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The map label for this gene is cyaA [H]

Identifier: 193214219

GI number: 193214219

Start: 589999

End: 592359

Strand: Direct

Name: cyaA [H]

Synonym: Ctha_0500

Alternate gene names: 193214219

Gene position: 589999-592359 (Clockwise)

Preceding gene: 193214217

Following gene: 193214220

Centisome position: 17.91

GC content: 48.12

Gene sequence:

>2361_bases
ATGCCTGAAATTATGACGAAGCTTTCCAAAATACTCAAGCCGGTTAGCACATTCCTCCAAGAAAAAATCCTACGGAAGAT
TTGGTTCATTGCCATTTTTATTGCGCCGCTGCTTGTGCTCATCGCCTATGGAGCTGCCAGCATTGGCGTTTTCTCCAACA
TCGAACTAAAAATTCTCGATAATAAATTTAACGAGCGCGGCCCCGTTCCAGACCTGAACAAAAATGCCGAAGTCCTTCTT
ATCGCCATCGATGATCAAGCGCAAAACGCACTTGGACAATACCCTTGGCCTCGCGACTATTACGCGCGCATGATCCGCAA
CCTTATGCAAGCTGGCGCCAGCGTTGTTGCATTTGACTTGATTTTTTCCGATGACGCCGAAAATCCACAAGAAGATTACG
CGCTGCGCGACGCCATTCAATACTACAAACGCGTGGTGCTCGCAGGCCGAACCTCTACCTCGCTCACCGACGAAAGCTTC
TTGCAATACACCGCCGTCGATGAGCTGAACTTGCAAAACATTTTTGACGGCACGCCCGGCTCTACCACCGGCATCGTTTA
TGTGCGCAACGACGCCGACGGCGTTTATCGCCGCTATCATCCCTATAGCATGGAATTTGGCAAACAGCTGCTTTCGTTTG
CCTACGCCACGCTGCAAACCCACTTTGCAACCAACGATTCGGTCGAGCGTAAATCCAGAAATTTATTTGAATTTTCTGGC
CAAGAAATTCCGAGCTACGATGGCTACTCCGTTCTGCTGAACTACTATGGGCCGAGCAAAACTTTTCCCACTATTTCCGC
AAGCGAAATTCTCGACACGCGCGATTTTATGACCAGCGACGAAAAGATCCTTTTCCGAGAAACAATGGCCGAAACTGGCC
TGGACTCGCTCTCGCTTGCCAGAGATGAATCGCTACGGGAACTTTGGGCAATGGATATTTTCGACGATCCTCTTTCCGGG
CTGCGTTCGCGTGTGAAAGGAAAAATTTGTGTGATTGGTCCCATGTTTCCCGAATCTAAAGACCTGTTCCCCATTCCGAT
GTATCCGGGCGATCGCTCCGATGAAAACCAAATGTACGGCGTAGAAATCCACGCAACGGCCATGCAAAATTACATCGATA
AAAATTTCATCACCAAAGCCGATCCGCTTTTCCAAATCATCACGCTTCTGGCCATCAGTTATTTGATTTTTGGCGGCTCG
GTGGAGCTTAAGCGTTTTCGCATCAAAAATCCGCGAGTGCTTTTCGGCGTTTCTATTTTAGCCGCGTTCGGTGTGCTGGC
CACGGTTATGTGGATCATTTTTTTCATTGCCGGCATCGCGCAATCCGGGCCGATTGATTTTTACCTCATTCAAAACTTGC
GCATTCAGCTCACGCTTTTAAGCGTGCTGGTACTTTTGTCCGTTGCGGTGGCGTACTATTTCAAACGCGCGGGCTCATCG
TCCGAGTTTGTGACGGAAATCGGCGCGATTCTGATCACGGCCATCACATTCTTGGTTGTTTATAAATACACCAACTATAT
TTTTCTGCACGAAAGAATTTTAGTTCCTGTTATGCCTTTTGGCGCTACAATTATTCTTGCCTACGGCGCGAGCATTTTTT
ATCAATATTTCACCGAATCGCGCCAAAAAAAGTTGATTCGCGGCTTCTTTACGGTTTATGTCAACCGCGAGCTTGTCGAC
CAACTGATCGATAATCCGAACCAATTCCGACTCGGTGGTGAAAAACGAGAACTGTCTATTCTGTTTAGCGACGTGAAAGG
CTTCACGAACATTTCCGAAGCGATGGATCCTGCCGACCTCGTTATTTTGCTCAATGAATATCTTGGCGCCATGACGGACA
TCGTGTTTAAATATGGCGGCACGCTCGATAAATATATCGGCGATGCGGTCATGGCTTTTTGGGGCGCGCCTGTGCCGCAA
GAAGATCACGCCAAACGCTGCTGCTGGGCAGCGCTCGAAATGCAGGAAAAGCTTGAGGAACTTCGTGAAAAATGGAAAAG
CGAAGGAAAACCGGAGCTTTACGCCAGAATTGGCATTAACACCGGACAAGTGATCGTTGGAAATATGGGTTCGGAATCAC
GCTTTAACTATACGGTGATGGGCGATTCGGTCAACCTTGCCGCTCGACTTGAACCGGCCAATAAAGCCTTTGGCACGTCT
ATCATCGTTTCGGAATTTACAAACGAGCAGATTTACGATTTTTGCCGAACCCGAGAGCTTGCCACGATCACGGTTCAAGG
AAAAGCCAAGCCTGTGAAAATTTTTGAACTCGTTGCCAAAAAGCGCGCTGGCGTATTTTATGAGCCACTTCCGCCTGCGC
CAACTGCCGGCAAAGACATTATGGCAATTAAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTATTAAATTTAAAAAGAGTTTTTTTGACCTTCAGTTCCGTTCAAAAAGCGCTGAAAAAAGGTTCATTTAGTGCGGCTTT
GCTTTCCACAAACGTCAAAC

Downstream 100 bases:

>100_bases
TTCCGGCTCAGGCGATTTAACCAGAGAGCCCATACGCGCGGAACGAACAGAACAGGTTTCGACTTTTTAAGAGAAGCTTC
TCACTTTTTCTTAAATTTTT

Product: adenylate/guanylate cyclase with Chase sensor

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MPEIMTKLSKILKPVSTFLQEKILRKIWFIAIFIAPLLVLIAYGAASIGVFSNIELKILDNKFNERGPVPDLNKNAEVLL
IAIDDQAQNALGQYPWPRDYYARMIRNLMQAGASVVAFDLIFSDDAENPQEDYALRDAIQYYKRVVLAGRTSTSLTDESF
LQYTAVDELNLQNIFDGTPGSTTGIVYVRNDADGVYRRYHPYSMEFGKQLLSFAYATLQTHFATNDSVERKSRNLFEFSG
QEIPSYDGYSVLLNYYGPSKTFPTISASEILDTRDFMTSDEKILFRETMAETGLDSLSLARDESLRELWAMDIFDDPLSG
LRSRVKGKICVIGPMFPESKDLFPIPMYPGDRSDENQMYGVEIHATAMQNYIDKNFITKADPLFQIITLLAISYLIFGGS
VELKRFRIKNPRVLFGVSILAAFGVLATVMWIIFFIAGIAQSGPIDFYLIQNLRIQLTLLSVLVLLSVAVAYYFKRAGSS
SEFVTEIGAILITAITFLVVYKYTNYIFLHERILVPVMPFGATIILAYGASIFYQYFTESRQKKLIRGFFTVYVNRELVD
QLIDNPNQFRLGGEKRELSILFSDVKGFTNISEAMDPADLVILLNEYLGAMTDIVFKYGGTLDKYIGDAVMAFWGAPVPQ
EDHAKRCCWAALEMQEKLEELREKWKSEGKPELYARIGINTGQVIVGNMGSESRFNYTVMGDSVNLAARLEPANKAFGTS
IIVSEFTNEQIYDFCRTRELATITVQGKAKPVKIFELVAKKRAGVFYEPLPPAPTAGKDIMAIKKE

Sequences:

>Translated_786_residues
MPEIMTKLSKILKPVSTFLQEKILRKIWFIAIFIAPLLVLIAYGAASIGVFSNIELKILDNKFNERGPVPDLNKNAEVLL
IAIDDQAQNALGQYPWPRDYYARMIRNLMQAGASVVAFDLIFSDDAENPQEDYALRDAIQYYKRVVLAGRTSTSLTDESF
LQYTAVDELNLQNIFDGTPGSTTGIVYVRNDADGVYRRYHPYSMEFGKQLLSFAYATLQTHFATNDSVERKSRNLFEFSG
QEIPSYDGYSVLLNYYGPSKTFPTISASEILDTRDFMTSDEKILFRETMAETGLDSLSLARDESLRELWAMDIFDDPLSG
LRSRVKGKICVIGPMFPESKDLFPIPMYPGDRSDENQMYGVEIHATAMQNYIDKNFITKADPLFQIITLLAISYLIFGGS
VELKRFRIKNPRVLFGVSILAAFGVLATVMWIIFFIAGIAQSGPIDFYLIQNLRIQLTLLSVLVLLSVAVAYYFKRAGSS
SEFVTEIGAILITAITFLVVYKYTNYIFLHERILVPVMPFGATIILAYGASIFYQYFTESRQKKLIRGFFTVYVNRELVD
QLIDNPNQFRLGGEKRELSILFSDVKGFTNISEAMDPADLVILLNEYLGAMTDIVFKYGGTLDKYIGDAVMAFWGAPVPQ
EDHAKRCCWAALEMQEKLEELREKWKSEGKPELYARIGINTGQVIVGNMGSESRFNYTVMGDSVNLAARLEPANKAFGTS
IIVSEFTNEQIYDFCRTRELATITVQGKAKPVKIFELVAKKRAGVFYEPLPPAPTAGKDIMAIKKE
>Mature_785_residues
PEIMTKLSKILKPVSTFLQEKILRKIWFIAIFIAPLLVLIAYGAASIGVFSNIELKILDNKFNERGPVPDLNKNAEVLLI
AIDDQAQNALGQYPWPRDYYARMIRNLMQAGASVVAFDLIFSDDAENPQEDYALRDAIQYYKRVVLAGRTSTSLTDESFL
QYTAVDELNLQNIFDGTPGSTTGIVYVRNDADGVYRRYHPYSMEFGKQLLSFAYATLQTHFATNDSVERKSRNLFEFSGQ
EIPSYDGYSVLLNYYGPSKTFPTISASEILDTRDFMTSDEKILFRETMAETGLDSLSLARDESLRELWAMDIFDDPLSGL
RSRVKGKICVIGPMFPESKDLFPIPMYPGDRSDENQMYGVEIHATAMQNYIDKNFITKADPLFQIITLLAISYLIFGGSV
ELKRFRIKNPRVLFGVSILAAFGVLATVMWIIFFIAGIAQSGPIDFYLIQNLRIQLTLLSVLVLLSVAVAYYFKRAGSSS
EFVTEIGAILITAITFLVVYKYTNYIFLHERILVPVMPFGATIILAYGASIFYQYFTESRQKKLIRGFFTVYVNRELVDQ
LIDNPNQFRLGGEKRELSILFSDVKGFTNISEAMDPADLVILLNEYLGAMTDIVFKYGGTLDKYIGDAVMAFWGAPVPQE
DHAKRCCWAALEMQEKLEELREKWKSEGKPELYARIGINTGQVIVGNMGSESRFNYTVMGDSVNLAARLEPANKAFGTSI
IVSEFTNEQIYDFCRTRELATITVQGKAKPVKIFELVAKKRAGVFYEPLPPAPTAGKDIMAIKKE

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557257, Length=178, Percent_Identity=29.2134831460674, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI115387102, Length=188, Percent_Identity=26.5957446808511, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI4557255, Length=141, Percent_Identity=30.4964539007092, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI148536830, Length=134, Percent_Identity=35.0746268656716, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI24497587, Length=186, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI50959205, Length=205, Percent_Identity=29.7560975609756, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI31083193, Length=176, Percent_Identity=26.7045454545455, Blast_Score=70, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551720, Length=150, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=191, Percent_Identity=28.7958115183246, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=134, Percent_Identity=32.089552238806, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=134, Percent_Identity=32.089552238806, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=134, Percent_Identity=32.089552238806, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62484298, Length=172, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62484477, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI116008008, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24585694, Length=139, Percent_Identity=33.0935251798561, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078020, Length=247, Percent_Identity=28.3400809716599, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330470, Length=139, Percent_Identity=31.6546762589928, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24647268, Length=159, Percent_Identity=32.7044025157233, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221330468, Length=139, Percent_Identity=31.6546762589928, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 88653; Mature: 88522

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIMTKLSKILKPVSTFLQEKILRKIWFIAIFIAPLLVLIAYGAASIGVFSNIELKILD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEECCCEEEEEC
NKFNERGPVPDLNKNAEVLLIAIDDQAQNALGQYPWPRDYYARMIRNLMQAGASVVAFDL
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
IFSDDAENPQEDYALRDAIQYYKRVVLAGRTSTSLTDESFLQYTAVDELNLQNIFDGTPG
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCC
STTGIVYVRNDADGVYRRYHPYSMEFGKQLLSFAYATLQTHFATNDSVERKSRNLFEFSG
CCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCC
QEIPSYDGYSVLLNYYGPSKTFPTISASEILDTRDFMTSDEKILFRETMAETGLDSLSLA
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
RDESLRELWAMDIFDDPLSGLRSRVKGKICVIGPMFPESKDLFPIPMYPGDRSDENQMYG
HHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCCCCCCCCEEE
VEIHATAMQNYIDKNFITKADPLFQIITLLAISYLIFGGSVELKRFRIKNPRVLFGVSIL
EEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHH
AAFGVLATVMWIIFFIAGIAQSGPIDFYLIQNLRIQLTLLSVLVLLSVAVAYYFKRAGSS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SEFVTEIGAILITAITFLVVYKYTNYIFLHERILVPVMPFGATIILAYGASIFYQYFTES
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCHHHHHHHHHHHHHHHHHHH
RQKKLIRGFFTVYVNRELVDQLIDNPNQFRLGGEKRELSILFSDVKGFTNISEAMDPADL
HHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHCCHHHH
VILLNEYLGAMTDIVFKYGGTLDKYIGDAVMAFWGAPVPQEDHAKRCCWAALEMQEKLEE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LREKWKSEGKPELYARIGINTGQVIVGNMGSESRFNYTVMGDSVNLAARLEPANKAFGTS
HHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCEEEEECCCCHHCCCC
IIVSEFTNEQIYDFCRTRELATITVQGKAKPVKIFELVAKKRAGVFYEPLPPAPTAGKDI
CEEHHHCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCC
MAIKKE
EEEECC
>Mature Secondary Structure 
PEIMTKLSKILKPVSTFLQEKILRKIWFIAIFIAPLLVLIAYGAASIGVFSNIELKILD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCEECCCEEEEEC
NKFNERGPVPDLNKNAEVLLIAIDDQAQNALGQYPWPRDYYARMIRNLMQAGASVVAFDL
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEE
IFSDDAENPQEDYALRDAIQYYKRVVLAGRTSTSLTDESFLQYTAVDELNLQNIFDGTPG
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCC
STTGIVYVRNDADGVYRRYHPYSMEFGKQLLSFAYATLQTHFATNDSVERKSRNLFEFSG
CCEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCC
QEIPSYDGYSVLLNYYGPSKTFPTISASEILDTRDFMTSDEKILFRETMAETGLDSLSLA
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
RDESLRELWAMDIFDDPLSGLRSRVKGKICVIGPMFPESKDLFPIPMYPGDRSDENQMYG
HHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCEECCCCCCCCCCCCCEEE
VEIHATAMQNYIDKNFITKADPLFQIITLLAISYLIFGGSVELKRFRIKNPRVLFGVSIL
EEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHH
AAFGVLATVMWIIFFIAGIAQSGPIDFYLIQNLRIQLTLLSVLVLLSVAVAYYFKRAGSS
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SEFVTEIGAILITAITFLVVYKYTNYIFLHERILVPVMPFGATIILAYGASIFYQYFTES
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCHHHHHHHHHHHHHHHHHHH
RQKKLIRGFFTVYVNRELVDQLIDNPNQFRLGGEKRELSILFSDVKGFTNISEAMDPADL
HHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHCCHHHH
VILLNEYLGAMTDIVFKYGGTLDKYIGDAVMAFWGAPVPQEDHAKRCCWAALEMQEKLEE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LREKWKSEGKPELYARIGINTGQVIVGNMGSESRFNYTVMGDSVNLAARLEPANKAFGTS
HHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCEEEEECCCCHHCCCC
IIVSEFTNEQIYDFCRTRELATITVQGKAKPVKIFELVAKKRAGVFYEPLPPAPTAGKDI
CEEHHHCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCC
MAIKKE
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]