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The map label for this gene is hldD [H]

Identifier: 195952610

GI number: 195952610

Start: 207147

End: 208079

Strand: Direct

Name: hldD [H]

Synonym: HY04AAS1_0230

Alternate gene names: 195952610

Gene position: 207147-208079 (Clockwise)

Preceding gene: 195952599

Following gene: 195952611

Centisome position: 13.28

GC content: 36.76

Gene sequence:

>933_bases
ATGAGAAAATTTCTAATAACAGGTGGAAGCGGTTTTATAGGCTCAAGGATAGCCTTAAGGCTTCAAGAGCTTTACCCAAA
AGCTTATATCCTTGTGGTGGATAACTTTTCTTCAGGATACTTTAAAACTCTTTATGGATTTAAAGGCGATGTGATAGAAG
GGGCTATAGAAGATAAAGACCTATGGGAATATCTTAAAAAAGAATACGCCTCTTTTGAAGCGGTCTTTCACAACGGAGCT
ATTACAGATACCACAATCCTTGATCAGAAGTTTATGATGGATGTAAACACCAATAGCATGAAATATATAATAGATGCTTG
TATAAAATGGGATGCAAAGCTTATATACGCTTCTTCTGCTGGAGTGTATGGCAACACAGAAGCACCTATGAGAGAAGATA
GGGGTCTTATACCGGAAAACGTATACGGCTTTTCAAAGCTAATGGCTGATAACCTCGTTAAAAATAAGATGGAAGAATAT
CCTTCTTTTAGGGCAGTGGGTTTTAGATACTTCAACGTATACGGCATGGGAGAGCAATACAAAGGCAAAACCGCCAGTAT
GATTTATCAACTTGCCATGCAGATGAAATCTGGCAAAAACCCAAGACTTTTTAAATATGGTGAGCAAAAAAGAGATTTTG
TTTATATAGAAGATGTATTGCAAGCAAATATAAAGGCTTTGGAAAGATACGATGCTAGTGGTATATTTAACGTAGGCTAT
GGCAAGGCAAGAAGCTTCAACGATATAGTAGAGATTTTAAACCATCTCATGGGTGCAAACTACGAAATAGAGTATTTTGA
CTGTCCATACGAATTTTATCAAAACTACACAGAAGCCGATATAAGTGCTATCAAAGAAAAGCTTGGCTACGAGCCCAAAT
ATGATTTGGAATCTGGTATAGAGCATTATCTTAAAAGCTTGAAGCTGATATGA

Upstream 100 bases:

>100_bases
GAAAGTCCAACATATAATATGGTATATATCATATTTTTCTTTGATGTTTTTCAATATATTTAAAGCCTTATACCTTAAAT
ATTTAAGTTAAAATATTTTT

Downstream 100 bases:

>100_bases
GTTTAAAGGGTATTTTTTGGGTATTAGGAGAACACGACGAGCCTTATTTAAAACCAAGGGAAAGCTCTTTGGAGCTTGTG
GGCAACACACCTTTGGTAAG

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRKFLITGGSGFIGSRIALRLQELYPKAYILVVDNFSSGYFKTLYGFKGDVIEGAIEDKDLWEYLKKEYASFEAVFHNGA
ITDTTILDQKFMMDVNTNSMKYIIDACIKWDAKLIYASSAGVYGNTEAPMREDRGLIPENVYGFSKLMADNLVKNKMEEY
PSFRAVGFRYFNVYGMGEQYKGKTASMIYQLAMQMKSGKNPRLFKYGEQKRDFVYIEDVLQANIKALERYDASGIFNVGY
GKARSFNDIVEILNHLMGANYEIEYFDCPYEFYQNYTEADISAIKEKLGYEPKYDLESGIEHYLKSLKLI

Sequences:

>Translated_310_residues
MRKFLITGGSGFIGSRIALRLQELYPKAYILVVDNFSSGYFKTLYGFKGDVIEGAIEDKDLWEYLKKEYASFEAVFHNGA
ITDTTILDQKFMMDVNTNSMKYIIDACIKWDAKLIYASSAGVYGNTEAPMREDRGLIPENVYGFSKLMADNLVKNKMEEY
PSFRAVGFRYFNVYGMGEQYKGKTASMIYQLAMQMKSGKNPRLFKYGEQKRDFVYIEDVLQANIKALERYDASGIFNVGY
GKARSFNDIVEILNHLMGANYEIEYFDCPYEFYQNYTEADISAIKEKLGYEPKYDLESGIEHYLKSLKLI
>Mature_310_residues
MRKFLITGGSGFIGSRIALRLQELYPKAYILVVDNFSSGYFKTLYGFKGDVIEGAIEDKDLWEYLKKEYASFEAVFHNGA
ITDTTILDQKFMMDVNTNSMKYIIDACIKWDAKLIYASSAGVYGNTEAPMREDRGLIPENVYGFSKLMADNLVKNKMEEY
PSFRAVGFRYFNVYGMGEQYKGKTASMIYQLAMQMKSGKNPRLFKYGEQKRDFVYIEDVLQANIKALERYDASGIFNVGY
GKARSFNDIVEILNHLMGANYEIEYFDCPYEFYQNYTEADISAIKEKLGYEPKYDLESGIEHYLKSLKLI

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790049, Length=312, Percent_Identity=37.5, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786974, Length=284, Percent_Identity=26.056338028169, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=343, Percent_Identity=25.9475218658892, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982035, Length=332, Percent_Identity=26.2048192771084, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 35717; Mature: 35717

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFLITGGSGFIGSRIALRLQELYPKAYILVVDNFSSGYFKTLYGFKGDVIEGAIEDKD
CCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCHHHCCCCCHH
LWEYLKKEYASFEAVFHNGAITDTTILDQKFMMDVNTNSMKYIIDACIKWDAKLIYASSA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHCCCEEEEEECC
GVYGNTEAPMREDRGLIPENVYGFSKLMADNLVKNKMEEYPSFRAVGFRYFNVYGMGEQY
CCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEEECCCCC
KGKTASMIYQLAMQMKSGKNPRLFKYGEQKRDFVYIEDVLQANIKALERYDASGIFNVGY
CCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCEEECCC
GKARSFNDIVEILNHLMGANYEIEYFDCPYEFYQNYTEADISAIKEKLGYEPKYDLESGI
CCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
EHYLKSLKLI
HHHHHHHCCC
>Mature Secondary Structure
MRKFLITGGSGFIGSRIALRLQELYPKAYILVVDNFSSGYFKTLYGFKGDVIEGAIEDKD
CCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCHHHCCCCCHH
LWEYLKKEYASFEAVFHNGAITDTTILDQKFMMDVNTNSMKYIIDACIKWDAKLIYASSA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHCCCEEEEEECC
GVYGNTEAPMREDRGLIPENVYGFSKLMADNLVKNKMEEYPSFRAVGFRYFNVYGMGEQY
CCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEEEECCCCC
KGKTASMIYQLAMQMKSGKNPRLFKYGEQKRDFVYIEDVLQANIKALERYDASGIFNVGY
CCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCEEECCC
GKARSFNDIVEILNHLMGANYEIEYFDCPYEFYQNYTEADISAIKEKLGYEPKYDLESGI
CCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
EHYLKSLKLI
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA