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The map label for this gene is prpE [H]

Identifier: 193214275

GI number: 193214275

Start: 654616

End: 655320

Strand: Direct

Name: prpE [H]

Synonym: Ctha_0556

Alternate gene names: 193214275

Gene position: 654616-655320 (Clockwise)

Preceding gene: 193214274

Following gene: 193214276

Centisome position: 19.88

GC content: 42.41

Gene sequence:

>705_bases
ATGCCTCAAGATGAAACGGGCACGAAAAACATCATCGCTATTGGCGATATTCACGGTTGTATTCTTTCCTTGAAAGCACT
AATCCAGAAACTTGATCTTTCAGAAAAACCGCAACTTGTATTTTTAGGTGATTATGTTGATCGTGGCCCGAACTCAAAAG
GTGTCATTGATTTTTTAATCGAATTAAACGATTCGTATCCTTGCGTTTTTCTGAAAGGCAATCACGAAGTGATGATGCAG
GATTATTTAATCGGCGACTGCATTTTTGACAATTGGAAATACAACGGCGGAACAGAAACCCTGGCTTCTTATCAGGAAAA
CGGACATCTTTCCATTCCAAGTTCGCATCTTAAATTTTTGGCGCAGTGCCGCTATACTTACGAAACCGATGATTATGTTT
TCGTGCATGGTGGCCTGAAGCCCGAATTTTCCATTCGGGAAAATTTGGAGAATGGCAGCAACGAAAGTATGGTCTGGGAA
CGCACCCATTTATCCAAAGAGGCTATTTCCACAGAACACCCCAATTGGGAAAAAACGGTAATTTGTGGACACACGCCGCA
GCACTCGCCGCTTCTGCTCAAAAGACTGATTTGCATCGACACGGGCTGCGTATATTATTCAACTCGCCCTGGGTTTGGAA
GATTAACGGCCATTGAACTTCCATCGCGAAAAATTACACAGGTTGAAAATCAAGATTTACCTTAA

Upstream 100 bases:

>100_bases
TTCAAAAAAAATTCATCTGAGCCGATAAGAAACCCTTTTGAAGGGAACAAGTCACCGCAACCACCACAAAAAACGCTCAG
GCGCAAAAAAAAGTAATTCC

Downstream 100 bases:

>100_bases
ACCTGTCTCTAAAATTTTTATCGAACAAAATGACACGAGACGAAAAACTTGAACTGGTAGCTAAAATTCTTGGGGCAAAA
CATCCTGCACCAAAAACAGA

Product: metallophosphoesterase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPQDETGTKNIIAIGDIHGCILSLKALIQKLDLSEKPQLVFLGDYVDRGPNSKGVIDFLIELNDSYPCVFLKGNHEVMMQ
DYLIGDCIFDNWKYNGGTETLASYQENGHLSIPSSHLKFLAQCRYTYETDDYVFVHGGLKPEFSIRENLENGSNESMVWE
RTHLSKEAISTEHPNWEKTVICGHTPQHSPLLLKRLICIDTGCVYYSTRPGFGRLTAIELPSRKITQVENQDLP

Sequences:

>Translated_234_residues
MPQDETGTKNIIAIGDIHGCILSLKALIQKLDLSEKPQLVFLGDYVDRGPNSKGVIDFLIELNDSYPCVFLKGNHEVMMQ
DYLIGDCIFDNWKYNGGTETLASYQENGHLSIPSSHLKFLAQCRYTYETDDYVFVHGGLKPEFSIRENLENGSNESMVWE
RTHLSKEAISTEHPNWEKTVICGHTPQHSPLLLKRLICIDTGCVYYSTRPGFGRLTAIELPSRKITQVENQDLP
>Mature_233_residues
PQDETGTKNIIAIGDIHGCILSLKALIQKLDLSEKPQLVFLGDYVDRGPNSKGVIDFLIELNDSYPCVFLKGNHEVMMQD
YLIGDCIFDNWKYNGGTETLASYQENGHLSIPSSHLKFLAQCRYTYETDDYVFVHGGLKPEFSIRENLENGSNESMVWER
THLSKEAISTEHPNWEKTVICGHTPQHSPLLLKRLICIDTGCVYYSTRPGFGRLTAIELPSRKITQVENQDLP

Specific function: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP [H]

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.6.1.17 [H]

Molecular weight: Translated: 26495; Mature: 26364

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQDETGTKNIIAIGDIHGCILSLKALIQKLDLSEKPQLVFLGDYVDRGPNSKGVIDFLI
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCEEEEEE
ELNDSYPCVFLKGNHEVMMQDYLIGDCIFDNWKYNGGTETLASYQENGHLSIPSSHLKFL
EECCCCCEEEEECCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHCCCCEECCHHHHHHH
AQCRYTYETDDYVFVHGGLKPEFSIRENLENGSNESMVWERTHLSKEAISTEHPNWEKTV
HHHHEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEHHHCCHHHHCCCCCCCCEEE
ICGHTPQHSPLLLKRLICIDTGCVYYSTRPGFGRLTAIELPSRKITQVENQDLP
EECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHCCCCCCC
>Mature Secondary Structure 
PQDETGTKNIIAIGDIHGCILSLKALIQKLDLSEKPQLVFLGDYVDRGPNSKGVIDFLI
CCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCEEEEEE
ELNDSYPCVFLKGNHEVMMQDYLIGDCIFDNWKYNGGTETLASYQENGHLSIPSSHLKFL
EECCCCCEEEEECCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHCCCCEECCHHHHHHH
AQCRYTYETDDYVFVHGGLKPEFSIRENLENGSNESMVWERTHLSKEAISTEHPNWEKTV
HHHHEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEHHHCCHHHHCCCCCCCCEEE
ICGHTPQHSPLLLKRLICIDTGCVYYSTRPGFGRLTAIELPSRKITQVENQDLP
EECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]