Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 190571303

GI number: 190571303

Start: 973334

End: 975358

Strand: Direct

Name: comEC [H]

Synonym: WPa_0906

Alternate gene names: 190571303

Gene position: 973334-975358 (Clockwise)

Preceding gene: 190571302

Following gene: 190571304

Centisome position: 65.66

GC content: 32.89

Gene sequence:

>2025_bases
ATGATAGTAAATTATATACATAACAATCTGTGCAATGAAAAATGTAACTTGATATTGTGGTTCCCTATTTTTCAGTGTGC
AGGAATTTTAACCTATTTCTCATTAAATTTTGAACCAAGCTGTGCTTTCACTATATCTATTTTTCTCTTGCTTTCACCTA
TACTAATTCTGATTGCAATATTATACAGGAAATACGCAATATTATGCATTTCTTTAATTGCAGTGCTCATAGGATTTACA
GCCAGCAAATTCAGAACAGATTCAGTTAATACTCATATTCTTGATAAGGAAAGGTATGTGAAAGATATTGTTGCTACAGT
GAAGGATATTAACGATAGGGGCTCATATAAACAATTTTTGCTTTATGAAATAAAAAACACGAAGTTCAAGCTGGATAACA
TCAGAATATCAGTTAAAACAAAAGCGGAAGAAGGCATTAAAATAGGGGATCAAGTAAAATTATCAGCAAAACTCTTTCCT
CCAAAAATTGCGCCTTCGGAATATGCATATGATTTTGCAAGAATAGCATATTATCAGAAAATAAGTGCAACAGGCTTTGC
AACAAGCAAAATAGTCCTGTACAAAAAGGCTGAAGCAAGAAAATTTCAAGAGTATATAGAATCTTTCCGTCAATATATCT
ATGAAAACCTACAGCAAAATACCAAAAAGCCACACGCGGACATAATCTCTGCATTATTAATTGGCAAAAAAGACGGGATA
GATCAAAAAACTATGAATGCGATACGAGATTCAGGTATAGCACATTTATTCGCTATATCTGGTTTACATTTATCGTTTGT
TGCTGGTCTATTTTTTATAGTATTCCGTAATTTATTTGCAATATCTGAAACTTTGACTCTTAAATATAACACTAAAAAAA
TATCTGCATTCTTTACTATCTTGCCAACTACCTTTTATTTGTTGATTACCGGTATGCAAATTTCTGCTCAGCGTGCCTAC
ATCATGGTGATCTTGGTACTTGTTGCAATAATCATAGAAAGGAAATATCGAGGATTAATAGCAATTGCGTTTGCTGCTTC
GGTGATACTCATAGTGGAGCCAGAAGCAATCTTAAAGCCAGGTTTTCAAATGTCATTTTCTGCTGTTTTGGCACTAGTTG
CCAGCTATCAGATCAATGCTAATAAGTTATTCAAAATAAAAATAATAAAATATTTTGTGTCGATAATGATCAGCTCAGTC
ATAGCAAGTTTAGCAACTGTTCCGTACACAATATACAATTTTAACTATTTTTCAATCAGTGGCATTATCACAAATTTGAT
TGCTATACCAATAGTTACACTCATTATTATTCCACTTGGAATAATTTATGTTTTATTGATTCCTTTAGGTATTGAATGGA
TTATAGCGCCATTTATAGAGCGCCCAATTGACAGTATCTTGTGTATAACAAATGCAATCGCTAGTCTTCAGTATTTGGTT
ATTCCCACTCGCACTTTTCCTGGCTCATCAATTATTATAATAACACTTGGGTTATTGTGGCTATGCTTGTGGGAAAGGAA
TTGGCGTTTCTTTGGAATTTTCTTTATTGTGCTAGGTATTTTCTCTAGCGCTATGTATACAACTCCTGACATTCTAGTCA
GTGCTGATAATCTTGCTGTAAAAGAAGATGACAATTTACTATATTCCCTTACTAGAAAAAACAGAAATTTTGTTGTCAAA
ACGTGGGCAAAGCAAAACGGGCAGAATCAAATTGTGAATCATACTAAATTCAGTAATTCAAACAAAAGGCTAAAATGTAA
TGATTATGGCTGTATATATAATAAAGGAAATAATAAGTCAGTGTTGCTAGCTCACAAAAGAGAAGATATTTTAGAAAATT
GTAACAATGTCGATCTAGTAATTCAGTTAAGCAAGTTTAACTATCCAGCTTGCAATACTAAAATCATCAAATACGCTGAC
TTAGAGGCATATGGCACACACTCTGTTTGGCTAACAGATAGTGGTATAAAGGTTAGTAAAGTGCGTTCTAATCGTCCTTG
GCATAAGCCAAAAACTTGTTTTTAA

Upstream 100 bases:

>100_bases
CGCGTCGTTGCTTATTTATTATTATATGCGTAATAATAATAAATAAAAGAATAAAATCACACTATTACATATATTTATAT
ATCTATTAACCTTTCTTAAC

Downstream 100 bases:

>100_bases
AGTATCATTTATATATAATTACTTAATTAGGATGTGAGGAAATTTATGCCTTTAGATACAACAAATCCTTTCAATGTTAA
AGTAGATCATAATTTTGCCA

Product: ComEC/Rec2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MIVNYIHNNLCNEKCNLILWFPIFQCAGILTYFSLNFEPSCAFTISIFLLLSPILILIAILYRKYAILCISLIAVLIGFT
ASKFRTDSVNTHILDKERYVKDIVATVKDINDRGSYKQFLLYEIKNTKFKLDNIRISVKTKAEEGIKIGDQVKLSAKLFP
PKIAPSEYAYDFARIAYYQKISATGFATSKIVLYKKAEARKFQEYIESFRQYIYENLQQNTKKPHADIISALLIGKKDGI
DQKTMNAIRDSGIAHLFAISGLHLSFVAGLFFIVFRNLFAISETLTLKYNTKKISAFFTILPTTFYLLITGMQISAQRAY
IMVILVLVAIIIERKYRGLIAIAFAASVILIVEPEAILKPGFQMSFSAVLALVASYQINANKLFKIKIIKYFVSIMISSV
IASLATVPYTIYNFNYFSISGIITNLIAIPIVTLIIIPLGIIYVLLIPLGIEWIIAPFIERPIDSILCITNAIASLQYLV
IPTRTFPGSSIIIITLGLLWLCLWERNWRFFGIFFIVLGIFSSAMYTTPDILVSADNLAVKEDDNLLYSLTRKNRNFVVK
TWAKQNGQNQIVNHTKFSNSNKRLKCNDYGCIYNKGNNKSVLLAHKREDILENCNNVDLVIQLSKFNYPACNTKIIKYAD
LEAYGTHSVWLTDSGIKVSKVRSNRPWHKPKTCF

Sequences:

>Translated_674_residues
MIVNYIHNNLCNEKCNLILWFPIFQCAGILTYFSLNFEPSCAFTISIFLLLSPILILIAILYRKYAILCISLIAVLIGFT
ASKFRTDSVNTHILDKERYVKDIVATVKDINDRGSYKQFLLYEIKNTKFKLDNIRISVKTKAEEGIKIGDQVKLSAKLFP
PKIAPSEYAYDFARIAYYQKISATGFATSKIVLYKKAEARKFQEYIESFRQYIYENLQQNTKKPHADIISALLIGKKDGI
DQKTMNAIRDSGIAHLFAISGLHLSFVAGLFFIVFRNLFAISETLTLKYNTKKISAFFTILPTTFYLLITGMQISAQRAY
IMVILVLVAIIIERKYRGLIAIAFAASVILIVEPEAILKPGFQMSFSAVLALVASYQINANKLFKIKIIKYFVSIMISSV
IASLATVPYTIYNFNYFSISGIITNLIAIPIVTLIIIPLGIIYVLLIPLGIEWIIAPFIERPIDSILCITNAIASLQYLV
IPTRTFPGSSIIIITLGLLWLCLWERNWRFFGIFFIVLGIFSSAMYTTPDILVSADNLAVKEDDNLLYSLTRKNRNFVVK
TWAKQNGQNQIVNHTKFSNSNKRLKCNDYGCIYNKGNNKSVLLAHKREDILENCNNVDLVIQLSKFNYPACNTKIIKYAD
LEAYGTHSVWLTDSGIKVSKVRSNRPWHKPKTCF
>Mature_674_residues
MIVNYIHNNLCNEKCNLILWFPIFQCAGILTYFSLNFEPSCAFTISIFLLLSPILILIAILYRKYAILCISLIAVLIGFT
ASKFRTDSVNTHILDKERYVKDIVATVKDINDRGSYKQFLLYEIKNTKFKLDNIRISVKTKAEEGIKIGDQVKLSAKLFP
PKIAPSEYAYDFARIAYYQKISATGFATSKIVLYKKAEARKFQEYIESFRQYIYENLQQNTKKPHADIISALLIGKKDGI
DQKTMNAIRDSGIAHLFAISGLHLSFVAGLFFIVFRNLFAISETLTLKYNTKKISAFFTILPTTFYLLITGMQISAQRAY
IMVILVLVAIIIERKYRGLIAIAFAASVILIVEPEAILKPGFQMSFSAVLALVASYQINANKLFKIKIIKYFVSIMISSV
IASLATVPYTIYNFNYFSISGIITNLIAIPIVTLIIIPLGIIYVLLIPLGIEWIIAPFIERPIDSILCITNAIASLQYLV
IPTRTFPGSSIIIITLGLLWLCLWERNWRFFGIFFIVLGIFSSAMYTTPDILVSADNLAVKEDDNLLYSLTRKNRNFVVK
TWAKQNGQNQIVNHTKFSNSNKRLKCNDYGCIYNKGNNKSVLLAHKREDILENCNNVDLVIQLSKFNYPACNTKIIKYAD
LEAYGTHSVWLTDSGIKVSKVRSNRPWHKPKTCF

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=286, Percent_Identity=27.6223776223776, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 76523; Mature: 76523

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVNYIHNNLCNEKCNLILWFPIFQCAGILTYFSLNFEPSCAFTISIFLLLSPILILIAI
CEEHHHHHHCCCCCCCEEEEEHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
LYRKYAILCISLIAVLIGFTASKFRTDSVNTHILDKERYVKDIVATVKDINDRGSYKQFL
HHHHHHHHHHHHHHHHHCCCHHHEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHEE
LYEIKNTKFKLDNIRISVKTKAEEGIKIGDQVKLSAKLFPPKIAPSEYAYDFARIAYYQK
EEEECCCEEEEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHH
ISATGFATSKIVLYKKAEARKFQEYIESFRQYIYENLQQNTKKPHADIISALLIGKKDGI
HCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DQKTMNAIRDSGIAHLFAISGLHLSFVAGLFFIVFRNLFAISETLTLKYNTKKISAFFTI
CHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHH
LPTTFYLLITGMQISAQRAYIMVILVLVAIIIERKYRGLIAIAFAASVILIVEPEAILKP
HHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHCC
GFQMSFSAVLALVASYQINANKLFKIKIIKYFVSIMISSVIASLATVPYTIYNFNYFSIS
CCCHHHHHHHHHHHHCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEHH
GIITNLIAIPIVTLIIIPLGIIYVLLIPLGIEWIIAPFIERPIDSILCITNAIASLQYLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
IPTRTFPGSSIIIITLGLLWLCLWERNWRFFGIFFIVLGIFSSAMYTTPDILVSADNLAV
EECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
KEDDNLLYSLTRKNRNFVVKTWAKQNGQNQIVNHTKFSNSNKRLKCNDYGCIYNKGNNKS
ECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCE
VLLAHKREDILENCNNVDLVIQLSKFNYPACNTKIIKYADLEAYGTHSVWLTDSGIKVSK
EEEEECHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEE
VRSNRPWHKPKTCF
ECCCCCCCCCCCCC
>Mature Secondary Structure
MIVNYIHNNLCNEKCNLILWFPIFQCAGILTYFSLNFEPSCAFTISIFLLLSPILILIAI
CEEHHHHHHCCCCCCCEEEEEHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
LYRKYAILCISLIAVLIGFTASKFRTDSVNTHILDKERYVKDIVATVKDINDRGSYKQFL
HHHHHHHHHHHHHHHHHCCCHHHEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHEE
LYEIKNTKFKLDNIRISVKTKAEEGIKIGDQVKLSAKLFPPKIAPSEYAYDFARIAYYQK
EEEECCCEEEEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHH
ISATGFATSKIVLYKKAEARKFQEYIESFRQYIYENLQQNTKKPHADIISALLIGKKDGI
HCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DQKTMNAIRDSGIAHLFAISGLHLSFVAGLFFIVFRNLFAISETLTLKYNTKKISAFFTI
CHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHH
LPTTFYLLITGMQISAQRAYIMVILVLVAIIIERKYRGLIAIAFAASVILIVEPEAILKP
HHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHCC
GFQMSFSAVLALVASYQINANKLFKIKIIKYFVSIMISSVIASLATVPYTIYNFNYFSIS
CCCHHHHHHHHHHHHCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECEEEHH
GIITNLIAIPIVTLIIIPLGIIYVLLIPLGIEWIIAPFIERPIDSILCITNAIASLQYLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
IPTRTFPGSSIIIITLGLLWLCLWERNWRFFGIFFIVLGIFSSAMYTTPDILVSADNLAV
EECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
KEDDNLLYSLTRKNRNFVVKTWAKQNGQNQIVNHTKFSNSNKRLKCNDYGCIYNKGNNKS
ECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCE
VLLAHKREDILENCNNVDLVIQLSKFNYPACNTKIIKYADLEAYGTHSVWLTDSGIKVSK
EEEEECHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEE
VRSNRPWHKPKTCF
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]