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The map label for this gene is thyX [H]

Identifier: 190571163

GI number: 190571163

Start: 827648

End: 828490

Strand: Direct

Name: thyX [H]

Synonym: WPa_0761

Alternate gene names: 190571163

Gene position: 827648-828490 (Clockwise)

Preceding gene: 190571162

Following gene: 190571168

Centisome position: 55.83

GC content: 34.16

Gene sequence:

>843_bases
ATGAATGAGACAACTAAGCGAACTACAGTAAAAGAAATAGATGACATTCTATACGAAGAACATAAGGTATTAGATCATGG
ATTTGTTCGAGTAATTGATTATATGGGCTCTGATAGCGCCATAGTTCAAGCTGCTCGCGTTTCTTATGGAAAAGGAACGA
AACAGATAAATCAAGATGAAGCGCTTATAAAGTATTTGATGAGGCATCATCATACAACTCCATTTGAAATGTGTGAAATT
AAGTTTCACGTGAAACTTCCAATTTTTATTGCAAGACAGTGGATAAGACACAGAACTGCAAATGTGAATGAATATTCCGG
AAGGTATTCGATACTTGATAATGAATTTTATATACCAGAACAGGTTGCAAAACAATCTGATAATAATAAACAAGGCAGCG
GTGAAGCTTTTGACTCAAGTACTTCAAAAGAAATAATAGATTCTCTAATAAATGATTCTAATTTAGTATATTCTCATTAT
GAGAAATTTATTGAACAGGGCCTTGCAAGGGAAATTGCCCGAACTAATCTAACACTTAATTACTATACTCAGTTTTATTG
GAAAATAGATTTACACAACCTTCTTCACTTTTTAAGGCTTAGAGCTGATCAGCACGCCCAATATGAAATTAGAGTCTATG
CAGAAGTTATGTTGGACATAGTAAAGAAATGGGTCCCGCTGGCCTATAATGCTTTCATTGAATACTCCTTAAAATCAGCC
TGTATTTCAAAAACTGGTCTTGAAATAATTCGCAAGCTAATAAAAGGAGAAAATGTTGCGAGAGAAGAAAGTGGCATTGG
TAAAAGAGAATGGAATGAGCTGATGTCTATACTTGGTAAATAG

Upstream 100 bases:

>100_bases
AATAAATAACTCACATCATTTATGGAGAGGATATGAGGCAATGCACGAAAAACTCAATTCATGCGGGGCTGATATTTTCG
TTTCATCTTGAGGATATATT

Downstream 100 bases:

>100_bases
CCAAAAAGATCGAGTTATGTCCTTTCACAGACTTGCAGGTGTGAGCAACAATTTATTCATACCTTTATCAACTGATATAT
CAATTATTTTTGAATTTGTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNETTKRTTVKEIDDILYEEHKVLDHGFVRVIDYMGSDSAIVQAARVSYGKGTKQINQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFIARQWIRHRTANVNEYSGRYSILDNEFYIPEQVAKQSDNNKQGSGEAFDSSTSKEIIDSLINDSNLVYSHY
EKFIEQGLAREIARTNLTLNYYTQFYWKIDLHNLLHFLRLRADQHAQYEIRVYAEVMLDIVKKWVPLAYNAFIEYSLKSA
CISKTGLEIIRKLIKGENVAREESGIGKREWNELMSILGK

Sequences:

>Translated_280_residues
MNETTKRTTVKEIDDILYEEHKVLDHGFVRVIDYMGSDSAIVQAARVSYGKGTKQINQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFIARQWIRHRTANVNEYSGRYSILDNEFYIPEQVAKQSDNNKQGSGEAFDSSTSKEIIDSLINDSNLVYSHY
EKFIEQGLAREIARTNLTLNYYTQFYWKIDLHNLLHFLRLRADQHAQYEIRVYAEVMLDIVKKWVPLAYNAFIEYSLKSA
CISKTGLEIIRKLIKGENVAREESGIGKREWNELMSILGK
>Mature_280_residues
MNETTKRTTVKEIDDILYEEHKVLDHGFVRVIDYMGSDSAIVQAARVSYGKGTKQINQDEALIKYLMRHHHTTPFEMCEI
KFHVKLPIFIARQWIRHRTANVNEYSGRYSILDNEFYIPEQVAKQSDNNKQGSGEAFDSSTSKEIIDSLINDSNLVYSHY
EKFIEQGLAREIARTNLTLNYYTQFYWKIDLHNLLHFLRLRADQHAQYEIRVYAEVMLDIVKKWVPLAYNAFIEYSLKSA
CISKTGLEIIRKLIKGENVAREESGIGKREWNELMSILGK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 32735; Mature: 32735

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETTKRTTVKEIDDILYEEHKVLDHGFVRVIDYMGSDSAIVQAARVSYGKGTKQINQDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
ALIKYLMRHHHTTPFEMCEIKFHVKLPIFIARQWIRHRTANVNEYSGRYSILDNEFYIPE
HHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHH
QVAKQSDNNKQGSGEAFDSSTSKEIIDSLINDSNLVYSHYEKFIEQGLAREIARTNLTLN
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
YYTQFYWKIDLHNLLHFLRLRADQHAQYEIRVYAEVMLDIVKKWVPLAYNAFIEYSLKSA
EEEEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CISKTGLEIIRKLIKGENVAREESGIGKREWNELMSILGK
HHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNETTKRTTVKEIDDILYEEHKVLDHGFVRVIDYMGSDSAIVQAARVSYGKGTKQINQDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
ALIKYLMRHHHTTPFEMCEIKFHVKLPIFIARQWIRHRTANVNEYSGRYSILDNEFYIPE
HHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHH
QVAKQSDNNKQGSGEAFDSSTSKEIIDSLINDSNLVYSHYEKFIEQGLAREIARTNLTLN
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
YYTQFYWKIDLHNLLHFLRLRADQHAQYEIRVYAEVMLDIVKKWVPLAYNAFIEYSLKSA
EEEEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CISKTGLEIIRKLIKGENVAREESGIGKREWNELMSILGK
HHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA