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The map label for this gene is nuoC [H]

Identifier: 194736818

GI number: 194736818

Start: 2439587

End: 2441389

Strand: Reverse

Name: nuoC [H]

Synonym: SeSA_A2554

Alternate gene names: 194736818

Gene position: 2441389-2439587 (Counterclockwise)

Preceding gene: 194736744

Following gene: 194736216

Centisome position: 51.84

GC content: 56.52

Gene sequence:

>1803_bases
ATGGTGAACAATATGACCGACTTAACCGCGCAAGACGCTGCATGGAGTACCCGCGATCATCTTGATGATCCGGTTATCGG
CGAACTGCGCAACCGTTTTGGGCCGGATGCCTTTACCGTTCAGGCGACCCGCACCGGTATCCCCGTTGTTTGGGTCAAGC
GTGAACAACTACTGGAGGTTGGCGATTTCTTAAAGAAACTGCCGAAACCTTACGTCATGCTGTTTGACTTACACGGCATG
GATGAACGCCTGCGTACGCACCGTGACGGGTTACCCGCCGCGGATTTTTCCGTTTTCTACCACCTGATTTCCATTGAGCG
TAATCGCGATATCATGCTCAAGGTGGCGTTGTCTGAAAACGACCTTCGCGTGCCGACCTTCACTAAACTTTTCCCTAACG
CCAACTGGTACGAGCGTGAGACCTGGGAGATGTTTGGCATTGATATCGAAGGCCACCCGCACCTGACGCGCATCATGATG
CCGCAAACCTGGGAAGGCCATCCGCTGCGTAAAGATTATCCGGCGCGTGCGACCGAATTCGACCCGTTTGAGCTGACCAA
AGCTAAGCAGGATCTGGAAATGGAAGCGCTGACCTTTAAGCCGGAAGACTGGGGGATGAAGCGCGGGACTGACAACGAGG
ACTTTATGTTCCTCAACCTCGGCCCGAACCATCCGTCTGCGCACGGTGCGTTTCGTATTATCCTGCAACTTGACGGCGAA
GAAATCGTCGATTGCGTGCCGGATATCGGCTATCACCATCGCGGCGCCGAAAAAATGGGCGAGCGCCAGTCCTGGCATAG
CTACATTCCCTATACCGACCGTATCGAATATCTCGGTGGTTGCGTCAATGAAATGCCGTACGTGCTGGCGGTAGAAAAGT
TGGCAGGGATCACCGTCCCGGATCGTGTGAACGTCATCCGCGTGATGCTCTCCGAACTGTTCCGCATTAACAGTCATCTG
CTGTACATCTCGACCTTTATTCAGGACGTCGGCGCGATGACGCCGGTCTTCTTTGCCTTTACCGACCGGCAGAAAATTTA
TGACCTGGTGGAAGCCATTACCGGTTTCCGTATGCACCCGGCCTGGTTCCGTATCGGCGGCGTCGCGCACGACTTGCCGC
GCGGTTGGGATCGCCTGCTGCGAGAGTTCCTTGAGTGGATGCCGAAGCGTTTGGATTCTTACGAGAAAGCCGCGCTGCGT
AACACCATTCTGAAAGGGCGTTCGCAGGGCGTTGCCGCTTACGGCGCGAAAGAAGCGCTGGAGTGGGGCACCACCGGCGC
AGGGCTGCGTGCGACCGGGATCGACTTCGACGTGCGTAAATGGCGTCCATACTCTGGCTACGAAAACTTTGACTTTGAAG
TGCCGGTGGGCGGCGGTGTTTCCGACTGCTATACCCGCGTGATGCTGAAAGTGGAAGAGCTGCGCCAGAGTCTGCGCATT
CTTCAGCAGTGCCTCGATAACATGCCGGAAGGCCCGTTCAAAGCGGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCG
CACGCTGCAACATATCGAAACCCTGATCACCCACTTCCTGCAGGTCTCCTGGGGCCCGGTGATGCCGGCGCAGGAGTCCT
TCCAGATGGTGGAAGCGACTAAGGGGATTAACAGTTACTACCTGACCAGCGACGGCAGCACTATGAGCTACCGTACCCGC
GTGCGCACGCCGAGCTTTGCGCACCTGCAGCAGATTCCCTCGGCGATCCGCGGTAGCCTGGTCTCCGACCTGATTGTCTA
TCTGGGTAGTATCGATTTTGTTATGTCAGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
CGGACGAGATTTAATTTGCGCCTGTCGGCAGCAGCACTTCACTTCGCTAACCACTATTTTAATAGCGCGAAGCACTGCCG
ACCACCACGGACCATTTGCA

Downstream 100 bases:

>100_bases
TTATGCACGAGAATCAACAACCACAAACCGAGGCTTTTGAGCTGAGTGCGGCAGAGCGTGAAGCGATAGAGCACGAGAAG
CACCACTACGAAGACCCGCG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSENDLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMM
PQTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALR
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRI
LQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEATKGINSYYLTSDGSTMSYRTR
VRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_600_residues
MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSENDLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMM
PQTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALR
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRI
LQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEATKGINSYYLTSDGSTMSYRTR
VRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_600_residues
MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSENDLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMM
PQTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALR
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRI
LQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEATKGINSYYLTSDGSTMSYRTR
VRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.4699738903394, Blast_Score=306, Evalue=5e-83,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.2144772117962, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI4758788, Length=101, Percent_Identity=38.6138613861386, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI145693162, Length=596, Percent_Identity=94.7986577181208, Blast_Score=1188, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=563, Percent_Identity=26.4653641207815, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788832, Length=532, Percent_Identity=28.9473684210526, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555284, Length=402, Percent_Identity=40.2985074626866, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17568379, Length=402, Percent_Identity=40.0497512437811, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.84375, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=40.2088772845953, Blast_Score=316, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24656494, Length=126, Percent_Identity=34.1269841269841, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68862; Mature: 68862

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEV
CCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
DLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMMPQTWEGHPLRKDYPARATEF
CCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGE
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCC
DRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEV
CCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
DLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMMPQTWEGHPLRKDYPARATEF
CCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGE
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCC
DRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA