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The map label for this gene is rmlA1 [H]

Identifier: 194334531

GI number: 194334531

Start: 1884977

End: 1885852

Strand: Reverse

Name: rmlA1 [H]

Synonym: Paes_1726

Alternate gene names: 194334531

Gene position: 1885852-1884977 (Counterclockwise)

Preceding gene: 194334532

Following gene: 194334530

Centisome position: 75.05

GC content: 52.85

Gene sequence:

>876_bases
ATGAAAGGAATTATACTTGCCGGGGGTTCGGGTACACGGTTGTATCCGGTGACGAAGGCGGTGTCGAAGCAGTTGCTGCC
GATTTATGATAAGCCGATGATCTATTATCCTTTGAGTACGCTGATGCTGGCGGGGATACGTGAGGTGCTGGTGATTTCGA
CGCCTCAGGATCTTCCGTTGTTTGAGCGGGTGCTTGGTGATGGGAGTGATTGGGGGATCAGCTTGTCGTATGTGGAGCAG
CCGTCACCGGATGGTTTGGCTCAGGCGTTTCTGCTGGGTGATGAGTTTATCGGCGGGGATGATGTGTCGCTGATTCTGGG
GGATAATATCTTTTTCGGGTACGGGTTCAGCGGCATGCTGAAGGATGCGGTTGAGAGCGTGCGCGAGGAGCGGGTGGCTA
ATATTTTCGGTTATTATGTGAATGATCCCGAGCGGTATGGGGTGGCTGAATTTAATGAATCGGGTCGGGTGCTGTCGATC
GAGGAGAAGCCATCGGATCCGAAGTCGAATTATGCGGTGGTCGGGTTGTATTTTTATCCGAACGAGGTGGTTGAAGTGGC
CAGGAGTGTGAAGCCGTCAGCGCGTGGGGAACTGGAGATTACGTCGGTGAATGAGGAGTTTCTCCGCCAGAACCGGTTGA
AGATGTCGATGTTAGGGCGCGGTTTTGCGTGGCTTGATACGGGAACGCACGAGTCGTTTCAGGAAGCGGGTAATTTTATT
GAGACGGTGGAAAAACGCCAGGGGCTGAAGATCGCTTGTCCGGAGGAGATTGCCTGGCGCAATAAATGGATTGACGACGA
TCGCCTTGAAGAACTTGCTGATCCATTGATGAAGAGCCAGTACGGGGTGTATTTGCGTCAGTTGCTGAAGCGTTGA

Upstream 100 bases:

>100_bases
GACGCAGGCGCCAACTGGTAACGGATAACGAATAACGGATAACGATTCACCAATCACCAATTACTGTTCACGAGTAACGA
AATAACGAATATCGATTTTT

Downstream 100 bases:

>100_bases
TGGATTTGGCGCTTTTGGTGCGGGGATGCGCTTCGCGCGGGAGGCTGGAGCGCCTTTGGCGCAGTGACGAGTGACGCGTG
ACAAGTGACGAGTGACAAGT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERVLGDGSDWGISLSYVEQ
PSPDGLAQAFLLGDEFIGGDDVSLILGDNIFFGYGFSGMLKDAVESVREERVANIFGYYVNDPERYGVAEFNESGRVLSI
EEKPSDPKSNYAVVGLYFYPNEVVEVARSVKPSARGELEITSVNEEFLRQNRLKMSMLGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDDRLEELADPLMKSQYGVYLRQLLKR

Sequences:

>Translated_291_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERVLGDGSDWGISLSYVEQ
PSPDGLAQAFLLGDEFIGGDDVSLILGDNIFFGYGFSGMLKDAVESVREERVANIFGYYVNDPERYGVAEFNESGRVLSI
EEKPSDPKSNYAVVGLYFYPNEVVEVARSVKPSARGELEITSVNEEFLRQNRLKMSMLGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDDRLEELADPLMKSQYGVYLRQLLKR
>Mature_291_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERVLGDGSDWGISLSYVEQ
PSPDGLAQAFLLGDEFIGGDDVSLILGDNIFFGYGFSGMLKDAVESVREERVANIFGYYVNDPERYGVAEFNESGRVLSI
EEKPSDPKSNYAVVGLYFYPNEVVEVARSVKPSARGELEITSVNEEFLRQNRLKMSMLGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDDRLEELADPLMKSQYGVYLRQLLKR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=254, Percent_Identity=25.1968503937008, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI11761619, Length=254, Percent_Identity=25.1968503937008, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=65.3979238754325, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1790224, Length=290, Percent_Identity=63.7931034482759, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931050, Length=240, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=272, Percent_Identity=25.7352941176471, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355443, Length=236, Percent_Identity=24.5762711864407, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=236, Percent_Identity=24.5762711864407, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32675; Mature: 32675

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPL
CCCEEEECCCCCEEEHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHEEEEECCCCCHH
FERVLGDGSDWGISLSYVEQPSPDGLAQAFLLGDEFIGGDDVSLILGDNIFFGYGFSGML
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEECCEEEECCHHHHH
KDAVESVREERVANIFGYYVNDPERYGVAEFNESGRVLSIEEKPSDPKSNYAVVGLYFYP
HHHHHHHHHHHHHHHHHEECCCHHHCCCCEECCCCCEEEEECCCCCCCCCEEEEEEEECC
NEVVEVARSVKPSARGELEITSVNEEFLRQNRLKMSMLGRGFAWLDTGTHESFQEAGNFI
HHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
ETVEKRQGLKIACPEEIAWRNKWIDDDRLEELADPLMKSQYGVYLRQLLKR
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPL
CCCEEEECCCCCEEEHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHEEEEECCCCCHH
FERVLGDGSDWGISLSYVEQPSPDGLAQAFLLGDEFIGGDDVSLILGDNIFFGYGFSGML
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEEEECCEEEECCHHHHH
KDAVESVREERVANIFGYYVNDPERYGVAEFNESGRVLSIEEKPSDPKSNYAVVGLYFYP
HHHHHHHHHHHHHHHHHEECCCHHHCCCCEECCCCCEEEEECCCCCCCCCEEEEEEEECC
NEVVEVARSVKPSARGELEITSVNEEFLRQNRLKMSMLGRGFAWLDTGTHESFQEAGNFI
HHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
ETVEKRQGLKIACPEEIAWRNKWIDDDRLEELADPLMKSQYGVYLRQLLKR
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]