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The map label for this gene is comEC [H]

Identifier: 194334304

GI number: 194334304

Start: 1637142

End: 1639328

Strand: Reverse

Name: comEC [H]

Synonym: Paes_1497

Alternate gene names: 194334304

Gene position: 1639328-1637142 (Counterclockwise)

Preceding gene: 194334306

Following gene: 194334298

Centisome position: 65.24

GC content: 53.5

Gene sequence:

>2187_bases
ATGTCTTTTTCCCCCGCTCAATATCCCTCTTTGCGTCTTCTTCTGGCGGCTTGTTCAGGCATTCTCGCTGGTGTAGGCTT
GTCGGTGACGATCTCTTTCTGGCTTATCTCTGCTGGAGTTTCGGCATTGCTGATTGTCGTTTTTAGCTATGGGATTGAAC
GGCGTTCTGTCGGCAAGAGCTTTCCCGGGCCTGTAACGATCCTCTGTTTTCTGGCGCTTGTCGTATCAGCCTTTGCCGCC
TGGGGCACCTACCGTTACAACTATGTCGACAGTGATTCAGTTCTCCGTTATCTTGACAGGGAGGTCTTGCTGCACGGAAC
CGTTTCCGACCGACCCGGGAAGTCCGGTTCCGGAGAACGTTTTATTATAGATGTTCATGAGGTATTTGTCGACGATGCAA
CCGTTTCTGCTTCAGGGCGAGTCTCAGTCTTTGTCCGCTCTTCAATGCCGGAGGAGGATCACTTGACGCAACCGGGAGAT
AGCGTGTGGTTGAAAGGGACGCTGAAGCTTATCGATGAAGCGGCCAATGCCGGTGATTTTGATGCACGCGAGTACTATCG
CCGGCTCAGTGTGCATAGTTCTGTATTTGTTGCCGGTCCCTGGCTTGTGCAGAACGAGGGTGCTGGCAAAGGCGTGCCGT
TCGACTCATATGTTGTACGTCCTGTGCGACATTTTCTTGAAGACGCTCTCGATACGTTGTTCCCGTCCGGGCACGAACGG
GATTTTTTCAGGGGGCTTCTTCTTGGAGAACGCTCGATGATCGATCCCGAGGTCTACGATCAGTTTCGGCGAACCGGTAC
AGCCCATGTACTGGCGATTTCAGGCCTGCATGTCGGACTGCTTGTTCTTGTCGTCCTTCTTTTTCTGCAGCGTTTCAGGC
AGTCAATGTCGGGAAAATGGCTGGTTGTCATTGTACTTGCCTTTCTGTTGCTGATTTACTCACAGGTGACAGGTAACGCG
CCATCGGTGAGACGGGCATCCATCATGACCGGTGTACTGCTTGGGGGGTATGCGGCTGGACGTCAGGTCTATCCTTTGAA
CTCTCTCGCATTTGCCGACCTGCTCATGCTTGCCTTTGATCCGCTCGAACTCTATCAGGCCGGTTTTCTCATGACGAACG
CTGCCGTGGCAGCGATTCTGCTGCTCTATCCGCTGCTCAGTGCTCCGGCGCTATCCTGGCAGGGGAGCGTCGGACGGGCC
TGTCGGGCGATCTGGAATCCTTTCTGTATCAGTCTTTCTGCCATGGCCGGGGTTTCTCCTCTCATCGCCCTCTATTTCGG
TTCCTTTTCCGTTGCAGGTATCGTTGCTAATCTTCCTGTTGTGTTTCTTGTCACCGCCATGGTTTTTTCCCTTCTTCCGG
CGCTTTTCCTCCATCTGCTCAACCTGCCGTTGGCAGAACTCTATGCCTCCTCTGCATGGTTTTTTGCCCACACGGCGCTT
TCTGTTACCGGTTTCTTCAGTAGTCTTGAATGGGCCGCACTTCCTGTTCGCACAGATCCGCTCATGGTCGTCATCTACTA
TCTGTCGATAGTTGCCCTGCTGTATTTCTTCTATGAGAAAAAGAATGCCGGATTGATCATTACACTGCTCAGCCTGGCTA
ATTTCATCTGCTGGTACCCTCTGCTGCATGCCATGCAAGCGTCTGAACGGCTGATTCCTGTCAGAACCGGCAGATACATA
GCGCTCTTGTATGCCTCACAAGCCTCAACGGTGCTCATCGATGCCGGATCCGGTCCAGAAGATCTGCCAATAATAGAACG
TCAGATGCTTCGTAGCGGCATAGCATCAATCGATGTGGCACTGCAGTTGAGTTCGCCGGACACTCTTGTCGCTCGGGTTG
ACGCTGAGACGTTCATGCTGTCGGACCGGCAGAAGCTTGTCTTGCCCTCTATGCTCGTTGCCAGAGGGGGAAAGGATCTG
CTTTCCATATGGAGCGGCGATGGGTCCTCACTGCTTGTTGCTGCAGGTGTCGAAGCTCTGATACGTCGTGCAGGAGGGCA
GCCGGAGCGGAGTGTTGTCGTTCTTCTCAGACGTTTCGGTATTGATGAGTATCGCGAGCTTGCTGCATGGCTCGACAGAT
ATGAGCCAACGGAGTGCAGGATCGTCTGTGCCTCTCGAATGCCGCAGAAGCAGCGTGCTCTGGTCGAGCATCTTGCCCTG
AGAGGTTCAGCCGTGTCTGTTGAGTGA

Upstream 100 bases:

>100_bases
TTTTGTTCCTCGGTTCAAAAAAAAATAATATAGGAAAATCTGATAGACACAGAGGTAAAATAATAGGCTTATCTCCAAAA
CCTTCTCCCAAGGGTCTGTT

Downstream 100 bases:

>100_bases
GCATGTTCTGTGATGACGAATAGCGATGAGTGGTCCTTCTGCCGAGCCTCAGGCTTTTCACTCATCATCTATGAGCGGCA
GCTGGTTGCTGGTGTTGAAG

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSFSPAQYPSLRLLLAACSGILAGVGLSVTISFWLISAGVSALLIVVFSYGIERRSVGKSFPGPVTILCFLALVVSAFAA
WGTYRYNYVDSDSVLRYLDREVLLHGTVSDRPGKSGSGERFIIDVHEVFVDDATVSASGRVSVFVRSSMPEEDHLTQPGD
SVWLKGTLKLIDEAANAGDFDAREYYRRLSVHSSVFVAGPWLVQNEGAGKGVPFDSYVVRPVRHFLEDALDTLFPSGHER
DFFRGLLLGERSMIDPEVYDQFRRTGTAHVLAISGLHVGLLVLVVLLFLQRFRQSMSGKWLVVIVLAFLLLIYSQVTGNA
PSVRRASIMTGVLLGGYAAGRQVYPLNSLAFADLLMLAFDPLELYQAGFLMTNAAVAAILLLYPLLSAPALSWQGSVGRA
CRAIWNPFCISLSAMAGVSPLIALYFGSFSVAGIVANLPVVFLVTAMVFSLLPALFLHLLNLPLAELYASSAWFFAHTAL
SVTGFFSSLEWAALPVRTDPLMVVIYYLSIVALLYFFYEKKNAGLIITLLSLANFICWYPLLHAMQASERLIPVRTGRYI
ALLYASQASTVLIDAGSGPEDLPIIERQMLRSGIASIDVALQLSSPDTLVARVDAETFMLSDRQKLVLPSMLVARGGKDL
LSIWSGDGSSLLVAAGVEALIRRAGGQPERSVVVLLRRFGIDEYRELAAWLDRYEPTECRIVCASRMPQKQRALVEHLAL
RGSAVSVE

Sequences:

>Translated_728_residues
MSFSPAQYPSLRLLLAACSGILAGVGLSVTISFWLISAGVSALLIVVFSYGIERRSVGKSFPGPVTILCFLALVVSAFAA
WGTYRYNYVDSDSVLRYLDREVLLHGTVSDRPGKSGSGERFIIDVHEVFVDDATVSASGRVSVFVRSSMPEEDHLTQPGD
SVWLKGTLKLIDEAANAGDFDAREYYRRLSVHSSVFVAGPWLVQNEGAGKGVPFDSYVVRPVRHFLEDALDTLFPSGHER
DFFRGLLLGERSMIDPEVYDQFRRTGTAHVLAISGLHVGLLVLVVLLFLQRFRQSMSGKWLVVIVLAFLLLIYSQVTGNA
PSVRRASIMTGVLLGGYAAGRQVYPLNSLAFADLLMLAFDPLELYQAGFLMTNAAVAAILLLYPLLSAPALSWQGSVGRA
CRAIWNPFCISLSAMAGVSPLIALYFGSFSVAGIVANLPVVFLVTAMVFSLLPALFLHLLNLPLAELYASSAWFFAHTAL
SVTGFFSSLEWAALPVRTDPLMVVIYYLSIVALLYFFYEKKNAGLIITLLSLANFICWYPLLHAMQASERLIPVRTGRYI
ALLYASQASTVLIDAGSGPEDLPIIERQMLRSGIASIDVALQLSSPDTLVARVDAETFMLSDRQKLVLPSMLVARGGKDL
LSIWSGDGSSLLVAAGVEALIRRAGGQPERSVVVLLRRFGIDEYRELAAWLDRYEPTECRIVCASRMPQKQRALVEHLAL
RGSAVSVE
>Mature_727_residues
SFSPAQYPSLRLLLAACSGILAGVGLSVTISFWLISAGVSALLIVVFSYGIERRSVGKSFPGPVTILCFLALVVSAFAAW
GTYRYNYVDSDSVLRYLDREVLLHGTVSDRPGKSGSGERFIIDVHEVFVDDATVSASGRVSVFVRSSMPEEDHLTQPGDS
VWLKGTLKLIDEAANAGDFDAREYYRRLSVHSSVFVAGPWLVQNEGAGKGVPFDSYVVRPVRHFLEDALDTLFPSGHERD
FFRGLLLGERSMIDPEVYDQFRRTGTAHVLAISGLHVGLLVLVVLLFLQRFRQSMSGKWLVVIVLAFLLLIYSQVTGNAP
SVRRASIMTGVLLGGYAAGRQVYPLNSLAFADLLMLAFDPLELYQAGFLMTNAAVAAILLLYPLLSAPALSWQGSVGRAC
RAIWNPFCISLSAMAGVSPLIALYFGSFSVAGIVANLPVVFLVTAMVFSLLPALFLHLLNLPLAELYASSAWFFAHTALS
VTGFFSSLEWAALPVRTDPLMVVIYYLSIVALLYFFYEKKNAGLIITLLSLANFICWYPLLHAMQASERLIPVRTGRYIA
LLYASQASTVLIDAGSGPEDLPIIERQMLRSGIASIDVALQLSSPDTLVARVDAETFMLSDRQKLVLPSMLVARGGKDLL
SIWSGDGSSLLVAAGVEALIRRAGGQPERSVVVLLRRFGIDEYRELAAWLDRYEPTECRIVCASRMPQKQRALVEHLALR
GSAVSVE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=413, Percent_Identity=24.6973365617433, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 79533; Mature: 79401

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSPAQYPSLRLLLAACSGILAGVGLSVTISFWLISAGVSALLIVVFSYGIERRSVGKS
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
FPGPVTILCFLALVVSAFAAWGTYRYNYVDSDSVLRYLDREVLLHGTVSDRPGKSGSGER
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHEEEECCCCCCCCCCCCCE
FIIDVHEVFVDDATVSASGRVSVFVRSSMPEEDHLTQPGDSVWLKGTLKLIDEAANAGDF
EEEEHHHHHHCCCEECCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC
DAREYYRRLSVHSSVFVAGPWLVQNEGAGKGVPFDSYVVRPVRHFLEDALDTLFPSGHER
HHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
DFFRGLLLGERSMIDPEVYDQFRRTGTAHVLAISGLHVGLLVLVVLLFLQRFRQSMSGKW
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCC
LVVIVLAFLLLIYSQVTGNAPSVRRASIMTGVLLGGYAAGRQVYPLNSLAFADLLMLAFD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCC
PLELYQAGFLMTNAAVAAILLLYPLLSAPALSWQGSVGRACRAIWNPFCISLSAMAGVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCHHH
LIALYFGSFSVAGIVANLPVVFLVTAMVFSLLPALFLHLLNLPLAELYASSAWFFAHTAL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHH
SVTGFFSSLEWAALPVRTDPLMVVIYYLSIVALLYFFYEKKNAGLIITLLSLANFICWYP
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
LLHAMQASERLIPVRTGRYIALLYASQASTVLIDAGSGPEDLPIIERQMLRSGIASIDVA
HHHHHHHCCCEEEEECCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEE
LQLSSPDTLVARVDAETFMLSDRQKLVLPSMLVARGGKDLLSIWSGDGSSLLVAAGVEAL
EEECCCCEEEEEECHHHHEECCCCHHHHHHHHHHCCCCHHHHEECCCCCCEEHHHHHHHH
IRRAGGQPERSVVVLLRRFGIDEYRELAAWLDRYEPTECRIVCASRMPQKQRALVEHLAL
HHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHH
RGSAVSVE
CCCCCCCC
>Mature Secondary Structure 
SFSPAQYPSLRLLLAACSGILAGVGLSVTISFWLISAGVSALLIVVFSYGIERRSVGKS
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
FPGPVTILCFLALVVSAFAAWGTYRYNYVDSDSVLRYLDREVLLHGTVSDRPGKSGSGER
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHEEEECCCCCCCCCCCCCE
FIIDVHEVFVDDATVSASGRVSVFVRSSMPEEDHLTQPGDSVWLKGTLKLIDEAANAGDF
EEEEHHHHHHCCCEECCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC
DAREYYRRLSVHSSVFVAGPWLVQNEGAGKGVPFDSYVVRPVRHFLEDALDTLFPSGHER
HHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
DFFRGLLLGERSMIDPEVYDQFRRTGTAHVLAISGLHVGLLVLVVLLFLQRFRQSMSGKW
HHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCC
LVVIVLAFLLLIYSQVTGNAPSVRRASIMTGVLLGGYAAGRQVYPLNSLAFADLLMLAFD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCC
PLELYQAGFLMTNAAVAAILLLYPLLSAPALSWQGSVGRACRAIWNPFCISLSAMAGVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCHHH
LIALYFGSFSVAGIVANLPVVFLVTAMVFSLLPALFLHLLNLPLAELYASSAWFFAHTAL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHH
SVTGFFSSLEWAALPVRTDPLMVVIYYLSIVALLYFFYEKKNAGLIITLLSLANFICWYP
HHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHH
LLHAMQASERLIPVRTGRYIALLYASQASTVLIDAGSGPEDLPIIERQMLRSGIASIDVA
HHHHHHHCCCEEEEECCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEE
LQLSSPDTLVARVDAETFMLSDRQKLVLPSMLVARGGKDLLSIWSGDGSSLLVAAGVEAL
EEECCCCEEEEEECHHHHEECCCCHHHHHHHHHHCCCCHHHHEECCCCCCEEHHHHHHHH
IRRAGGQPERSVVVLLRRFGIDEYRELAAWLDRYEPTECRIVCASRMPQKQRALVEHLAL
HHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHEEEECCCCCHHHHHHHHHHHH
RGSAVSVE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]