Click here to switch to the map view.

The map label for this gene is rpfC [H]

Identifier: 194334444

GI number: 194334444

Start: 1782583

End: 1784613

Strand: Reverse

Name: rpfC [H]

Synonym: Paes_1639

Alternate gene names: 194334444

Gene position: 1784613-1782583 (Counterclockwise)

Preceding gene: 194334445

Following gene: 194334431

Centisome position: 71.02

GC content: 48.15

Gene sequence:

>2031_bases
ATGGATCCTTCACAAAGAGAAGAAAACAGCTTACCCCTTTTGCGTTATGATATGCTTGAGTTCCGACCGGAATGGCAGTT
TGACGATCCGGATTCGGGAGCGTATTACCATAGCGGAGTGGTTGTCAATAAGCTGTTTTTCACATCCCTCGGAGGAGATA
TACAGTATGAGGTGGCAGAGAAGGCGCTTGCGTTTGTAAGAAAGCTCTTTTCCGACGGGGTCCTCAGGGATTGCGAGTAT
ATCAGAATCGCTGATTATTCAGGTGTGAGCAAGGCGACCATCAACAGCAGAATTCTCTATGCAAATACACTCAACAAGCT
TACCGAAGAGTATAACTGCCGTCCGTCTGTAACCTATATCTGCGGCGCTTCAGTGCTCCTGAAGACTATGCTTCGGATTT
TTTCCCATATTGTCAGCCAGCGTTTCTTTTTTGTGGATTCTGTCGATGAAGCGTTTCGTCGTATCAACGCTCATGAGATG
TCAGGATGTGTCGTTTCTTCGGAAAGCCTTGTGGTCACAAGAAAAGAGATTGATGAATTTGCCGCCCTTTGCGGCCATCT
TTTATTTGAGGACACCAATGTCAAGAGCTTTTCACGAGACTATATATCGGAGGATCATCCGCTTAACGAGCTCTACAAAA
TTATCGGGGTTCTGCACAATGATCTCGGCGAGCTGAAGCAGAAAGAAAAGGATCAGAAGAAACGGCTTGAGGAGGCACTG
TTCGAAGCACGTTCTCTTAACCAGAAGCTTATTGATGAAAAGCGTAATGTCGAGGAAAACGAGAGGGTTCAGCAGGAGCT
GATCGATACCCTCAAAAAAGCGCGTGTCGAGGCTGAGAGCGCCAACAAGGCTAAAAGTGAATTTCTGGCCAATATCTCTC
ATGAGATCAGGACGCCGCTGCATGCGGTGATTGGGATGACAGAGCTTCTTCTTGAATCATCGCTTGCAAAAGATCAGCAG
TATTATGCCGATACCATCTCTTCGAGTGCCCACCTGCTTCTGCTTCTGATCAACGATCTGCTTGATTTCAGTCGCATTGA
AGCCGGATATATCGACCAGGAGAAAGAGGATTTTGATATGCGGCGCCTTATTGGCGATATCATGTCGCTCATGAAGGATA
GTGCCAGCAGAAAAAGGTTGTTGCTCGACAGCAGGGTGGATGAACGCCTGTCGTTTTGTTTGACCGGGTATCCCGGGTAT
CTGCGACAGGTGCTCATGAACCTGATACAGAATGCTGTCAAGTTTACCTATAAGGGGATGGTCTCTCTTCACGTAACGCT
GCTTTCAGAGACACCGGAACACGTTTCGCTTGAATTTTCTGTCAAGGATACCGGTGTCGGTATTGCCGAAGAACAGTTAA
AGGTTATTTTTCATCGATTTACGCAGATTGACGCCTCTTCAACAAGAAAAGAAGGGGGGACAGGTCTTGGCCTGGCTATC
GTCAAACAGCTTGTTACCTTCATGGGTGGAGAGGTTTCGGTCGATAGTCGTCAGGGAGAGGGATCTGATTTTCGTTTCTC
TCTTACATTTGACAAGGCCGGTGAGGCAAAAGCGGATCAGTCTTCTGCAGACCTTTCATGCAGGCAAAAAGACGGATTCC
GATCATCACGTTCTGTTGACGATATTATCCGTCCTCATCGGATTCTGCTGGTTGAAGACAACGTTATCAACCAGAAAGTT
GCCCAGGCGATGATTGAAAAAATCGGCTACGAGATCGACATTGCCGTCAACGGGGAGGAAGCTGTCGAAGCTCTTCAGCA
GAAGCAATACGGACTTGTTCTTATGGATCTGCAGATGCCGGTCATGGACGGTTTTGAAGCGACACGACGCATCAGGAAAT
TCGGAGGACTTGCGTCTAACGCGAGGGTTCCGGTTGTTGCTATGACGGCAAATGCCACAAGAGAAGACAGGGAGTTATGC
CTTCGGGCGGGAATGGACGATTACCTGTCCAAGCCTGTTGAACGGCAGGTGCTTCTCGATATGCTTCAGCGATGGCTCCC
CTTCAAGGATGAGCCGGGCGTTGAGACCTGA

Upstream 100 bases:

>100_bases
ACTTCGAAACGATACGTCGTTGTTGAAAACTGTGTTCTCCGATGTGTGAGCAGAGGATGTTCACTGCAACTTATGACGTT
TGGCTATAAACGGAATCTTA

Downstream 100 bases:

>100_bases
GTTACAGAACAACTTCCGGCATAACGGTTCAGCTTATCCCTATAATGACGCTCGAAGCCTTGAACATTGCGCACGCTTTA
CCCCCTTCTTTCACCTTGAG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MDPSQREENSLPLLRYDMLEFRPEWQFDDPDSGAYYHSGVVVNKLFFTSLGGDIQYEVAEKALAFVRKLFSDGVLRDCEY
IRIADYSGVSKATINSRILYANTLNKLTEEYNCRPSVTYICGASVLLKTMLRIFSHIVSQRFFFVDSVDEAFRRINAHEM
SGCVVSSESLVVTRKEIDEFAALCGHLLFEDTNVKSFSRDYISEDHPLNELYKIIGVLHNDLGELKQKEKDQKKRLEEAL
FEARSLNQKLIDEKRNVEENERVQQELIDTLKKARVEAESANKAKSEFLANISHEIRTPLHAVIGMTELLLESSLAKDQQ
YYADTISSSAHLLLLLINDLLDFSRIEAGYIDQEKEDFDMRRLIGDIMSLMKDSASRKRLLLDSRVDERLSFCLTGYPGY
LRQVLMNLIQNAVKFTYKGMVSLHVTLLSETPEHVSLEFSVKDTGVGIAEEQLKVIFHRFTQIDASSTRKEGGTGLGLAI
VKQLVTFMGGEVSVDSRQGEGSDFRFSLTFDKAGEAKADQSSADLSCRQKDGFRSSRSVDDIIRPHRILLVEDNVINQKV
AQAMIEKIGYEIDIAVNGEEAVEALQQKQYGLVLMDLQMPVMDGFEATRRIRKFGGLASNARVPVVAMTANATREDRELC
LRAGMDDYLSKPVERQVLLDMLQRWLPFKDEPGVET

Sequences:

>Translated_676_residues
MDPSQREENSLPLLRYDMLEFRPEWQFDDPDSGAYYHSGVVVNKLFFTSLGGDIQYEVAEKALAFVRKLFSDGVLRDCEY
IRIADYSGVSKATINSRILYANTLNKLTEEYNCRPSVTYICGASVLLKTMLRIFSHIVSQRFFFVDSVDEAFRRINAHEM
SGCVVSSESLVVTRKEIDEFAALCGHLLFEDTNVKSFSRDYISEDHPLNELYKIIGVLHNDLGELKQKEKDQKKRLEEAL
FEARSLNQKLIDEKRNVEENERVQQELIDTLKKARVEAESANKAKSEFLANISHEIRTPLHAVIGMTELLLESSLAKDQQ
YYADTISSSAHLLLLLINDLLDFSRIEAGYIDQEKEDFDMRRLIGDIMSLMKDSASRKRLLLDSRVDERLSFCLTGYPGY
LRQVLMNLIQNAVKFTYKGMVSLHVTLLSETPEHVSLEFSVKDTGVGIAEEQLKVIFHRFTQIDASSTRKEGGTGLGLAI
VKQLVTFMGGEVSVDSRQGEGSDFRFSLTFDKAGEAKADQSSADLSCRQKDGFRSSRSVDDIIRPHRILLVEDNVINQKV
AQAMIEKIGYEIDIAVNGEEAVEALQQKQYGLVLMDLQMPVMDGFEATRRIRKFGGLASNARVPVVAMTANATREDRELC
LRAGMDDYLSKPVERQVLLDMLQRWLPFKDEPGVET
>Mature_676_residues
MDPSQREENSLPLLRYDMLEFRPEWQFDDPDSGAYYHSGVVVNKLFFTSLGGDIQYEVAEKALAFVRKLFSDGVLRDCEY
IRIADYSGVSKATINSRILYANTLNKLTEEYNCRPSVTYICGASVLLKTMLRIFSHIVSQRFFFVDSVDEAFRRINAHEM
SGCVVSSESLVVTRKEIDEFAALCGHLLFEDTNVKSFSRDYISEDHPLNELYKIIGVLHNDLGELKQKEKDQKKRLEEAL
FEARSLNQKLIDEKRNVEENERVQQELIDTLKKARVEAESANKAKSEFLANISHEIRTPLHAVIGMTELLLESSLAKDQQ
YYADTISSSAHLLLLLINDLLDFSRIEAGYIDQEKEDFDMRRLIGDIMSLMKDSASRKRLLLDSRVDERLSFCLTGYPGY
LRQVLMNLIQNAVKFTYKGMVSLHVTLLSETPEHVSLEFSVKDTGVGIAEEQLKVIFHRFTQIDASSTRKEGGTGLGLAI
VKQLVTFMGGEVSVDSRQGEGSDFRFSLTFDKAGEAKADQSSADLSCRQKDGFRSSRSVDDIIRPHRILLVEDNVINQKV
AQAMIEKIGYEIDIAVNGEEAVEALQQKQYGLVLMDLQMPVMDGFEATRRIRKFGGLASNARVPVVAMTANATREDRELC
LRAGMDDYLSKPVERQVLLDMLQRWLPFKDEPGVET

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=419, Percent_Identity=32.9355608591885, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1788713, Length=397, Percent_Identity=30.7304785894207, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1789149, Length=267, Percent_Identity=38.9513108614232, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI87081816, Length=410, Percent_Identity=32.9268292682927, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=37.9032258064516, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=32.5892857142857, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786912, Length=319, Percent_Identity=28.8401253918495, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=30.6034482758621, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=27.0742358078603, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=217, Percent_Identity=27.1889400921659, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790861, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789402, Length=106, Percent_Identity=36.7924528301887, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=129, Percent_Identity=31.7829457364341, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=28.1818181818182, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787229, Length=110, Percent_Identity=30.9090909090909, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI87082012, Length=106, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=125, Percent_Identity=37.6, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323034, Length=142, Percent_Identity=33.8028169014084, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322000, Length=120, Percent_Identity=35, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76678; Mature: 76678

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPSQREENSLPLLRYDMLEFRPEWQFDDPDSGAYYHSGVVVNKLFFTSLGGDIQYEVAE
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHH
KALAFVRKLFSDGVLRDCEYIRIADYSGVSKATINSRILYANTLNKLTEEYNCRPSVTYI
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCEEEEHHHHHHHHHHCCCCCCHHHH
CGASVLLKTMLRIFSHIVSQRFFFVDSVDEAFRRINAHEMSGCVVSSESLVVTRKEIDEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEECCCCEEEEHHHHHHH
AALCGHLLFEDTNVKSFSRDYISEDHPLNELYKIIGVLHNDLGELKQKEKDQKKRLEEAL
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEARSLNQKLIDEKRNVEENERVQQELIDTLKKARVEAESANKAKSEFLANISHEIRTPL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVIGMTELLLESSLAKDQQYYADTISSSAHLLLLLINDLLDFSRIEAGYIDQEKEDFDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RRLIGDIMSLMKDSASRKRLLLDSRVDERLSFCLTGYPGYLRQVLMNLIQNAVKFTYKGM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VSLHVTLLSETPEHVSLEFSVKDTGVGIAEEQLKVIFHRFTQIDASSTRKEGGTGLGLAI
HHEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VKQLVTFMGGEVSVDSRQGEGSDFRFSLTFDKAGEAKADQSSADLSCRQKDGFRSSRSVD
HHHHHHHHCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCHH
DIIRPHRILLVEDNVINQKVAQAMIEKIGYEIDIAVNGEEAVEALQQKQYGLVLMDLQMP
HHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEEEEECCC
VMDGFEATRRIRKFGGLASNARVPVVAMTANATREDRELCLRAGMDDYLSKPVERQVLLD
HHCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
MLQRWLPFKDEPGVET
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDPSQREENSLPLLRYDMLEFRPEWQFDDPDSGAYYHSGVVVNKLFFTSLGGDIQYEVAE
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHH
KALAFVRKLFSDGVLRDCEYIRIADYSGVSKATINSRILYANTLNKLTEEYNCRPSVTYI
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCEEEEHHHHHHHHHHCCCCCCHHHH
CGASVLLKTMLRIFSHIVSQRFFFVDSVDEAFRRINAHEMSGCVVSSESLVVTRKEIDEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEECCCCEEEEHHHHHHH
AALCGHLLFEDTNVKSFSRDYISEDHPLNELYKIIGVLHNDLGELKQKEKDQKKRLEEAL
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEARSLNQKLIDEKRNVEENERVQQELIDTLKKARVEAESANKAKSEFLANISHEIRTPL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVIGMTELLLESSLAKDQQYYADTISSSAHLLLLLINDLLDFSRIEAGYIDQEKEDFDM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RRLIGDIMSLMKDSASRKRLLLDSRVDERLSFCLTGYPGYLRQVLMNLIQNAVKFTYKGM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VSLHVTLLSETPEHVSLEFSVKDTGVGIAEEQLKVIFHRFTQIDASSTRKEGGTGLGLAI
HHEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VKQLVTFMGGEVSVDSRQGEGSDFRFSLTFDKAGEAKADQSSADLSCRQKDGFRSSRSVD
HHHHHHHHCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCHH
DIIRPHRILLVEDNVINQKVAQAMIEKIGYEIDIAVNGEEAVEALQQKQYGLVLMDLQMP
HHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEEEEECCC
VMDGFEATRRIRKFGGLASNARVPVVAMTANATREDRELCLRAGMDDYLSKPVERQVLLD
HHCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
MLQRWLPFKDEPGVET
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]