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The map label for this gene is gyaR [H]

Identifier: 192290337

GI number: 192290337

Start: 2097266

End: 2098180

Strand: Reverse

Name: gyaR [H]

Synonym: Rpal_1944

Alternate gene names: 192290337

Gene position: 2098180-2097266 (Counterclockwise)

Preceding gene: 192290338

Following gene: 192290336

Centisome position: 36.53

GC content: 67.76

Gene sequence:

>915_bases
ATGCACGCGGTGTTCGTCGACGCCAGCGATACGCTCGCCGAGCTGATGGAGCGCATGGCGACGCCGGGCGATCCACCCGT
GAAGATCCACTGCGACCCGGACGTGACGCCGGAGCAGTTGCCCGAGGTGCAGGCCGGCGCCGCGATCGCGCTGATCGACC
ACACCTACCTGCCGACCGAGGTCGCCCGGCGCTGCATCGGGCTGAAGCACGTCGTGTTCCTCGGAACCGGCGCCCGGAGC
TACATGAACATCGAAGAGCTCGCTGAGCTCGGCATCGAGGTTCACCTGATCCGCGGCTACGGCGACACCGCGGTCGCAGA
AGCAACCATCGCGCTGATGTGGGCCGCGTCCCGCAACCTTGCGATCATGGATCGCGAGATGCGGCACGGCCAATGGCTGC
GTGAAGACGGCATGCAGCTCACCGGCAAGACGCTCGGCCTGATCGGCTTCGGCGGCATTGGCGCAGAAGTCGCGCGGATC
GCTCACGGCTCGGGCATGAAGGTGATCGCCTGGAACAGGAGTACGAAGCAGATCGACGGCGTCCGCTTCGTCGATCTCGA
CACTCTGCTGCGCGACAGCCACGTCGTCTCGATGCATCTCTTGCTCAACGACGAGACCCGCGGGTTCTTGTCGCGCCAGC
GGATCGCCGCGATGCGGCCGGGCGCCATCCTGGTCAACACTGCGCGCGGCGCCCTCGTCGATGAGGCCGCGATGATCGAC
GCGCTGCGTTCGGGTCACCTCCGCCATGCCGCGCTCGACGTGTTCGACATCGAGCCGCTGCCCGCCGGCCATCCCCTCAC
GGTGCTACCCAACGTGACGCTCTCGGCGCATTCGGCCTTCCGCACCCCGGAGGCGAGCGAGAACCTGATCGCAGCCGCGC
GCGCCCATTGCCGGCGGATCGCAGCCGCGAGCTAA

Upstream 100 bases:

>100_bases
GACTGCGCCGCCGGTGCCAACGTGCTGCTGCACACCGTGCTGTCACTCGCCGGCGTCGCCAAGTAATCGCCGACAAACCA
GCCGATAGGGGGAGATCACG

Downstream 100 bases:

>100_bases
GCCCCACAACGGCAATTAGTTACCGCAAGATCCCAGGTCGCCAGCCTGCCTCCGCCACACAGGTGTCGCGGCCTGATCCG
AATCAACGGCACGCAAACTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHAVFVDASDTLAELMERMATPGDPPVKIHCDPDVTPEQLPEVQAGAAIALIDHTYLPTEVARRCIGLKHVVFLGTGARS
YMNIEELAELGIEVHLIRGYGDTAVAEATIALMWAASRNLAIMDREMRHGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRSTKQIDGVRFVDLDTLLRDSHVVSMHLLLNDETRGFLSRQRIAAMRPGAILVNTARGALVDEAAMID
ALRSGHLRHAALDVFDIEPLPAGHPLTVLPNVTLSAHSAFRTPEASENLIAAARAHCRRIAAAS

Sequences:

>Translated_304_residues
MHAVFVDASDTLAELMERMATPGDPPVKIHCDPDVTPEQLPEVQAGAAIALIDHTYLPTEVARRCIGLKHVVFLGTGARS
YMNIEELAELGIEVHLIRGYGDTAVAEATIALMWAASRNLAIMDREMRHGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRSTKQIDGVRFVDLDTLLRDSHVVSMHLLLNDETRGFLSRQRIAAMRPGAILVNTARGALVDEAAMID
ALRSGHLRHAALDVFDIEPLPAGHPLTVLPNVTLSAHSAFRTPEASENLIAAARAHCRRIAAAS
>Mature_304_residues
MHAVFVDASDTLAELMERMATPGDPPVKIHCDPDVTPEQLPEVQAGAAIALIDHTYLPTEVARRCIGLKHVVFLGTGARS
YMNIEELAELGIEVHLIRGYGDTAVAEATIALMWAASRNLAIMDREMRHGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRSTKQIDGVRFVDLDTLLRDSHVVSMHLLLNDETRGFLSRQRIAAMRPGAILVNTARGALVDEAAMID
ALRSGHLRHAALDVFDIEPLPAGHPLTVLPNVTLSAHSAFRTPEASENLIAAARAHCRRIAAAS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=287, Percent_Identity=34.1463414634146, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4557499, Length=287, Percent_Identity=34.1463414634146, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI145580575, Length=287, Percent_Identity=34.1463414634146, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI61743967, Length=287, Percent_Identity=31.7073170731707, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=287, Percent_Identity=31.7073170731707, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI23308577, Length=254, Percent_Identity=31.1023622047244, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI6912396, Length=234, Percent_Identity=27.3504273504274, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI87082289, Length=199, Percent_Identity=34.1708542713568, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=31.2757201646091, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=32.183908045977, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87081824, Length=140, Percent_Identity=35, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=187, Percent_Identity=29.9465240641711, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25147481, Length=291, Percent_Identity=27.8350515463918, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=196, Percent_Identity=33.6734693877551, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=214, Percent_Identity=32.2429906542056, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=26.2172284644195, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=159, Percent_Identity=28.9308176100629, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=127, Percent_Identity=33.8582677165354, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=33.6842105263158, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=33.6842105263158, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=33.6842105263158, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=33.6842105263158, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=285, Percent_Identity=33.6842105263158, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI28574286, Length=266, Percent_Identity=29.3233082706767, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585516, Length=211, Percent_Identity=32.2274881516588, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28571528, Length=220, Percent_Identity=33.6363636363636, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45552429, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24585514, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574282, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45551003, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19921140, Length=195, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574284, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32871; Mature: 32871

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVFVDASDTLAELMERMATPGDPPVKIHCDPDVTPEQLPEVQAGAAIALIDHTYLPTE
CEEEEECCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCCEEEEEEECCCCCHH
VARRCIGLKHVVFLGTGARSYMNIEELAELGIEVHLIRGYGDTAVAEATIALMWAASRNL
HHHHHHCCEEEEEEECCCHHHCCHHHHHHCCCEEEEEECCCCHHHHHHHEEEEEECCCCE
AIMDREMRHGQWLREDGMQLTGKTLGLIGFGGIGAEVARIAHGSGMKVIAWNRSTKQIDG
EEEEHHHHCCCHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
VRFVDLDTLLRDSHVVSMHLLLNDETRGFLSRQRIAAMRPGAILVNTARGALVDEAAMID
EEEEEHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
ALRSGHLRHAALDVFDIEPLPAGHPLTVLPNVTLSAHSAFRTPEASENLIAAARAHCRRI
HHHCCCCCEEEEEEEECCCCCCCCCEEEECCCEEECCHHCCCCCCCHHHHHHHHHHHHHH
AAAS
HCCC
>Mature Secondary Structure
MHAVFVDASDTLAELMERMATPGDPPVKIHCDPDVTPEQLPEVQAGAAIALIDHTYLPTE
CEEEEECCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCCEEEEEEECCCCCHH
VARRCIGLKHVVFLGTGARSYMNIEELAELGIEVHLIRGYGDTAVAEATIALMWAASRNL
HHHHHHCCEEEEEEECCCHHHCCHHHHHHCCCEEEEEECCCCHHHHHHHEEEEEECCCCE
AIMDREMRHGQWLREDGMQLTGKTLGLIGFGGIGAEVARIAHGSGMKVIAWNRSTKQIDG
EEEEHHHHCCCHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
VRFVDLDTLLRDSHVVSMHLLLNDETRGFLSRQRIAAMRPGAILVNTARGALVDEAAMID
EEEEEHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
ALRSGHLRHAALDVFDIEPLPAGHPLTVLPNVTLSAHSAFRTPEASENLIAAARAHCRRI
HHHCCCCCEEEEEEEECCCCCCCCCEEEECCCEEECCHHCCCCCCCHHHHHHHHHHHHHH
AAAS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]