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The map label for this gene is coaBC [H]

Identifier: 192288517

GI number: 192288517

Start: 92629

End: 94074

Strand: Reverse

Name: coaBC [H]

Synonym: Rpal_0084

Alternate gene names: 192288517

Gene position: 94074-92629 (Counterclockwise)

Preceding gene: 192288518

Following gene: 192288516

Centisome position: 1.64

GC content: 69.23

Gene sequence:

>1446_bases
ATGGCCAATCTGACGATCCGCAAGCTCGACGACGTCCTCAAATCCGAACTGCGCCAGCGCGCGGCCGCCAACGGCCGCTC
GATGGAGGACGAGGTCCGGGTGATCCTACGCGACGCCTGCCACAAGCGGCTCGGCTTCGCGGAGCCCGCCTCGGCTGACT
TGTCCGTGCCAGCACCTCCCGCAGCCGATGAGCCGGCGGACGGGCCGCGTGCCCAGCCACAGGCCGGCACCGTGCGGGTG
ACGCTGATCGTCGGCGGAGGCATTGCGGCCTACAAGGCGATGGACCTGATCCGCCGGCTCAAGGAGCGCGGCGCCGACGT
CCGTGTGGTGCTGACCAAGGCGGCCCAGCAATTCGTCACGCCGCTGACCGCGAGCGCGCTGTCGCATCAGCGCTGCTACA
CCGACCTGTTCGATCCCTCGAGCGAGTTCGATGCAGGCCACATCCGCCTCGCGCGCGACTGTGACCTGATCGTCGTCGCG
CCCGCGACCGCCGACCTGATGGCCAAGATCGCCGGCGGCCATGCCGACGATCTGGCGACCGCGATCCTACTCGCCACCAA
TCGCCAGATCCTGTTGGCGCCGGCGATGAACCCGCTGATGTGGAACAACGCCGCGACCCGGCGCAACGTCGCCCAGCTCA
AGCAGGACGGCGTCGCAATGGTCGGCCCCAATGCCGGCGAGATGGCCGAGCGCGGCGAGGCCGGCATCGGCCGGATGGCG
GAGCCGACCGAGATTGCGGTCGCGGCCGAAGCGCTGTGGCGGCCGCAGCCGCCAAAGCCGCTGCTCGGCAAGCGCGTGCT
GATCACTGCAGGCCCCACCCATGAGCCGATCGATCCGGTGCGTTACATCGCCAACCGCTCGTCCGGCAAACAAGGCTACG
CAATCGCGGCGGCCGCAGCTGCCGCCGGCGCCGAGGTGGCGCTGATTTCCGGTCCGGTCGAGCTGCGCGCGCCGGCGGGG
GTCGATTGCATCCGCGTGGAGTCAGCCCGCGAGATGCTCGCCGCCGTGCAATCCGCGCTGCCGGCGGATGTGGCGATCTT
CGCCGCCGCGGTGGCGGACTGGCGGGTTGCTGCCGAAGGGATGCAGAAGCTCAAGAAGGGCGCCGCCGGACCGCCACCGC
TGCAGCTCACCGAAAACCCCGACATCCTCGCGATGATCTCGAAGCTGACCGAAGGCCGGCCGCCGCTGGTGATCGGCTTT
GCGGCCGAGACCGAGAATCTGATCGACAACGCGACCGCCAAGCTCGCCCGCAAGGGCTGCGACTGGATCGTCGCCAATGA
CGTCTCGCCGGCCACCGGCGTGATGGGGGGCGACCGCAACACCGTGCATCTGCTGATGCGCCACGATGCCGCCACCGATC
TCGAATCGTGGCCGCTGATGACCAAGGATGAAGTCGCGACCGCGCTGGTGGCGCGGATCGCTCAAGCAATGGCAGTTCAC
GCATGA

Upstream 100 bases:

>100_bases
CGGCGACCTTCATTGGCGTCCTGATCGCGCTATCGCGGATGATCTGATTGCATTGCATTCATCGCTTGAACGCAATGCCT
GCGTCCGCTAGCTTTTCGTT

Downstream 100 bases:

>100_bases
CCCAAAAGATCACCGTTTCGATTCGCCATCTGCCGCACGGCGAAGGCTTGCCGCTGCCGGAGTATCAGACCGCGCACGCC
GCCGGGCTCGACCTGATCGC

Product: bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MANLTIRKLDDVLKSELRQRAAANGRSMEDEVRVILRDACHKRLGFAEPASADLSVPAPPAADEPADGPRAQPQAGTVRV
TLIVGGGIAAYKAMDLIRRLKERGADVRVVLTKAAQQFVTPLTASALSHQRCYTDLFDPSSEFDAGHIRLARDCDLIVVA
PATADLMAKIAGGHADDLATAILLATNRQILLAPAMNPLMWNNAATRRNVAQLKQDGVAMVGPNAGEMAERGEAGIGRMA
EPTEIAVAAEALWRPQPPKPLLGKRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVALISGPVELRAPAG
VDCIRVESAREMLAAVQSALPADVAIFAAAVADWRVAAEGMQKLKKGAAGPPPLQLTENPDILAMISKLTEGRPPLVIGF
AAETENLIDNATAKLARKGCDWIVANDVSPATGVMGGDRNTVHLLMRHDAATDLESWPLMTKDEVATALVARIAQAMAVH
A

Sequences:

>Translated_481_residues
MANLTIRKLDDVLKSELRQRAAANGRSMEDEVRVILRDACHKRLGFAEPASADLSVPAPPAADEPADGPRAQPQAGTVRV
TLIVGGGIAAYKAMDLIRRLKERGADVRVVLTKAAQQFVTPLTASALSHQRCYTDLFDPSSEFDAGHIRLARDCDLIVVA
PATADLMAKIAGGHADDLATAILLATNRQILLAPAMNPLMWNNAATRRNVAQLKQDGVAMVGPNAGEMAERGEAGIGRMA
EPTEIAVAAEALWRPQPPKPLLGKRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVALISGPVELRAPAG
VDCIRVESAREMLAAVQSALPADVAIFAAAVADWRVAAEGMQKLKKGAAGPPPLQLTENPDILAMISKLTEGRPPLVIGF
AAETENLIDNATAKLARKGCDWIVANDVSPATGVMGGDRNTVHLLMRHDAATDLESWPLMTKDEVATALVARIAQAMAVH
A
>Mature_480_residues
ANLTIRKLDDVLKSELRQRAAANGRSMEDEVRVILRDACHKRLGFAEPASADLSVPAPPAADEPADGPRAQPQAGTVRVT
LIVGGGIAAYKAMDLIRRLKERGADVRVVLTKAAQQFVTPLTASALSHQRCYTDLFDPSSEFDAGHIRLARDCDLIVVAP
ATADLMAKIAGGHADDLATAILLATNRQILLAPAMNPLMWNNAATRRNVAQLKQDGVAMVGPNAGEMAERGEAGIGRMAE
PTEIAVAAEALWRPQPPKPLLGKRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVALISGPVELRAPAGV
DCIRVESAREMLAAVQSALPADVAIFAAAVADWRVAAEGMQKLKKGAAGPPPLQLTENPDILAMISKLTEGRPPLVIGFA
AETENLIDNATAKLARKGCDWIVANDVSPATGVMGGDRNTVHLLMRHDAATDLESWPLMTKDEVATALVARIAQAMAVHA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=193, Percent_Identity=32.1243523316062, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=45.2020202020202, Blast_Score=274, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17560194, Length=197, Percent_Identity=31.9796954314721, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322925, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 50654; Mature: 50523

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLTIRKLDDVLKSELRQRAAANGRSMEDEVRVILRDACHKRLGFAEPASADLSVPAPP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AADEPADGPRAQPQAGTVRVTLIVGGGIAAYKAMDLIRRLKERGADVRVVLTKAAQQFVT
CCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
PLTASALSHQRCYTDLFDPSSEFDAGHIRLARDCDLIVVAPATADLMAKIAGGHADDLAT
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHH
AILLATNRQILLAPAMNPLMWNNAATRRNVAQLKQDGVAMVGPNAGEMAERGEAGIGRMA
HHHEECCCEEEEECCCCCHHCCCCHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCC
EPTEIAVAAEALWRPQPPKPLLGKRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAA
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEHHHH
AAGAEVALISGPVELRAPAGVDCIRVESAREMLAAVQSALPADVAIFAAAVADWRVAAEG
HCCCEEEEEECCEEECCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MQKLKKGAAGPPPLQLTENPDILAMISKLTEGRPPLVIGFAAETENLIDNATAKLARKGC
HHHHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
DWIVANDVSPATGVMGGDRNTVHLLMRHDAATDLESWPLMTKDEVATALVARIAQAMAVH
CEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
A
C
>Mature Secondary Structure 
ANLTIRKLDDVLKSELRQRAAANGRSMEDEVRVILRDACHKRLGFAEPASADLSVPAPP
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AADEPADGPRAQPQAGTVRVTLIVGGGIAAYKAMDLIRRLKERGADVRVVLTKAAQQFVT
CCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
PLTASALSHQRCYTDLFDPSSEFDAGHIRLARDCDLIVVAPATADLMAKIAGGHADDLAT
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHH
AILLATNRQILLAPAMNPLMWNNAATRRNVAQLKQDGVAMVGPNAGEMAERGEAGIGRMA
HHHEECCCEEEEECCCCCHHCCCCHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCC
EPTEIAVAAEALWRPQPPKPLLGKRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAA
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEHHHH
AAGAEVALISGPVELRAPAGVDCIRVESAREMLAAVQSALPADVAIFAAAVADWRVAAEG
HCCCEEEEEECCEEECCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MQKLKKGAAGPPPLQLTENPDILAMISKLTEGRPPLVIGFAAETENLIDNATAKLARKGC
HHHHHHCCCCCCCCEECCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
DWIVANDVSPATGVMGGDRNTVHLLMRHDAATDLESWPLMTKDEVATALVARIAQAMAVH
CEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA