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The map label for this gene is hisN [H]

Identifier: 194334349

GI number: 194334349

Start: 1684224

End: 1684985

Strand: Reverse

Name: hisN [H]

Synonym: Paes_1542

Alternate gene names: 194334349

Gene position: 1684985-1684224 (Counterclockwise)

Preceding gene: 194334350

Following gene: 194334348

Centisome position: 67.05

GC content: 50.79

Gene sequence:

>762_bases
ATGACCGATGACCTTCAACTCGCCATTGAACTTGCCGATGAAGCAGGGAAGCTGACGCTGACCTACTTTCAGAACAAATC
GCTTAAAATTGATGAGAAACGAGACGATACTCCCGTCACCGAGGCGGATCGCAAAGCCGAGCAGCTGATACGTAAGGGTA
TAGAGGCCAGATATCCGGAAGACGGTATTTTTGGTGAGGAATTTGGTGAGAAAATAGCGGTTAACGGGAGACGATGGATT
CTTGATCCCATTGACGGAACCCGTTCTTTTATTCATGGAGTTCCTCTATACGGCGTAATGATTGCTCTCGAAGTCAATCG
TGCCATGCAGCTTGGCGTCATCTTTTTTCCGGCTCTTCAGGAGATGTACTATGCTCAATCCGGTTGCGGCGCGTTTATGA
ACGGTGAACCGTTAAAGGTTTCCGAGATCGGTGATACGCGTGAAGCGACGGTGGTGTATACTGAAAAGGAATATCTGCTT
GATCCTCCTTCAGATCATCCTGTCGACAGACTGCGTTATGATGCAGGCCTTGTTCGCGGATGGGGCGACTGCTACGGGCA
TATGCTCGTTGCATCGGGAAGGGCGGAGGTTGCTGTCGATAAGGTGATGAGCCCCTGGGATTGCGCTGCCGTCATTCCTG
TTGTGACAGAGGCCGGAGGGTGTTGTTTCGACTACAATGCCAGAACAACGATTTACGGCGAAGGCCTGGTCAGCGCTAAC
CGCAAAATCGGTGATGAGCTCGTCAGGGATATTCTTGGATGA

Upstream 100 bases:

>100_bases
GCAGGCCGTCGCTGAATTTGAGCGCCGTCATCCTCTCGGGGAGGGGATGCGGTCGGCATTGTTTACCACAAACCATCTAA
AGTAGAGAGTATCCGACCTT

Downstream 100 bases:

>100_bases
TCTGATCTACGCCATTTTTTTGTGAGCCTCGTTTTCCCGGTTCATATTCCTCCAACACTCCTTTTCATGGTAATCTATGT
TCAATGCAGTTTCTCTGGAA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTDDLQLAIELADEAGKLTLTYFQNKSLKIDEKRDDTPVTEADRKAEQLIRKGIEARYPEDGIFGEEFGEKIAVNGRRWI
LDPIDGTRSFIHGVPLYGVMIALEVNRAMQLGVIFFPALQEMYYAQSGCGAFMNGEPLKVSEIGDTREATVVYTEKEYLL
DPPSDHPVDRLRYDAGLVRGWGDCYGHMLVASGRAEVAVDKVMSPWDCAAVIPVVTEAGGCCFDYNARTTIYGEGLVSAN
RKIGDELVRDILG

Sequences:

>Translated_253_residues
MTDDLQLAIELADEAGKLTLTYFQNKSLKIDEKRDDTPVTEADRKAEQLIRKGIEARYPEDGIFGEEFGEKIAVNGRRWI
LDPIDGTRSFIHGVPLYGVMIALEVNRAMQLGVIFFPALQEMYYAQSGCGAFMNGEPLKVSEIGDTREATVVYTEKEYLL
DPPSDHPVDRLRYDAGLVRGWGDCYGHMLVASGRAEVAVDKVMSPWDCAAVIPVVTEAGGCCFDYNARTTIYGEGLVSAN
RKIGDELVRDILG
>Mature_252_residues
TDDLQLAIELADEAGKLTLTYFQNKSLKIDEKRDDTPVTEADRKAEQLIRKGIEARYPEDGIFGEEFGEKIAVNGRRWIL
DPIDGTRSFIHGVPLYGVMIALEVNRAMQLGVIFFPALQEMYYAQSGCGAFMNGEPLKVSEIGDTREATVVYTEKEYLLD
PPSDHPVDRLRYDAGLVRGWGDCYGHMLVASGRAEVAVDKVMSPWDCAAVIPVVTEAGGCCFDYNARTTIYGEGLVSANR
KIGDELVRDILG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=254, Percent_Identity=31.1023622047244, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI221625487, Length=254, Percent_Identity=31.1023622047244, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI221625507, Length=139, Percent_Identity=35.9712230215827, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI7657236, Length=238, Percent_Identity=31.9327731092437, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788882, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790659, Length=166, Percent_Identity=30.1204819277108, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=232, Percent_Identity=32.3275862068966, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193202570, Length=231, Percent_Identity=32.034632034632, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320493, Length=230, Percent_Identity=27.8260869565217, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321836, Length=101, Percent_Identity=33.6633663366337, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664922, Length=228, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357957, Length=222, Percent_Identity=32.8828828828829, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664918, Length=224, Percent_Identity=32.5892857142857, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21357329, Length=229, Percent_Identity=30.1310043668122, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24664926, Length=226, Percent_Identity=30.0884955752212, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357303, Length=233, Percent_Identity=31.7596566523605, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28023; Mature: 27892

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDLQLAIELADEAGKLTLTYFQNKSLKIDEKRDDTPVTEADRKAEQLIRKGIEARYPE
CCCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DGIFGEEFGEKIAVNGRRWILDPIDGTRSFIHGVPLYGVMIALEVNRAMQLGVIFFPALQ
CCCCHHHHCCEEEECCCEEEECCCCCHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHH
EMYYAQSGCGAFMNGEPLKVSEIGDTREATVVYTEKEYLLDPPSDHPVDRLRYDAGLVRG
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEECHHEECCCCCCCCHHHHHHHHHHHCC
WGDCYGHMLVASGRAEVAVDKVMSPWDCAAVIPVVTEAGGCCFDYNARTTIYGEGLVSAN
CHHHHCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCHHHCC
RKIGDELVRDILG
HHHHHHHHHHHCC
>Mature Secondary Structure 
TDDLQLAIELADEAGKLTLTYFQNKSLKIDEKRDDTPVTEADRKAEQLIRKGIEARYPE
CCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DGIFGEEFGEKIAVNGRRWILDPIDGTRSFIHGVPLYGVMIALEVNRAMQLGVIFFPALQ
CCCCHHHHCCEEEECCCEEEECCCCCHHHHHCCCCHHHEEEEEECCCHHHHHHHHHHHHH
EMYYAQSGCGAFMNGEPLKVSEIGDTREATVVYTEKEYLLDPPSDHPVDRLRYDAGLVRG
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEECHHEECCCCCCCCHHHHHHHHHHHCC
WGDCYGHMLVASGRAEVAVDKVMSPWDCAAVIPVVTEAGGCCFDYNARTTIYGEGLVSAN
CHHHHCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCHHHCC
RKIGDELVRDILG
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]