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The map label for this gene is folK [H]

Identifier: 192290435

GI number: 192290435

Start: 2213995

End: 2214486

Strand: Reverse

Name: folK [H]

Synonym: Rpal_2042

Alternate gene names: 192290435

Gene position: 2214486-2213995 (Counterclockwise)

Preceding gene: 192290436

Following gene: 192290434

Centisome position: 38.55

GC content: 68.29

Gene sequence:

>492_bases
ATGCCGCGCGCCCTGATCGCGCTCGGCGGCAATGTCGGCGACGTCCGCGCCACCTTCGACAAGGCGATCGCCAACATCTG
TGGCATGACCCAAGCCGAACTAATCGCGCGCTCCCCGGACTACGCCACGCCGCCGTGGGGCGATGAACAGCAGGACCGCT
TCGTCAATGCCTGCGTGGCGATCGAAACCGCGCTCGATCCGCACGCGCTGTTGTTCACGCTGCACAAAATCGAGAAGCGC
TTCGGCCGCGACCGCGCCAACGAACGGCGCTGGGGACCGCGCACGCTCGACCTCGACCTGATCGCCTACGACGACGCGGT
AATCAATCGGCCGGACCTGACGCTGCCGCATCCGCGGCTGTTCGAGCGCGCCTTCGTGCTGGTGCCGCTGCTCGACGTCG
TGCCGGATCCGGTGATCGCCGGCCGCTCGCTGAAAGACGCCCTCGCCGGGCTGTCGACCGCCGGGATCGAACGGCTGCCA
GACCGCGACTGA

Upstream 100 bases:

>100_bases
AAGATCACCGCGGTGAAGGTGACGGTGCACAAGCCGCACGCGCCGATCCCGGCGATCTTCGAGGACGTCGGCGTGATCAT
CACCCGCAGGCGGAGCTGAG

Downstream 100 bases:

>100_bases
GCCGCCGCTTCTGGGAATATCCCGCAACACGGTCCGCCGCAGTGCACAGGGCCCAATCTCGTCCTTATTGCCTCAAACAA
CTGTTTGGCATCGCCGTCCG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MPRALIALGGNVGDVRATFDKAIANICGMTQAELIARSPDYATPPWGDEQQDRFVNACVAIETALDPHALLFTLHKIEKR
FGRDRANERRWGPRTLDLDLIAYDDAVINRPDLTLPHPRLFERAFVLVPLLDVVPDPVIAGRSLKDALAGLSTAGIERLP
DRD

Sequences:

>Translated_163_residues
MPRALIALGGNVGDVRATFDKAIANICGMTQAELIARSPDYATPPWGDEQQDRFVNACVAIETALDPHALLFTLHKIEKR
FGRDRANERRWGPRTLDLDLIAYDDAVINRPDLTLPHPRLFERAFVLVPLLDVVPDPVIAGRSLKDALAGLSTAGIERLP
DRD
>Mature_162_residues
PRALIALGGNVGDVRATFDKAIANICGMTQAELIARSPDYATPPWGDEQQDRFVNACVAIETALDPHALLFTLHKIEKRF
GRDRANERRWGPRTLDLDLIAYDDAVINRPDLTLPHPRLFERAFVLVPLLDVVPDPVIAGRSLKDALAGLSTAGIERLPD
RD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=149, Percent_Identity=38.255033557047, Blast_Score=100, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=137, Percent_Identity=35.7664233576642, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18018; Mature: 17887

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRALIALGGNVGDVRATFDKAIANICGMTQAELIARSPDYATPPWGDEQQDRFVNACVA
CCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IETALDPHALLFTLHKIEKRFGRDRANERRWGPRTLDLDLIAYDDAVINRPDLTLPHPRL
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHCCCCCCCCCCHHH
FERAFVLVPLLDVVPDPVIAGRSLKDALAGLSTAGIERLPDRD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PRALIALGGNVGDVRATFDKAIANICGMTQAELIARSPDYATPPWGDEQQDRFVNACVA
CCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IETALDPHALLFTLHKIEKRFGRDRANERRWGPRTLDLDLIAYDDAVINRPDLTLPHPRL
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHCCCCCCCCCCHHH
FERAFVLVPLLDVVPDPVIAGRSLKDALAGLSTAGIERLPDRD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]