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The map label for this gene is mutA [H]

Identifier: 192290434

GI number: 192290434

Start: 2211966

End: 2213837

Strand: Reverse

Name: mutA [H]

Synonym: Rpal_2041

Alternate gene names: 192290434

Gene position: 2213837-2211966 (Counterclockwise)

Preceding gene: 192290435

Following gene: 192290433

Centisome position: 38.54

GC content: 70.03

Gene sequence:

>1872_bases
ATGTCTTCTGCAAACCAAGAGCTGCGGCTCGCCGCCGATTTCGCCCCGGCCGGCTATGAGGACTGGCGCAAGCTGGTCGA
CGGCGTGCTGAAGGGCGCACCGTTCGAGAAGCTGATCAGCAAGAGCTACGACGGCATCCAGATCGATCCGATCTACGTGC
GGGCGCGCGACGCCGCACCGATCGCCGGCCGTGCTCCCGCGGCGCCATGGCGGATCATGCAGCGGGTCGATCACCCCGAG
CCAAAGGAAGCCAACAAGCAGGCCCTGCAGGACCTCGAAAACGGCGCCACCGGCCTGACGCTGGTGTTCGCAGGCAGCGT
CGGCGCGCGCGGCTTCGGTCTGCCCGCCACGCAGGAAGCCATCGCGCAGGTGCTGGAGGGTGTCCACCTCGACGCCGGCA
TCGCAATCGAACTGCAGTTCCCGCCGCAGTCCTGTGACGTGGTCCGCCACCTCGCCGACCTGATCAAGAGCCGCGGCACC
GACCCGGCAGCCTGCGATATCCGCTTCGGCATCGATCCGCTCGGCGCGCGCGCTGTGCAAGGATCGAGCGCCACCGACTG
GAGCGAGATCGCCAAGGGCCTCGGCGACGTCGCCGCCGGCCTCGCCAGCACCGGGTTCAAGGGCCCGTTCCTGGTCGCCG
ACGGCCGCGTGATCCACGATGCTGGCGGTTCGGAGGCCCAGGAGCTGGCTTACGTGCTCGGCTGCAGCGTCGCCTATCTG
CGGGCGCTGGAGGCCGCCGGCGTGTCTCCCGAAGCCGCCCGCGGCATGATCTACGCGCGGCTGTCGGCGGACGCCGATCA
ATTCCTCACCCTGTCGAAGTTCCGCGCGCTGCGTCTCTTGTGGGCGCGGATCGAGCAAGCCTGCGGCGTGACGCCGAAGC
CGCTCTTCGTCGCCGCCGAGACCGCGTGGCGGATGCTGACCCAGCGCGACCCTTACGTGAACATGCTGCGCGCCACGATG
GCGACGTTCGCCGCCGCACTCGGCGGGGCTAACTCGGTGCAGGTGCTGCCGCACACGCTGGCGCTCGGCCTGCCAGATAG
CTTCGCGCGACGCGTCGCTCGCAACACGCAGTTGATCCTGCTGGAAGAGTCCAACCTCGACAAGGTCGCCGATCCGGCTG
CCGGTGCCGGCGGCATCGAAGCGCTGACCAAGGAGCTGTGCGACGCCGCCTGGTCCCAGTTCCAGGAGATCGAGCGCGCC
GGCGGCGCGCTCGCCGCGCTGCAGGCCGGGCTGATCCAGCCGAAGGTTGCGGCGAGCCGCGCCGCTCGCGACAAGGCGAT
AGCCAAACGCCGCGACGTTCTGACCGGCGCCTCCGAGTTCCCGAACCTGCACGAGGCACAGGCCAAGGTGCTCGACGTCA
AGCCAGCCGCGGTACCGCCCGCCGGTGAGGCGAAGATCAGCTTCACGGCGCTGACGCCGATCCGCGTTGCGACGCCGTTC
GAGACCCTGCGCGACAAGTCCGATGCGGTGCTCGCCGCCAAGGCGTCGCGGCCCAAGGTGTTCCTCGCCAATCTCGGCAC
GCCGGCCGACTTCACCGCGCGCGCCACTTTCGCCAAGAGCTTCTTCGAGACCGGCGGCATCGAGGCGATCGACAGCGAAG
GCTTCACCGATGCGGCTGCGCTCGCCGACGCCTTCAAGGCGTCCGGTGCGGCGTTCGCGTGCCTGTGCTCGTCCGACAAG
GCCTACCCGGCCTATGCGGCCCCGGCCGCCCAGGCGCTGCGCGCCGCGGGCGCAAAGCGGATCTATCTGGCCGGCCGCCC
CGGCGAGCAGGAGAGCGCGCTGCGCGAAGCCGGTGTGCAGGAGTTCGTGTTCGCCGGCGGCGACGCGCTGGCGACGCTCA
GTGACGCCTGGAAGGGCATCGAAGCGGCATGA

Upstream 100 bases:

>100_bases
CTCGTCCTTATTGCCTCAAACAACTGTTTGGCATCGCCGTCCGCACGTGGCATTTTCCGGCCAAATCACGTTCCGGTATT
CTGGGAGTTCGATTTCACCG

Downstream 100 bases:

>100_bases
CGGGGACCGGCAAAGCGGTGCTCTCCGGCGGCTGCCAGTGCGGCGCGATCCGCTACGCGCTGTCGGCGCCGCCGCTGAGC
ACGGCGCTGTGCCATTGCCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MSSANQELRLAADFAPAGYEDWRKLVDGVLKGAPFEKLISKSYDGIQIDPIYVRARDAAPIAGRAPAAPWRIMQRVDHPE
PKEANKQALQDLENGATGLTLVFAGSVGARGFGLPATQEAIAQVLEGVHLDAGIAIELQFPPQSCDVVRHLADLIKSRGT
DPAACDIRFGIDPLGARAVQGSSATDWSEIAKGLGDVAAGLASTGFKGPFLVADGRVIHDAGGSEAQELAYVLGCSVAYL
RALEAAGVSPEAARGMIYARLSADADQFLTLSKFRALRLLWARIEQACGVTPKPLFVAAETAWRMLTQRDPYVNMLRATM
ATFAAALGGANSVQVLPHTLALGLPDSFARRVARNTQLILLEESNLDKVADPAAGAGGIEALTKELCDAAWSQFQEIERA
GGALAALQAGLIQPKVAASRAARDKAIAKRRDVLTGASEFPNLHEAQAKVLDVKPAAVPPAGEAKISFTALTPIRVATPF
ETLRDKSDAVLAAKASRPKVFLANLGTPADFTARATFAKSFFETGGIEAIDSEGFTDAAALADAFKASGAAFACLCSSDK
AYPAYAAPAAQALRAAGAKRIYLAGRPGEQESALREAGVQEFVFAGGDALATLSDAWKGIEAA

Sequences:

>Translated_623_residues
MSSANQELRLAADFAPAGYEDWRKLVDGVLKGAPFEKLISKSYDGIQIDPIYVRARDAAPIAGRAPAAPWRIMQRVDHPE
PKEANKQALQDLENGATGLTLVFAGSVGARGFGLPATQEAIAQVLEGVHLDAGIAIELQFPPQSCDVVRHLADLIKSRGT
DPAACDIRFGIDPLGARAVQGSSATDWSEIAKGLGDVAAGLASTGFKGPFLVADGRVIHDAGGSEAQELAYVLGCSVAYL
RALEAAGVSPEAARGMIYARLSADADQFLTLSKFRALRLLWARIEQACGVTPKPLFVAAETAWRMLTQRDPYVNMLRATM
ATFAAALGGANSVQVLPHTLALGLPDSFARRVARNTQLILLEESNLDKVADPAAGAGGIEALTKELCDAAWSQFQEIERA
GGALAALQAGLIQPKVAASRAARDKAIAKRRDVLTGASEFPNLHEAQAKVLDVKPAAVPPAGEAKISFTALTPIRVATPF
ETLRDKSDAVLAAKASRPKVFLANLGTPADFTARATFAKSFFETGGIEAIDSEGFTDAAALADAFKASGAAFACLCSSDK
AYPAYAAPAAQALRAAGAKRIYLAGRPGEQESALREAGVQEFVFAGGDALATLSDAWKGIEAA
>Mature_622_residues
SSANQELRLAADFAPAGYEDWRKLVDGVLKGAPFEKLISKSYDGIQIDPIYVRARDAAPIAGRAPAAPWRIMQRVDHPEP
KEANKQALQDLENGATGLTLVFAGSVGARGFGLPATQEAIAQVLEGVHLDAGIAIELQFPPQSCDVVRHLADLIKSRGTD
PAACDIRFGIDPLGARAVQGSSATDWSEIAKGLGDVAAGLASTGFKGPFLVADGRVIHDAGGSEAQELAYVLGCSVAYLR
ALEAAGVSPEAARGMIYARLSADADQFLTLSKFRALRLLWARIEQACGVTPKPLFVAAETAWRMLTQRDPYVNMLRATMA
TFAAALGGANSVQVLPHTLALGLPDSFARRVARNTQLILLEESNLDKVADPAAGAGGIEALTKELCDAAWSQFQEIERAG
GALAALQAGLIQPKVAASRAARDKAIAKRRDVLTGASEFPNLHEAQAKVLDVKPAAVPPAGEAKISFTALTPIRVATPFE
TLRDKSDAVLAAKASRPKVFLANLGTPADFTARATFAKSFFETGGIEAIDSEGFTDAAALADAFKASGAAFACLCSSDKA
YPAYAAPAAQALRAAGAKRIYLAGRPGEQESALREAGVQEFVFAGGDALATLSDAWKGIEAA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=478, Percent_Identity=26.1506276150628, Blast_Score=127, Evalue=4e-29,
Organism=Escherichia coli, GI1789284, Length=478, Percent_Identity=25.5230125523013, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25144500, Length=489, Percent_Identity=24.3353783231084, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65277; Mature: 65145

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSANQELRLAADFAPAGYEDWRKLVDGVLKGAPFEKLISKSYDGIQIDPIYVRARDAAP
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECEEEEEECCCCC
IAGRAPAAPWRIMQRVDHPEPKEANKQALQDLENGATGLTLVFAGSVGARGFGLPATQEA
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHH
IAQVLEGVHLDAGIAIELQFPPQSCDVVRHLADLIKSRGTDPAACDIRFGIDPLGARAVQ
HHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHCC
GSSATDWSEIAKGLGDVAAGLASTGFKGPFLVADGRVIHDAGGSEAQELAYVLGCSVAYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHHH
RALEAAGVSPEAARGMIYARLSADADQFLTLSKFRALRLLWARIEQACGVTPKPLFVAAE
HHHHHCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TAWRMLTQRDPYVNMLRATMATFAAALGGANSVQVLPHTLALGLPDSFARRVARNTQLIL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCCCHHHHHHHHCCCEEEE
LEESNLDKVADPAAGAGGIEALTKELCDAAWSQFQEIERAGGALAALQAGLIQPKVAASR
EECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHH
AARDKAIAKRRDVLTGASEFPNLHEAQAKVLDVKPAAVPPAGEAKISFTALTPIRVATPF
HHHHHHHHHHHHHHCCHHHCCCHHHHHHHEEECCCCCCCCCCCCEEEEEEECCEEECCCH
ETLRDKSDAVLAAKASRPKVFLANLGTPADFTARATFAKSFFETGGIEAIDSEGFTDAAA
HHHCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHH
LADAFKASGAAFACLCSSDKAYPAYAAPAAQALRAAGAKRIYLAGRPGEQESALREAGVQ
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHH
EFVFAGGDALATLSDAWKGIEAA
HHHHCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSANQELRLAADFAPAGYEDWRKLVDGVLKGAPFEKLISKSYDGIQIDPIYVRARDAAP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECEEEEEECCCCC
IAGRAPAAPWRIMQRVDHPEPKEANKQALQDLENGATGLTLVFAGSVGARGFGLPATQEA
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHH
IAQVLEGVHLDAGIAIELQFPPQSCDVVRHLADLIKSRGTDPAACDIRFGIDPLGARAVQ
HHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHCC
GSSATDWSEIAKGLGDVAAGLASTGFKGPFLVADGRVIHDAGGSEAQELAYVLGCSVAYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHHHHH
RALEAAGVSPEAARGMIYARLSADADQFLTLSKFRALRLLWARIEQACGVTPKPLFVAAE
HHHHHCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TAWRMLTQRDPYVNMLRATMATFAAALGGANSVQVLPHTLALGLPDSFARRVARNTQLIL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHCCCHHHHHHHHCCCEEEE
LEESNLDKVADPAAGAGGIEALTKELCDAAWSQFQEIERAGGALAALQAGLIQPKVAASR
EECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHH
AARDKAIAKRRDVLTGASEFPNLHEAQAKVLDVKPAAVPPAGEAKISFTALTPIRVATPF
HHHHHHHHHHHHHHCCHHHCCCHHHHHHHEEECCCCCCCCCCCCEEEEEEECCEEECCCH
ETLRDKSDAVLAAKASRPKVFLANLGTPADFTARATFAKSFFETGGIEAIDSEGFTDAAA
HHHCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHH
LADAFKASGAAFACLCSSDKAYPAYAAPAAQALRAAGAKRIYLAGRPGEQESALREAGVQ
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHH
EFVFAGGDALATLSDAWKGIEAA
HHHHCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]