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The map label for this gene is proA

Identifier: 195953049

GI number: 195953049

Start: 603290

End: 604615

Strand: Direct

Name: proA

Synonym: HY04AAS1_0674

Alternate gene names: 195953049

Gene position: 603290-604615 (Clockwise)

Preceding gene: 195953048

Following gene: 195953069

Centisome position: 38.68

GC content: 35.52

Gene sequence:

>1326_bases
ATGAAAGAGTACGCTTTAGAAATAGCAACAAAAGCAAAAGCTGTATTACCCAAACTTTCAAGTTTAAACCCGGCTGTGAA
AAATTCTATTCTTATAAGAGTATCTCAGCTTTTAAAAGAAAACAAAGAGCTAATCCAAAAAGAAAACGAAAAAGACATAG
AGTTTGCAAAGTCCATAAATCTTTCAAAGGCAATGATAGATAGGCTTAAAGTGGGAGAAAAACAAATAAACGGTATGATA
AAGATATTGGAGGATGTGGCAAAGCTAAAAGATCCAGTGGGCGAAATAACCTCTATGTGGACGGTAGATAACGGCCTTAA
AATAGGTAGAATGAGAGTTCCCCTTGGAGTTATTTTTATAATATACGAATCAAGGCCAAACGTTACCATAGAAGCAGCTA
GTTTGTGCTTTAAATCTTCCAATGCCGTTATCCTAAGAGGTGGTAAAGAAGCTATTCACACAAACAAAATACTTTCAGAT
CTGTTTAGACAAGCTATAAGAGAGCATGTAGAGGGTTTAGAAGATGCCGTTTGCTTTGTAGATAAAAGGGAAAGAGAGAT
AGTTACAGAGCTTTTACAGCTAGAGGGTTTAGTAGACGTAGCTATACCAAGAGGAGGGGAAAGTCTTATAAAGGCTGTAT
CAGAAACTGCCAAAATATCTGTTATAAAACATTACAAAGGTGTTTGCAGTATATATGTAGACAACGAAGCAGATCTTAAA
AAAGCTTACAATATCGTATACAATGCAAAGGTACAAAGGCCATCAGTTTGCAACGCCATAGAAAACCTTGTTATACATAA
AGATCTCTTACAAGATTTTTGGCCAAAAATGGCTATGGTGCTTTTAGAAAGCGATGTTGAACTAAGATGCGATGAAGATA
GCTATGAAATATTGCAAAATAAGGATTTTGATTCTTTTAAAAGCAAAATAAAAAAAGCAACTGAAAAAGATTACTACGAA
GAATTTTTAGATCTCATATTGGCTGTTAAAACGGTAAATTCTTTGGAAGAGGCAATGCAGTTTATAGAAAAATATGGTTC
TAAGCATTCTGATGCCATTATCACCGAGAACCATACAAAAGCTATGAGGTTTTTGCAAGAAGTGGATTCGGCAGCAGTTT
ACGTAAACGCTTCTACAAGGTTTACAGATGGCAACGAGTTTGGCTTAGGGGCTGAGATGGGTATTTCTACAGACAAAATC
CATGCAAGAGGACCGATGGCTTTAAGAGAGCTTACCATAGAAAAATTTATAATCTTTGGAAACGGGCAACTAAGAGAAAA
TGTAGGCATACCAAAGGAACTAAAGGAAAAGCTTCAAATAGATTAA

Upstream 100 bases:

>100_bases
CAAGCAGAAAAAGGCACAGCTATAGGTTTAAAAGTGAACGAAAAAGTAAGAGAAAAAGATAAAGTTTATATTGTAAAAGA
AAAATAGTATAATATTTTTT

Downstream 100 bases:

>100_bases
TTTAGTTTTTAGGATTTTGATGTTGTAAAACAAAAGCTTCTACGTTTTTCAAATAGCAAGCTTTGATAGAATTTGTATAA
TATATAAATTTTGTTAGCTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSINLSKAMIDRLKVGEKQINGMI
KILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFIIYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSD
LFRQAIREHVEGLEDAVCFVDKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLK
KAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQNKDFDSFKSKIKKATEKDYYE
EFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTKAMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKI
HARGPMALRELTIEKFIIFGNGQLRENVGIPKELKEKLQID

Sequences:

>Translated_441_residues
MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSINLSKAMIDRLKVGEKQINGMI
KILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFIIYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSD
LFRQAIREHVEGLEDAVCFVDKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLK
KAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQNKDFDSFKSKIKKATEKDYYE
EFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTKAMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKI
HARGPMALRELTIEKFIIFGNGQLRENVGIPKELKEKLQID
>Mature_441_residues
MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSINLSKAMIDRLKVGEKQINGMI
KILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFIIYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSD
LFRQAIREHVEGLEDAVCFVDKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLK
KAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQNKDFDSFKSKIKKATEKDYYE
EFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTKAMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKI
HARGPMALRELTIEKFIIFGNGQLRENVGIPKELKEKLQID

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=429, Percent_Identity=36.1305361305361, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI21361368, Length=429, Percent_Identity=36.1305361305361, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1786438, Length=420, Percent_Identity=41.4285714285714, Blast_Score=331, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17569969, Length=424, Percent_Identity=36.0849056603774, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17569967, Length=424, Percent_Identity=36.0849056603774, Blast_Score=260, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=432, Percent_Identity=37.037037037037, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21357643, Length=418, Percent_Identity=35.4066985645933, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_HYDS0 (B4U8A0)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121339.1
- ProteinModelPortal:   B4U8A0
- SMR:   B4U8A0
- GeneID:   6743474
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0674
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 49698; Mature: 49698

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSIN
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
LSKAMIDRLKVGEKQINGMIKILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFI
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHHHHEEECCCCEECEEECCEEEEEE
IYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSDLFRQAIREHVEGLEDAVCFV
EEECCCCEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLK
CCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
KAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQN
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCC
KDFDSFKSKIKKATEKDYYEEFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHH
AMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKIHARGPMALRELTIEKFIIFG
HHHHHHHHCCCEEEEECCCEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHEEEEC
NGQLRENVGIPKELKEKLQID
CCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKEYALEIATKAKAVLPKLSSLNPAVKNSILIRVSQLLKENKELIQKENEKDIEFAKSIN
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
LSKAMIDRLKVGEKQINGMIKILEDVAKLKDPVGEITSMWTVDNGLKIGRMRVPLGVIFI
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHHHHEEECCCCEECEEECCEEEEEE
IYESRPNVTIEAASLCFKSSNAVILRGGKEAIHTNKILSDLFRQAIREHVEGLEDAVCFV
EEECCCCEEEEHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKREREIVTELLQLEGLVDVAIPRGGESLIKAVSETAKISVIKHYKGVCSIYVDNEADLK
CCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
KAYNIVYNAKVQRPSVCNAIENLVIHKDLLQDFWPKMAMVLLESDVELRCDEDSYEILQN
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCC
KDFDSFKSKIKKATEKDYYEEFLDLILAVKTVNSLEEAMQFIEKYGSKHSDAIITENHTK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHH
AMRFLQEVDSAAVYVNASTRFTDGNEFGLGAEMGISTDKIHARGPMALRELTIEKFIIFG
HHHHHHHHCCCEEEEECCCEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHEEEEC
NGQLRENVGIPKELKEKLQID
CCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA