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The map label for this gene is algA [H]

Identifier: 194334532

GI number: 194334532

Start: 1886034

End: 1887455

Strand: Reverse

Name: algA [H]

Synonym: Paes_1727

Alternate gene names: 194334532

Gene position: 1887455-1886034 (Counterclockwise)

Preceding gene: 194334534

Following gene: 194334531

Centisome position: 75.11

GC content: 56.89

Gene sequence:

>1422_bases
ATGATTATTCCTGTTATTCTTAGTGGCGGGTCGGGGACCCGGTTGTGGCCGTTGTCGAGGGCGATGTATCCTAAGCAGTT
GCTGCCGCTTGCCGGAAAGGGGACGATGCTGCAGGAGACGGTGTCTCGATTGGCTGCTATGATAGATATTGGACCGGTGT
TTTGCGTGTGTAACGAGGAACACCGGTTTCTTGTTGCTGAGCAGCTTCGCCAGGTGACGGATTCGGTCGGGGGTATTATT
CTTGAGCCTGTCGGGCGTAATACTGCGCCTGCGGTTGCTGTTGCTGCGATGCAGGTGCGCAAGCAGTTTCCTGATGCGGT
GATGCTGGTGCTGCCGGCTGACCATGTGATACGCGATGTTGATGCATTTGCTGCGGCGGTTGCTGTGGGGACGGCGGCGG
CGGAGCAGGGGGCTCTTGTGACGTTTGGCGTTGTGCCTGATGCGCCGGAGACCGGTTATGGTTATATCCGGGCGGCTGAT
GCGGGAACGGGATCTAACCTTCCTGACGGGGTGATGCCGGTTGCGGAATTTGTTGAGAAACCTGATCGTGAGACCGCTGA
GGGGTATGTGGCGTCCGGGAATTATTTCTGGAATAGCGGCATGTTTCTTTTTCGGGCCGACAGGTATCTGGAGGAGCTTG
AGATTCATGCGCCGGCTATTTTTGAGGCGAGTGGGGCTGCGTTGGAACAGGCGGCTACGGATCTTGATTTTCTGCGGCTT
GAGCGTGGGTCGTTTGAGGCGTGTCCGTCTGATTCGATTGATTATGCGGTGATGGAGCGTACGTCGCGTGCGGCGGTGGT
GCCGCTTGATGCGGGGTGGAACGATGTGGGGGCGTGGTCGGCGCTTTGGGGGGTTGAGTCGCGCGATGATGATGGGAATG
TGAGGAAGGGTGATGTGCTGGTTCAGAACGTGACGGGCAGCTATATCCATTCGACGAGCCGTCTGGTTGCTGCTGTGGGG
CTTGATGATTGTGTTGTTGTGGAGACGTCGGATGCGGTGCTGGTGGCTTCGAAGGATCGGGTGCAGGATGTGAAGGCGAT
TGTGCAGGAATTGAAGGAGAGAGGGCGGCCGGAGGCGTTGACGCATCAGCGGGTCTATCGTCCCTGGGGCTCGTATGAGA
CGATCGATATGGCTGACCGGTATCAGGTGAAGCGGATTGTGGTGAATCCGGGTGCGACGTTGTCGCTGCAGATGCATTTT
CACCGTGCTGAACACTGGGTTGTGGTGAAGGGGACGGCGTTGATTCGTAACGGGGAGAAGGAGATTACGCTTAGTGAGGA
TCAGTCGACCTATATTTCTCTGGGGACGCTGCATCGATTGGAGAACCCGGGGAAGATTCCTCTGGAGTTGATCGAGGTGC
AGACGGGAAGCTACCTGGGCGAGGATGATATTGTGCGCTATGATGATAAGTATGGGAGGTGA

Upstream 100 bases:

>100_bases
TGGCTCAGATTGAATGGAGAAAGGGGATGGGTTTTCTATATTACTTCATCTTGTTTTTCGGGCATGAGAATTCCTCCATT
CTTTAACTCCATATTGTACG

Downstream 100 bases:

>100_bases
GAGCGCCTGCGGCGCAGGGGTGCGCTTCGCGCGGTGACTGGTGACCAGTGACGCGTGACGAGTGACGCGTGACTCGTTTG
CGACGCAGGCGCCAACTGGT

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MIIPVILSGGSGTRLWPLSRAMYPKQLLPLAGKGTMLQETVSRLAAMIDIGPVFCVCNEEHRFLVAEQLRQVTDSVGGII
LEPVGRNTAPAVAVAAMQVRKQFPDAVMLVLPADHVIRDVDAFAAAVAVGTAAAEQGALVTFGVVPDAPETGYGYIRAAD
AGTGSNLPDGVMPVAEFVEKPDRETAEGYVASGNYFWNSGMFLFRADRYLEELEIHAPAIFEASGAALEQAATDLDFLRL
ERGSFEACPSDSIDYAVMERTSRAAVVPLDAGWNDVGAWSALWGVESRDDDGNVRKGDVLVQNVTGSYIHSTSRLVAAVG
LDDCVVVETSDAVLVASKDRVQDVKAIVQELKERGRPEALTHQRVYRPWGSYETIDMADRYQVKRIVVNPGATLSLQMHF
HRAEHWVVVKGTALIRNGEKEITLSEDQSTYISLGTLHRLENPGKIPLELIEVQTGSYLGEDDIVRYDDKYGR

Sequences:

>Translated_473_residues
MIIPVILSGGSGTRLWPLSRAMYPKQLLPLAGKGTMLQETVSRLAAMIDIGPVFCVCNEEHRFLVAEQLRQVTDSVGGII
LEPVGRNTAPAVAVAAMQVRKQFPDAVMLVLPADHVIRDVDAFAAAVAVGTAAAEQGALVTFGVVPDAPETGYGYIRAAD
AGTGSNLPDGVMPVAEFVEKPDRETAEGYVASGNYFWNSGMFLFRADRYLEELEIHAPAIFEASGAALEQAATDLDFLRL
ERGSFEACPSDSIDYAVMERTSRAAVVPLDAGWNDVGAWSALWGVESRDDDGNVRKGDVLVQNVTGSYIHSTSRLVAAVG
LDDCVVVETSDAVLVASKDRVQDVKAIVQELKERGRPEALTHQRVYRPWGSYETIDMADRYQVKRIVVNPGATLSLQMHF
HRAEHWVVVKGTALIRNGEKEITLSEDQSTYISLGTLHRLENPGKIPLELIEVQTGSYLGEDDIVRYDDKYGR
>Mature_473_residues
MIIPVILSGGSGTRLWPLSRAMYPKQLLPLAGKGTMLQETVSRLAAMIDIGPVFCVCNEEHRFLVAEQLRQVTDSVGGII
LEPVGRNTAPAVAVAAMQVRKQFPDAVMLVLPADHVIRDVDAFAAAVAVGTAAAEQGALVTFGVVPDAPETGYGYIRAAD
AGTGSNLPDGVMPVAEFVEKPDRETAEGYVASGNYFWNSGMFLFRADRYLEELEIHAPAIFEASGAALEQAATDLDFLRL
ERGSFEACPSDSIDYAVMERTSRAAVVPLDAGWNDVGAWSALWGVESRDDDGNVRKGDVLVQNVTGSYIHSTSRLVAAVG
LDDCVVVETSDAVLVASKDRVQDVKAIVQELKERGRPEALTHQRVYRPWGSYETIDMADRYQVKRIVVNPGATLSLQMHF
HRAEHWVVVKGTALIRNGEKEITLSEDQSTYISLGTLHRLENPGKIPLELIEVQTGSYLGEDDIVRYDDKYGR

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=475, Percent_Identity=57.0526315789474, Blast_Score=531, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 51534; Mature: 51534

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPVILSGGSGTRLWPLSRAMYPKQLLPLAGKGTMLQETVSRLAAMIDIGPVFCVCNEE
CEEEEEEECCCCCEEEECHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
HRFLVAEQLRQVTDSVGGIILEPVGRNTAPAVAVAAMQVRKQFPDAVMLVLPADHVIRDV
CCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
DAFAAAVAVGTAAAEQGALVTFGVVPDAPETGYGYIRAADAGTGSNLPDGVMPVAEFVEK
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHC
PDRETAEGYVASGNYFWNSGMFLFRADRYLEELEIHAPAIFEASGAALEQAATDLDFLRL
CCCCCCCCEEECCEEEECCCEEEEEHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHEEE
ERGSFEACPSDSIDYAVMERTSRAAVVPLDAGWNDVGAWSALWGVESRDDDGNVRKGDVL
CCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCEEECCEE
VQNVTGSYIHSTSRLVAAVGLDDCVVVETSDAVLVASKDRVQDVKAIVQELKERGRPEAL
EEECCCHHHHHHHHEEEEECCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCHH
THQRVYRPWGSYETIDMADRYQVKRIVVNPGATLSLQMHFHRAEHWVVVKGTALIRNGEK
HHHHHHCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEEEECCCEEEEEECEEEEECCCC
EITLSEDQSTYISLGTLHRLENPGKIPLELIEVQTGSYLGEDDIVRYDDKYGR
EEEEECCCCEEEEEHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MIIPVILSGGSGTRLWPLSRAMYPKQLLPLAGKGTMLQETVSRLAAMIDIGPVFCVCNEE
CEEEEEEECCCCCEEEECHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
HRFLVAEQLRQVTDSVGGIILEPVGRNTAPAVAVAAMQVRKQFPDAVMLVLPADHVIRDV
CCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
DAFAAAVAVGTAAAEQGALVTFGVVPDAPETGYGYIRAADAGTGSNLPDGVMPVAEFVEK
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHC
PDRETAEGYVASGNYFWNSGMFLFRADRYLEELEIHAPAIFEASGAALEQAATDLDFLRL
CCCCCCCCEEECCEEEECCCEEEEEHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHEEE
ERGSFEACPSDSIDYAVMERTSRAAVVPLDAGWNDVGAWSALWGVESRDDDGNVRKGDVL
CCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCEEECCEE
VQNVTGSYIHSTSRLVAAVGLDDCVVVETSDAVLVASKDRVQDVKAIVQELKERGRPEAL
EEECCCHHHHHHHHEEEEECCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCHH
THQRVYRPWGSYETIDMADRYQVKRIVVNPGATLSLQMHFHRAEHWVVVKGTALIRNGEK
HHHHHHCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEEEECCCEEEEEECEEEEECCCC
EITLSEDQSTYISLGTLHRLENPGKIPLELIEVQTGSYLGEDDIVRYDDKYGR
EEEEECCCCEEEEEHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]