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The map label for this gene is cysM [H]

Identifier: 195952611

GI number: 195952611

Start: 208076

End: 209041

Strand: Direct

Name: cysM [H]

Synonym: HY04AAS1_0231

Alternate gene names: 195952611

Gene position: 208076-209041 (Clockwise)

Preceding gene: 195952610

Following gene: 195952612

Centisome position: 13.34

GC content: 40.27

Gene sequence:

>966_bases
ATGAGTTTAAAGGGTATTTTTTGGGTATTAGGAGAACACGACGAGCCTTATTTAAAACCAAGGGAAAGCTCTTTGGAGCT
TGTGGGCAACACACCTTTGGTAAGAATAAAAAAAGTTTTAGAGGCTTTTGATATAAACCCAAATGTGAAAATATATGCAA
AGCTTGAATCTACGAATCCAGGGGGCTCTGTAAAAGATAGGGCTGCTCTTTCTATGTTTTTAAACGCCATAAAAAAAGGT
ATTATACAAAAAGATAAGGCTGTGATAGACGCCACCTCTGGTAATACGGGTATAGCGCTTGCTATGGTAGGAGCTTCACT
TGGTATAAAAGTAGAGCTTGCTATGCCATCAAACGTAAGCGAAGAGCGTAAGAAGATACTGGAGGCTTATGGGGCTATAA
CCCACTATACTGATCCTTTGGAGGGCACAGACGGGGCTATCTTATACGTTAGAGATATTGTAAAAAAATATCCAGATAGA
TATGTGTATCTAGACCAATACAACAACCAAGCCAACTGGCAAGCTCATTTTTACTCTACTGGTATAGAGATATACAATCA
AACTAAAGGTCAGATTACTCATTTTGTAGCAGGGATTGGTACCGGTGGGACTATAATGGGTACTGGTAGAAGGTTAAAGG
TTTACAATCCCAACATAGAGGTTATAGGCATCCAACCAGCCTATCCATTTCATGGCATAGAAGGCCTAAAGCATATAGAG
TCTTCTATAAAACCAGGTATTTTTGATGAAACGTTTTTAGATAGAACAATCTTTGTAGATACGGAAGAAGCTTACGAACT
TACAAGAAGACTTGCCAAGGAAGAAGGGCTTTTCGTAGGACAATCTTCTGGAGCTGCCTTGGCTGGTGCTATAAAACTTG
CCAAAGAGCTTGAAAGTGGGCTCATTGTGACGGTGTTTCCAGATGGCGGGGATAGATATCTATCCACTAGAGTGTGGGGT
AAGTGA

Upstream 100 bases:

>100_bases
CAGAAGCCGATATAAGTGCTATCAAAGAAAAGCTTGGCTACGAGCCCAAATATGATTTGGAATCTGGTATAGAGCATTAT
CTTAAAAGCTTGAAGCTGAT

Downstream 100 bases:

>100_bases
TATGGAGATTTTAAACCTTGTAGATATTTTTAAAAGCCAAAAAACTTACTCCTTTGAAGAGGATATAAAAAAGGATTTTT
GGAAAGATTTTTTACCTGAG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSLKGIFWVLGEHDEPYLKPRESSLELVGNTPLVRIKKVLEAFDINPNVKIYAKLESTNPGGSVKDRAALSMFLNAIKKG
IIQKDKAVIDATSGNTGIALAMVGASLGIKVELAMPSNVSEERKKILEAYGAITHYTDPLEGTDGAILYVRDIVKKYPDR
YVYLDQYNNQANWQAHFYSTGIEIYNQTKGQITHFVAGIGTGGTIMGTGRRLKVYNPNIEVIGIQPAYPFHGIEGLKHIE
SSIKPGIFDETFLDRTIFVDTEEAYELTRRLAKEEGLFVGQSSGAALAGAIKLAKELESGLIVTVFPDGGDRYLSTRVWG
K

Sequences:

>Translated_321_residues
MSLKGIFWVLGEHDEPYLKPRESSLELVGNTPLVRIKKVLEAFDINPNVKIYAKLESTNPGGSVKDRAALSMFLNAIKKG
IIQKDKAVIDATSGNTGIALAMVGASLGIKVELAMPSNVSEERKKILEAYGAITHYTDPLEGTDGAILYVRDIVKKYPDR
YVYLDQYNNQANWQAHFYSTGIEIYNQTKGQITHFVAGIGTGGTIMGTGRRLKVYNPNIEVIGIQPAYPFHGIEGLKHIE
SSIKPGIFDETFLDRTIFVDTEEAYELTRRLAKEEGLFVGQSSGAALAGAIKLAKELESGLIVTVFPDGGDRYLSTRVWG
K
>Mature_320_residues
SLKGIFWVLGEHDEPYLKPRESSLELVGNTPLVRIKKVLEAFDINPNVKIYAKLESTNPGGSVKDRAALSMFLNAIKKGI
IQKDKAVIDATSGNTGIALAMVGASLGIKVELAMPSNVSEERKKILEAYGAITHYTDPLEGTDGAILYVRDIVKKYPDRY
VYLDQYNNQANWQAHFYSTGIEIYNQTKGQITHFVAGIGTGGTIMGTGRRLKVYNPNIEVIGIQPAYPFHGIEGLKHIES
SIKPGIFDETFLDRTIFVDTEEAYELTRRLAKEEGLFVGQSSGAALAGAIKLAKELESGLIVTVFPDGGDRYLSTRVWGK

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=336, Percent_Identity=33.0357142857143, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI295821200, Length=336, Percent_Identity=33.0357142857143, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4557415, Length=336, Percent_Identity=33.0357142857143, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=41.7218543046358, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=38.1877022653722, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=310, Percent_Identity=39.3548387096774, Blast_Score=200, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=39.2857142857143, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=39.9339933993399, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115535073, Length=311, Percent_Identity=38.5852090032154, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=39.1585760517799, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=37.3831775700935, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=33.4384858044164, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=31.4465408805031, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321594, Length=325, Percent_Identity=35.6923076923077, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321449, Length=337, Percent_Identity=35.3115727002967, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=34.0836012861736, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=34.0836012861736, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35289; Mature: 35158

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKGIFWVLGEHDEPYLKPRESSLELVGNTPLVRIKKVLEAFDINPNVKIYAKLESTNP
CCCCEEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGSVKDRAALSMFLNAIKKGIIQKDKAVIDATSGNTGIALAMVGASLGIKVELAMPSNVS
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCH
EERKKILEAYGAITHYTDPLEGTDGAILYVRDIVKKYPDRYVYLDQYNNQANWQAHFYST
HHHHHHHHHHCCHHCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEC
GIEIYNQTKGQITHFVAGIGTGGTIMGTGRRLKVYNPNIEVIGIQPAYPFHGIEGLKHIE
CEEEEECCCCCEEEEEEECCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHH
SSIKPGIFDETFLDRTIFVDTEEAYELTRRLAKEEGLFVGQSSGAALAGAIKLAKELESG
HHCCCCCCCHHHCCCEEEEECHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCC
LIVTVFPDGGDRYLSTRVWGK
EEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure 
SLKGIFWVLGEHDEPYLKPRESSLELVGNTPLVRIKKVLEAFDINPNVKIYAKLESTNP
CCCEEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGSVKDRAALSMFLNAIKKGIIQKDKAVIDATSGNTGIALAMVGASLGIKVELAMPSNVS
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCH
EERKKILEAYGAITHYTDPLEGTDGAILYVRDIVKKYPDRYVYLDQYNNQANWQAHFYST
HHHHHHHHHHCCHHCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEC
GIEIYNQTKGQITHFVAGIGTGGTIMGTGRRLKVYNPNIEVIGIQPAYPFHGIEGLKHIE
CEEEEECCCCCEEEEEEECCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHH
SSIKPGIFDETFLDRTIFVDTEEAYELTRRLAKEEGLFVGQSSGAALAGAIKLAKELESG
HHCCCCCCCHHHCCCEEEEECHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCC
LIVTVFPDGGDRYLSTRVWGK
EEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]