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The map label for this gene is lpxA

Identifier: 193211905

GI number: 193211905

Start: 240599

End: 241393

Strand: Direct

Name: lpxA

Synonym: Cpar_0231

Alternate gene names: 193211905

Gene position: 240599-241393 (Clockwise)

Preceding gene: 193211904

Following gene: 193211906

Centisome position: 10.51

GC content: 61.64

Gene sequence:

>795_bases
ATGAGTAGTATTCACCCGACAGCGGTCATCGGTTCCGGAGCCACGATTGGCGAGGATGTACAGATCGGCCCCTACACCGT
CATCGACGACGACGTGGTCATCGGCGACCGTACGGTCATCGCGCCCCACGTCTATATCGCCGACGGCGCGCGCATTGGCA
GCGAGTGTCGCATCCATTCCGGAGCGGTGCTTTCCACCGCGCCTCAGGATCTGAAATATGCAGGCGAGAAAACAGAGCTG
TACGTCGGCGACCGCACGGTCATCCGCGAGTGCGTGACCCTGAACCGCGGCACGAAGGCCAGCGGCAAGACCGTGGTGGG
CTCGGACAACCTGCTCATGGCTTACGTCCATGCGGGTCACGACTGCGTGATCGGCAACCATGTAGTGATTGCCAACTCGG
TGCAGTTCGGCGGCCACTGCGAGGTGGGCGATTACGTGGTGGTCGGCGGTCTGGCCGGCATCCACCAGTTCGTCAGAATT
GGTCGTTACGCGATGGTCGGTGGCATCTCCCGTGGTGCGCTCGATGTGCCGCCGTTCGTGATGGCCGGCGGTCACAACTC
GTTCCGCTACGAGGGGCTCAACGTAATTGGCCTGAAGCGGCGCGGCTTCACCTCCGAGCAGATCAGCACCATCCGGGATG
TCTATCGCGTGATCTTCCAGTCCGGTCTGTTGCTCAGCAACGCGCTCGAAGCCGTGCGGCGCGATTTCGAGCAGACGCCC
GAAGTGAAGGAAATTCTCGGCTTCTTCGCGTCGGGCGCGCATGGCAGGAAGTTCCTCAAGCCCTTCAATTCATAA

Upstream 100 bases:

>100_bases
GAGAGAGCGGCAAGGCGGATGCCGTCCTGAATCATCTGAAGCAGGCCCTTCCTGCACTGCGGGAGCGGCTGGATTCCCTA
AAGCAATAGCTGGACTTTTC

Downstream 100 bases:

>100_bases
CCGTTTACGAGTATGCCTTCATGGGCTATCGGCATCGATCTTGGCGGGACGAACATCAAGACGGCCGTCATCGACGAGGC
CGGGGGCATACTTTTCGAGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSSIHPTAVIGSGATIGEDVQIGPYTVIDDDVVIGDRTVIAPHVYIADGARIGSECRIHSGAVLSTAPQDLKYAGEKTEL
YVGDRTVIRECVTLNRGTKASGKTVVGSDNLLMAYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYVVVGGLAGIHQFVRI
GRYAMVGGISRGALDVPPFVMAGGHNSFRYEGLNVIGLKRRGFTSEQISTIRDVYRVIFQSGLLLSNALEAVRRDFEQTP
EVKEILGFFASGAHGRKFLKPFNS

Sequences:

>Translated_264_residues
MSSIHPTAVIGSGATIGEDVQIGPYTVIDDDVVIGDRTVIAPHVYIADGARIGSECRIHSGAVLSTAPQDLKYAGEKTEL
YVGDRTVIRECVTLNRGTKASGKTVVGSDNLLMAYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYVVVGGLAGIHQFVRI
GRYAMVGGISRGALDVPPFVMAGGHNSFRYEGLNVIGLKRRGFTSEQISTIRDVYRVIFQSGLLLSNALEAVRRDFEQTP
EVKEILGFFASGAHGRKFLKPFNS
>Mature_263_residues
SSIHPTAVIGSGATIGEDVQIGPYTVIDDDVVIGDRTVIAPHVYIADGARIGSECRIHSGAVLSTAPQDLKYAGEKTELY
VGDRTVIRECVTLNRGTKASGKTVVGSDNLLMAYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYVVVGGLAGIHQFVRIG
RYAMVGGISRGALDVPPFVMAGGHNSFRYEGLNVIGLKRRGFTSEQISTIRDVYRVIFQSGLLLSNALEAVRRDFEQTPE
VKEILGFFASGAHGRKFLKPFNS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=43.8735177865613, Blast_Score=217, Evalue=6e-58,
Organism=Escherichia coli, GI1786376, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLP8 (B3QR04)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001997858.1
- ProteinModelPortal:   B3QR04
- GeneID:   6419144
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0231
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28259; Mature: 28127

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIHPTAVIGSGATIGEDVQIGPYTVIDDDVVIGDRTVIAPHVYIADGARIGSECRIHS
CCCCCCCEEEECCCCCCCCCEECCEEEECCCEEECCCEEEECEEEEECCCCCCCCCEEEC
GAVLSTAPQDLKYAGEKTELYVGDRTVIRECVTLNRGTKASGKTVVGSDNLLMAYVHAGH
CEEEECCCHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCC
DCVIGNHVVIANSVQFGGHCEVGDYVVVGGLAGIHQFVRIGRYAMVGGISRGALDVPPFV
EEEECCEEEEEECEECCCCCCCCCEEEECCHHHHHHHHHHHHHHEECCCCCCCCCCCCEE
MAGGHNSFRYEGLNVIGLKRRGFTSEQISTIRDVYRVIFQSGLLLSNALEAVRRDFEQTP
EECCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EVKEILGFFASGAHGRKFLKPFNS
CHHHHHHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure 
SSIHPTAVIGSGATIGEDVQIGPYTVIDDDVVIGDRTVIAPHVYIADGARIGSECRIHS
CCCCCCEEEECCCCCCCCCEECCEEEECCCEEECCCEEEECEEEEECCCCCCCCCEEEC
GAVLSTAPQDLKYAGEKTELYVGDRTVIRECVTLNRGTKASGKTVVGSDNLLMAYVHAGH
CEEEECCCHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCC
DCVIGNHVVIANSVQFGGHCEVGDYVVVGGLAGIHQFVRIGRYAMVGGISRGALDVPPFV
EEEECCEEEEEECEECCCCCCCCCEEEECCHHHHHHHHHHHHHHEECCCCCCCCCCCCEE
MAGGHNSFRYEGLNVIGLKRRGFTSEQISTIRDVYRVIFQSGLLLSNALEAVRRDFEQTP
EECCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EVKEILGFFASGAHGRKFLKPFNS
CHHHHHHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA