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The map label for this gene is dctA [H]

Identifier: 197103818

GI number: 197103818

Start: 356584

End: 357843

Strand: Reverse

Name: dctA [H]

Synonym: PHZ_c0352

Alternate gene names: 197103818

Gene position: 357843-356584 (Counterclockwise)

Preceding gene: 197103826

Following gene: 197103816

Centisome position: 8.95

GC content: 68.17

Gene sequence:

>1260_bases
ATGAACCGCCTTTTCACCGCCTTCATCGTCGGGTCCATGGTGCTCGGCGTCGCCGTGGGCTGGGCCCTGAACCAGTTCCT
GCCGGCCGAACAGGCCGCCGCCACGGCCGACAATCTCTCGATCATCACCGACGTCTTCCTGCGGCTGATCAAGATGATCA
TCGCCCCGCTCGTCTTCGCGACCCTGGTCGCCGGGATCGCCCACATGGGCGACGCCTCCGAGATCGGCCGCGTCGGCGTG
AAGACCATCGGCTGGTTCATCGTCGCCTCGATCGTCTCGCTGACCATCGGCCTGGTGATGGTCCACATCCTGCAGCCGGG
CGCCAGCCTGTCGCTCGCAGCACCGGCCGCCGACACCGCCGGCCCCGCGCTCGACACCGCCAAGTTCACCCTGCGCGAGT
TCGTCACCCACCTGGTCCCCAGCTCGATCTTCGACGCCATGGCGCGCAACGAGATCCTGCAGATCGTGGTGTTCTCGGTG
CTCGTCGGCACCGCCGTCTCGGCCATCGACGACAAGGCGCCCCAGGTGCTGGTGCTCGTCGAGCAGGTCGCCTCGATCAT
GCTGAAGGTCACCGGCTATGTGATGAAGACCGCCCCGCTGGCGATCTTCGCCGCCCTGGCCGCCAGCATCGCCACCCAGG
GGATCGAGATCCTCGGCACCTACGCGGCGTTCATCGGCGGCTTCTACCTCTCGCTCGGCCTGCTCTGGGCGCTGCTGATC
GGCGCCGTGGTGCTGATCGTCGGGCCGCGCGCCATGAAGCTGATCGGGGCGATCCGCAGCCCGGCGCTGCTGGCGTTCTC
GGTCGCTTCGTCCGAGGCCGCCTATCCGCGGACGCTCGAGGAGCTGCAGAAGTGGGGGATCAGCCGCAAGGTGGCCAGCT
TCGTCCTGCCCCTCGGCTACTCGTTCAACCTCGACGGCTCGATGATGTACTGCACCTTCGCGGTGCTGTTCATCGCCCAG
GTCTACGGGATCGAGATGTCGATCCTCCAGCAGATCACCATGCTGGGCCTGCTGATGGTGACCTCGAAGGGCATGGCGGG
CGTGCCGCGGGCCTCGCTCGTGGTGATCGCCGCCACCCTGACCTACTTCGACCTGCCCGAGGCGGGGCTGCTGCTGATCC
TGGCGGTGGACCACCTGCTCGACATGGGCCGCTCGGCCACCAACGTGGTCGGCAACTCGGTGGCCGCCGCCGTGGTCGCC
AAGTGGGAAGGGCAGATCACCGAGCCCGAAGCCCGGGCCGCGGGGGCGCCGGCCGAGTAG

Upstream 100 bases:

>100_bases
GCCTTATAGACGCCCTCCGTGACGCTTGCGAATCCGCCGCGCTGGACTGTGGGGCGGTTCTTCGCGACAAAGGCGCCTCT
CGAAAATGCCCGGGGGCTTA

Downstream 100 bases:

>100_bases
GCCGTCCGGACGCCCTACTAAGTGGGGCGGCTATTCGGCGGGCCGTTATTCGGAAGGGCGGGCGCGGTAGACCTCCGCGT
CCAGCTCGCCTTCCCACTTG

Product: Na+/H+-dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNRLFTAFIVGSMVLGVAVGWALNQFLPAEQAAATADNLSIITDVFLRLIKMIIAPLVFATLVAGIAHMGDASEIGRVGV
KTIGWFIVASIVSLTIGLVMVHILQPGASLSLAAPAADTAGPALDTAKFTLREFVTHLVPSSIFDAMARNEILQIVVFSV
LVGTAVSAIDDKAPQVLVLVEQVASIMLKVTGYVMKTAPLAIFAALAASIATQGIEILGTYAAFIGGFYLSLGLLWALLI
GAVVLIVGPRAMKLIGAIRSPALLAFSVASSEAAYPRTLEELQKWGISRKVASFVLPLGYSFNLDGSMMYCTFAVLFIAQ
VYGIEMSILQQITMLGLLMVTSKGMAGVPRASLVVIAATLTYFDLPEAGLLLILAVDHLLDMGRSATNVVGNSVAAAVVA
KWEGQITEPEARAAGAPAE

Sequences:

>Translated_419_residues
MNRLFTAFIVGSMVLGVAVGWALNQFLPAEQAAATADNLSIITDVFLRLIKMIIAPLVFATLVAGIAHMGDASEIGRVGV
KTIGWFIVASIVSLTIGLVMVHILQPGASLSLAAPAADTAGPALDTAKFTLREFVTHLVPSSIFDAMARNEILQIVVFSV
LVGTAVSAIDDKAPQVLVLVEQVASIMLKVTGYVMKTAPLAIFAALAASIATQGIEILGTYAAFIGGFYLSLGLLWALLI
GAVVLIVGPRAMKLIGAIRSPALLAFSVASSEAAYPRTLEELQKWGISRKVASFVLPLGYSFNLDGSMMYCTFAVLFIAQ
VYGIEMSILQQITMLGLLMVTSKGMAGVPRASLVVIAATLTYFDLPEAGLLLILAVDHLLDMGRSATNVVGNSVAAAVVA
KWEGQITEPEARAAGAPAE
>Mature_419_residues
MNRLFTAFIVGSMVLGVAVGWALNQFLPAEQAAATADNLSIITDVFLRLIKMIIAPLVFATLVAGIAHMGDASEIGRVGV
KTIGWFIVASIVSLTIGLVMVHILQPGASLSLAAPAADTAGPALDTAKFTLREFVTHLVPSSIFDAMARNEILQIVVFSV
LVGTAVSAIDDKAPQVLVLVEQVASIMLKVTGYVMKTAPLAIFAALAASIATQGIEILGTYAAFIGGFYLSLGLLWALLI
GAVVLIVGPRAMKLIGAIRSPALLAFSVASSEAAYPRTLEELQKWGISRKVASFVLPLGYSFNLDGSMMYCTFAVLFIAQ
VYGIEMSILQQITMLGLLMVTSKGMAGVPRASLVVIAATLTYFDLPEAGLLLILAVDHLLDMGRSATNVVGNSVAAAVVA
KWEGQITEPEARAAGAPAE

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=456, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=26.8585131894484, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI169790839, Length=455, Percent_Identity=25.0549450549451, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI21314632, Length=410, Percent_Identity=24.1463414634146, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4827012, Length=269, Percent_Identity=31.5985130111524, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=26.0651629072682, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI66773030, Length=418, Percent_Identity=23.2057416267943, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=27.2058823529412, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=27.2058823529412, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI301601644, Length=182, Percent_Identity=29.6703296703297, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI262359914, Length=399, Percent_Identity=22.3057644110276, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=38.5922330097087, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1789947, Length=398, Percent_Identity=36.1809045226131, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1788024, Length=389, Percent_Identity=24.9357326478149, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996953, Length=455, Percent_Identity=26.1538461538462, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=25.6756756756757, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17537407, Length=389, Percent_Identity=26.9922879177378, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983106, Length=467, Percent_Identity=24.8394004282655, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=464, Percent_Identity=24.7844827586207, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=443, Percent_Identity=24.1534988713318, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=399, Percent_Identity=26.0651629072682, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24583025, Length=416, Percent_Identity=25.7211538461538, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137668, Length=416, Percent_Identity=25.7211538461538, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24583023, Length=416, Percent_Identity=25.7211538461538, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281360481, Length=414, Percent_Identity=24.3961352657005, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281360483, Length=414, Percent_Identity=24.3961352657005, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137666, Length=414, Percent_Identity=24.3961352657005, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43907; Mature: 43907

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure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HHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA