPDLVLIDGGRGQLDAAMEVMADLGVDDIPVVGVAKGPDRDAGLER
FFMPGKEPFMLEPKSPVLYYLQRLRDEAHRFAIGSHRTRRAMDMKKNPLDEIDGVGPGRKRALLHTFGSARGVSRASVAD
LAKVEGVSEALAQRIYDHFHKA

Sequences:

>Translated_662_residues
MAISSDVSFTLNPRFAPNVQRRSWLHRGRMPCRRGANLPIFPPMLETQAPLKGAALIKDEVRRLPDRPGVYRMIGEDGEV
LYVGKARSLKKRVLQYAQGRFHTQRIAHMVDLTRAMEFVTTRTETDALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRD
HAAPQLRKHRGAHSIKGDYFGPFASAWAVNRTLNTLQKAFLLRSCSDSVYETRTRPCMLHQIRRCSAPCTGLISLEDYNA
LVDEAGAFLRGKSRAVMERMAGEMQAAAEDLEFERAARLRDRIRALASVAQEQQINPETVDEADVFALHAEGGQACVQVF
FFRAGQNWGNRAYFPRVDKSDEDPDVMGAFLGQFYDDKPIPRMILVNVVPAECELLSEAFCQKSGRKVEISRPQRGEKRQ
IVQHALTNAREALGRKMAESSAQSKLLAGVCEAFGLEGSPERIEVYDNSHIMGTNAVGGMIVAGPEGFQKSQYRKFNIRS
SELTPGDDYGMMREVLRRRFSRLVKEEEEGGEAVRPDLVLIDGGRGQLDAAMEVMADLGVDDIPVVGVAKGPDRDAGLER
FFMPGKEPFMLEPKSPVLYYLQRLRDEAHRFAIGSHRTRRAMDMKKNPLDEIDGVGPGRKRALLHTFGSARGVSRASVAD
LAKVEGVSEALAQRIYDHFHKA
>Mature_661_residues
AISSDVSFTLNPRFAPNVQRRSWLHRGRMPCRRGANLPIFPPMLETQAPLKGAALIKDEVRRLPDRPGVYRMIGEDGEVL
YVGKARSLKKRVLQYAQGRFHTQRIAHMVDLTRAMEFVTTRTETDALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDH
AAPQLRKHRGAHSIKGDYFGPFASAWAVNRTLNTLQKAFLLRSCSDSVYETRTRPCMLHQIRRCSAPCTGLISLEDYNAL
VDEAGAFLRGKSRAVMERMAGEMQAAAEDLEFERAARLRDRIRALASVAQEQQINPETVDEADVFALHAEGGQACVQVFF
FRAGQNWGNRAYFPRVDKSDEDPDVMGAFLGQFYDDKPIPRMILVNVVPAECELLSEAFCQKSGRKVEISRPQRGEKRQI
VQHALTNAREALGRKMAESSAQSKLLAGVCEAFGLEGSPERIEVYDNSHIMGTNAVGGMIVAGPEGFQKSQYRKFNIRSS
ELTPGDDYGMMREVLRRRFSRLVKEEEEGGEAVRPDLVLIDGGRGQLDAAMEVMADLGVDDIPVVGVAKGPDRDAGLERF
FMPGKEPFMLEPKSPVLYYLQRLRDEAHRFAIGSHRTRRAMDMKKNPLDEIDGVGPGRKRALLHTFGSARGVSRASVADL
AKVEGVSEALAQRIYDHFHKA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=41.4473684210526, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1788037, Length=177, Percent_Identity=31.0734463276836, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 74293; Mature: 74162

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISSDVSFTLNPRFAPNVQRRSWLHRGRMPCRRGANLPIFPPMLETQAPLKGAALIKDE
CCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
VRRLPDRPGVYRMIGEDGEVLYVGKARSLKKRVLQYAQGRFHTQRIAHMVDLTRAMEFVT
HHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TRTETDALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDHAAPQLRKHRGAHSIKGDYF
HCCCCCEEEEEHHHHHHCCHHHCEEEECCCCCCHHEEECCCCCHHHHHHCCCCCCCCCCC
GPFASAWAVNRTLNTLQKAFLLRSCSDSVYETRTRPCMLHQIRRCSAPCTGLISLEDYNA
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHH
LVDEAGAFLRGKSRAVMERMAGEMQAAAEDLEFERAARLRDRIRALASVAQEQQINPETV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DEADVFALHAEGGQACVQVFFFRAGQNWGNRAYFPRVDKSDEDPDVMGAFLGQFYDDKPI
CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PRMILVNVVPAECELLSEAFCQKSGRKVEISRPQRGEKRQIVQHALTNAREALGRKMAES
CCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SAQSKLLAGVCEAFGLEGSPERIEVYDNSHIMGTNAVGGMIVAGPEGFQKSQYRKFNIRS
HHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCCCCCCCCEEECCCC
SELTPGDDYGMMREVLRRRFSRLVKEEEEGGEAVRPDLVLIDGGRGQLDAAMEVMADLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
DDIPVVGVAKGPDRDAGLERFFMPGKEPFMLEPKSPVLYYLQRLRDEAHRFAIGSHRTRR
CCCCEEEECCCCCCCCCHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AMDMKKNPLDEIDGVGPGRKRALLHTFGSARGVSRASVADLAKVEGVSEALAQRIYDHFH
HHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KA
CC
>Mature Secondary Structure 
AISSDVSFTLNPRFAPNVQRRSWLHRGRMPCRRGANLPIFPPMLETQAPLKGAALIKDE
CCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
VRRLPDRPGVYRMIGEDGEVLYVGKARSLKKRVLQYAQGRFHTQRIAHMVDLTRAMEFVT
HHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TRTETDALLLEINLIKQLKPRFNVLLRDDKSFPEIVIRRDHAAPQLRKHRGAHSIKGDYF
HCCCCCEEEEEHHHHHHCCHHHCEEEECCCCCCHHEEECCCCCHHHHHHCCCCCCCCCCC
GPFASAWAVNRTLNTLQKAFLLRSCSDSVYETRTRPCMLHQIRRCSAPCTGLISLEDYNA
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHH
LVDEAGAFLRGKSRAVMERMAGEMQAAAEDLEFERAARLRDRIRALASVAQEQQINPETV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DEADVFALHAEGGQACVQVFFFRAGQNWGNRAYFPRVDKSDEDPDVMGAFLGQFYDDKPI
CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PRMILVNVVPAECELLSEAFCQKSGRKVEISRPQRGEKRQIVQHALTNAREALGRKMAES
CCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SAQSKLLAGVCEAFGLEGSPERIEVYDNSHIMGTNAVGGMIVAGPEGFQKSQYRKFNIRS
HHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCCCCCCCCCEEECCCC
SELTPGDDYGMMREVLRRRFSRLVKEEEEGGEAVRPDLVLIDGGRGQLDAAMEVMADLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
DDIPVVGVAKGPDRDAGLERFFMPGKEPFMLEPKSPVLYYLQRLRDEAHRFAIGSHRTRR
CCCCEEEECCCCCCCCCHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AMDMKKNPLDEIDGVGPGRKRALLHTFGSARGVSRASVADLAKVEGVSEALAQRIYDHFH
HHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]