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The map label for this gene is hisA

Identifier: 193212140

GI number: 193212140

Start: 501563

End: 502345

Strand: Direct

Name: hisA

Synonym: Cpar_0471

Alternate gene names: 193212140

Gene position: 501563-502345 (Clockwise)

Preceding gene: 193212139

Following gene: 193212141

Centisome position: 21.91

GC content: 54.41

Gene sequence:

>783_bases
ATGTTGATCATACCCGCTATCGATATTAAGGAAGGCAAGTGCGTCAGACTGACCAGGGGTGATTTTGCTCAGAAAAAGAT
TTATCTCGACAATCCTGCTGACATGGCGATTATCTGGCGGAAACAGAACGCCAAGATGCTCCATGTGGTCGATCTCGATG
CGGCTCTGACCGGTGAGATGGTCAACTTCGAGAAGATTCGCGAGATTGTGGAACTGCTCGATATTCCGATCCAGGTCGGC
GGCGGCATTCGCTCGGTCGAAGCGGTCGAAAAGTATCTCAGCATCGGCGTCAGCCGTGTGGTCATTGGCTCAGCGGCGGT
TACCAATCCAAGCCTTGTGGCCGATCTCCTCAAAAAGTATCGTCCCTCGCAGATCGTCGTCGGCATCGATGCCGAGCACG
GCGTGCCAAAAATCAAGGGGTGGACCGAGAGCAGCAACATGCAGGATTACGAGCTGGCTCTTGAAATGAAGAAACTTGGC
GTCGAGAGGATTATCTATACCGACATCACCCGCGATGGCATGTTGCAGGGCGTCGGATACGAAACCACCAAGCGTTTTGC
CGAAAAGGCGGGCATGAAGATCACCGCATCGGGCGGCGTGAGCACTTCTGATGACCTCCACAAACTCAGGTCGCTCGAAC
GGTTTGGCGTCGATTCGGTCATTATCGGCAAAGCTCTCTACGAGTGCAACTTCCCGTGCCAGGAGCTCTGGTACGCTTAC
GAGCAGGATTTGGGCATCGACGGCGAATTCTCCACGGCCCGAAAGAAAGAGTGCTGCCGCTGA

Upstream 100 bases:

>100_bases
GTATTTTCGCAGTTCAGTTCCACCCGGAAAAGAGCTCCGAAGCGGGCTTGCTGGTGTTGAAGAATTTTGCAGAGTTTTAA
GCTGTTGAGGGGTTTACGCT

Downstream 100 bases:

>100_bases
GCCCGGACGAATCCTCGCGCTTGCAACCATCATCAGTCATCGTGCAGGAACAGGACCGACAACTTCTCCAGTCTGTCGAA
GCGCTTATCTTCGCTTCTGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPADMAIIWRKQNAKMLHVVDLDAALTGEMVNFEKIREIVELLDIPIQVG
GGIRSVEAVEKYLSIGVSRVVIGSAAVTNPSLVADLLKKYRPSQIVVGIDAEHGVPKIKGWTESSNMQDYELALEMKKLG
VERIIYTDITRDGMLQGVGYETTKRFAEKAGMKITASGGVSTSDDLHKLRSLERFGVDSVIIGKALYECNFPCQELWYAY
EQDLGIDGEFSTARKKECCR

Sequences:

>Translated_260_residues
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPADMAIIWRKQNAKMLHVVDLDAALTGEMVNFEKIREIVELLDIPIQVG
GGIRSVEAVEKYLSIGVSRVVIGSAAVTNPSLVADLLKKYRPSQIVVGIDAEHGVPKIKGWTESSNMQDYELALEMKKLG
VERIIYTDITRDGMLQGVGYETTKRFAEKAGMKITASGGVSTSDDLHKLRSLERFGVDSVIIGKALYECNFPCQELWYAY
EQDLGIDGEFSTARKKECCR
>Mature_260_residues
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPADMAIIWRKQNAKMLHVVDLDAALTGEMVNFEKIREIVELLDIPIQVG
GGIRSVEAVEKYLSIGVSRVVIGSAAVTNPSLVADLLKKYRPSQIVVGIDAEHGVPKIKGWTESSNMQDYELALEMKKLG
VERIIYTDITRDGMLQGVGYETTKRFAEKAGMKITASGGVSTSDDLHKLRSLERFGVDSVIIGKALYECNFPCQELWYAY
EQDLGIDGEFSTARKKECCR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=33.7448559670782, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1788336, Length=236, Percent_Identity=27.9661016949153, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CHLP8 (B3QLK3)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998093.1
- ProteinModelPortal:   B3QLK3
- GeneID:   6419385
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0471
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 28936; Mature: 28936

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPADMAIIWRKQNAKMLHVVDLDAALTGEM
CEEECCEECCCCCEEEEECCCCCCCEEEECCCCCEEEEEEECCCCEEEEEECCHHHCCCC
VNFEKIREIVELLDIPIQVGGGIRSVEAVEKYLSIGVSRVVIGSAAVTNPSLVADLLKKY
CCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHC
RPSQIVVGIDAEHGVPKIKGWTESSNMQDYELALEMKKLGVERIIYTDITRDGMLQGVGY
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCH
ETTKRFAEKAGMKITASGGVSTSDDLHKLRSLERFGVDSVIIGKALYECNFPCQELWYAY
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
EQDLGIDGEFSTARKKECCR
HHCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPADMAIIWRKQNAKMLHVVDLDAALTGEM
CEEECCEECCCCCEEEEECCCCCCCEEEECCCCCEEEEEEECCCCEEEEEECCHHHCCCC
VNFEKIREIVELLDIPIQVGGGIRSVEAVEKYLSIGVSRVVIGSAAVTNPSLVADLLKKY
CCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHC
RPSQIVVGIDAEHGVPKIKGWTESSNMQDYELALEMKKLGVERIIYTDITRDGMLQGVGY
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCH
ETTKRFAEKAGMKITASGGVSTSDDLHKLRSLERFGVDSVIIGKALYECNFPCQELWYAY
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
EQDLGIDGEFSTARKKECCR
HHCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA