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The map label for this gene is emrA [H]

Identifier: 197103489

GI number: 197103489

Start: 19445

End: 20584

Strand: Direct

Name: emrA [H]

Synonym: PHZ_c0023

Alternate gene names: 197103489

Gene position: 19445-20584 (Clockwise)

Preceding gene: 197103487

Following gene: 197103490

Centisome position: 0.49

GC content: 74.56

Gene sequence:

>1140_bases
GTGACCCATCTTCAGTTTCCGGGATCTACCGACATGGCGGGGCTGCCGAGAAAGCGTCTGGTTCCCCTCGTCGCCGGCGG
CGCCGCCCTCGTGGCCGTGACGGCGGGCGGCGGGGTCTGGTGGTTCAACAAGCAGCACTACGAGACCACCGACAACGCCT
TCGTGCAGGCCGACACCGTGACGGTGGCCCCGCTCGTCGAGGGCTATGTGGCCGAGGTGCTGGTCAGCGACAACGAGGCC
GTCCGGCCCGGCCAGGTTCTCGTCCGCATCGATCCGGCGACCATCAAGGCCCGGCTCGCCCAGGCCGAGGCCAACGCCGC
GGCCCTCGAGGCGGCGGTCCGCCAGGTGGACGACAAGGCCCGGCTCGAGCAGGCGCTGATCGCCCAGCGCGCCGCCGCGG
TGGAGAGCGCCCGCGCCGACGCCCAGCTCGCCAGCGCGGAGCTGAAGCGCTACGGCGCCCTCGCCCAGTCGGGCTGGGTC
TCCTCGCAGCGGGCGCAGTCGGTCCGCACCGCCGAGCAACGGGCGAGCGCCGCGGTCGAACAGGCCGCCGCCGCGCTGGA
GGCCGAGCGCCGCACCGCCGCCTCGCTCGATTCCGCCAGGGCGCAGAGCCTGGCCCAGGCCGCCGCGGCCCGTGCGGCGG
TCGAACAGGCCCGCATCGACCTGGCCCGCACCGAGGTGCGCGCGCCCGTGGCCGGCGTCGTCGGCGCGCGCGGCGTCCGG
CCCGGCCAGTACGTGCGCCCCGGCGGTGCGCTGATGAGCCTGGTGCCGCTCGGCGACGCCTATGTCGTGGCCAACTTCAA
GGAGACCCAGGTGGCCCGCCTGCGCATCGGCCAGCCGGTGGAGATCCGCGCCGACGCCTTCGGCAAGAAGACGCTCCAGG
GCCGCGTCGACTCCTTCGCCCCGGCGACGGGCGCCGAGTTCGCCCTGATCCCGGTGGAGAACGCCGTCGGCAACTTCACC
AAGATCGCCCAGCGGCTGCCGGTGAAGATCGCCGTCGACCGCGGCCAGCCGCTCTCGGGCGCGCTGCGGCCGGGCCTTTC
CCTGCACGTGAAGGTCGATGTGACCGAGAAGACCGGCCCCTCCTTCGCCGAGGCCGGCGAGATCCCCGCCCGCTACGCCC
GCGAGGGCGCCTCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGGCATCGAAAAATGGACGCCGCCGTCCAAAGTTCGCTTGCCGGAGGACCGGGAGCAGCTTATCTGACGCCTCTGTTG
GACTCTCGGGTCCATTTTTA

Downstream 100 bases:

>100_bases
GCTGCGGGTCGTGACCGAAGCCGCCATCCATCCCGACAGCGGCCAGGCCAAGGCCGCCGCCCAGCCGCACGCCTACATGG
GCGCGGGCGGCGAGGCCGTG

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTHLQFPGSTDMAGLPRKRLVPLVAGGAALVAVTAGGGVWWFNKQHYETTDNAFVQADTVTVAPLVEGYVAEVLVSDNEA
VRPGQVLVRIDPATIKARLAQAEANAAALEAAVRQVDDKARLEQALIAQRAAAVESARADAQLASAELKRYGALAQSGWV
SSQRAQSVRTAEQRASAAVEQAAAALEAERRTAASLDSARAQSLAQAAAARAAVEQARIDLARTEVRAPVAGVVGARGVR
PGQYVRPGGALMSLVPLGDAYVVANFKETQVARLRIGQPVEIRADAFGKKTLQGRVDSFAPATGAEFALIPVENAVGNFT
KIAQRLPVKIAVDRGQPLSGALRPGLSLHVKVDVTEKTGPSFAEAGEIPARYAREGASR

Sequences:

>Translated_379_residues
MTHLQFPGSTDMAGLPRKRLVPLVAGGAALVAVTAGGGVWWFNKQHYETTDNAFVQADTVTVAPLVEGYVAEVLVSDNEA
VRPGQVLVRIDPATIKARLAQAEANAAALEAAVRQVDDKARLEQALIAQRAAAVESARADAQLASAELKRYGALAQSGWV
SSQRAQSVRTAEQRASAAVEQAAAALEAERRTAASLDSARAQSLAQAAAARAAVEQARIDLARTEVRAPVAGVVGARGVR
PGQYVRPGGALMSLVPLGDAYVVANFKETQVARLRIGQPVEIRADAFGKKTLQGRVDSFAPATGAEFALIPVENAVGNFT
KIAQRLPVKIAVDRGQPLSGALRPGLSLHVKVDVTEKTGPSFAEAGEIPARYAREGASR
>Mature_378_residues
THLQFPGSTDMAGLPRKRLVPLVAGGAALVAVTAGGGVWWFNKQHYETTDNAFVQADTVTVAPLVEGYVAEVLVSDNEAV
RPGQVLVRIDPATIKARLAQAEANAAALEAAVRQVDDKARLEQALIAQRAAAVESARADAQLASAELKRYGALAQSGWVS
SQRAQSVRTAEQRASAAVEQAAAALEAERRTAASLDSARAQSLAQAAAARAAVEQARIDLARTEVRAPVAGVVGARGVRP
GQYVRPGGALMSLVPLGDAYVVANFKETQVARLRIGQPVEIRADAFGKKTLQGRVDSFAPATGAEFALIPVENAVGNFTK
IAQRLPVKIAVDRGQPLSGALRPGLSLHVKVDVTEKTGPSFAEAGEIPARYAREGASR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=351, Percent_Identity=33.048433048433, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=31.9526627218935, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1790519, Length=294, Percent_Identity=35.0340136054422, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87081951, Length=311, Percent_Identity=29.5819935691318, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790012, Length=293, Percent_Identity=27.3037542662116, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789637, Length=305, Percent_Identity=27.2131147540984, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790024, Length=282, Percent_Identity=25.886524822695, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789900, Length=285, Percent_Identity=27.0175438596491, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39714; Mature: 39583

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLQFPGSTDMAGLPRKRLVPLVAGGAALVAVTAGGGVWWFNKQHYETTDNAFVQADTV
CCEECCCCCCCCCCCCHHHCCEEEECCEEEEEEEECCEEEEECCCCCCCCCCCEEEECCE
TVAPLVEGYVAEVLVSDNEAVRPGQVLVRIDPATIKARLAQAEANAAALEAAVRQVDDKA
EEHHHHHHHHHHHEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEQALIAQRAAAVESARADAQLASAELKRYGALAQSGWVSSQRAQSVRTAEQRASAAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QAAAALEAERRTAASLDSARAQSLAQAAAARAAVEQARIDLARTEVRAPVAGVVGARGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
PGQYVRPGGALMSLVPLGDAYVVANFKETQVARLRIGQPVEIRADAFGKKTLQGRVDSFA
CCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHCCCCCCEEEHHHCCHHHHHCCHHCCC
PATGAEFALIPVENAVGNFTKIAQRLPVKIAVDRGQPLSGALRPGLSLHVKVDVTEKTGP
CCCCCCEEEEECCHHHCHHHHHHHHCCEEEEECCCCCCCHHHCCCCEEEEEEEEECCCCC
SFAEAGEIPARYAREGASR
CHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure 
THLQFPGSTDMAGLPRKRLVPLVAGGAALVAVTAGGGVWWFNKQHYETTDNAFVQADTV
CEECCCCCCCCCCCCHHHCCEEEECCEEEEEEEECCEEEEECCCCCCCCCCCEEEECCE
TVAPLVEGYVAEVLVSDNEAVRPGQVLVRIDPATIKARLAQAEANAAALEAAVRQVDDKA
EEHHHHHHHHHHHEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEQALIAQRAAAVESARADAQLASAELKRYGALAQSGWVSSQRAQSVRTAEQRASAAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QAAAALEAERRTAASLDSARAQSLAQAAAARAAVEQARIDLARTEVRAPVAGVVGARGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
PGQYVRPGGALMSLVPLGDAYVVANFKETQVARLRIGQPVEIRADAFGKKTLQGRVDSFA
CCCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHCCCCCCEEEHHHCCHHHHHCCHHCCC
PATGAEFALIPVENAVGNFTKIAQRLPVKIAVDRGQPLSGALRPGLSLHVKVDVTEKTGP
CCCCCCEEEEECCHHHCHHHHHHHHCCEEEEECCCCCCCHHHCCCCEEEEEEEEECCCCC
SFAEAGEIPARYAREGASR
CHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]