Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 190571302

GI number: 190571302

Start: 972412

End: 973029

Strand: Direct

Name: tmk

Synonym: WPa_0905

Alternate gene names: 190571302

Gene position: 972412-973029 (Clockwise)

Preceding gene: 190571298

Following gene: 190571303

Centisome position: 65.59

GC content: 31.07

Gene sequence:

>618_bases
ATGTTCATAACCTTCGAAGGAATAGATGGTTCTGGTAAAACAACACAGTCTGAGTTACTTGCAAATTATTTCAAGCAAAT
TCACGGTGAAAATAATGTCGTATTGACTAGAGAACCAGGTGGTACTGATTTTGCAGAAAAAATAAGAGGATCACTACTTA
AGGATAATATTGATCCCATCTCTGAACTTTTATTATTTACCTCAATGAGATATGAACATATGAAAGAATTAATACTACCA
GCTCTTAAAGAGGGAAAGACAGTTATTTGTGATCGATTTATCGATTCAACTATTGCGTATCAAGGGTATGGACTAGGTGT
TGACTTGAGTCTAATAAGAGACTTACACAAATTAGTGGAAATTAAATATCCAGATATCACATTTATTTTAGATATTGATG
TTCAAGTTGGACTCAGCAGAGCAAAGGATAAAAATAAGTATGAAGAAATGAGCATTGATTTCTATCATAAAATTCGAAAA
GGATTTCAAGAAATAGCTATAAAAGAATCTAATAGATGTAATGTTATTACTGGAATTGCAGATAAAGACAACAATAAAGT
GTATAGTGAAATTATTGATGTAATAAGAAAAAAGAAAAAAGGCATGCAGCCGCTATAA

Upstream 100 bases:

>100_bases
TAGAGAATTGTATACCGTATATAATTTATGATCTTATTGCTTAAATGTCAAATGGTTTCTATGTACACTATTTGCATTTA
GCATTGTAATTATAAAATTT

Downstream 100 bases:

>100_bases
TTTTGTCAATAAATACCCTGAGTTTTTTACTGAATGTTACGATTGAGCCTACAGGTCAAAAACAAGCTTTGAGTTAGAAA
TAACATTGCTATTATAATAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MFITFEGIDGSGKTTQSELLANYFKQIHGENNVVLTREPGGTDFAEKIRGSLLKDNIDPISELLLFTSMRYEHMKELILP
ALKEGKTVICDRFIDSTIAYQGYGLGVDLSLIRDLHKLVEIKYPDITFILDIDVQVGLSRAKDKNKYEEMSIDFYHKIRK
GFQEIAIKESNRCNVITGIADKDNNKVYSEIIDVIRKKKKGMQPL

Sequences:

>Translated_205_residues
MFITFEGIDGSGKTTQSELLANYFKQIHGENNVVLTREPGGTDFAEKIRGSLLKDNIDPISELLLFTSMRYEHMKELILP
ALKEGKTVICDRFIDSTIAYQGYGLGVDLSLIRDLHKLVEIKYPDITFILDIDVQVGLSRAKDKNKYEEMSIDFYHKIRK
GFQEIAIKESNRCNVITGIADKDNNKVYSEIIDVIRKKKKGMQPL
>Mature_205_residues
MFITFEGIDGSGKTTQSELLANYFKQIHGENNVVLTREPGGTDFAEKIRGSLLKDNIDPISELLLFTSMRYEHMKELILP
ALKEGKTVICDRFIDSTIAYQGYGLGVDLSLIRDLHKLVEIKYPDITFILDIDVQVGLSRAKDKNKYEEMSIDFYHKIRK
GFQEIAIKESNRCNVITGIADKDNNKVYSEIIDVIRKKKKGMQPL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=34.1463414634146, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_WOLPP (B3CM94)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975660.1
- EnsemblBacteria:   EBWOLT00000001004
- GeneID:   6385127
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0905
- GeneTree:   EBGT00050000031457
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK13976
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23395; Mature: 23395

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITFEGIDGSGKTTQSELLANYFKQIHGENNVVLTREPGGTDFAEKIRGSLLKDNIDPI
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHH
SELLLFTSMRYEHMKELILPALKEGKTVICDRFIDSTIAYQGYGLGVDLSLIRDLHKLVE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IKYPDITFILDIDVQVGLSRAKDKNKYEEMSIDFYHKIRKGFQEIAIKESNRCNVITGIA
CCCCCEEEEEEECHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DKDNNKVYSEIIDVIRKKKKGMQPL
CCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFITFEGIDGSGKTTQSELLANYFKQIHGENNVVLTREPGGTDFAEKIRGSLLKDNIDPI
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHH
SELLLFTSMRYEHMKELILPALKEGKTVICDRFIDSTIAYQGYGLGVDLSLIRDLHKLVE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IKYPDITFILDIDVQVGLSRAKDKNKYEEMSIDFYHKIRKGFQEIAIKESNRCNVITGIA
CCCCCEEEEEEECHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
DKDNNKVYSEIIDVIRKKKKGMQPL
CCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA