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The map label for this gene is pleC [H]

Identifier: 192290576

GI number: 192290576

Start: 2366308

End: 2367903

Strand: Reverse

Name: pleC [H]

Synonym: Rpal_2185

Alternate gene names: 192290576

Gene position: 2367903-2366308 (Counterclockwise)

Preceding gene: 192290577

Following gene: 192290575

Centisome position: 41.22

GC content: 66.6

Gene sequence:

>1596_bases
ATGAGTGAGTCCGCCGAAAAGCCTGAAGTCTTCCAGCTTCCGGCTGAGCCTCCGGTGGCCGCGCCGGCGCGCAACCGGCG
CGCGGCGGCACAGCGGGTGCGCGAGGCGCGCGACCGGCTGACCTCGACCAGCGGCACCCGCCCCGCTTTCGACCACGAAC
TCGTCCGGCAATATGCCGAGACCCGGCTGTCCGCCTCTTACGTCGTGATGCTGCTGGTGGTCGTCACCGGCGTGCTGTTT
GGGATCTGGATGGATCCACTGGCGGCGGGCGCCTGGACCGTGGCGATGCTCAGCATCCACGCCGTGGTGATCCGCAACTG
CAATCGCTTCCTCAAGGAGCCGGCCTCGGTGCCGCGCACCCGCACCTGGCGGCGGCGCTTTGTGCTGCTCGACCTGCTGT
ATGGGTTGGCGTGGACCGCGATCCTGATCCACCCGACCGAACTCAACGTCGTTTCCAGCACGCTTCTGATGTTCCTGATG
CTGCTGGTGGTGGCGGTGTCGTCGATGCTGGCGGCGAGCCTGCCGATCGCGGCGCTGGCCGCGACGATGCCGGTGACCGC
AGCGATCGCCGTCAACTTCGCGCTCAGCGGCTCGTTCGACAAATACGTGCTGGCGGCGCTGACCGTCGCGGCGGAAGGCT
ACTTCGCCCTGCTCGCCCACCGGCTGCACTCGACCACGCTGGCGACGCTGCAGGCCCGCGCCGAAAAGGACGTGCTGATC
GCCGAGCTCGAACAATCCAAGGCGATCTCCGACGAGGCCCGGCATCGCGCCGAGGCCGCCAACGTCGCCAAGTCGCGCTT
TCTGGCACAGATGAGCCACGAGCTGCGCACGCCGCTCAACGCCATTCTGGGCTTTTCGGAAGTGATGAAGAGCGAGATCT
TCGGCGCCCATGCGGTGCCGGCCTACAAGGACTACTCGGCCGACATCCACAATTCCGGCGTCCACCTGCTCAACCTGATC
AACGAAATCCTCGATCTGTCGCGGATCGAGGCCGGCCGCTACGAGTTGAACGAGGAAGCGATCTCGCTGGTGCATGTGGT
GACCGATTGTCATCACCTGCTGAAGCTGCGCGCGACGAGCCGTGGCATCACCATCCACGAAGTGTTCGAACAGGGCATGC
CGCGGATCTGGGGCGACGAGCGCGCGGTGCGCCAAGTGGTGCTCAACCTCTTGTCGAACGCCATCAAGTTCACGCCTCAA
GGCGGCGAGATCTGGCTGAAGGCCGGCTGGACGGCGTCCGGCGGGCAGTATCTCAGCGTCAAGGACACCGGGTCCGGGAT
CCCCGAAGAGGAGATTCCGATCGTGCTGGCCTCGTTCGGCCAGGGGTCGAATTCGATCAAGTCGGCCGAACAGGGCGCCG
GCCTCGGCCTGCCGATCGCCAAGAGCCTGATCGACATGCACGGCGGCACCTTCACCCTGAAATCCAAGCTGCGGATCGGC
ACCGAAGTGATCGTCACCTTCCCGCCCGAGCGGGTGATGTCGGCGCTGGCGCCGCTCGCCGACGAGGCGCCGCCGCTGCA
GCCGGACACGATCGACACCTCCGAGAACGCCCGCGCGCGGCGGCAGCCGATCATGAACGCCGGCACCGGCTTGTGA

Upstream 100 bases:

>100_bases
AACCGGAATAACTTTCCCTCTAAGGCTGCTCTTAAGGATTTGTGGCCAGATATAGGCTGGGGAAACCGCGCGCATTCTCG
CGCAGGATTTGTGTTGGTTG

Downstream 100 bases:

>100_bases
GATCGGGACTTGCGGGAGGCGACCAATGTCAGCCACCATCCGATATGAGCATCGAAACGCCCTGCATCGCAGTCTGCATG
ATCAATCCGCAGACCAACCT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSESAEKPEVFQLPAEPPVAAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQYAETRLSASYVVMLLVVVTGVLF
GIWMDPLAAGAWTVAMLSIHAVVIRNCNRFLKEPASVPRTRTWRRRFVLLDLLYGLAWTAILIHPTELNVVSSTLLMFLM
LLVVAVSSMLAASLPIAALAATMPVTAAIAVNFALSGSFDKYVLAALTVAAEGYFALLAHRLHSTTLATLQARAEKDVLI
AELEQSKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPAYKDYSADIHNSGVHLLNLI
NEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRATSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNAIKFTPQ
GGEIWLKAGWTASGGQYLSVKDTGSGIPEEEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKSLIDMHGGTFTLKSKLRIG
TEVIVTFPPERVMSALAPLADEAPPLQPDTIDTSENARARRQPIMNAGTGL

Sequences:

>Translated_531_residues
MSESAEKPEVFQLPAEPPVAAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQYAETRLSASYVVMLLVVVTGVLF
GIWMDPLAAGAWTVAMLSIHAVVIRNCNRFLKEPASVPRTRTWRRRFVLLDLLYGLAWTAILIHPTELNVVSSTLLMFLM
LLVVAVSSMLAASLPIAALAATMPVTAAIAVNFALSGSFDKYVLAALTVAAEGYFALLAHRLHSTTLATLQARAEKDVLI
AELEQSKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPAYKDYSADIHNSGVHLLNLI
NEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRATSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNAIKFTPQ
GGEIWLKAGWTASGGQYLSVKDTGSGIPEEEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKSLIDMHGGTFTLKSKLRIG
TEVIVTFPPERVMSALAPLADEAPPLQPDTIDTSENARARRQPIMNAGTGL
>Mature_530_residues
SESAEKPEVFQLPAEPPVAAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQYAETRLSASYVVMLLVVVTGVLFG
IWMDPLAAGAWTVAMLSIHAVVIRNCNRFLKEPASVPRTRTWRRRFVLLDLLYGLAWTAILIHPTELNVVSSTLLMFLML
LVVAVSSMLAASLPIAALAATMPVTAAIAVNFALSGSFDKYVLAALTVAAEGYFALLAHRLHSTTLATLQARAEKDVLIA
ELEQSKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPAYKDYSADIHNSGVHLLNLIN
EILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRATSRGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNAIKFTPQG
GEIWLKAGWTASGGQYLSVKDTGSGIPEEEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKSLIDMHGGTFTLKSKLRIGT
EVIVTFPPERVMSALAPLADEAPPLQPDTIDTSENARARRQPIMNAGTGL

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=256, Percent_Identity=32.421875, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=35.9375, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=35.8778625954198, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI48994928, Length=247, Percent_Identity=28.7449392712551, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=33.6065573770492, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=29.2181069958848, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082128, Length=213, Percent_Identity=30.9859154929577, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=335, Percent_Identity=23.2835820895522, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=27.4678111587983, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=24.1525423728814, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=25.3012048192771, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=26.4423076923077, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=251, Percent_Identity=24.7011952191235, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=22.0338983050847, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57690; Mature: 57559

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS50109 HIS_KIN ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESAEKPEVFQLPAEPPVAAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQYAE
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TRLSASYVVMLLVVVTGVLFGIWMDPLAAGAWTVAMLSIHAVVIRNCNRFLKEPASVPRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RTWRRRFVLLDLLYGLAWTAILIHPTELNVVSSTLLMFLMLLVVAVSSMLAASLPIAALA
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATMPVTAAIAVNFALSGSFDKYVLAALTVAAEGYFALLAHRLHSTTLATLQARAEKDVLI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AELEQSKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AYKDYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRATS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNAIKFTPQGGEIWLKAGWTASGGQYLSV
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEE
KDTGSGIPEEEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKSLIDMHGGTFTLKSKLRIG
ECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHCCC
TEVIVTFPPERVMSALAPLADEAPPLQPDTIDTSENARARRQPIMNAGTGL
CEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SESAEKPEVFQLPAEPPVAAPARNRRAAAQRVREARDRLTSTSGTRPAFDHELVRQYAE
CCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TRLSASYVVMLLVVVTGVLFGIWMDPLAAGAWTVAMLSIHAVVIRNCNRFLKEPASVPRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RTWRRRFVLLDLLYGLAWTAILIHPTELNVVSSTLLMFLMLLVVAVSSMLAASLPIAALA
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ATMPVTAAIAVNFALSGSFDKYVLAALTVAAEGYFALLAHRLHSTTLATLQARAEKDVLI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AELEQSKAISDEARHRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AYKDYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAISLVHVVTDCHHLLKLRATS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGITIHEVFEQGMPRIWGDERAVRQVVLNLLSNAIKFTPQGGEIWLKAGWTASGGQYLSV
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEE
KDTGSGIPEEEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKSLIDMHGGTFTLKSKLRIG
ECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHCCC
TEVIVTFPPERVMSALAPLADEAPPLQPDTIDTSENARARRQPIMNAGTGL
CEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]