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The map label for this gene is groEL [H]

Identifier: 192289741

GI number: 192289741

Start: 1403319

End: 1404962

Strand: Reverse

Name: groEL [H]

Synonym: Rpal_1331

Alternate gene names: 192289741

Gene position: 1404962-1403319 (Counterclockwise)

Preceding gene: 192289742

Following gene: 192289740

Centisome position: 24.46

GC content: 65.82

Gene sequence:

>1644_bases
ATGGCTGCTAAAGACGTCAAGTTTGCCGGCGATGCCCGCGACCGCATGCTGCGCGGCGTGGACGTGCTCGCCAACGCCGT
GAAGGTCACGCTCGGTCCGAAGGGCCGGAACGTGCTGATCGAGAAGAGCTTCGGTGCCCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAAGTGGAGCTCGAGGACAAGTTCGAGAACATGGGCGCGCAGATGGTGCGCGAGGTGGCCTCGAAG
ACCAACGACCTCGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCGATCGTCCGTGAGGGCGCCAAGGCCGT
CGCGGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGAGATCGCGGTCGCGGCCGTGGTCAAGGACATCCAGAAGC
GCGCCAAGCCGGTCGCCTCCTCGGCTGAAATCGCCCAGGTCGGCACCATCTCGGCCAACGGCGACGCGCCGATCGGCAAG
ATGATCGCCCAGGCGATGCAGAAGGTCGGCAACGAGGGTGTCATCACGGTCGAAGAGAACAAGTCGCTCGAGACCGAAGT
CGACATCGTCGAAGGCATGAAGTTCGACCGCGGCTATCTGTCGCCGTACTTCGTGACCAACGCCGAAAAGATGACCGTCG
AACTCGACGACGCCTACATCCTGCTGCACGAGAAGAAGCTCTCGGGCCTGCAGTCGATGCTGCCGGTGCTCGAAGCGGTG
GTGCAGTCGGGCAAGCCGCTGCTGATCATCGCCGAGGACGTCGAAGGCGAAGCGCTCGCGACCCTCGTGGTCAACCGCCT
GCGCGGCGGCCTCAAGGTTTCGGCCGTGAAGGCGCCGGGCTTCGGCGATCGCCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACCGGCGGCCAGCTGATCTCGGAAGACCTCGGCATCAAGCTCGAGACCGTGACGCTGAAGATGCTCGGCCGCGCC
AAGAAGGTGGTGATCGACAAGGAGAACACCACCATCGTCAACGGCGCCGGCAAGAAGCCGGAGATCGAGGCCCGCGTTTC
GCAGATCAAGGCGCAGATCGAGGAAACCTCCTCGGACTACGACCGTGAGAAGCTGCAGGAGCGTCTGGCCAAGCTCGCGG
GCGGCGTCGCGGTGATCCGCGTCGGCGGCGCGACCGAAGTCGAGGTCAAGGAGAAGAAGGACCGTGTCGAGGACGCGCTG
AACGCGACCCGCGCTGCGGTTCAGGAAGGCATCGTGCCGGGCGGCGGCGTCGCCCTGCTGCGCGCCAAGAAGGCCGTCGG
CCGCATCAGCAACGACAATCCGGACGTCCAGGCCGGCATCAACATCGTGCTGAAGGCGCTCGAAGCTCCGATCCGCCAGA
TCGCCGAGAACGCCGGTGTCGAAGGCTCGATCGTGGTCGGCAAGATCCTCGAGAACAAGACCGAGACGTTCGGCTTCGAC
GCCCAGACCGAGGAATATGTCGACATGCTCGCCAAGGGTATCGTCGATCCGGCCAAGGTCGTGCGCACCGCGCTGCAGGA
CGCCTCGTCGGTCGCCTCGCTGCTGGTCACCACCGAAGCGATGGTCGCCGAGCTGCCGAAGGCCGACGCTCCGGCAATGC
CGGCCGGTGGTGGCATGGGCGGTATGGGCGGCATGGGCTTCTAA

Upstream 100 bases:

>100_bases
GCTGGACGGCGAAGAACTCCTGATCATGAAGGAGTCGGACATCATGGGCGTGGTCGGCTGAGCCGCATCGCGACAGTATC
GAGATATCAGGAGCGAATGA

Downstream 100 bases:

>100_bases
GCCCACCCCTCTCGCACTGAAGATCGATCATGCAAGGCCGCCTCCGGGCGGCCTTGCTTTTTGGCGCCGCACCTCGCGCG
CCTTGGTTCGGATGCAATTC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFAGDARDRMLRGVDVLANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEVELEDKFENMGAQMVREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIEIAVAAVVKDIQKRAKPVASSAEIAQVGTISANGDAPIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDAYILLHEKKLSGLQSMLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEDLGIKLETVTLKMLGRA
KKVVIDKENTTIVNGAGKKPEIEARVSQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRISNDNPDVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKTETFGFD
AQTEEYVDMLAKGIVDPAKVVRTALQDASSVASLLVTTEAMVAELPKADAPAMPAGGGMGGMGGMGF

Sequences:

>Translated_547_residues
MAAKDVKFAGDARDRMLRGVDVLANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEVELEDKFENMGAQMVREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIEIAVAAVVKDIQKRAKPVASSAEIAQVGTISANGDAPIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDAYILLHEKKLSGLQSMLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEDLGIKLETVTLKMLGRA
KKVVIDKENTTIVNGAGKKPEIEARVSQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRISNDNPDVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKTETFGFD
AQTEEYVDMLAKGIVDPAKVVRTALQDASSVASLLVTTEAMVAELPKADAPAMPAGGGMGGMGGMGF
>Mature_546_residues
AAKDVKFAGDARDRMLRGVDVLANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEVELEDKFENMGAQMVREVASKT
NDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIEIAVAAVVKDIQKRAKPVASSAEIAQVGTISANGDAPIGKM
IAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDAYILLHEKKLSGLQSMLPVLEAVV
QSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEDLGIKLETVTLKMLGRAK
KVVIDKENTTIVNGAGKKPEIEARVSQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALN
ATRAAVQEGIVPGGGVALLRAKKAVGRISNDNPDVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKTETFGFDA
QTEEYVDMLAKGIVDPAKVVRTALQDASSVASLLVTTEAMVAELPKADAPAMPAGGGMGGMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=55.7034220532319, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=55.7034220532319, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI5453607, Length=547, Percent_Identity=23.0347349177331, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=66.2264150943396, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.820415879017, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193210679, Length=222, Percent_Identity=54.5045045045045, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.6539923954373, Blast_Score=598, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.0075757575758, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.0075757575758, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=53.1428571428571, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=53.1428571428571, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=53.1428571428571, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=46.3235294117647, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=37.7570093457944, Blast_Score=345, Evalue=6e-95,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=37.7570093457944, Blast_Score=345, Evalue=6e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57610; Mature: 57479

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFAGDARDRMLRGVDVLANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
EIAVAAVVKDIQKRAKPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDAYILLHEKKLSGLQSMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLKMLGRAKKVVIDKENTTIVNGAGKKPEIEARVSQIKAQIEETSSDY
HHHCCCCEEEEEHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRISNDNPDVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKTETFGFD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHCCCC
AQTEEYVDMLAKGIVDPAKVVRTALQDASSVASLLVTTEAMVAELPKADAPAMPAGGGMG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMGF
CCCCCCC
>Mature Secondary Structure 
AAKDVKFAGDARDRMLRGVDVLANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEV
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
EIAVAAVVKDIQKRAKPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDAYILLHEKKLSGLQSMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLKMLGRAKKVVIDKENTTIVNGAGKKPEIEARVSQIKAQIEETSSDY
HHHCCCCEEEEEHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRISNDNPDVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKTETFGFD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHCCCC
AQTEEYVDMLAKGIVDPAKVVRTALQDASSVASLLVTTEAMVAELPKADAPAMPAGGGMG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMGF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA