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The map label for this gene is murA

Identifier: 190571162

GI number: 190571162

Start: 826361

End: 827638

Strand: Direct

Name: murA

Synonym: WPa_0760

Alternate gene names: 190571162

Gene position: 826361-827638 (Clockwise)

Preceding gene: 190571161

Following gene: 190571163

Centisome position: 55.74

GC content: 35.68

Gene sequence:

>1278_bases
ATGCATAAAATATTAGTAAGAAGTAACCATAAGCCCTTGATTGGAAAAATCAAGATTAATGGTTCAAAGAATGCAGTCTT
GCCAATAATGGCGGCAAGCTTGTTTAGTAATTCTTCAATAACTTTGCATAACGTACCTGATTTAATTGACGTGCATTTGA
TGTCTGAGCTGCTTAAGAGTCTTGGTGCAGAAGTAAATTTTATATGCAATAAAGACTATAAAGCAAATCATACTTTGGAA
ATTGACTGTAGCAATATCAATAACCATTTAATATCACATGAAATTGCAAGCAGACTGCGAGCATCTTTTTTAATGCTAGG
TCCAATGCTCAGCAGATTTGGTAGAGTTTCAACAGTATTTCCTGGTGGATGTAATATTGGAAAACGTCCTGTTGACATTC
ATATCAAGGCACTTGAAGCAATGGGAGCTAAAATTGAAATTGATAGCTGTAATATAACTGCAACAACAAAGGGAAAATTG
CAAGGCAAAGAAATAACATTTGAAAAAGTAAGTGTTGGCGCAACAGAAAACATAATCATGTCAGCAACACTTGCAGAAGG
AGTAACAACAATAAACAATGCCGCAACGGAGCCGGAAGTTCTTGATTTAATAGAGTTTCTGAAGATTATGGGTGCCAATA
TTGAAGTTAATAATACAAAAATCACAATAGAAGGTGTTGAAGCATTAAATGGGTGTGAGCATAAAATAATACCAGATCGC
ATAGAGGCCGGTACTTATGCTTTGGCTGCTATCATTACCGACGGCGAGCTAAAGTTAGAAGGAGTAAGTTTGTCTGATAT
AGAATGTATTGCAAATGAATTGAAGACTATAGGAGCCAGAGTTGAGTTACATGATGATGGTATTATTATTTCTAGAAAAA
ATGGCTCTATTAAATCTGCTCACGTTGCAACAAATCCATATCCCAACTTTCCCAGTGATATGCAACCACAACTAATGTCT
GCTATGTCAATTGCAGGTGGAATATCAATCATTGAAGAGAACGTTTTTGAAAGTAGATTTGCACATGCAAATGAGCTAAG
AAAATTAGGTGCTAATATCAGCATCGAAAAAAATAAAGCTACTATAAGTGGAATAAAGAGCTTATCTGGAGCTAATCTGC
ATGCTAATGACTTAAGGTCAACAGCAGCTTTAATTCTCGCTTCTTTGGTAGCTAAAGGAGAAACTACAATAAATAACTCA
CATCATTTATGGAGAGGATATGAGGCAATGCACGAAAAACTCAATTCATGCGGGGCTGATATTTTCGTTTCATCTTGA

Upstream 100 bases:

>100_bases
CCAGTGTCAGCTACTCGAATGACTGAAGAAGAAAAAGCAAAATTTTGCCTTTTACCGCTAACCTATTATACTTACTTGAT
AAGTTCTATCGCTTGATTAA

Downstream 100 bases:

>100_bases
GGATATATTATGAATGAGACAACTAAGCGAACTACAGTAAAAGAAATAGATGACATTCTATACGAAGAACATAAGGTATT
AGATCATGGATTTGTTCGAG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MHKILVRSNHKPLIGKIKINGSKNAVLPIMAASLFSNSSITLHNVPDLIDVHLMSELLKSLGAEVNFICNKDYKANHTLE
IDCSNINNHLISHEIASRLRASFLMLGPMLSRFGRVSTVFPGGCNIGKRPVDIHIKALEAMGAKIEIDSCNITATTKGKL
QGKEITFEKVSVGATENIIMSATLAEGVTTINNAATEPEVLDLIEFLKIMGANIEVNNTKITIEGVEALNGCEHKIIPDR
IEAGTYALAAIITDGELKLEGVSLSDIECIANELKTIGARVELHDDGIIISRKNGSIKSAHVATNPYPNFPSDMQPQLMS
AMSIAGGISIIEENVFESRFAHANELRKLGANISIEKNKATISGIKSLSGANLHANDLRSTAALILASLVAKGETTINNS
HHLWRGYEAMHEKLNSCGADIFVSS

Sequences:

>Translated_425_residues
MHKILVRSNHKPLIGKIKINGSKNAVLPIMAASLFSNSSITLHNVPDLIDVHLMSELLKSLGAEVNFICNKDYKANHTLE
IDCSNINNHLISHEIASRLRASFLMLGPMLSRFGRVSTVFPGGCNIGKRPVDIHIKALEAMGAKIEIDSCNITATTKGKL
QGKEITFEKVSVGATENIIMSATLAEGVTTINNAATEPEVLDLIEFLKIMGANIEVNNTKITIEGVEALNGCEHKIIPDR
IEAGTYALAAIITDGELKLEGVSLSDIECIANELKTIGARVELHDDGIIISRKNGSIKSAHVATNPYPNFPSDMQPQLMS
AMSIAGGISIIEENVFESRFAHANELRKLGANISIEKNKATISGIKSLSGANLHANDLRSTAALILASLVAKGETTINNS
HHLWRGYEAMHEKLNSCGADIFVSS
>Mature_425_residues
MHKILVRSNHKPLIGKIKINGSKNAVLPIMAASLFSNSSITLHNVPDLIDVHLMSELLKSLGAEVNFICNKDYKANHTLE
IDCSNINNHLISHEIASRLRASFLMLGPMLSRFGRVSTVFPGGCNIGKRPVDIHIKALEAMGAKIEIDSCNITATTKGKL
QGKEITFEKVSVGATENIIMSATLAEGVTTINNAATEPEVLDLIEFLKIMGANIEVNNTKITIEGVEALNGCEHKIIPDR
IEAGTYALAAIITDGELKLEGVSLSDIECIANELKTIGARVELHDDGIIISRKNGSIKSAHVATNPYPNFPSDMQPQLMS
AMSIAGGISIIEENVFESRFAHANELRKLGANISIEKNKATISGIKSLSGANLHANDLRSTAALILASLVAKGETTINNS
HHLWRGYEAMHEKLNSCGADIFVSS

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=422, Percent_Identity=40.521327014218, Blast_Score=327, Evalue=9e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_WOLPP (B3CLV0)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975520.1
- EnsemblBacteria:   EBWOLT00000000727
- GeneID:   6385225
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0760
- GeneTree:   EBGT00050000031372
- HOGENOM:   HBG482701
- OMA:   LVPKAMV
- ProtClustDB:   PRK09369
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45798; Mature: 45798

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKILVRSNHKPLIGKIKINGSKNAVLPIMAASLFSNSSITLHNVPDLIDVHLMSELLKS
CCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHH
LGAEVNFICNKDYKANHTLEIDCSNINNHLISHEIASRLRASFLMLGPMLSRFGRVSTVF
CCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PGGCNIGKRPVDIHIKALEAMGAKIEIDSCNITATTKGKLQGKEITFEKVSVGATENIIM
CCCCCCCCCCEEEEEEEHHHCCCEEEEECCEEEEECCCCCCCCEEEEEEEECCCCCCEEE
SATLAEGVTTINNAATEPEVLDLIEFLKIMGANIEVNNTKITIEGVEALNGCEHKIIPDR
EEHHHHCHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEEEEECHHCCCCCCCCCCCH
IEAGTYALAAIITDGELKLEGVSLSDIECIANELKTIGARVELHDDGIIISRKNGSIKSA
HCCCCEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCEEE
HVATNPYPNFPSDMQPQLMSAMSIAGGISIIEENVFESRFAHANELRKLGANISIEKNKA
EEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
TISGIKSLSGANLHANDLRSTAALILASLVAKGETTINNSHHLWRGYEAMHEKLNSCGAD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCCE
IFVSS
EEEEC
>Mature Secondary Structure
MHKILVRSNHKPLIGKIKINGSKNAVLPIMAASLFSNSSITLHNVPDLIDVHLMSELLKS
CCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHH
LGAEVNFICNKDYKANHTLEIDCSNINNHLISHEIASRLRASFLMLGPMLSRFGRVSTVF
CCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
PGGCNIGKRPVDIHIKALEAMGAKIEIDSCNITATTKGKLQGKEITFEKVSVGATENIIM
CCCCCCCCCCEEEEEEEHHHCCCEEEEECCEEEEECCCCCCCCEEEEEEEECCCCCCEEE
SATLAEGVTTINNAATEPEVLDLIEFLKIMGANIEVNNTKITIEGVEALNGCEHKIIPDR
EEHHHHCHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEEEEECHHCCCCCCCCCCCH
IEAGTYALAAIITDGELKLEGVSLSDIECIANELKTIGARVELHDDGIIISRKNGSIKSA
HCCCCEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCEEE
HVATNPYPNFPSDMQPQLMSAMSIAGGISIIEENVFESRFAHANELRKLGANISIEKNKA
EEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
TISGIKSLSGANLHANDLRSTAALILASLVAKGETTINNSHHLWRGYEAMHEKLNSCGAD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCCE
IFVSS
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA