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The map label for this gene is lpxD [H]

Identifier: 194334298

GI number: 194334298

Start: 1631717

End: 1632790

Strand: Reverse

Name: lpxD [H]

Synonym: Paes_1491

Alternate gene names: 194334298

Gene position: 1632790-1631717 (Counterclockwise)

Preceding gene: 194334304

Following gene: 194334295

Centisome position: 64.98

GC content: 50.19

Gene sequence:

>1074_bases
ATGAATGTATTTGACCTGCAGACCTTCCTGCAACAGTTTTTTGACCATGTGGACCTGGTAGGCGATGGAGATGTGGCTAT
TACGGGCCCGGCAAGGATTGAACAGGCATCGAAGGGCAACGTGACCTTTGTCGCCAATGAGAAATACAGCAAATACATCA
GTACTACCAAAGCTTCTTTGCTTATCGTCAGCCGGCAGATGCCGGTTGATCAATATAGTGACCGGCTTACTTTTCTGAAA
GTAAAAGACCCCTACACCGCCTTCGTTTTTATTCTCAAAAAGTTTGCTGCTCCTCGCAGACTCGCTTCTCCCGGTATCGC
CCCCACTGCGGTTGTTGGTAGCAATGTCAGTATGGGCAGTAATGTTTCCATAGGCGATTACGCTGTTATCGGCGACGGTT
GCACTATCGGCGACAACGCAATCATTGCGCCGCACTGTGTCTTGATGGATGGCGTCTCTCTCGGCGATGGCTGTATGCTG
TTTCCCCATGTGGTCTGTTATGATGCGGTCAGGATCGGCAACAGGGTTACCCTGCACAGCGGTGTTGTTATCGGAGCTGA
TGGTTTTGGTTTTGCTCCTCAGAGTGATGGTTCGTATATCAAAATTCCCCAGATGGGCATTGTTGAAATCGGTGATGATG
TCGAAGTCGGCGCTAATACCACCATCGACCGGGCAACGATGGGAAGCACGGTTGTTGAGCATGGAGCTAAAATCGATAAT
CTTGTTCAGATCGGCCATAACTGCAGGATTGGCAACGATACCGTGATCGCTTCTCAGACAGGGGTTTCCGGAAGTGTTTC
GATCGGGAGTCAGTGCATGATCGGAGGGCAGGTCGGTATGGCGGGACATCTTTCTCTGGCCGATCACACCCAGGTAGCGG
CAAAAGCCGGGATTACAAAATCATTTACCCGACCGGGACAAGTGTTAAGGGGATATCCTGCCCAGACTATGAAAGAGCAG
CTTCGTCAGGAAGTGCTCATTCGTAACCTCGACAGGATGAAAACCCGTCTTAAAGAGCTTGAGGCAGAGTTTGAATCGAT
CAGAAACGGAGAGAACCCATCGCTTTCTCTATGA

Upstream 100 bases:

>100_bases
CGTTTTGATGCTGTTGGGACTGCAAAAATCCTCGAATTTTTAATATAGCAAAAAAGTTGAAAATAATCACTTTTACTGTT
TATAAAGTTTATCCTTTCTC

Downstream 100 bases:

>100_bases
GCGAGGGGGCTCAACCGTTGTCTTTCACATTGCTGATGCTTCGCCCGCTTCGAGGGCGCTGTTCAGATTCCAGTTATAGG
GCATGTATGTGATCTTCAAG

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MNVFDLQTFLQQFFDHVDLVGDGDVAITGPARIEQASKGNVTFVANEKYSKYISTTKASLLIVSRQMPVDQYSDRLTFLK
VKDPYTAFVFILKKFAAPRRLASPGIAPTAVVGSNVSMGSNVSIGDYAVIGDGCTIGDNAIIAPHCVLMDGVSLGDGCML
FPHVVCYDAVRIGNRVTLHSGVVIGADGFGFAPQSDGSYIKIPQMGIVEIGDDVEVGANTTIDRATMGSTVVEHGAKIDN
LVQIGHNCRIGNDTVIASQTGVSGSVSIGSQCMIGGQVGMAGHLSLADHTQVAAKAGITKSFTRPGQVLRGYPAQTMKEQ
LRQEVLIRNLDRMKTRLKELEAEFESIRNGENPSLSL

Sequences:

>Translated_357_residues
MNVFDLQTFLQQFFDHVDLVGDGDVAITGPARIEQASKGNVTFVANEKYSKYISTTKASLLIVSRQMPVDQYSDRLTFLK
VKDPYTAFVFILKKFAAPRRLASPGIAPTAVVGSNVSMGSNVSIGDYAVIGDGCTIGDNAIIAPHCVLMDGVSLGDGCML
FPHVVCYDAVRIGNRVTLHSGVVIGADGFGFAPQSDGSYIKIPQMGIVEIGDDVEVGANTTIDRATMGSTVVEHGAKIDN
LVQIGHNCRIGNDTVIASQTGVSGSVSIGSQCMIGGQVGMAGHLSLADHTQVAAKAGITKSFTRPGQVLRGYPAQTMKEQ
LRQEVLIRNLDRMKTRLKELEAEFESIRNGENPSLSL
>Mature_357_residues
MNVFDLQTFLQQFFDHVDLVGDGDVAITGPARIEQASKGNVTFVANEKYSKYISTTKASLLIVSRQMPVDQYSDRLTFLK
VKDPYTAFVFILKKFAAPRRLASPGIAPTAVVGSNVSMGSNVSIGDYAVIGDGCTIGDNAIIAPHCVLMDGVSLGDGCML
FPHVVCYDAVRIGNRVTLHSGVVIGADGFGFAPQSDGSYIKIPQMGIVEIGDDVEVGANTTIDRATMGSTVVEHGAKIDN
LVQIGHNCRIGNDTVIASQTGVSGSVSIGSQCMIGGQVGMAGHLSLADHTQVAAKAGITKSFTRPGQVLRGYPAQTMKEQ
LRQEVLIRNLDRMKTRLKELEAEFESIRNGENPSLSL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=337, Percent_Identity=38.2789317507418, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1786378, Length=178, Percent_Identity=29.2134831460674, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 38085; Mature: 38085

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFDLQTFLQQFFDHVDLVGDGDVAITGPARIEQASKGNVTFVANEKYSKYISTTKASL
CCCHHHHHHHHHHHHHCCEECCCCEEEECCHHHHHCCCCCEEEEECCHHHHHHHHCCEEE
LIVSRQMPVDQYSDRLTFLKVKDPYTAFVFILKKFAAPRRLASPGIAPTAVVGSNVSMGS
EEEECCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCEEECCCCCCCC
NVSIGDYAVIGDGCTIGDNAIIAPHCVLMDGVSLGDGCMLFPHVVCYDAVRIGNRVTLHS
CCCCCCEEEEECCEEECCCCEECCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GVVIGADGFGFAPQSDGSYIKIPQMGIVEIGDDVEVGANTTIDRATMGSTVVEHGAKIDN
CEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
LVQIGHNCRIGNDTVIASQTGVSGSVSIGSQCMIGGQVGMAGHLSLADHTQVAAKAGITK
HHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
SFTRPGQVLRGYPAQTMKEQLRQEVLIRNLDRMKTRLKELEAEFESIRNGENPSLSL
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNVFDLQTFLQQFFDHVDLVGDGDVAITGPARIEQASKGNVTFVANEKYSKYISTTKASL
CCCHHHHHHHHHHHHHCCEECCCCEEEECCHHHHHCCCCCEEEEECCHHHHHHHHCCEEE
LIVSRQMPVDQYSDRLTFLKVKDPYTAFVFILKKFAAPRRLASPGIAPTAVVGSNVSMGS
EEEECCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCEEECCCCCCCC
NVSIGDYAVIGDGCTIGDNAIIAPHCVLMDGVSLGDGCMLFPHVVCYDAVRIGNRVTLHS
CCCCCCEEEEECCEEECCCCEECCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GVVIGADGFGFAPQSDGSYIKIPQMGIVEIGDDVEVGANTTIDRATMGSTVVEHGAKIDN
CEEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
LVQIGHNCRIGNDTVIASQTGVSGSVSIGSQCMIGGQVGMAGHLSLADHTQVAAKAGITK
HHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
SFTRPGQVLRGYPAQTMKEQLRQEVLIRNLDRMKTRLKELEAEFESIRNGENPSLSL
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA