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The map label for this gene is aceK [H]

Identifier: 192288781

GI number: 192288781

Start: 369262

End: 371094

Strand: Reverse

Name: aceK [H]

Synonym: Rpal_0350

Alternate gene names: 192288781

Gene position: 371094-369262 (Counterclockwise)

Preceding gene: 192288782

Following gene: 192288780

Centisome position: 6.46

GC content: 65.41

Gene sequence:

>1833_bases
ATGACCGCCACTGCTTCCCACACCCGCGCCAGGCCGCTCGGTGCCTCCGAGATCGAACACGCCACGCGGATCGCCGAGCC
CGACTTCGACCTGCTCGACGCGCTGTACCGCACCGACGATCCCGACGATCAGGCGCGCCTGCTGGCGCGCGTGGTGCTGT
CGGCCTTCGATAACTATTACGCGGTGTCGCGGCGAATTCCGGCGCTGGCTCAGGCGGCGTTCGAGGCGCGCGACTGGCCG
GTGACGGTGCGGCTGTCGAAGATCCGGATCGGGCTGTACACGGCCTGCATCGACCAGCTGGTGCCGCTGCTGAAAGCCGG
GCTGCCGGAGCTGACGACCGACGAACAGCTCTGGCCGACCGCCGAGGCCGAACTGCTGGCCGCGATCGAGGGCCGCTACG
AGGCCGATTTCGCCTTCGCGTTCTGGCAGTCGCTGCGCCGCAAGCTGGTCAGCGACGAATGGCGGCCGGTGTCCTATGAC
GCCGGCTCCACCGCACGTCGCACAACATCGCCCGCAGCGGTGCTGAAGACGACCACCACCACGCTGCCGATCACCGCCGA
GGTGATCGCCGGGATTCTTGGCGACGCCGGCTTCCGCGTGCCGTGGCGGGATCGCGACGGCGACGCGGCGCTCGCCGCGC
AGGCGATCGAGACGGCGCTGGAGCCGCTCAGCCCGCGGCCCGGCGAACCGGTCAAAATCGAGATCGCCGACGCCGGCTTC
TTCCGCAATCGCGGCGCCTGCCTGGTCGGCCGGATCCAACTGCGCGATCGCGGCGACATGCCGATGCGCAACCTGCCGCT
GCTGATCGCGCTGCTCAACGAGAAGGACGGGCTGGTCGTCGACGCTGTGCTGACCGACAGCGACGAGCTGCAATACGCAT
TCTCCTCGACGCTGGCAAACTATCACGCCACCAATCCGCGCTATCATGAACTGGCCCGGCTGCTTTACGAGCTGATGCCG
AAGCGGCCGCTCGGCACGCAGTACTCGTGCATCGGCTTCCATCACCTCGGCAAGGTCGCGGTGATGAGCGAGATCCTGGC
GGAACATCGCAAGACAAAGGAGAGACTCGCCACCGCGCCAGGCTTCAAGGGAACGGTCGCGATCGCCTTCACGATGCCAT
CGTCGGCCTATGTGCTGAAGATCATCCGCGACCATCCGACCGACGACTACAAGTTCGATTACTTCGACGGCCTCGACGAG
GTGTTGCGCAAATACAACCTGGTGCACGAGATCGACCGCGCCGGCTCGATGCTCGACAACATCATCTATTCCAACGTCAA
GCTCGACCGCGCGATGTTCGCGCCGGAGCTGCTCGATGAACTGCTGGAAGCAGGGATCGGAACGGTGACGCTCGATCGCG
GCGCGCTGGTGTTCCGGCATCTGATCGTGCAGATCAAACTGACGCCGCTCCCGCTGTATCTCGCCAACGCATCCGCAGCC
GAATCCCGCGCCGCGGTGATCAATCTCGGCGATTGCATCAAGAACAACGCCGCGGCCGATATCTTCAACAAAGATCTCGA
CGGCCGCAATTACGGCGTCAGCCGAATCCGCAAAGTCTATCTGTTCGACTACGACGCAGTGGAGCCGCTGACCTCGGTCA
CCGTGAGCCGTGACGGTGCGGCGCCGGGTGAATTCGACAATGGCATGGTGTTCAGGCCGCAGGAGATGCTGGAGGGGCTG
CGGATCGACGACCCCGGCCTGCGCCGCGCCTTCCGCGATGCGCATCCCGAACTGATGCAGGCCGATTATTGGGAAGGCAT
GCAGCGCGCGCTTCGCGACGGCAAGGTGCCGAAGGTGATGAATTATCCGGCGTCGCGGCGGCTGCAACGGTAG

Upstream 100 bases:

>100_bases
TGGCGTGATCGCCCCGGTGGTTCGGTCGGCGGCCGGCTGACAGGTCGGCGCCAACAAGCGGCCGGAGGCGCGAAACGACG
AGATGCGCTGACCCCACGCA

Downstream 100 bases:

>100_bases
GCGCGCGCCGCAGACATCCCGGCCCTTGCCGAACATCGGCGCGGTCTCTACCTGTTCGAGGCTGTTTTTCGGGACGAGGA
CGCCGCCATGCTCGACGCCG

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYYAVSRRIPALAQAAFEARDWP
VTVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPTAEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYD
AGSTARRTTSPAAVLKTTTTTLPITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADAGF
FRNRGACLVGRIQLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLANYHATNPRYHELARLLYELMP
KRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKERLATAPGFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDE
VLRKYNLVHEIDRAGSMLDNIIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAA
ESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGAAPGEFDNGMVFRPQEMLEGL
RIDDPGLRRAFRDAHPELMQADYWEGMQRALRDGKVPKVMNYPASRRLQR

Sequences:

>Translated_610_residues
MTATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYYAVSRRIPALAQAAFEARDWP
VTVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPTAEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYD
AGSTARRTTSPAAVLKTTTTTLPITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADAGF
FRNRGACLVGRIQLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLANYHATNPRYHELARLLYELMP
KRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKERLATAPGFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDE
VLRKYNLVHEIDRAGSMLDNIIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAA
ESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGAAPGEFDNGMVFRPQEMLEGL
RIDDPGLRRAFRDAHPELMQADYWEGMQRALRDGKVPKVMNYPASRRLQR
>Mature_609_residues
TATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYYAVSRRIPALAQAAFEARDWPV
TVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPTAEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYDA
GSTARRTTSPAAVLKTTTTTLPITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADAGFF
RNRGACLVGRIQLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLANYHATNPRYHELARLLYELMPK
RPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKERLATAPGFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDEV
LRKYNLVHEIDRAGSMLDNIIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAAE
SRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGAAPGEFDNGMVFRPQEMLEGLR
IDDPGLRRAFRDAHPELMQADYWEGMQRALRDGKVPKVMNYPASRRLQR

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=581, Percent_Identity=26.3339070567986, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 67979; Mature: 67848

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYY
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AVSRRIPALAQAAFEARDWPVTVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPT
HHHHCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYDAGSTARRTTSPAAVLKTTTT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHEEEECCC
TLPITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADAGF
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
FRNRGACLVGRIQLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLAN
CCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
YHATNPRYHELARLLYELMPKRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKERLATAP
HCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDEVLRKYNLVHEIDRAGSMLDN
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAA
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHEEECCCEEEEECCCCC
ESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGA
CCCEEEEECHHHHCCCCHHHHHHCCCCCCCCCHHHHEEEEEECCHHHCHHHHEEEECCCC
APGEFDNGMVFRPQEMLEGLRIDDPGLRRAFRDAHPELMQADYWEGMQRALRDGKVPKVM
CCCCCCCCCEECHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHH
NYPASRRLQR
CCCHHHHCCC
>Mature Secondary Structure 
TATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYY
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AVSRRIPALAQAAFEARDWPVTVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPT
HHHHCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYDAGSTARRTTSPAAVLKTTTT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHEEEECCC
TLPITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADAGF
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
FRNRGACLVGRIQLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLAN
CCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
YHATNPRYHELARLLYELMPKRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKERLATAP
HCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDEVLRKYNLVHEIDRAGSMLDN
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAA
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHEEECCCEEEEECCCCC
ESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGA
CCCEEEEECHHHHCCCCHHHHHHCCCCCCCCCHHHHEEEEEECCHHHCHHHHEEEECCCC
APGEFDNGMVFRPQEMLEGLRIDDPGLRRAFRDAHPELMQADYWEGMQRALRDGKVPKVM
CCCCCCCCCEECHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHH
NYPASRRLQR
CCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA