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The map label for this gene is lysA [H]

Identifier: 194334306

GI number: 194334306

Start: 1640444

End: 1641694

Strand: Reverse

Name: lysA [H]

Synonym: Paes_1499

Alternate gene names: 194334306

Gene position: 1641694-1640444 (Counterclockwise)

Preceding gene: 194334309

Following gene: 194334304

Centisome position: 65.33

GC content: 48.92

Gene sequence:

>1251_bases
GTGCTTGATTCAAGGTTTTTTTCATATAAGGATACTGTGCTCTCTTGTGAAGGAGTTGCTCTCGATGCCCTTGCGGCAGA
GTACTCCACTCCATTGTTTGTCGTGAGCCGTAACGCTCTTGTTGAGCAGTACAGGGCTTTTGAGGAGGCTTTTTCTTCTC
TCAGTCATTTTACCTGCTATTCGGTCAAGGCAAACTTCAATATTCATGTTATCAAGGCTCTCTCCGATCAAGGCTGCGGT
TGTGACGTCAACTCGGGAGGAGAGCTTTTCAGGGCCCTTAAAGCAGGGGTGGATCCGCAGAAGATCATTATGGCAGGTGT
TGGTAAAAGCGATCAGGATATCGAGTACGCTTTGCAATCAGGCATTTTTATGCTGAAGGCTGAATCTCTTTCCGAATTGC
GCCACATCGAAGCTGTTGCCCGGCGACTTGGTGTGACAGCTTCGGTCGGTGTTCGCATCAATCCTAATGTAACTGCTGAA
ACGCACCCTTATATCACGACCGGCGACAGTAAAGAGAAATTCGGCATTGATGAGGGGTCATTGGACGAGATGTTCGATCT
GTTCAAGTCGATGAAGCATGTCAATTTCATGTGTCTGGATATGCATATTGGTTCCCAGATTTTCGATACGGAATTTTATC
ATGCAGCAACAGAGAAGCTTCTCGATGTACTCGACGCGGCCCGTGCCAAAGGGTTTTCGATCGACTATCTCGATATCGGG
GGAGGATTTCCGGTCACCTATGAACCGCAGAAGCCGGCTACGCCGATCGAGCAGTTTGCCTCGGTTCTGATCCCTGTTCT
CAAAAAAACGGGAACGACGATCATTTTTGAACCAGGGCGGTTTATTGCCGCTAATTCAGGCGTTATGGTGACAAAGGTGC
TCTATCGCAAACGCAATCATATTGGCAAGGAGTTTGTCATTGTTGATGCCGGCATGACTGAACTGATTCGGCCTGCGCTC
TATCAGTCCTATCATGAAATCATCGGTGTCAAGCAGCAGGAGGCGACCATTGTTGCCGATGTCGTTGGTCCTGTTTGTGA
ATCGGGCGACTTTTTTGCCAGAGGCAGGACCATTGATGCTGTCGGGGAAGGAGAGTACCTTGCAATTCTATCAGCAGGAG
CGTATGGTGCCGTTATGAGTAATAATTATAACGGACGTCTGCGTCCGGCCGAGGTGATGGTCGATAACGGCCGGACCAGT
CTGATTCGCAAGCGGGATACTTTCGAGCAGCTCATTGAGAATGAGGTTTGA

Upstream 100 bases:

>100_bases
TAGATTATCTGTTTGGAATTTGCAAGCCGATTGTTTTTTGTATGGTTAGATTATAACAGCTATTATTCAACTTTCCGTCA
ACACTCAAGATTTTTATGCT

Downstream 100 bases:

>100_bases
TTGCCAGGAGGCGTCAGGAACGTTCTGTTGCACGGGGGGCGAATCAGCCCCCCTTTTTTTTCTATGAGACAGCTCTTGTC
CGCGAAAGAGCGATATCCTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLDSRFFSYKDTVLSCEGVALDALAAEYSTPLFVVSRNALVEQYRAFEEAFSSLSHFTCYSVKANFNIHVIKALSDQGCG
CDVNSGGELFRALKAGVDPQKIIMAGVGKSDQDIEYALQSGIFMLKAESLSELRHIEAVARRLGVTASVGVRINPNVTAE
THPYITTGDSKEKFGIDEGSLDEMFDLFKSMKHVNFMCLDMHIGSQIFDTEFYHAATEKLLDVLDAARAKGFSIDYLDIG
GGFPVTYEPQKPATPIEQFASVLIPVLKKTGTTIIFEPGRFIAANSGVMVTKVLYRKRNHIGKEFVIVDAGMTELIRPAL
YQSYHEIIGVKQQEATIVADVVGPVCESGDFFARGRTIDAVGEGEYLAILSAGAYGAVMSNNYNGRLRPAEVMVDNGRTS
LIRKRDTFEQLIENEV

Sequences:

>Translated_416_residues
MLDSRFFSYKDTVLSCEGVALDALAAEYSTPLFVVSRNALVEQYRAFEEAFSSLSHFTCYSVKANFNIHVIKALSDQGCG
CDVNSGGELFRALKAGVDPQKIIMAGVGKSDQDIEYALQSGIFMLKAESLSELRHIEAVARRLGVTASVGVRINPNVTAE
THPYITTGDSKEKFGIDEGSLDEMFDLFKSMKHVNFMCLDMHIGSQIFDTEFYHAATEKLLDVLDAARAKGFSIDYLDIG
GGFPVTYEPQKPATPIEQFASVLIPVLKKTGTTIIFEPGRFIAANSGVMVTKVLYRKRNHIGKEFVIVDAGMTELIRPAL
YQSYHEIIGVKQQEATIVADVVGPVCESGDFFARGRTIDAVGEGEYLAILSAGAYGAVMSNNYNGRLRPAEVMVDNGRTS
LIRKRDTFEQLIENEV
>Mature_416_residues
MLDSRFFSYKDTVLSCEGVALDALAAEYSTPLFVVSRNALVEQYRAFEEAFSSLSHFTCYSVKANFNIHVIKALSDQGCG
CDVNSGGELFRALKAGVDPQKIIMAGVGKSDQDIEYALQSGIFMLKAESLSELRHIEAVARRLGVTASVGVRINPNVTAE
THPYITTGDSKEKFGIDEGSLDEMFDLFKSMKHVNFMCLDMHIGSQIFDTEFYHAATEKLLDVLDAARAKGFSIDYLDIG
GGFPVTYEPQKPATPIEQFASVLIPVLKKTGTTIIFEPGRFIAANSGVMVTKVLYRKRNHIGKEFVIVDAGMTELIRPAL
YQSYHEIIGVKQQEATIVADVVGPVCESGDFFARGRTIDAVGEGEYLAILSAGAYGAVMSNNYNGRLRPAEVMVDNGRTS
LIRKRDTFEQLIENEV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=394, Percent_Identity=23.8578680203046, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI16506287, Length=404, Percent_Identity=23.2673267326733, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI22538418, Length=388, Percent_Identity=23.4536082474227, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI21361583, Length=388, Percent_Identity=23.4536082474227, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789203, Length=424, Percent_Identity=29.9528301886792, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=400, Percent_Identity=24.5, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24586472, Length=375, Percent_Identity=23.4666666666667, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45718; Mature: 45718

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSRFFSYKDTVLSCEGVALDALAAEYSTPLFVVSRNALVEQYRAFEEAFSSLSHFTCY
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEE
SVKANFNIHVIKALSDQGCGCDVNSGGELFRALKAGVDPQKIIMAGVGKSDQDIEYALQS
EEEECCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHC
GIFMLKAESLSELRHIEAVARRLGVTASVGVRINPNVTAETHPYITTGDSKEKFGIDEGS
CEEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEECCCCCHHCCCCCCC
LDEMFDLFKSMKHVNFMCLDMHIGSQIFDTEFYHAATEKLLDVLDAARAKGFSIDYLDIG
HHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGFPVTYEPQKPATPIEQFASVLIPVLKKTGTTIIFEPGRFIAANSGVMVTKVLYRKRNH
CCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHC
IGKEFVIVDAGMTELIRPALYQSYHEIIGVKQQEATIVADVVGPVCESGDFFARGRTIDA
CCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHCCCCEEECCCEEEE
VGEGEYLAILSAGAYGAVMSNNYNGRLRPAEVMVDNGRTSLIRKRDTFEQLIENEV
CCCCCEEEEEECCCCEEEEECCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDSRFFSYKDTVLSCEGVALDALAAEYSTPLFVVSRNALVEQYRAFEEAFSSLSHFTCY
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEE
SVKANFNIHVIKALSDQGCGCDVNSGGELFRALKAGVDPQKIIMAGVGKSDQDIEYALQS
EEEECCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHC
GIFMLKAESLSELRHIEAVARRLGVTASVGVRINPNVTAETHPYITTGDSKEKFGIDEGS
CEEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEECCCCCHHCCCCCCC
LDEMFDLFKSMKHVNFMCLDMHIGSQIFDTEFYHAATEKLLDVLDAARAKGFSIDYLDIG
HHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGFPVTYEPQKPATPIEQFASVLIPVLKKTGTTIIFEPGRFIAANSGVMVTKVLYRKRNH
CCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHC
IGKEFVIVDAGMTELIRPALYQSYHEIIGVKQQEATIVADVVGPVCESGDFFARGRTIDA
CCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHCCCCEEECCCEEEE
VGEGEYLAILSAGAYGAVMSNNYNGRLRPAEVMVDNGRTSLIRKRDTFEQLIENEV
CCCCCEEEEEECCCCEEEEECCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]