Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 195977229

GI number: 195977229

Start: 80472

End: 81224

Strand: Direct

Name: adk [H]

Synonym: Sez_0077

Alternate gene names: 195977229

Gene position: 80472-81224 (Clockwise)

Preceding gene: 195977228

Following gene: 195977230

Centisome position: 3.98

GC content: 39.31

Gene sequence:

>753_bases
ATGACAATAAGATTTACAGAGCCTTGGTTCCTATCTTCTTATTGCCATTTGAAAACAAAAACAAGGAAAACTAAATTTCC
TATTATCTTTATGTCAAAAGAGGAGAAAAAGATGAATCTTTTAATCATGGGCTTACCTGGTGCCGGTAAGGGTACACAGG
CTGCAAAGATTGTTGAAACCTTTGAGCTTATTCATATTTCAACAGGAGATATGTTCCGCGCTGCAATGGCTAATCAGACT
GAAATGGGAGTTCTTGCGAAATCTTATATCGATAAGGGTGATTTGGTGCCAGATGAGGTAACCAATGGTATCGTTAAAGA
ACGCTTAGCACAAGCTGATATTAAAGAAAAGGGATTTCTTTTAGATGGCTATCCTCGTACCATTGAGCAGGCACATGCCT
TAGATGAAACCTTAAAAGCATTGGGACTTACGTTAGATGGTGTGATCAACATTGAGGTTGATTCTGCGTCACTCATTGAC
AGGCTTAGCGGTCGTATCATCAACAAAAAAACAGGGGAAACCTTCCATAAGATCTTTAACCCACCAGTGGGAGACTATAA
GGAAGAGGACTTTTATCAACGTGAAGATGATAAGCCTGAAACAGTTAAGCGTCGCTTAGATGTTAATATTGCACAAGGTG
AGCCTATTATCAAGCATTATCGTCAAGCAGGCATTGTTCGTGACATTGACGGAAACAAGGACATTTCTGAGGTCTTTGCT
GACATTAAAAAGGTCATCGAAAACCTGAAATAA

Upstream 100 bases:

>100_bases
CAGCTTGAAGGTTACCTTCTCAAGAGAAAATATGTCGGATTTATGAATATTACAGAATAGAATATGGGTTGACACTGTCA
ACCTTCTATTTTGTTTTTAA

Downstream 100 bases:

>100_bases
ATTCCAGAAAATCGCTTGCGAAAGTGATTTTATCGTGATATACTAGACTAGTCTGACTTATAATTGTTACCTCTGTGCTC
AGAGGACATCAAATCGAAAT

Product: adenylate kinase Adk

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTIRFTEPWFLSSYCHLKTKTRKTKFPIIFMSKEEKKMNLLIMGLPGAGKGTQAAKIVETFELIHISTGDMFRAAMANQT
EMGVLAKSYIDKGDLVPDEVTNGIVKERLAQADIKEKGFLLDGYPRTIEQAHALDETLKALGLTLDGVINIEVDSASLID
RLSGRIINKKTGETFHKIFNPPVGDYKEEDFYQREDDKPETVKRRLDVNIAQGEPIIKHYRQAGIVRDIDGNKDISEVFA
DIKKVIENLK

Sequences:

>Translated_250_residues
MTIRFTEPWFLSSYCHLKTKTRKTKFPIIFMSKEEKKMNLLIMGLPGAGKGTQAAKIVETFELIHISTGDMFRAAMANQT
EMGVLAKSYIDKGDLVPDEVTNGIVKERLAQADIKEKGFLLDGYPRTIEQAHALDETLKALGLTLDGVINIEVDSASLID
RLSGRIINKKTGETFHKIFNPPVGDYKEEDFYQREDDKPETVKRRLDVNIAQGEPIIKHYRQAGIVRDIDGNKDISEVFA
DIKKVIENLK
>Mature_249_residues
TIRFTEPWFLSSYCHLKTKTRKTKFPIIFMSKEEKKMNLLIMGLPGAGKGTQAAKIVETFELIHISTGDMFRAAMANQTE
MGVLAKSYIDKGDLVPDEVTNGIVKERLAQADIKEKGFLLDGYPRTIEQAHALDETLKALGLTLDGVINIEVDSASLIDR
LSGRIINKKTGETFHKIFNPPVGDYKEEDFYQREDDKPETVKRRLDVNIAQGEPIIKHYRQAGIVRDIDGNKDISEVFAD
IKKVIENLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=38.8625592417062, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=38.8625592417062, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI19923437, Length=217, Percent_Identity=38.7096774193548, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=36.6336633663366, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=36.6336633663366, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=36.6336633663366, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=36.6336633663366, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=30.1435406698565, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=28.9099526066351, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706497, Length=230, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI28144897, Length=220, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28144899, Length=220, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI21450759, Length=145, Percent_Identity=26.8965517241379, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI237858799, Length=145, Percent_Identity=26.8965517241379, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=41.2844036697248, Blast_Score=157, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=33.8028169014084, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=29.6650717703349, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=29.4392523364486, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567503, Length=211, Percent_Identity=30.3317535545024, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=211, Percent_Identity=26.0663507109005, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=41.2037037037037, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=211, Percent_Identity=24.1706161137441, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22026816, Length=225, Percent_Identity=35.1111111111111, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17737899, Length=203, Percent_Identity=36.4532019704434, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645822, Length=203, Percent_Identity=36.4532019704434, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221459597, Length=220, Percent_Identity=30, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356893, Length=220, Percent_Identity=30, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647141, Length=208, Percent_Identity=25, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663208, Length=208, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 28230; Mature: 28099

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRFTEPWFLSSYCHLKTKTRKTKFPIIFMSKEEKKMNLLIMGLPGAGKGTQAAKIVET
CEEEECCCHHHHHHHHEECCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHH
FELIHISTGDMFRAAMANQTEMGVLAKSYIDKGDLVPDEVTNGIVKERLAQADIKEKGFL
HHHEEECCCHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
LDGYPRTIEQAHALDETLKALGLTLDGVINIEVDSASLIDRLSGRIINKKTGETFHKIFN
ECCCCHHHHHHHHHHHHHHHHCCEECCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHCC
PPVGDYKEEDFYQREDDKPETVKRRLDVNIAQGEPIIKHYRQAGIVRDIDGNKDISEVFA
CCCCCCCCCHHHCCCCCCHHHHHHHHCCEECCCCHHHHHHHHCCCEEECCCCCCHHHHHH
DIKKVIENLK
HHHHHHHHCC
>Mature Secondary Structure 
TIRFTEPWFLSSYCHLKTKTRKTKFPIIFMSKEEKKMNLLIMGLPGAGKGTQAAKIVET
EEEECCCHHHHHHHHEECCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHH
FELIHISTGDMFRAAMANQTEMGVLAKSYIDKGDLVPDEVTNGIVKERLAQADIKEKGFL
HHHEEECCCHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
LDGYPRTIEQAHALDETLKALGLTLDGVINIEVDSASLIDRLSGRIINKKTGETFHKIFN
ECCCCHHHHHHHHHHHHHHHHCCEECCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHCC
PPVGDYKEEDFYQREDDKPETVKRRLDVNIAQGEPIIKHYRQAGIVRDIDGNKDISEVFA
CCCCCCCCCHHHCCCCCCHHHHHHHHCCEECCCCHHHHHHHHCCCEEECCCCCCHHHHHH
DIKKVIENLK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA