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The map label for this gene is ubiB [H]

Identifier: 192288518

GI number: 192288518

Start: 94128

End: 95705

Strand: Reverse

Name: ubiB [H]

Synonym: Rpal_0085

Alternate gene names: 192288518

Gene position: 95705-94128 (Counterclockwise)

Preceding gene: 192288519

Following gene: 192288517

Centisome position: 1.67

GC content: 67.11

Gene sequence:

>1578_bases
GTGATCGCAGCACTCACTCATGTGGCGCGGCTCGGCCGCGCCGCCTTCGTGTTCGCGCGCGAGGGTGTGTTCGGCGTGGT
CGATCCGGCGTTGATTCCGCCCGCCGGTCAGGTGCCGGTGCGGCTGGCGCGGCTGATCGAGCGCCGCGGCGCCAAGTCGG
GGGCGCGGCTGTCGCGGGCGCTGACCCGGCTCGGCCCGGCCTATCTCAAGCTCGGCCAATTTCTCGCCACCCGCCCCGAC
GTCGTCGGCGTCGCGATGGCACGCGATCTCGAAAGCCTGCAGGACCGGTTGCCGCCGTTCTCGCAGGACGAAGCCGAGCA
GGTGATCGCCATTTCGCTGGAGCGGCCGGTCCGCGATCTGTTCGTCAGCCTCAGCCCGCCGGTCGCGGCCGCGTCGATTG
CTCAGGTGCATCGCGGCGAGATCGAACTCGACGGCGTTCGCAAGCAGGTCGCCGTCAAGGTGCTGCGGCCGAACGTGTCG
TCGCGGTTCAGGCGTGACCTGTCCGACTTCTTCTACGTGGCCGAGAAGGCCGAGCTGTACTCCGCTGAAGCGCGGCGGTT
GCGGCTGGTCGAGGTCATCAACACGATGTCGCGCTCGGTCGCGATGGAGATGGACCTGCGGCTGGAAGCGGCCGCGGCGT
CCGAGATGGCCGAGAACACCAAGGACGATCCGGACTTCCGTGTCCCCACCGTCGATTGGGACCGCACCAGCCACAACGTA
CTGACGATGGAGTGGATCGACGGCATCCCGCTGAACGATCACGCCCGTCTCAAAGAAGCCAACGTCGACACCGTCGAGCT
CGGCCGCAAGGTGATCCAGAGCTTCCTGCGCCACGCGCTGCGCGACGGTTTCTTCCACGCCGACATGCATCCGGGCAATC
TGTTCCTGGATCGCGACGGCAAGCTGGTCGCGGTCGATTTCGGCATCATGGGCCGGCTGCTGCCGAAGGAGCGGCGCTTC
CTCGCCGAGATTTTGCTCGGCTTCATCACCCGCAACTATCGCCGCGTCGCCGAGGTACATTTCGAGGCCGGCTACGTGCC
GCCGCATCATTCGGTCGAGAACTTCGCCCAGGCGATCCGTGCCATCGGCGAGCCGATCCACAATCGCCTCGCCGAAGAAA
TCTCGATGGCCAAGCTGCTGACGCTGCTGCTCGAGGTCACCGGCCTGTTCGACATGCGGACCCGGCCGGAGCTGATCCTG
CTGCAGAAGACCATGGTGGTGGTCGAAGGCGTGGCGCGGTCGTTCGATCCCAAGCTCGACATCTGGAAGGTGGCCGACCC
GGTGGTGCGCGAATGGATCCAGCGCAACCTCGGGCCGATCGGCAAGGTCGAGGGCGCGCTGGCTGGCGCCGGCGAGCTCG
GCCACACCCTGACCAGCCTGCCGACCATCGTGTCGCGGGCCGTCACCGTGCTTAATCAGCTTGAGGTGATGACCAAGGAT
GGCCTGGTGCTGGCGCCGGAAACTATCGCCGCGATCGGCCGGACCGAGCGCGGCCGGACCCGAGGCCGGACCGTGGCGCT
GTGGGTGATCGCGGCGACCTTCATTGGCGTCCTGATCGCGCTATCGCGGATGATCTGA

Upstream 100 bases:

>100_bases
CGTATGATTTCGCCGAGATGATGCGCGACGCCGGCTTTGCGCGCGCCAACTGGCAGGTGATGAGCGGCGGCATCGTCGCG
CTGCATTCGGGCTGGCGTTT

Downstream 100 bases:

>100_bases
TTGCATTGCATTCATCGCTTGAACGCAATGCCTGCGTCCGCTAGCTTTTCGTTATGGCCAATCTGACGATCCGCAAGCTC
GACGACGTCCTCAAATCCGA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MIAALTHVARLGRAAFVFAREGVFGVVDPALIPPAGQVPVRLARLIERRGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLESLQDRLPPFSQDEAEQVIAISLERPVRDLFVSLSPPVAAASIAQVHRGEIELDGVRKQVAVKVLRPNVS
SRFRRDLSDFFYVAEKAELYSAEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTSHNV
LTMEWIDGIPLNDHARLKEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDRDGKLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGALAGAGELGHTLTSLPTIVSRAVTVLNQLEVMTKD
GLVLAPETIAAIGRTERGRTRGRTVALWVIAATFIGVLIALSRMI

Sequences:

>Translated_525_residues
MIAALTHVARLGRAAFVFAREGVFGVVDPALIPPAGQVPVRLARLIERRGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLESLQDRLPPFSQDEAEQVIAISLERPVRDLFVSLSPPVAAASIAQVHRGEIELDGVRKQVAVKVLRPNVS
SRFRRDLSDFFYVAEKAELYSAEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTSHNV
LTMEWIDGIPLNDHARLKEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDRDGKLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGALAGAGELGHTLTSLPTIVSRAVTVLNQLEVMTKD
GLVLAPETIAAIGRTERGRTRGRTVALWVIAATFIGVLIALSRMI
>Mature_525_residues
MIAALTHVARLGRAAFVFAREGVFGVVDPALIPPAGQVPVRLARLIERRGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLESLQDRLPPFSQDEAEQVIAISLERPVRDLFVSLSPPVAAASIAQVHRGEIELDGVRKQVAVKVLRPNVS
SRFRRDLSDFFYVAEKAELYSAEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTSHNV
LTMEWIDGIPLNDHARLKEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDRDGKLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGALAGAGELGHTLTSLPTIVSRAVTVLNQLEVMTKD
GLVLAPETIAAIGRTERGRTRGRTVALWVIAATFIGVLIALSRMI

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=341, Percent_Identity=26.099706744868, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=29.3040293040293, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI217035081, Length=248, Percent_Identity=26.2096774193548, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI34147522, Length=256, Percent_Identity=27.34375, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI32261307, Length=370, Percent_Identity=23.2432432432432, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI27363457, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=391, Percent_Identity=38.3631713554987, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17559152, Length=304, Percent_Identity=25.9868421052632, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=453, Percent_Identity=23.6203090507726, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321319, Length=322, Percent_Identity=25.1552795031056, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24662575, Length=329, Percent_Identity=27.0516717325228, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22024280, Length=268, Percent_Identity=24.2537313432836, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859849, Length=294, Percent_Identity=27.2108843537415, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58232; Mature: 58232

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAALTHVARLGRAAFVFAREGVFGVVDPALIPPAGQVPVRLARLIERRGAKSGARLSRA
CCHHHHHHHHHCHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
LTRLGPAYLKLGQFLATRPDVVGVAMARDLESLQDRLPPFSQDEAEQVIAISLERPVRDL
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEHHCCHHHH
FVSLSPPVAAASIAQVHRGEIELDGVRKQVAVKVLRPNVSSRFRRDLSDFFYVAEKAELY
HHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTSHNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIPLNDHARLKEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDRDG
EEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCC
KLVAVDFGIMGRLLPKERRFLAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIR
CEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELILLQKTMVVVEGVARSFDPKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCC
IWKVADPVVREWIQRNLGPIGKVEGALAGAGELGHTLTSLPTIVSRAVTVLNQLEVMTKD
HHHHCCHHHHHHHHHCCCCCCHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVLAPETIAAIGRTERGRTRGRTVALWVIAATFIGVLIALSRMI
CEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIAALTHVARLGRAAFVFAREGVFGVVDPALIPPAGQVPVRLARLIERRGAKSGARLSRA
CCHHHHHHHHHCHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
LTRLGPAYLKLGQFLATRPDVVGVAMARDLESLQDRLPPFSQDEAEQVIAISLERPVRDL
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEHHCCHHHH
FVSLSPPVAAASIAQVHRGEIELDGVRKQVAVKVLRPNVSSRFRRDLSDFFYVAEKAELY
HHHCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SAEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTSHNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
LTMEWIDGIPLNDHARLKEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDRDG
EEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCC
KLVAVDFGIMGRLLPKERRFLAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIR
CEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELILLQKTMVVVEGVARSFDPKLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCC
IWKVADPVVREWIQRNLGPIGKVEGALAGAGELGHTLTSLPTIVSRAVTVLNQLEVMTKD
HHHHCCHHHHHHHHHCCCCCCHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVLAPETIAAIGRTERGRTRGRTVALWVIAATFIGVLIALSRMI
CEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA